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KOCAKAYA, DERYA

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2015 - 2019102020 - 202315
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Author: CEYHAN, BERRİN ×

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    İlerı ve son evre akciğer hastalığına ikincil solunum yetmezliği olan hastaların bakım verenlerinde bakım verici yükü ve depresyon ilişkisi
    (2018-04-18) OLGUN YILDIZELİ, ŞEHNAZ; KASAPOĞLU, UMUT SABRİ; KOCAKAYA, DERYA; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; KARAKURT, SAİT; ARIKAN, HÜSEYİN; OLGUN YILDIZELİ Ş., ARIKAN H., KASAPOĞLU U. S., KOCAKAYA D., ERYÜKSEL S. E., CEYHAN B., KARAKURT S.
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    PublicationOpen Access
    The role of procalcitonin as a biomarker for acute pulmonary exacerbation in subjects with cystic fibrosis and non-cystic fibrosis bronchiectasis
    (2022-01-01) KOCAKAYA, DERYA; ARIKAN, HÜSEYİN; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; Mammadov F., Olgun Yildizel S., Kocakaya D., ARIKAN H., Cinar C., Eryuksel E., CEYHAN B.
    Objective: Patients with cystic fibrosis (CF) and non-CF bronchiectasis are prone to exacerbations of pulmonary infections. C-reactive protein (CRP) and procalcitonin (PCT) are inflammatory markers. The aim of this study is to evaluate the role of CRP and PCT on exacerbations of CF and non-CF bronchiectasis. Patients and Methods: The medical records of 18 CF (52 hospitalizations) and 20 non-CF bronchiectasis patients (51 hospitalizations) were reviewed retrospectively. CRP, PCT levels and, white blood cell (WBC) counts on admission and follow-up were evaluated. Results: C-reactive protein levels correlated with PCT levels on admission in all patients. Baseline PCT levels were markedly higher (>0.5µg/L) in 12% of CF and 10% of non-CF bronchiectasis patients, however, baseline CRP values were markedly higher (>5mg/L) in 96% of CF and non-CF bronchiectasis patients (p=0.760 and p=0.100, respectively). Baseline CRP and PCT levels were positively correlated with hospitalization length (r=0.501, p=0.001 and r=0.289, p=0.04, respectively) in CF patients, but not in non-CF bronchiectasis. Conclusion: Our study shows the potential utility of these biomarkers to determine the severity of the exacerbation particularly predicting hospitalization length in CF patients. Both biomarkers could be able to guide antibiotic treatment of infective exacerbations in CF and non-CF bronchiectasis patients.
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    Eri̇şki̇n ki̇sti̇k fi̇brozi̇s hastalarinda İlaç uyumu ve anksi̇yete/depresyonu etki̇leyen faktörler
    (2018-05-18) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; CEYHAN, BERRİN; USLU N. Z. , KOCAKAYA D., OLGUN YILDIZELİ Ş., CEYHAN B.
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    THE EFFECT OF GLOBAL LONGITUDINAL STRAIN ON IMPAIRED SIX-MINUTE WALK TEST PERFORMANCE IN PATIENTS WITH SARCOIDOSIS
    (MATTIOLI 1885, 2020) KEPEZ, ALPER; Ozen, Deniz Kaptan; Mutlu, Bulent; Kocakaya, Derya; Turan, Burak; Sekerci, Sena Sert; Ceyhan, Berrin; Kepez, Alper; Erdogan, Okan
    Background: Sarcoidosis is a multisystem and granulomatous disease associated with impaired functional capacity as a result of pulmonary and cardiac involvement. Factors adversely effecting functional capacity in patients with sarcoidosis have not been systematically assessed including myocardial strain imaging on echocardiography which enable to diagnose subclinical cardiac dysfunction. We aimed to evaluate the effect of left and right ventricular global longitudinal strain (GLS) on submaximal exercise capacity in patients with sarcoidosis who do not have clinically manifest cardiac involvement. Methods: Extracardiac biopsy proven 56 patients with sarcoidosis and 26 controls were included consecutively. Submaximal exercise capacity of the subjects was assessed with six-minute walk test (6 MWT). Pulmonary function tests and standard transthoracic and two-dimensional speckle tracking echocardiography were performed to the all subjects. Linear regression analysis was performed to find independent predictors of 6 MWT. Results: Fifty-six patients (18% male) with a mean age of 52.5 +/- 10.7 years were included. Patients with sarcoidosis had low 6 MWT performance and higher New York Heart Association classes and NT-proBNP levels. There were no significant differences between controls and patients with sarcoidosis in parameters of pulmonary function test. Biventricular GLS levels and biatrial reservoir and conduit function values were lower and systolic pulmonary artery pressure (SPAP) was significantly higher in patients with sarcoidosis as compared with controls. Older age and higher SPAP were found as independent predictors of poor 6 MWT performance. Conclusion: Although biventricular GLS levels were lower in the patients with sarcoidosis, only age and SPAP elevations were independent predictors of the submaximal exercise capacity.
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    KOAH hastalarında D vitamini düzeyinin kilinik bulgularla ilişkisi
    (2021-05-18) KOCAKAYA, DERYA; CEYHAN, BERRİN; KOCAKAYA D., KOCAKAYA O., CEYHAN B.
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    PublicationOpen Access
    The impact of cystic fibrosis- and noncystic fibrosis-bronchiectasis on pulmonary artery wall thickness and right heart functions assessed by speckle-tracking echocardiography
    (2023-06-01) GÜREL, YUSUF EMRE; VEZİR, DUYGU; KOCAKAYA, DERYA; SÜNBÜL, MURAT; ÇİNÇİN, AHMET ALTUĞ; ÖZBEN SADIÇ, BESTE; SAYAR, NURTEN; CEYHAN, BERRİN; Gürel E., VEZİR D., Güçtekin T., Doğan Z., KOCAKAYA D., Olgun S., SÜNBÜL M., Çinçin A., Özben B., SAYAR N., et al.
    BACKGROUND: Right heart functions are affected in patients with bronchiectasis as a result of pulmonary hypertension induced by chronic hypoxemia. Pulmonary artery wall thickness has recently been introduced as a sign of intensive and prolonged inflammation. The aim of this study was to analyze right ventricular and right atrial functions and to mea-sure pulmonary artery wall thickness in patients with cystic fibrosis-bronch iecta sis in comparison to those with noncystic fibrosis-bronchiectasis and healthy individuals. METHODS: We studied 36 patients with cystic fibrosis-bronchiectasis, 34 patients with noncystic fibrosis-bronchiectasis, and 32 age- and sex-matched control subjects. Lung function tests were performed. All subjects underwent comprehensive echocardiographic evaluation including conventional, tissue Doppler, speckle-tracking, and pulmonary artery wall thickness measurements. RESULTS: Right ventricular global longitudinal strain and global longitudinal right atrial strain during ventricular systole decreased in cystic fibrosis-bronchiectasis group compared with noncystic fibrosis-bronchiectasis and control groups (P <.001, both). Conversely, pulmonary artery wall thickness was increased in cystic fibrosis-bronchiectasis group in comparison to other groups (P <.001). Moreover, right ventricular global longitudinal strain was lower and pulmonary artery wall thickness was higher in patients with airflow obstruction (P <.001 and P =.025, respectively) than in those without. Only right ventricular global longitudinal strain was significantly correlated with pulmonary function test parameters. The negative effect of cystic fibrosis on right ventricular and right atrial functions was independent of age, gender, and disease duration. CONCLUSION: Our study showed that right ventricular and right atrial functions were deteriorated and pulmonary artery wall was thickened in cystic fibrosis-bronchiectasis patients more than noncystic fibrosis-bronchiectasis patients. Right ventricular global longitudinal strain detected subclinical right ventricular dysfunction and was associated with the severity of pulmonary disease.
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    Aktif kanaması olan vena cava superior sendromuna yol açan venöz tromboz olgusunda antikoagülan tedavi yaklaşımı
    (2015-04-01) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; CEYHAN, BERRİN; BEKIR KULAH M., KOCAKAYA D., OLGUN YILDIZELİ Ş., CEYHAN B.
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    PublicationOpen Access
    Anxiety and depression in patients with chronic obstructive pulmonary disease and their relation to serum vitamin D levels
    (MARMARA UNIV, FAC MEDICINE, 2018-02-26) CEYHAN, BERRİN; Kocakaya, Derya; Olgun Yildizeli, Sehnaz; Kocakaya, Ozan; Arikan, Huseyin; Eryuksel, Emel; Ceyhan, Berrin
    Objectives: To determine whether serum vitamin D levels were related to the risk of anxiety and depression among patients with chronic obstructive pulmonary disease (COPD), as well as their spirometry parameters, disease severity, and other clinical findings. Materials and Methods: Ninety-two stable patients with COPD aged over 18 years with no exacerbations in the previous month were included. Symptom severity was assessed using the modified Medical Research Council (mMRC) dyspnea scale and COPD Assessment Test (CAT) scores. Spirometry tests were performed and previous hospitalization histories were recorded to determine ABCD groups of the patients according to their combined COPD assessments. Their Body mass index, airflow Obstruction, Dyspnea and Exercise capacity (BODE) indices were calculated and the Hospital Anxiety and Depression Scale (HADS) was administered. Serum vitamin D levels were determined using immune electrochemiluminescence. Results: According to the HADS scores, 16 patients (17.4%) had the risk of anxiety and 29 (31.5%) had the risk of depression. The risk of anxiety differed significantly (P=0.016 Fischer's exact test) between the ABCD groups. Anxiety scores were positively correlated with both mMRC (r=0.315; P=0.002) and CAT (r=0.445; P=0.000) scores. Similarly, depression scores correlated positively with mMRC (r= 0.249; P=0.017) and CAT (r=0.373; P=0.000) scores. Neither anxiety nor depression scores were significantly correlated with % of predicted FEV1. Serum vitamin D levels were inversely correlated with anxiety (r=-0.215; P=0.039) and depression (r=-0.244; P=0.019) scores. Anxiety scores were positively correlated with BODE although not statistically significantly (r=0.199; P=0.058). Conclusion: A negative correlation was revealed between serum vitamin D levels and HADS scores, and symptom scores were positively correlated to HADS scores, independent of % of predicted FEV1.
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    KF ve KF dışı bronşektazi hastalarında obstrüktif uyku apnesinin depresyon üzerine etkisi
    (2022-06-28) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; CEYHAN, BERRİN; VEZİR D., BALCAN M. B. , KOCAKAYA D., ÇINAR C., OLGUN YILDIZELİ Ş., CEYHAN B.
    AMAÇ: Erişkin kistik fibrozis (KF) ve KF dışı bronşektazi hastalarında obstrüktif uyku apnesi (OUA) sıklığını belirlemek ve bu hastaların demografik, klinik, mikrobiyolojik, spirometrik özelliklerinin uyku apnesi ile ilişkisini ortaya koymaktır. YÖNTEM: 35 KF ( ortalama yaş: 27(18-38)) ve 35 KF dışı bronşektazi (ortalama yaş: 24 (19-75)) hastası dahil edilmiştir. Hastaların demografik özellikleri, kullandığı ilaçlar, komorbiditeleri, vücut kitle indeksleri (VKI), Modified Medical Research Center (mMRC) dispne skalası değerleri, balgam kültür üremeleri, son bir yıl içindeki atak ve hastaneye yatışları kaydedildi. Solunum fonksiyon testleri (SFT) yapıldı. Her hastaya Epworth Uykululuk Skorlaması (ESS) anketi dolduruldu ve Polisomnografi (PSG) uygulandı. BULGULAR: Hastalarımızın ESS’leri karşılaştırıldığında KF ve KF dışı bronşektazi hastalarında istatistiksel olarak anlamlı fark görülmemiştir. PSG bulguları karşılaştırıldığında toplam uyku süresi, uyku etkinliği, uykuya dalma süresi, uykuya daldıktan sonra uyanık geçen süre, ODI, AHI, supin pozisyondaki AHI değerleri, REM evresinde geçirdikleri zaman değerlendirildiğinde iki grup arasında istatistiksel olarak anlamlı fark bulunmadı. KF hastalarının Non-REM Evre 2 uykuda geçirdikleri süre KF dışı bronşektazi hastalarına göre daha kısaydı (%47’ye karşın %52 (p:0.034)). KF hastalarının uyku boyunca ortalama oksijen saturasyonları (p:0.001) ve en düşük oksijen saturasyon değerlerinin (p:0.024) daha düşük, ortalama kalp hızının daha yüksek olduğu bulundu (p:0.02). Tüm hastaların uyku test sonuçları değerlendirildiğinde toplamda 37 (%53) kişide OUA saptandı. Gruplar ayrı ayrı değerlendirildiğinde ise KF bronşektazili hastaların 19’unda (%54) KF dışı bronşektazi hastalarının da 18’inde (%51) OUA saptanması nedeniyle hastalık tipinin uyku apnesi için bir risk oluşturmadığı görüldü. Hastaların multipl logistik regresyon analizi değerlendirildiğinde erkek cinsiyet ile hastalık süresinin (p:0.023 ve p:0.041) uyku apnesi geliştirmelerinde risk faktörü olduğu görüldü. SONUÇ: Çalışmamızda erişkin KF ve KF dışı bronşektazi hastalarının yarısından fazlasında obstrüktif uyku apnesi saptanması dikkat çekici bir bulgudur. Erkek cinsiyet ile hastalık süresinin riski artırdığı saptanmıştır. Çalışmamızda bronşiektazi hastalarımızı takip ederken gündüz uykululuk sorgulamalarının ve PSG uygulamasının yaygınlaştırılmasının gerekli olduğunun önemi gösterilmiştir.
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    The predictive role of psychological status and disease severity indexes on quality of life among patients with non-CF bronchiectasis
    (2022-01-01) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; CEYHAN B., Bekir M., KOCAKAYA D., OLGUN YILDIZELİ Ş., ERYÜKSEL S. E.
    OBJECTIVE: Bronchiectasis is a chronic suppurative lung disease that significantly impacts the patients\" quality of life. The aim of this study is to evaluate the relationship between quality of life and patient\"s psychological status and bronchiectasis disease severity indexes in patients with non-cystic fibrosis bronchiectasis. We also aimed to investigate the validity and reliability of Turkish version of Quality of Life Questionnaire-Bronchiectasis (V3.1) in Turkish adult bronchiectatic patients.