Person: TAŞKIN, TURGUT
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TAŞKIN
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TURGUT
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Publication Metadata only The biological activities of endemic Ballota pseudodictamnus subsp. lycia(2022-05-25) RAYAMAN, ERKAN; YILMAZ, BEYZA NUR; TAŞKIN, TURGUT; Akduman B., RAYAMAN E., YILMAZ B. N., Ermanoğlu M., GÜRDAL ABAMOR M. B., TAŞKIN T.Publication Metadata only Bazı bitki ekstreleri ile saf fenolik bileşiklerin probiyotik ve patojen mikroorganizmalar üzerine antimikrobiyal aktivitesinin araştırılması(2019-12-10) RAYAMAN, PERVİN; RAYAMAN, ERKAN; TAŞKIN, TURGUT; KARPUZ E., RAYAMAN P., RAYAMAN E., TAŞKIN T.Publication Metadata only Phenolic composition and biological properties of Achillea nobilis L. subsp neilreichii (Kerner) Formanek(ELSEVIER, 2018) RAYAMAN, ERKAN; Taskin, Duygu; Taskin, Turgut; Rayaman, ErkanAchillea species are widely distributed medicinal plant throughout the world and have been used since ancient time. There are many reports about the traditional use and highly bioactive compounds of these plants. Therefore, it is fundamental to study in detail the chemical composition and biological activities of Achillea species. Thus, the objective of this study was to determine for the first time the effects of methods/solvents on biological activities (antioxidant, antimicrobial, and anti-urease) of Achillea nobilis L.subsp. neilreichii (Kerner) Formanek 15 extracts obtained from different extraction methods/solvents and then to analysis the phenolic contents of the active extracts. The phenolic contents in ethyl acetate and ethanol extracts, which showed strongest phenolic contents and antioxidant activity were analysed separately by high-performance liquid chromatography with diode array detection and were confirmed by liquid chromatography with quadrupole time-of-flight mass spectrometry using targeted mass spectra techniques with accurate mass. The active phenolic compounds were identified as dicaffeoylquinic acid, luteolin-7-O-glucoside, orientin, vitexin, luteolin, quercetin-methyl-ether, isorhamnetin-glucoside in ethyl acetate extract; chlorogenic acid luteolin-7-O-glucoside, quercetin-methyl-ether, luteolin, orientin, vitexin, dicaffeoylquinic acid, apigenin-6,8-di-C-glucoside, luteolin hexoside hexoside in ethanol extract. As a result of this study, dicaffeoylquinic acid, isorhamnetin-glucoside, chlorogenic acid, and apigenin-6,8-di-C-glucoside compounds were analysed for the first time in Achillea nobilis L. subsp. neilreichii (Kerner) Formanek. Therefore, it is thought that ethanol and ethyl acetate extracts can be used as a natural source in the future for food and pharmaceutical industry.Publication Metadata only In vitro and In vivo biological activities and phenolic characterization of Thymus praecox subsp. skorpilii var. skorpilii(SPRINGER, 2019) RAYAMAN, ERKAN; Taskin, Turgut; Cam, Muhammet Emin; Taskin, Duygu; Rayaman, ErkanThymus species are used as food and spices in several Mediterranean and other countries as well as for medical purposes on account of their biological properties. The extraction procedures and solvents are an important step in processing bioactive constituents from the plant materials. Therefore, the aim of this study was to evaluate in vitro antioxidant, anticholinesterase, antimicrobial, anti-urease and in vivo anti-inflammatory activities of Thymus praecox subsp. skorpilii var. skorpilii using a variety of extracts. In addition, the phenolic characterization of the fraction methanol extract, which showed the highest phenolic contents and the strongest antioxidant and anticholinesterase activity were performed by HPLC-DAD and LC-MS/MS techniques. In the present study, the fraction methanol and direct methanol extracts exhibited strong DPPH, ABTS, and ferric reducing activity and strong antibacterial activity against Staphylococcus epidermidis strains. The fraction chloroform and fraction petroleum ether extracts showed the strongest anti-urease activity and also, the petroleum ether extract exhibited strong antibacterial activity against the Staphylococcus aureus strain. The fraction methanol and direct methanol extracts showed in vivo anti-inflammatory activity very similar to each other. As a result of this study, chlorogenic acid, luteolin-7-O-glucoside, 3-O-feruloylquinic acid, quercetin-3-O-hexoside, and apigenin-7-O-glucuronide compounds were analyzed for the first time in the methanol extract of the plant. This latter study revealed the effects of the extraction methods and phenolic compounds on its biological properties.Publication Metadata only Investigation on biological activities of Melissa officinalis subsp. altissima(2022-05-25) RAYAMAN, ERKAN; YILMAZ, BEYZA NUR; ŞENKARDEŞ, İSMAİL; TAŞKIN, TURGUT; Koç G., RAYAMAN E., ÖZDATLI KURTULUŞ Ş., Ermanoğlu M., YILMAZ B. N., ŞENKARDEŞ İ., TAŞKIN T.Publication Metadata only Investigation of antioxidant and antibicrobial activities of muscari armeniacum(2023-05-04) RAYAMAN, ERKAN; YILMAZ, BEYZA NUR; EMRE, GİZEM; TAŞKIN, TURGUT; Avcı E., Rayaman E., Yılmaz B. N., Emre G., Taşkın T.Publication Open Access Investigation on biological activities of Melissa officinalis subsp. altissima(2022-05-23) RAYAMAN, ERKAN; ŞENKARDEŞ, İSMAİL; TAŞKIN, TURGUT; Koç G., Rayaman E., Özdatlı Kurtuluş Ş., Ermanoğlu M., Yılmaz B. N. , Şenkardeş İ., Taşkın T.The genus Melissa is used as antibacterial, sedative, digestive aid, carminative, diaphoretic and bile secretion enhancer. It is included in the composition of the preparations used during nervous digestive system disorders, psychosomatic heart disorders and migraine. The flowering branches and leaves of Melissa officinalis L. subsp. altissima. are used as carminative, sedative and its antipyretic effects. It is also used in vascular occlusion, stomach aches, heart ailments, kidney inflammation, cholesterol, blood pressure, and diabetes. According to our knowledge there are not enough studies on these species grown in Turkey. The aim of this study is to examine the antioxidant, cytotoxic, anticholinesterase, anti-urease and antimicrobial activities of plant’ various extracts obtained by using the sequential maceration method. In the determination of antimicrobial activity well diffusion method on 6 gram negative, 4 gram positive and 3 yeast strains was used. DPPH, CUPRAC and FRAP techniques were used to examine the antioxidant properties of plant\" extracts. The extracts\" anticholinesterase, cytotoxic and anti-urease activity were determined using the Ellman, MTT and Indophenol techniques, respectively. In addition, the phenolic contents of the extracts were determined by FCR method. It was found that petroleum ether extract of the plant was effective against Enterecoccus faecalis and Staphylococcus aureus strains and ethyl acetate extract were effective against Staphylococcus aureus strains. The methanol extract of the plant exhibited the highest antioxidant activity when compared to other extracts. It was determined that the petroleum ether extract of Melissa officinalis L. subsp. altissima has stronger acetylcholinesterase and urease enzyme inhibition potential than its other extracts. Furthermore, in this study the ethyl acetate extract of the plant was found to have high cytotoxic activity.Publication Metadata only Characterization of the Biological Activity and Phenolics in Achillea lycaonica(TAYLOR & FRANCIS INC, 2018) RAYAMAN, ERKAN; Taskin, Turgut; Taskin, Duygu; Rayaman, Erkan; Dikpinar, Tugce; Suzgec-Selcuk, Sevda; Arabaci, TuranThe purpose of this study was to comparatively evaluate for the first time the antioxidant, antimicrobial, and antiurease effects of A. lycaonica extracts obtained using three extraction methods and five solvents followed by identification of the phenolic compounds obtained by Soxhlet extraction with ethyl acetate and maceration with chloroform that showed the highest total phenolic and flavonoid contents with antioxidant and antiurease activity. The phenolic compounds were identified to be chlorogenic acid, caffeic acid, rutin, dicaffeoylquinic acid, salicylic acid, luteolin, quercetin, naringenin, apigenin, and 8-hydroxy- salvigenin. Among the solvent extraction procedures, Soxhlet approach was found to have higher recoveries than other approaches. The results of 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assays showed that the 1: 1 ethanol-water Soxhlet, ethanol ultrasonic bath, and ethyl acetate Soxhlet extraction methods had the highest DPPH antioxidant activities. The ethyl acetate Soxhlet extraction method showed the highest 2, 2'-azino-bis(3-ethylbenzthiazoline- 6-sulfonic acid) diammonium salt (ABTS) and ferric reducing antioxidant power (FRAP) antioxidant activity. In addition, the chloroform maceration extraction method exhibited the highest antiurease activity. Therefore, 1: 1 Soxhlet ethanol-water, ultrasonic bath ethanol, and Soxhlet ethyl acetate extracts may be used in medicine and food production as natural antioxidant sources. In addition, maceration with chloroform may provide a potential antiurease agent.Publication Open Access The Biological Activities of Endemic Ballota pseudodictamnus subsp. lycia.(2022-05-23) RAYAMAN, ERKAN; TAŞKIN, TURGUT; Akduman B., Rayaman E., Yılmaz B., Ermanoğlu M., Gürdal B., Taşkın T.The genus Ballota L. (Lamiaceae) includes species known as boz ot, bal otu, nemnem otu and have medicinal uses among the people. Additionally, it known to be used by the public in the treatment of cough, asthma, headache, nausea, hemorrhoids, wounds and burns. Ballota taxa have various phytochemical classes such as essential oils, iridoids, saponins, terpenoids, flavonoids, phenolic acids, tannins, and organic acids. Ballota pseudodictamnus subsp. lycia is one of the endemic species growing in southwestern Turkey. As a result of our research on the literature a limited number of studies have been found on the biological activities of this species. The aim of this study is to examine the antioxidant, antimicrobial, anticholinesterase and anti-urease activities of different extracts (petroleum ether, chloroform and methanol) obtained from the aerial part of B. pseudodictamnus subsp. lycia. DPPH, CUPRAC, and FRAP techniques were used to examine the antioxidant properties of plant\" extracts. The extracts\" anti-urease, anticholinesterase and antimicrobial activity were determined using the Indophenol, Ellman and agar well diffusion method techniques, respectively. While the petroleum ether extract obtained from plant, was found to be effective against S. aureus, S.epidermidis and E. faecalis strains; its chloroform extract was effective against S.aureus and S.epidermidis strains and its methanol extract was found to be effective against Acinetobacter baumannii strains. It was found that the plant’ methanol extract showed the highest antioxidant activity when compared to the other extracts.Publication Open Access Chemical Composition and In Vitro Biological Activity of Two Thymus L. Varieties Growing in Turkey(2024-01-01) TAŞKIN, TURGUT; RAYAMAN, ERKAN; YILMAZ, BEYZA NUR; TAŞKIN T., Öksüz M., Bulkurcuoğlu B., Ercelen S., RAYAMAN E., Ermanoğlu M., YILMAZ B. N., Taşkın D., Şahin T., Kılıç Ö.Thymus kotschyanus var. kotschyanus (TKK) and T. kotschyanus var. glabrescens (TKG) varieties were used as both spice and medicine by the people in Turkey. It was determined that plants’ methanol extracts had the strongest antioxidant, anticholinesterase, antiurease activity and high total phenolic contents. The ethyl acetate and methanol extracts were found to have strong antimicrobial activity. Methanol extracts showed low hemolytic effect against human erythrocytes. It was determined that TKG extract showed higher anti-proliferative effect compared to TKK extract. Both plants extract significantly decreased reactive oxygen species (ROS) generation in cancer cells. It was determined that amounts of chlorogenic and rosmarinic acid compounds were similar in both plants, but apigenin 7-O-neohesperidoside compound was found in higher amounts in TKK. The findings obtained in this study suggest that methanol and ethyl acetate extracts obtained from these two species can be used as antioxidant, anticholinesterase, antimicrobial and antiurease agents. The findings support the traditional use of these species.