Person: KOCAKAYA, DERYA
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KOCAKAYA
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DERYA
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Publication Metadata only Does preexisting immuncompromised status prevent mortality in COVID-19 patients: friend or foe?(2022-09-01) VEZİR, DUYGU; KOCAKAYA, DERYA; MERCANCI, ZEYNEP; KARAKURT, SAİT; Vezir D., Yildizeli S. O., KOCAKAYA D., Mercanci Z., Balcan B., Cinar C., Eryuksel E., KARAKURT S.Publication Open Access Outcome of solid and cavitary pulmonary nodules in rheumatoid arthritis patients— case series(2022-01-01) AKSOY, AYSUN; BOZKURTLAR, EMİNE; KARAKURT, SAİT; ERYÜKSEL, SEMİHA EMEL; İNANÇ, GÜZİDE NEVSUN; KOCAKAYA, DERYA; AKSOY A., KOCAKAYA D., Yalçinkaya Y., BOZKURTLAR E., KARAKURT S., Eryüksel E., İnanç N.© TÜBİTAK.Background/aim: Rheumatoid pulmonary nodule can be detected in up to 32% of rheumatoid arthritis (RA) patients and approximately one-third of nodules may cavitate. We aimed to evaluate characteristics of patients with RA developing cavitary pulmonary nodular (CPN) lesions under disease-modifying antirheumatic drugs (DMARDs), follow-up of both cavitary and solid nodules, and their outcome with the treatment. Materials and methods: RA patients who presented with CPN lesions during follow-up were recruited retrospectively in this case series analysis. Total numbers and mean diameters of cavitary and solid nodules in each thorax computed tomography (CT) have been determined and followed up by two experienced pulmonary physicians. Moreover, changes in treatment after the development of the CPN lesions and characteristics of cavitary nodules were collected. Results: Eleven patients with CPN lesions were reported. At the time of CPN diagnosis, more patients were taking leflunomide than methotrexate (81% vs 19%). Half of the patients were receiving biologic therapy and only 18% were taking anti-TNF drugs. After a median of 24 (3–65) months of follow-up, the regression of CPN lesions was determined in 45% (5/11) of patients. Four of these 5 (80%) patients were switched to a treatment regimen without leflunomide and three of them to nonanti-TNF biologic treatment or targeted synthetic DMARDs (tocilizumab, tofacitinib, and rituximab). Conclusion: CPN lesions seen in RA patients are often pulmonary manifestations of the underlying disease; however, one must rule out malignancies or infections. If lesions progress under DMARDs, it is advised to discontinue synthetic DMARDs (LEF/MTX) and switch to another biological DMARD with different modes of action.Publication Open Access The role of procalcitonin as a biomarker for acute pulmonary exacerbation in subjects with cystic fibrosis and non-cystic fibrosis bronchiectasis(2022-01-01) KOCAKAYA, DERYA; ARIKAN, HÜSEYİN; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; Mammadov F., Olgun Yildizel S., Kocakaya D., ARIKAN H., Cinar C., Eryuksel E., CEYHAN B.Objective: Patients with cystic fibrosis (CF) and non-CF bronchiectasis are prone to exacerbations of pulmonary infections. C-reactive protein (CRP) and procalcitonin (PCT) are inflammatory markers. The aim of this study is to evaluate the role of CRP and PCT on exacerbations of CF and non-CF bronchiectasis. Patients and Methods: The medical records of 18 CF (52 hospitalizations) and 20 non-CF bronchiectasis patients (51 hospitalizations) were reviewed retrospectively. CRP, PCT levels and, white blood cell (WBC) counts on admission and follow-up were evaluated. Results: C-reactive protein levels correlated with PCT levels on admission in all patients. Baseline PCT levels were markedly higher (>0.5µg/L) in 12% of CF and 10% of non-CF bronchiectasis patients, however, baseline CRP values were markedly higher (>5mg/L) in 96% of CF and non-CF bronchiectasis patients (p=0.760 and p=0.100, respectively). Baseline CRP and PCT levels were positively correlated with hospitalization length (r=0.501, p=0.001 and r=0.289, p=0.04, respectively) in CF patients, but not in non-CF bronchiectasis. Conclusion: Our study shows the potential utility of these biomarkers to determine the severity of the exacerbation particularly predicting hospitalization length in CF patients. Both biomarkers could be able to guide antibiotic treatment of infective exacerbations in CF and non-CF bronchiectasis patients.Publication Open Access Radial arterial thrombosis in COVID-19: A case report(2022-01-01) ÇİÇEK, FURKAN CUMA; EYÜPLER, ÇAĞLA; YETGİNOĞLU, ÖZGE; AK, KORAY; KOCAKAYA, DERYA; Durmus N. S. , ÇİÇEK F. C. , EYÜPLER Ç., Omur C., YETGİNOĞLU Ö., AK K., KOCAKAYA D.Thrombosis due to hypercoagulable state is an important cause of morbidity and mortality in coronavirus disease 2019 (COVID-19). Increased D-dimer levels are an important marker of the presence and risk of thrombosis. In this report, we present that a 59-year-old male patient developed thrombosis in the distal radial arteries despite normal D-dimer level. The patient was treated with enoxaparin, iloprost infusion, and cilostazol. This case should lead us to be very careful that people diagnosed with COVID-19 with normal D-dimer levels may also have thrombosis.Publication Open Access The impact of cystic fibrosis- and noncystic fibrosis-bronchiectasis on pulmonary artery wall thickness and right heart functions assessed by speckle-tracking echocardiography(2023-06-01) GÜREL, YUSUF EMRE; VEZİR, DUYGU; KOCAKAYA, DERYA; SÜNBÜL, MURAT; ÇİNÇİN, AHMET ALTUĞ; ÖZBEN SADIÇ, BESTE; SAYAR, NURTEN; CEYHAN, BERRİN; Gürel E., VEZİR D., Güçtekin T., Doğan Z., KOCAKAYA D., Olgun S., SÜNBÜL M., Çinçin A., Özben B., SAYAR N., et al.BACKGROUND: Right heart functions are affected in patients with bronchiectasis as a result of pulmonary hypertension induced by chronic hypoxemia. Pulmonary artery wall thickness has recently been introduced as a sign of intensive and prolonged inflammation. The aim of this study was to analyze right ventricular and right atrial functions and to mea-sure pulmonary artery wall thickness in patients with cystic fibrosis-bronch iecta sis in comparison to those with noncystic fibrosis-bronchiectasis and healthy individuals. METHODS: We studied 36 patients with cystic fibrosis-bronchiectasis, 34 patients with noncystic fibrosis-bronchiectasis, and 32 age- and sex-matched control subjects. Lung function tests were performed. All subjects underwent comprehensive echocardiographic evaluation including conventional, tissue Doppler, speckle-tracking, and pulmonary artery wall thickness measurements. RESULTS: Right ventricular global longitudinal strain and global longitudinal right atrial strain during ventricular systole decreased in cystic fibrosis-bronchiectasis group compared with noncystic fibrosis-bronchiectasis and control groups (P <.001, both). Conversely, pulmonary artery wall thickness was increased in cystic fibrosis-bronchiectasis group in comparison to other groups (P <.001). Moreover, right ventricular global longitudinal strain was lower and pulmonary artery wall thickness was higher in patients with airflow obstruction (P <.001 and P =.025, respectively) than in those without. Only right ventricular global longitudinal strain was significantly correlated with pulmonary function test parameters. The negative effect of cystic fibrosis on right ventricular and right atrial functions was independent of age, gender, and disease duration. CONCLUSION: Our study showed that right ventricular and right atrial functions were deteriorated and pulmonary artery wall was thickened in cystic fibrosis-bronchiectasis patients more than noncystic fibrosis-bronchiectasis patients. Right ventricular global longitudinal strain detected subclinical right ventricular dysfunction and was associated with the severity of pulmonary disease.Publication Metadata only The predictive role of psychological status and disease severity indexes on quality of life among patients with non-CF bronchiectasis(2022-01-01) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; CEYHAN B., Bekir M., KOCAKAYA D., OLGUN YILDIZELİ Ş., ERYÜKSEL S. E.OBJECTIVE: Bronchiectasis is a chronic suppurative lung disease that significantly impacts the patients\" quality of life. The aim of this study is to evaluate the relationship between quality of life and patient\"s psychological status and bronchiectasis disease severity indexes in patients with non-cystic fibrosis bronchiectasis. We also aimed to investigate the validity and reliability of Turkish version of Quality of Life Questionnaire-Bronchiectasis (V3.1) in Turkish adult bronchiectatic patients.Publication Open Access The angiogenic gene profile of pulmonary endarterectomy specimens: Initial study(2023-01-01) ERMERAK, NEZİH ONUR; YILMAZ, BETÜL; BATIREL, SAİME; OLGUN YILDIZELİ, ŞEHNAZ; KOCAKAYA, DERYA; MUTLU, BÜLENT; YILDIZELİ, BEDRETTİN; ERMERAK N. O., YILMAZ B., BATIREL S., OLGUN YILDIZELİ Ş., KOCAKAYA D., MUTLU B., Tas S., YILDIZELİ B.© 2023 The Author(s)Objectives: The underlying mechanisms for the development of chronic thromboembolic pulmonary hypertension and prognostic biomarkers are not clear yet. Thus, our aim is to assess and identify new biomarkers for the expression of 84 key genes linked to angiogenesis. Methods: Patients who had levels more than 1000 dynes·sec·cm−5 were included in the test group, and the other patients were included in the control group. Twelve specimens were taken from the patients. RT2 Profiler PCR Array (Qiagen) was used to quantify the expression of the 84 key genes. Results: Eight patients (6 male, 2 female, median age 54.4 ± 13.1 years) who underwent pulmonary endarterectomy were included. Pulmonary vascular resistance improved significantly from 811 ± 390 dyn/s/cm−5 to 413.3 ± 144.9 dyn/s/cm−5 (P .005) after surgery. Median length of hospital stay was 11.62 ± 2.97 days. The test group had a distinct pattern of impaired angiogenic and antiangiogenic genes. The expression levels of TGFA, TGFB1, THBS2, THBS1, TGFBR1, SERPINE1, SERPINF1, TGFB2, TIMP2, VEGFC, IFNA1, TNF, CXCL10, NOS3, IGF1, and MMP14 were downregulated in the specimens from the patients who had higher pulmonary vascular resistance values, whereas some genes, including PDGFA, showed upregulation that was statistically nonsignificant in the same group. Conclusions: These results can lead to the development of new markers that could predict adverse outcomes of patients with CTEPH. Identification of new markers that are related to worse outcomes would enable screening patients for early diagnosis and treatment.Publication Metadata only Late breaking abstract - association with changes in pulmonary artery diameters and outcomes before, during and after covid-19 hospitalization: Retrospective study(2023-09-09) KOCAKAYA, DERYA; Selcuk A., Kocakaya D., Olgun Yildizeli Ş., Karakurt S.Background:Enlarged main pulmonary artery diameter(MPAD)is a predictor of increased mortality in COVID-19. However, the changes in MPAD before and after COVID-19 remain obscure.Aim:To find the factors that affect changes in MPAD during COVID-19 and postCOVID-19 period; the relationship between the MPAD, thromboinflammation and radiological scores(RS), clinical outcomes in patients.Methods:This study is retrospective and single centered. Among the 3264 patients hospitalized followed at least 3 months between March 2020 and January 2023, 66 patients with previous and subsequent chest CT were included.3 measurements of MPAD before, during and after COVID-19, WHO Score, RS and laboratory variables have been recorded from the hospital information system. ICU admission and mortality as clinical outcomes and factors that affect MPAD evaluated by uni-and multivariate analysis.Results:MPAD of patients had increased during COVID-19 and showed tendency to decrease but persisted to increase after(p<0.001,p>0.05). Low Lymphocyte/CRP, high D-dimer and ICU admission had significantly increased risk for remained enlarged MPAD postCOVID-19(OR=10.37,p<0.01;OR=1.1, p<0.01,OR=5.14, p<0.01). Patient with higher postMPAD had significant correlation with increased WHO Score and RS after COVID-19(both R=0.3,p<0.05)but not mortality.Conclusion:MPAD significantly increases during COVID-19 and persisted after that. Apart from that, patients who admitted to ICU, had high d-dimer and inflammation markers in COVID-19,had increased risk for enlarged postMPAD that correlated WHO-Score and radiological scores in post-COVID-19. Especially these patients, can be followed carefully after the infection.Publication Open Access Nutrition risk assessed by nutritional risk screening 2002 is associated with in-hospital mortality in older patients with covid-19(2022-06-01) KOCAKAYA, DERYA; TUFAN ÇİNÇİN, ASLI; Can B., Durmus N. S., Yildizeli S. O., KOCAKAYA D., Ilhan B., TUFAN ÇİNÇİN A.Background Although numerous studies have been performed to determine predictors of coronavirus disease 2019 (COVID-19) mortality, studies that address the geriatric age group are limited. The aim of this study was to investigate the utility of the Nutritional Risk Screening 2002 (NRS-2002) and the Geriatric 8 (G8) screening tools in predicting clinical outcomes in older adults hospitalized with COVID-19. Methods Patients aged >= 60 years who were hospitalized with COVID-19 in the second wave of the pandemic were included in the study. COVID-19 infection was demonstrated by a positive real-time reverse transcriptase-polymerase chain reaction on nasopharyngeal swab or positive radiological findings. Disease severity was determined as defined by the National Institutes of Health. Patient demographics, laboratory values on admission, comorbidities, and medications were recorded. The NRS-2002 and the G8 screening tools were performed for all patients by the same geriatrician. Primary outcome was in-hospital mortality. Results A total of 121 patients were included. Mean age was 75 +/- 9 years, and 51% were female. Mean body mass index was 27 +/- 4.5 kg/m(2). Sixty-nine percent of the patients had nutrition risk according to the NRS-2002. Eighty-nine percent of the patients had a G8 score <= 14. In-hospital mortality occurred in 26 (22%) patients. Older age and having nutrition risk as determined by the NRS-2002 were independently associated with a higher risk of in-hospital mortality in older patients with COVID-19. Conclusion The NRS-2002 tool provides rapid assessment for risk stratification in hospitalized older patients with COVID-19.Publication Open Access Change in pulmonary arterial compliance and pulmonary pulsatile stress after balloon pulmonary angioplasty(2022-01-01) KOCAKAYA, DERYA; YILDIZELİ, BEDRETTİN; Akaslan D., Ataş H., Aslanger E., Kanar B. G., Kocakaya D., Yıldızeli B., Mutlu B.Objective: Although the underlying pathology of chronic thromboembolic pulmonary hypertension (CTEPH) is mechanical obliteration of the major pulmonary vessels, high pulsatile stress penetrating into the normal distal pulmonary microvasculature resulting from reduced pulmonary arterial compliance (CPA) may cause progressive deterioration in pulmonary hemodynamics. Hypothetically, balloon pulmonary angioplasty (BPA) may be beneficial in reducing CPA and pulsatile stress in patients with CTEPH. Methods: In total, 26 patients with available pre- and post-BPA right heart catheterization results were included in the study. BPA was performed in a series of staged procedures by 2 experienced interventional cardiologists. Results: The median CPA showed a 59.2% increase (1.03 to 1.64 mL/mm Hg, p=0.005). The median pre-BPA pulsatile stress product decreased by 20.7% (4,266 to 3,380 mm Hg/min, p=0.003). A linear regression model established that the percent change in CPA after BPA accounted for 21.8% of the explained variability in the change in 6-minute walk test (p=0.009). Conclusion: Our results indicate that BPA decreases CPA and pulmonary pulsatile stress. These changes may be partly responsible for the improvement in functional capacity after BPA.
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