Person: BOZKURTLAR, EMİNE
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
BOZKURTLAR
First Name
EMİNE
Name
8 results
Search Results
Now showing 1 - 8 of 8
Publication Metadata only Protective effect of cysteinyl leukotriene receptor antagonist montelukast in bleomycin-induced pulmonary fibrosis(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2018) CEYHAN, BERRİN; Topaloglu, Nurhayat; Yildizeli, Sehnaz Olgun; Sener, Goksel; Lacin, Tunc; Sehirli, Ozer; Bozkurtlar, Emine; Celikel, Cigdem; Ceyhan, BerrinBackground: This study aims to investigate the early- and late-term effects of pharmacological inhibition of cysteinyl leukotriene activity by using montelukast in bleomycin-induced inflammatory and oxidative lung injury in an animal model. Methods: The study included 48 male Wistar albino rats (weighing 250 g to 300 g). Rats were administered intratracheal bleomycin or saline and assigned into groups to receive montelukast or saline. Bronchoalveolar lavage fluid and lung tissue samples were collected four and 15 days after bleomycin administration. Results: Bleomycin resulted in significant increases in tumor necrosis factor-alpha levels (4.0 +/- 1.4 pg/mL in controls vs. 44.1 +/- 14.5 pg/mL in early-term vs. 30.3 +/- 5.7 pg/mL in late-term, p<0.001 and p<0.001, respectively), transforming growth factor beta 1 levels (28.6 +/- 6.6 pg/mL vs. 82.3 +/- 14.1 pg/mL in early-term vs. 60.1 +/- 2.9 pg/mL in late-term, p<0.001 and p<0.001, respectively), and fibrosis score (1.85 +/- 0.89 in early-term vs. 5.60 +/- 1.14 in late-term, p<0.001 and p<0.01, respectively). In bleomycin exposed rats, collagen content increased only in the late-term (15.3 +/- 3.0 mu g/mg in controls vs. 29.6 +/- 9.1 mu g/mg in late-term, p<0.001). Montelukast treatment reversed all these biochemical indices as well as histopathological alterations induced by bleomycin. Conclusion: Montelukast attenuates bleomycin-induced inflammatory and oxidative lung injury and prevents lung collagen deposition and fibrotic response. Thus, cysteinyl leukotriene receptor antagonists might be regarded as new therapeutic agents for idiopathic pulmonary fibrosis.Publication Open Access Is Laboratory Prognostic Index a Valuable Prognostic Index for Malignant Pleural Mesothelioma?(ELSEVIER SCIENCE INC, 2019-10) BOZKURTLAR, EMİNE; Tuylu, T. Basoglu; Demircan, N. C.; Arikan, R.; Telli, T. Akin; Alan, O.; Ercelep, O.; Bozkurtlar, E.; Kocakaya, D.; Kaya, S.; Babacan, N.; Lacin, T.; Dane, F.; Ahiskali, R.; Batirel, H.; Yumuk, P. F.Publication Open Access Problems in the reproducibility of classification of small lung adenocarcinoma: an international interobserver study(2019-11-01) BOZKURTLAR, EMİNE; Shih A. R., Uruga H., BOZKURTLAR E., Chung J., Hariri L. P., Minami Y., Wang H., Yoshizawa A., Muzikansky A., Moreira A. L., et al.Aims The 2015 WHO classification for lung adenocarcinoma (ACA) provides criteria for adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (INV), but differentiating these entities can be difficult. As our understanding of prognostic significance increases, inconsistent classification is problematic. This study assesses agreement within an international panel of lung pathologists and identifies factors contributing to inconsistent classification. Methods and results Sixty slides of small lung ACAs were reviewed digitally by six lung pathologists in three rounds, with consensus conferences and examination of elastic stains in round 3. The panel independently reviewed each case to assess final diagnosis, invasive component size and predominant pattern. The kappa value for AIS and MIA versus INV decreased from 0.44 (round 1) to 0.30 and 0.34 (rounds 2 and 3). Interobserver agreement for invasion (AIS versus other) decreased from 0.34 (round 1) to 0.29 and 0.29 (rounds 2 and 3). The range of the measured invasive component in a single case was up to 19.2 mm among observers. Agreement was excellent in tumours with high-grade cytology and fair with low-grade cytology. Conclusions Interobserver agreement in small lung ACAs was fair to moderate, and improved minimally with elastic stains. Poor agreement is primarily attributable to subjectivity in pattern recognition, but high-grade cytology increases agreement. More reliable methods to differentiate histological patterns may be necessary, including refinement of the definitions as well as recognition of other features (such as high-grade cytology) as a formal part of routine assessment.Publication Open Access Immunohistochemical expression of plasminogen activator inhibitor-1 in subcutaneous versus omental adipose tissue in patients after elective abdominal surgery(2019) BOZKURTLAR, EMİNE; Yildiz, Mehmet; Bozkurtlar, Emine; Azizy, Abdulmunir; Agirbasli, MehmetPlasminogen activator inhibitor-1 (PAI-1) is a biomarker of thrombosis. Adipose and vascular tissues are among the major sources of PAI-1 production. Previous studies indicated that fat deposits mediate increased cardiovascular risk among obese individuals. We investigated the immunohistochemical (IHC) expression of PAI-1 in adipose and vascular tissues from the omentum and the subcutaneous tissue. The pathology samples were selected from 37 random patients who underwent elective abdominal surgery between 2008-2009. PAI-1 expression was semi-quantitatively scored and compared between the groups. Significant differences were noted in the IHC expression of PAI-1 between the omental and the subcutaneous adipose tissues (1.1 ± 0.8 versus 0.8 ± 0.6, respectively (p=0.05)). Adipose tissue displayed higher IHC expression of PAI-1 compared to vascular wall tissue in both omentum and subcutaneous sections (1.1 ± 0.8 versus 0.5 ± 0.9 (p=0.004), and 0.8 ± 0.6 versus 0.4 ± 0.6 (p=0.003), respectively). In conclusion, our study compared PAI-1 expression in the omentum versus the subcutaneous tissue and adipose versus vascular tissues. IHC expression of PAI-1 level was significantly higher in the omental adipose tissue compared to the subcutaneous adipose tissue. Adipose tissue displayed significantly higher PAI-1 expression than vascular tissue. The study elucidates the biological differences of adipose and vascular tissue from subcutaneous versus omental sections.Publication Open Access Ebus: hasta başı değerlendi̇rmeni̇n önemi̇(2018-03-06) BOZKURTLAR, EMİNE; OLGUN YILDIZELİ, ŞEHNAZ; KOCAKAYA, DERYA; BOSTANCI, KORKUT; AHISKALI, ASİYE RENGİN; BOZKURTLAR E., ERÇETİN Y., OLGUN YILDIZELİ Ş., KOCAKAYA D., BOSTANCI K., AHISKALI A. R.Amaç: Endobronşial ultrasonografi (EBUS) aracılı biyopsi tüm dünyada yaygın olarak kullanılan ve hastaların morbidite sebebi olabilecek mediastinoskopi gibi işlemlerden kaçınmasını sağlayabilen kabul görmüş bir yöntemdir. Yapılan çalışmalarla duyarlılığı ve özgüllüğü kanıtlanmış bu yöntemin yakın zamanda merkezimizdeki uygulamalarda ortaya koyduğu sonuçları ve bunların klinikopatolojik yansımasını göstermeyi amaçlıyoruz. Gereç ve Yöntem: Mayıs 2016-Temmuz 2017 tarihleri arasında Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastanesi Patoloji Laboratuvarın’da değerlendirilen EBUS aracılı biyopsiler çalışmamıza alınmıştır. Olgulara ait klinik bilgiler retrospektif olarak merkezimiz sistemi üzerinden ve patolog eşliğinde işlem yapılan olgularda olgu patoloji formu üzerine patolog tarafından alınan notlardan elde edilmiştir. Bulgular: Toplam 61 olgunun değerlendirildiği çalışmamızda, 3 olguya 2 defa EBUS aracılı biyopsi uygulandığı görülmüştür. Bu olguların yalnız 5’inde hasta başı değerlendirme yapılmamıştır. Olgularda ortalama yaş 58, kadın/erkek oranı 20/41’dir. Olguların ön tanılarında sırasıyla malignite (%70, n=42), sarkoidoz (%30, n=18), enfeksiyon (tüberküloz dahil)(%16, n=10), lenfoma (%3, n=2) ve son olarak moleküler inceleme için yeni tümör dokusu (%2, n=1) yer almaktadır. Elli beş (%90) olguda mediastinal lenf noduna girilmiş, 4 (%7) olguda akciğerdeki kitleye, 2 (%3) mediastendeki kitleye ve 1 (%2) olguda hiler lenf noduna girilmiştir. Olgu başına yapılan ortalama girişim sayısı 4’tür. Dokuz olguda yetersiz sitolojik materyal değerlendirmesi yapılmıştır. Bu olguların 2’sinde hasta başı değerlendirme yapılamamış, 3 olguda 1’er girişim sonrası hasta uyumsuzluğu veya lezyon/lezyonların uygunsuzluğu nedeniyle işlem sonlandırılmak zorunda kalınmış, 4 olguda hasta başı değerlendirmede yetersiz ya da sınırlı sayıda hücre içeren materyal olduğu bildirilmiş kalıcı patolojik incelemede olgulara ait tüm materyal incelendiğinde tanı için yeterli materyalin olmadığı görülmüştür. Olguların kalıcı patoloji incelemesi/ hasta başı değerlendirme uyumuna bakacak olursak malignite pozitif olgularda %100 uyum (18/18) saptanırken, yetersiz olguları göz ardı edersek, malignite negatif olgularda da uyum %100 olarak saptanmaktadır. Granülom olarak raporlanan olgularda uyum %70 (10/7) olarak saptanmıştır. Malignite pozitif olgularımızdan 5’inde klinik istek üzerine hücre bloklarından moleküler inceleme yapılmış, bir olgudaki EGFR mutasyonu incelemesi açısından yetersizlik dışında, EGFR-ALK-ROS1 moleküler incelemelerinin tamamından sonuç alınabilmiştir. Sonuç EBUS aracılı biyopsi uygulamalarında klinik ön tanılarda sıkça yer alan malignite ve granülomatöz patolojiler çalışmamızda özellikle ele alınmıştır. Malignite pozitif olgularda hasta başı değerlendirme ve kalıcı patoloji incelemeleri uyumu %100 olarak saptanmıştır. Bu durum başta yeni tanı alan olgular olmak üzere klinik yönlendirmede hızlı ve doğru adımlar atılmasını sağlamaktadır. Ayrıca hasta başı değerlendirmenin “yetersiz” patoloji raporlarının sayısını azaltacağını düşündürmektedir. Aynı değerlendirme granülomatöz patolojiler açısından yapıldığında %70 olarak bulunmuştur. Bunun sebebinin büyük oranda işlem sırasındaki patoloji incelemesinde olguya ait tüm yayma lamlarının ve hücre bloğunun incelenememesinden kaynaklandığı görülmüştür.Publication Metadata only Is Perineural Invasio (PN) a Determinant of Disease Free Survival in Early Stage Colorectal Cancer?(H G E UPDATE MEDICAL PUBLISHING S A, 2015) ÇELİKEL, ÇİĞDEM; Ozturk, Mehmet Akif; Dane, Faysal; Karagoz, Sila; Tural, Deniz; Selcukbiricik, Fatih; Demirelli, Fuat; Buyukunal, Evin; Ozguroglu, Mustafa; Turna, Hande; Erdamar, Sibel; Celikel, Cigdem Ataizi; Bozkurtlar, Emine Bas; Yumuk, Perran Fulden; Mandel, Nil Molinas; Turhal, Nazim Serdar; Serdengecti, SuheylaBackground/Aims: The prognostic importance of perineural invasion (PN) in colorectal cancer (CRC) is unclear. The aim of this study to find out whether the PN was an independent stratification factor of postoperative relapse in curatively resected high-risk stage II & III CRC patients who were treated with adjuvant therapy. Methodology: Data of patients with high risk stage II & all stage III CRCs treated with adjuvant chemotherapy were retrospectively analyzed. Pathological features of final surgical specimen were noted. Disease-free survival was determined by Kaplan-Meier estimator, with differences determined by multivariate analysis using the Cox multiple hazards model. Results were compared using the log-ranktest. Results: PN was found to be positive in 26% in the files of 593 eligible patients. In 21% of the reports PN status was not reported. Presence of PN in the resected primary tumors did not have independent effect on DFS. Further analyses for importance of PN on DFS of colon or rectal cancers did not show any effect. Conclusions: This study had failed to demonstrate any prognostic effect of PN for DFS in surgically resected stage II and III CRC patients who received adjuvant treatments.Publication Open Access Macroscopic complete resection is not associated with improved survival in patients with malignant pleural mesothelioma(2018-06) YILDIZELİ, BEDRETTİN; Batirel, Hasan Fevzi; Metintas, Muzaffer; Caglar, Hale Basak; Ak, Guntulu; Yumuk, Perran Fulden; Ahiskali, Rengin; Bozkurtlar, Emine; Bekiroglu, Nural; Lacin, Tunc; Yildizeli, Bedrettin; Yuksel, MustafaPublication Open Access Should We Perform Thoracic Imaging for Every Patient with a Renal Mass?(GALENOS YAYINCILIK, 2016-09-23) BOZKURTLAR, EMİNE; Sahan, Ahmet; Garayev, Asgar; Akgul, Murat; Sener, Tarik Emre; Evman, Serdar; Batirel, Hasan; Bozkurtlar, Emine Bas; Ahiskali, Rengin; Turkeri, Levent; Tinay, IlkerObjective: Current guidelines for the management of renal mass recommend thoracic imaging for potential metastatic nodules. Small size of the renal mass can be associated with low metastatic potential, which might question the necessity of thoracic imaging in this patient population. This study sought to evaluate the association of thoracic imaging findings with the renal mass characteristics in patients with pathologically proven renal cell carcinoma (RCC). Materials and Methods: We performed a retrospective analysis of patients with RCC, who underwent radical/partial nephrectomy and had baseline thoracic imaging available for review. Patients with a suspicious pulmonary mass were evaluated by the Department of Thoracic Surgery. Presence of lung nodule(s) and metastasis was determined and compared with patient and renal mass characteristics. Results: A total of 215 patients were included in the study. Pulmonary nodules suspicious for malignancy were present in 26.8% of the cases and 42% of these patients underwent further examination for the presence of a pulmonary mass. Pathological examination of the pulmonary nodule revealed RCC metastasis in 80% of patients who underwent biopsy or excision of the pulmonary nodule. Of note, in the subgroup analysis according to the pathological stage of the renal mass, 19.3% of patients with pT1a disease had a suspicious pulmonary mass on thoracic imaging. Of these patients, 25% underwent further examination of the pulmonary nodule with a RCC metastasis in 66.6%. Conclusion: The presence of suspicious lung nodules in patients with RCC has metastatic potential regardless of the size of the renal mass. These findings underscore the importance of baseline thoracic imaging and vigilant further evaluation of patients in whom pulmonary nodules are identified.