Person: GÜVENÇ, YAHYA
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GÜVENÇ
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YAHYA
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Publication Metadata only What is the restorative effect of VEGF inhibitor bevacuzimab against subarachnoid hemorrhage in an experimental model?(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2021) GÜVENÇ, YAHYA; Demirci, Adnan Yalcin; Guvenc, Yahya; Ozeren, Ersin; Akyol, Cetin; Bayram, Pinar; Billur, Deniz; Aydin, Sevim; Seckin, Hakan; Yigitkanli, KazimBackground/aim: This study investigated the effect of vascular endothelial growth factor (VEGF) inhibitor bevacuzimab (BVZ) on the rabbit basilar artery using an experimental subarachnoid hemorrhage (SAH) model. Materials and methods: Eighteen adult male New-Zealand white rabbits were randomly divided into three groups: a control group (n = 6), SAH group (n = 6), and SAH+BVZ group (n = 6). Experimental SAH was created by injecting autologous arterial blood into the cisterna magna. In the treatment group, the subjects were administered a daily dose of 10 mg/kg, intravenous BVZ for 2 days after the SAH. Basilar artery diameters were measured with magnetic resonance angiography (MRA) 72 h after the SAH in all groups. After 72 h, whole brains, including the upper cervical region, were obtained from all the animals after perfusion and fixation of the animal. The wall thickness, luminal area, and the apoptosis at the basilar arteries were evaluated in all groups. Results: BVZ significantly prevented SAH-induced vasospasm confirmed in vivo with MRA imaging with additional suppression of apoptosis on basilar artery wall. Conclusion: VEGF inhibition with BVZ has shown to have a vasospasm and apoptosis attenuating effect on basilar artery in a SAH model.Publication Metadata only Farlateral approach and determaniton unilateral stabilization criteria for lesions located anterior to C1-2 in the craniocervical region: Cadaver study(2022-09-23) GÜVENÇ, YAHYA; VERİMLİ, URAL; BIYIKLI, ERHAN; GÜVENÇ Y., TOPAL B., VERİMLİ U., BIYIKLI E.Publication Metadata only Publication Open Access Evaluation of clinical and radiological outcomes in degenerative lumbar spine disorders treated with peek rod(2023-10-01) KARAGÖZ, AHMET; GÜVENÇ, YAHYA; Günerhan G., Gürpinar I., Çaǧil E., Karadeniz R., Karaman A., Karagöz A., GÜVENÇ Y., Dalgiç A.Objective: This study aimed to evaluate the clinical and radiological outcomes of patients undergoing transpedicular screw and polyetheretherketone (PEEK) rod stabilization for the surgical treatment of degenerative diseases of the lumbar spine. Materials and Methods: A retrospective analysis was conducted on 51 patients diagnosed with degenerative spine disease, such as recurrent disc herniation, spinal stenosis, spondylolisthesis, and adjacent segment disease, who underwent bilateral transpedicular screw-PEEK rod stabilization between May 2017 and November 2020. Preoperative and postoperative assessments included lumbar lordosis angles, sacral slope, pelvic incidence, pelvic tilt, visual analog scale (VAS) scores, PROLO economic and social scores, and the presence of adjacent segments and fusion. Results: The study included 51 patients with a mean age of 62.5 years (range: 18-85 years), with 56.8% (29 patients) being female and 43.2% (22 patients) being male. Surgical procedures involved single-level stabilization in 16 patients, two-level stabilization in 21 patients, three-level stabilization in 9 patients, and four-level stabilization in 5 patients. The mean follow-up period was 52.4 months. Postoperatively, there was a significant reduction in VAS scores from a mean of 8.2±1.3 to 3.4±1.7 (p≤0.01). No significant changes were observed in the lumbar lordosis angle, sacral slope, pelvic tilt angle, and pelvic incidence angle. The mean PROLO score improved from 3.5±1.2 preoperatively to 7.6±1.5 postoperatively. Fusion was observed in 43 patients during the follow-up period. Conclusion: The use of PEEK rods in the surgical treatment of degenerative lumbar spine diseases may lead to improved postoperative quality of life and reduced implant-related complications. Furthermore, our findings suggest that patients without sagittal balance impairment may benefit from PEEK rod stabilization without significant changes in spinal alignment. However, further comparative and long-term studies are required to better understand the efficacy and outcomes of PEEK rod systems in this treatment approach.Publication Metadata only Surgical correction techniques for spinal deformity(2022-09-23) GÜVENÇ, YAHYA; GÜVENÇ Y.Publication Open Access Introduction to the nervous system from tissue engineering perspective(Elsevier, 2023-01-01) GÜVENÇ, YAHYA; KIVRAK, CAN; GÜVENÇ Y., KIVRAK C.; Gündüz, Oğuzhan; Üstündağ, Cem Bülent; Şengör, MustafaThere are no currently medical interventions that can directly repair and restore the neural structure and function in the brain and spinal cord. The biggest problem with neurological injuries is that we have no tools or skills to reconstruct and repair the neural tissue itself. The complexity of neuroanatomical pathways and networks makes this even more difficult, and at the same time, cellular low neuroregenerative capacity causes loss of nerve function. Although stem cell–based studies are effective in damaged nerve regeneration, limited integration with neural tissue, cell transplantation difficulties, and short-term cell survival after transplantation are the limitations of these studies. The development of 3d scaffolds, which contain progenitor cells, created by neural tissue engineering creates a support function for cells and is one of the steps developed to overcome these problems. In this way, neural tissue integration is facilitated and the necessary physical support for the neural tissue is provided. As can be understood from this, neuronal regeneration can be made possible by remodeling at the cellular or subcellular levels.Publication Metadata only Omurga tümörlerinde biyopsi; endikasyonlar, teknik, perkütan girişimsel uygulamalar(Buluş Yayınevi, 2022-01-01) GÜVENÇ, YAHYA; GÜVENÇ Y., TOPAL B., TEMİZ C.Publication Metadata only Anterior surgery for CSM(2022-09-22) GÜVENÇ, YAHYA; GÜVENÇ Y.Publication Metadata only Airplane Landing Accident: How Safe Is Use of Passenger Lap Seat Belts in Aircrafts?(ELSEVIER SCIENCE INC, 2020) HARMAN, FERHAT; Harman, Ferhat; Guvenc, Yahya; Coskun, Mumin; Baran, OguzBACKGROUND: Seat belts are considered the reason for seat belt syndrome, which mainly occurs during rapid deceleration in motor vehicle accidents. Seat belt syndrome is characterized by contusion of the front torso, intrathoracic or intraabdominal organ injuries, and spinal thoracic or lumbar chance fractures. CASE DESCRIPTION: This case study presents a 21-year-old female who was injured by a lap-type seat belt and diagnosed with seat belt syndrome after an airplane landing accident. She underwent surgery for lumbar chance fracture and abdominal injury. We discussed the possible harmful effects of lap seat belts in passenger seats on airplanes. CONCLUSIONS: While an airplane is in a flying position, a lap seat belt functions to protect the passenger from any turbulence. However, during the landing or take-off phase, it may not be enough to fully protect the passenger, especially during sudden deceleration accidents, which cause seat belt injuries and head traumas. Therefore the unique design of a double functional passenger seat belt harness, along with a 3- or 4-point buckle protruding from the shoulder, can serve as a more favorable protective measure in limiting the severity of injury a passenger receives. After the plane has taken off, the diagonal seat belt can then be unlocked, leaving the lap seat belt to remain firmly in place and secured.Publication Metadata only Spinal enstrümantasyon revizyon cerrahisi(Buluş Yayınevi, 2023-05-01) SÖNMEZ, ÖZCAN; TOPAL, BAHADIR; GÜVENÇ, YAHYA; Sönmez Ö., Topal B., Güvenç Y..
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