Person:
TAŞKIN, TURGUT

Profile Picture

Email Address

Birth Date

Research Projects

Organizational Units

OrgUnit Logo
Organizational Unit

Job Title

Last Name

TAŞKIN

First Name

TURGUT

Name

Filters

2019 - 201922020 - 20232
Reset filters

Settings

Author: KABASAKAL, LEVENT × Subject: Klinik Tıp (MED) ×

Search Results

Now showing 1 - 4 of 4
  • No Thumbnail Available
    PublicationMetadata only
    Evaluation of antioxidant, analgesic, anti-inflammatory and antispasmodic activity and genotoxic effect of micromeria fruticosa subsp brachycalyx in vitro and in vivo
    (2021-07-22) KABASAKAL, LEVENT; TAŞKIN, TURGUT; AYDEMİR, SEZGİN; BECEREN, AYFER; Çelikkol I., Beceren A., Kabasakal L., Taşkın T., Aydemir S.
    EVALUATION OF ANTIOXIDANT, ANALGESIC AND ANTIINFLAMMAUTORY ACTIVITY AND GENOTOXIC EFFECT OF MICROMERIA FRUTICOSA SUBSP BRACHYCALYX IN VITRO AND IN VIVO1Celikkol I., 2Beceren A., 3Kabasakal L., 4Taskin T., 5Aydemir S.1Marmara University, Institute of Health Sciences, Department of Pharmaceutical Toxicology Istanbul, Turkey, celikkolisik@gmail.com 2Marmara University, Department of Pharmaceutical Toxicology, Istanbul, Turkey, ayfertozan@hotmail.com 3Marmara University, Department of Pharmacology, Istanbul, Turkey, lkabasakal@gmail.com 4Marmara University, Department of Pharmacognosy, Istanbul, Turkey, turguttaskin@marmara.edu.tr 5Marmara University, Vocational School of Health Services, Department of Medical Services and Techniques, Istanbul, Turkey, szgnaydemir@gmail.comIntroduction: Today, antioxidants have been using diversely in various medical conditions. Therefore, there are growing interest for discovering and developing more effective and safer antioxidants derived from natural sources. Certain Micromeria species were identified as a rich source of antioxidant agents (1). This study aimed to investigate possible antioxidant activity and genotoxicity of Micromeria fruticosa subsp brachycalyx in methanol extract both in vitro and in vivo.Materials and Methods: In vitro antioxidant activity of Micromeria fruticosa subsp brachycalyx in methanol extract was evaluated by DPPH, ABTS, FRAP and CUPRAC assays. In vivo analyses performed on Balb/c mice that divided to three groups (n=6 for each group) as control group (%0,04 Carboxymethyl cellulose solution (CMC), 0,1 mL/10 g, p.o.), positive control group (Indomethacin in %0,04 CMC, 10 mg/kg, p.o.) and treatment group (Micromeria extract in %0,04 CMC, 200 mg/kg, p.o.) and each regimen was applied for 10 days. Myeloperoxidase levels were analyzed in mice liver and kidney tissues. Genotoxic effect was determined in mice blood with Comet Technique. The 8-hydroxy-2’-deoxyguanosine was analyzed in mice liver and kidney tissues with commercial ELISA kit. Results: The results showed that plant extract showed stronger DPPH radical scavenging activity, however, lower ABTS, CUPRAC and FRAP values versus to standards. According to the graph, which shows the elapsed time (second) in pain behavior versus time (minute) for each group, treatment group exhibited its efficacy in late phase (20-30 min) similar with indomethacin group. Myeloperoxidase levels in liver tissues of the extract group were significantly lower compared to the control group (p<0.05). Myeloperoxidase levels in kidney tissues of the extract group were not significantly different compared to both control and indomethacin group. Micromeria fruticosa subsp brachycalyx extract exerted no genotoxic effect on DNA similarly both control and indomethacin group.Conclusions: Our study showed that Micromeria fruticosa subsp brachycalyx has a potential antioxidant activity. It has also been contributed to raise awareness to this species in terms of its safety with the obtained results. Therefore, the usage of this species as natural antioxidant source is promising for new drug candidates.Acknowledgements:Not available.References: 1. Salameh N et al., (2020) Screening of Antioxidant and Antimicrobial Activity of Micromeria fruticosa serpyllifolia Volatile Oils: A Comparative Study of Plants Collected from Different Regions of West. BioMed Research International, 1-7.
  • No Thumbnail Available
    PublicationMetadata only
    Investigation of antineoplastic activity of achillea nobilis subsp. Neilreichii plant in experimental breast cancer
    (2019-07-03) YAVUZ, AYŞE NUR; EKENTOK ATICI, CEYDA; TAŞKIN, TURGUT; ÖZBAŞ, SUNA; KABASAKAL, LEVENT; Sehlan S. S., Yavuz A. N., Ekentok Atıcı C., Taşkın T., Alan S., Özbaş S., Kabasakal L.
  • No Thumbnail Available
    PublicationMetadata only
    The effects of some traditional medical plants and beta amyloid protein in cell viability
    (2019-07-03) YAVUZ, AYŞE NUR; EKENTOK ATICI, CEYDA; TAŞKIN, TURGUT; ÖZBAŞ, SUNA; KABASAKAL, LEVENT; Saleh Al-Rabeei M. A., Yavuz A. N., Ekentok Atıcı C., Taşkın T., Özbaş S., Kabasakal L.
  • Thumbnail Image
    PublicationOpen Access
    The methanolic extracts of Teucrium polium L. and Micromeria fruticosa (L.) Druce subsp. brachycalyx P. H. Davis improve diabetes in streptozotocin/nicotinamide-induced type 2 diabetic female Sprague Dawley rats
    (2023-12-01) ÇAM, MUHAMMET EMİN; YAVUZ, AYŞE NUR; TAŞKIN, TURGUT; KABASAKAL, LEVENT; ELÇİOĞLU, HATİCE KÜBRA; Sermet S., ÇAM M. E., YAVUZ A. N., TAŞKIN T., Kabatas G. S., YAZIR Y., KABASAKAL L., ELÇİOĞLU H. K.
    Background: Teucrium polium and Micromeria fruticosa subspecies are known to be used in traditional medicine for diabetes treatment. Objective: The present study aimed to examine the potential antidiabetic effects and the mechanisms of antidiabetic actions of Teucrium polium L. methanolic extract (TP) and Micromeria fruticosa (L.) Druce subsp. brachycalyx P. H. Davis methanolic extract (MF) on rats with type 2 diabetes mellitus (DM). Methods: Streptozotocin (STZ) and nicotinamide (NA) were injected intraperitoneally to induce type 2 diabetes mellitus (T2DM) in rats. Plant extracts’ antidiabetic mechanisms of action were investigated with biochemical analyses and histopathological analyses performed. Results: TP and MF treatments reduced the blood glucose levels compared to the untreated diabetic rats. TP reduced TNF-α levels in serum, increased insulin levels in serum and pancreas, reduced SGLT-2 levels in kidneys, reduced GLUT-2 levels in the ileum; and MF reduced TNF-α levels, and increased insulin levels in serum and pancreas, increased GLP-1 levels, and reduced GLUT-2 levels in the ileum, and reduced SGLT-2 levels in kidneys. Treatments improved the histopathological results in the pancreas, kidney, and liver. Conclusions: The results presented in this study demonstrated that TP and MF both have potential antidiabetic effects and may be effective in T2DM treatment.