Person: TAŞKIN, TURGUT
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
TAŞKIN
First Name
TURGUT
Name
58 results
Search Results
Now showing 1 - 10 of 58
Publication Open Access Biological evaluation of Stachys iberica subsp. stenostachya (Boiss.) Rech.f. and Scutellaria orientalis subsp. sosnowskyi (Takht.) Fed. growing in eastern Anatolia(2021-09-01) TAŞKIN, TURGUT; GÜLSOY TOPLAN G., CİVAŞ A., MATARACI KARA E., TAŞKIN T., ECEVİT GENÇ G.Publication Metadata only Development of Satureja cuneifolia-loaded sodium alginate/polyethylene glycol scaffolds produced by 3D-printing technology as a diabetic wound dressing material(ELSEVIER, 2020) OKTAR, FAİK NÜZHET; Ilhan, Elif; Cesur, Sumeyye; Guler, Ece; Topal, Fadime; Albayrak, Deniz; Guncu, Mehmet Mucahit; Cam, Muhammet Emin; Taskin, Turgut; Sasmazel, Hilal Turkoglu; Aksu, Burak; Oktar, Faik Nuzhet; Gunduz, OguzhanAcute wounds are a common health problem, with millions of people affected and decreased granulation tissue formation and vascularization, it is also a big challenge for wound care researchers to promote acute wound healing around the globe. This study aims to produce and characterize Satureja cuneifolia plant extract (SC) blended with sodium alginate (SA) /polyethylene glycol (PEG) scaffolds for the potential treatment of diabetic ulcer. SA/PEG scaffolds were prepared by adding different concentrations (1, 3, and 5 wt%) of PEG to 9 wt% SA. The morphological and chemical composition of the resulting 3D printed composite scaffolds was determined using scanning electron microscopy (SEM) and Fourier transforms infrared spectroscopy (FTIR), respectively. Mechanical and thermal properties, swelling, and degradation behaviours were also investigated. The release kinetics of SC were performed. The antimicrobial analysis was evaluated against Escherichia coli and Staphylococcus aureus strains. 3D printed scaffolds have shown an excellent antibacterial effect, especially against gram-positive bacteria due to the antibacterial SC extract they contain. Furthermore, the cell viability of fibroblast (L929) cells on/within scaffolds were determined by the colourimetric MTT assay. The SA/PEG/SC scaffolds show a great promising potential candidate for diabetic wound healing and against bacterial infections. (c) 2020 Elsevier B.V. All rights reserved.Publication Metadata only Novel lutetium(III) phthalocyanine-coumarin dyads; synthesis, characterization, photochemical, theoretical and antioxidant properties(ELSEVIER SCIENCE SA, 2021) YALÇIN, BAHATTİN; Ozdemir, Mucahit; Koksoy, Baybars; Yalcin, Bahattin; Taskin, Turgut; Selcuki, Nursel Acar; Salan, Umit; Durmus, Mahmut; Bulut, MustafaIn this study, novel 7-oxy-3-ethyl-6-hexyl-4-methylcoumarin substituted lutetium(III) phthalocyanine compounds were synthesized, characterized and their photochemical, theoretical, and antioxidant properties were examined. All complexes were characterized by common spectroscopic methods such as FT-IR, UV?vis, 1H NMR, MALDI-TOF-MS and elemental analysis as well. Geometry optimization of phthalocyanine compounds was calculated in the B3LYP functional using 6-31G (d, p) + SDD basis set of the Density Functional Theory. Aggregation, singlet oxygen generation, and photodegradation behavior under light irradiation of the complexes (1?4) were investigated in dimethylformamide. The three phthalocyanine compounds (1, 2, and 4) showed a high level of singlet oxygen efficiency were compared with the unsubstituted zinc(II) and lutetium(III) phthalocyanine compounds because their quantum yield values were found to be over 0.80. The radical cation scavenging activities of the compounds 3 (120.344 mM trolox/mg) and 4 (188.733 mM trolox/mg) are quite remarkable in 2,2?-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid analysis according to butylated hydroxyanisole (52.63 mM trolox/mg).Publication Open Access In vitro carbonic anhydrase inhibitory effects of the extracts of satureja cuneifolia(2021-11-01) TAŞKIN, TURGUT; AYDIN F. G., TÜRKOĞLU E. A., KUZU M., TAŞKIN T.Carbonic anhydrases catalyze the interconversion between carbon dioxide and bicarbonate. Carbonic anhydrase inhibition has therapeutic importance and there are many drugs which use this mechanism. Carbonic anhydrase inhibitors are used as diuretic, antiglaucoma, antitumor and antiepileptic agents. As an alternative for synthetic chemicals with strong side effects, natural products have gained popularity in the recent years. In this study, Satureja cuneifolia, a medicinal plant used as folk medicine, was investigated for its inhibition effects on carbonic anhydrase I and II enzymes. Four different extracts were obtained with maceration method and three different solvents were used. The results have shown that methanol extracts of Satureja cuneifolia has the strongest inhibition activity on the enzymes with the IC50 values of 31 µg/mL for hCA I and 12 µg/mL for hCA II. Further purification and analytical studies will be needed to obtain the active natural molecules and their potential for pharma and food industries.Publication Open Access Antioxidant and antimicrobial activities of various extracts from Stachys cretica subsp. bulgarica Rech.f., Stachys byzantina K. Koch and Stachys thirkei K. Koch(2021-12-01) TAŞKIN, TURGUT; GÜLSOY TOPLAN G., TAŞKIN T., MATARACI KARA E., ECEVİT GENÇ G.Background and Aims: Stachys L. species, which are members of the Lamiaceae family, have long been applied for their therapeutic benefits especially to cure cough, infection, genital tumors, ulcers, inflammatory illnesses, and wounds in Anatolian traditional medicine. In the current study, various extracts prepared from the aerial parts of Stachys cretica subsp. bulgarica Rech.f. (SC), Stachys byzantina K. Koch (SB), Stachys thirkei K. Koch and were tested for their in vitro antioxidant, antibacterial, and anticandidal properties. Methods: The aerial parts of three Stachys species were sequentially extracted using n-hexane, chloroform, and methanol. Aqueous extracts of each sample was also prepared by infusion process. The total phenolic content of each extract was determined and the contribution of the biological activities in the samples was evaluated. To assess the antioxidant capacity, samples were studied using CUPRAC activity, DPPH• free radical scavenging, and FRAP methods. The antimicrobial activity of the extracts was tested against 7 bacteria and 3 yeast. Results: The infusion and methanol extract exhibited the strongest antioxidant potential and also had the highest percentage of phenolics among the studied extracts. The n-hexane extracts of all studied species showed considerable antifungal activity with MIC values ranging from 312.5-78.12 mg/L. Conclusion: According to our results, three Stachys species were found to be beneficial for their antioxidant and antimicrobial properties. Keywords: Stachys, antioxidant activity, total phenolic, antimicrobial activityPublication Metadata only Investigation of antioxidant and anticonvulsant activity of Hypericum triquetrifolium Turra(2022-01-01) ÇAM, MUHAMMET EMİN; TAŞKIN, TURGUT; Kirmizi Sonmez N. I. , Guler E., ÇAM M. E. , Ermanoglu M., Gurdal B., TAŞKIN T., Omurtag G. Z.© 2022 Marmara University Press.Epilepsy is a state characterized by sudden, recurrent epileptic seizures that are not initiated by an identifiable event. There are various studies has been shown that Hypericum species may be used for their anticonvulsant potentials. Besides, the relationship between anticonvulsant activity and antioxidant effect has already been shown in the literature. In the current study, H. triquetrifolium was investigated for the first time for its potential antioxidant and anticonvulsant potential using in vitro and in vivo test models. H. triquetrifolium extracts were tested with DPPH assay, FRAP assay, copper (II) ion reducing antioxidant capacity assay, and acetylcholinesterase inhibitory activity assay to understand their antioxidant potential. Especially, methanolic extract of H. triquetrifolium was shown the highest antioxidant activity. Moreover, a pentylenetetrazole (PTZ, 80 mg/kg, i.p.)-induced seizure model was conducted to analyze the anticonvulsant activities of H. triquetrifolium extracts in mice. In addition, this study revealed that H. triquetrifolium decreased the ratio of severe seizures and increased the mean onsite of mortality and survival rate in a dose-dependent manner. It is thought that the anticonvulsant effect may be either related to the antioxidant potential of H. triquetrifolium or its interference in the GABAergic system.Publication Metadata only The biological activities of endemic Ballota pseudodictamnus subsp. lycia(2022-05-25) RAYAMAN, ERKAN; YILMAZ, BEYZA NUR; TAŞKIN, TURGUT; Akduman B., RAYAMAN E., YILMAZ B. N., Ermanoğlu M., GÜRDAL ABAMOR M. B., TAŞKIN T.Publication Open Access In vitro antioxidant and cytotoxic activity of Muscari neglectum growing in Turkey(MARMARA UNIV, FAC PHARMACY, 2018-01-12) TAŞKIN, TURGUT; Eroglu Ozkan, Esra; Demirci Kayiran, Serpil; Taskin, Turgut; Abudayyak, MahmoudMuscari species have been used as antirheumatic, stomachic, diuretic, expectorant and anti verruca in folk medicine. The species have also been used as food for humans and animals in Turkey. In this study, the antioxidant and cytotoxic activities of different extracts obtained from Muscari neglectum were studied. The antioxidant capacities of the extracts were evaluated with DPPH free radical scavenging activity, metal chelating capacity and ABTS cation radical scavenging capacity assays. The cytotoxic potentials of the extracts were determined by MTT and LDH assays on HeLa-cells (human cancer cell line) and NRK-52E-cells (rat kidney cell line). The aqueous extracts from M. neglectum bulbs (IC50 : 2.83 +/- 0.54 mg/mL) and herba (IC 50 : 8.52 +/- 1.3 mg/mL) exhibited stronger DPPH free radical scavenging activity than other extracts, respectively. The ethanol extract from M. neglectum bulbs showed the highest ABTS (27.88 %) cation radical scavenging activity. According to the metal chelating activity test results, the aqueous extracts from M. neglectum herba and bulbs showed the strongest metal chelating activity (28.99% and 28.07%, respectively).Publication Metadata only Bazı bitki ekstreleri ile saf fenolik bileşiklerin probiyotik ve patojen mikroorganizmalar üzerine antimikrobiyal aktivitesinin araştırılması(2019-12-10) RAYAMAN, PERVİN; RAYAMAN, ERKAN; TAŞKIN, TURGUT; KARPUZ E., RAYAMAN P., RAYAMAN E., TAŞKIN T.Publication Metadata only Phenolic composition and biological properties of Achillea nobilis L. subsp neilreichii (Kerner) Formanek(ELSEVIER, 2018) RAYAMAN, ERKAN; Taskin, Duygu; Taskin, Turgut; Rayaman, ErkanAchillea species are widely distributed medicinal plant throughout the world and have been used since ancient time. There are many reports about the traditional use and highly bioactive compounds of these plants. Therefore, it is fundamental to study in detail the chemical composition and biological activities of Achillea species. Thus, the objective of this study was to determine for the first time the effects of methods/solvents on biological activities (antioxidant, antimicrobial, and anti-urease) of Achillea nobilis L.subsp. neilreichii (Kerner) Formanek 15 extracts obtained from different extraction methods/solvents and then to analysis the phenolic contents of the active extracts. The phenolic contents in ethyl acetate and ethanol extracts, which showed strongest phenolic contents and antioxidant activity were analysed separately by high-performance liquid chromatography with diode array detection and were confirmed by liquid chromatography with quadrupole time-of-flight mass spectrometry using targeted mass spectra techniques with accurate mass. The active phenolic compounds were identified as dicaffeoylquinic acid, luteolin-7-O-glucoside, orientin, vitexin, luteolin, quercetin-methyl-ether, isorhamnetin-glucoside in ethyl acetate extract; chlorogenic acid luteolin-7-O-glucoside, quercetin-methyl-ether, luteolin, orientin, vitexin, dicaffeoylquinic acid, apigenin-6,8-di-C-glucoside, luteolin hexoside hexoside in ethanol extract. As a result of this study, dicaffeoylquinic acid, isorhamnetin-glucoside, chlorogenic acid, and apigenin-6,8-di-C-glucoside compounds were analysed for the first time in Achillea nobilis L. subsp. neilreichii (Kerner) Formanek. Therefore, it is thought that ethanol and ethyl acetate extracts can be used as a natural source in the future for food and pharmaceutical industry.