Person: YANARTAŞ, ÖMER
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YANARTAŞ
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ÖMER
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Publication Open Access Use of therapist rotation model for eye movement desensitization and reprocessing (EMDR) in a patient with atopic dermatitis(2022-01-01) YANARTAŞ, ÖMER; BUDAK, CANSU; TOPÇUOĞLU, VOLKAN; ERGUN, SAFİYE ATLAS TÜLİN; Yasar A. B., YANARTAŞ Ö., Cam C. S., BUDAK C., Topcuoglu V., ERGUN S. A. T.Atopic dermatitis (AD) is described by lichenification, pruritus and excoriation of the skin. Up to 70% of patients may experience stressful life events before onset of AD. In this study, we aimed to present use of Eye Movement Desensitization and Reprocessing (EMDR) for psychotherapy of an AD patient. Our second goal is to demonstrate the effect of therapist rotation model (TRM) for this group of patients. We used EMDR and TRM based on Van Minnen\"s model. We compared test results including depression, anxiety, and AD disease severity before and after EMDR sessions. Our patient\"s depression and anxiety scores decreased after EMDR therapy. EMDR may be useful for psychogenic component and itching complaint of AD. TRM may be rational, effective and tolerable for these patients.Publication Metadata only Functional somatic symptoms and their predictors in patients with major depressive disorder and fibromyalgia syndrome(2022-12-01) YANARTAŞ, ÖMER; SAYAR, MUSTAFA KEMAL; Subaşi Tekintaş N., YANARTAŞ Ö., Benk Durmuş F., Sayar K.© 2022 by Turkish Association of Neuropsychiatry.Introduction: Despite being different medical conditions, functional somatic symptoms (FSSs) are common in patients with major depressive disorder (MDD) and fibromyalgia syndrome (FMS). Higher levels of depression, anxiety, somatosensory amplification, hypochondriacal worry and alexithymia may be related to the severity of somatization in patients with MDD and FMS. We aimed to investigate the typology and severity of FSSs and the association between FSSs and these psychiatric symptoms in patients with MDD and FMS. Method: 56 MDD, 33 FMS, 21 CoMF (Comorbidity of MDD and FMS) patients, and 50 healthy participants were included in the study, respectively. Diagnosis of MDD and FMS was established according to DSM-IV-TR (Diagnostic and Statistical Manual of Mental Disorders, Revised Text), and ACR (American College of Rheumatology) 2010 diagnostic criteria. All participants were evaluated with self-report questionnaires including Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Somatosensory Amplification Scale (SSAS), Toronto Alexithymia Scale-20 (TAS-20), Whiteley Index-7 (WI-7), The Symptom Checklist-90-R (SCL-90-R) somatization subscale and Bradford Somatic Inventory-44 (BSI-44). Results: The severity of somatization was statistically significantly highest in the CoMF group, and similar in the FMS and MDD groups, and lowest in the control group according to the BSI-44 and SCL-90-R results. The typology of FSSs was quite similar in patients with MDD and FMS, and weakness, tiredness and neck pain were the most common FSSs in both groups. Independent predictors of FSSs were age, the severity of anxiety and alexithymia in the MDD group, however, it was only the severity of anxiety in the FMS group. Conclusions: Our results show that the typology and severity of FSSs are similar in MDD and FMS patients. Moreover, somatization appears to be more associated with anxiety in patients with MDD and FMS.Publication Open Access The relationship between psychopathology and cognitive functions with cytokines in clinically stable patients with schizophrenia(TAYLOR & FRANCIS LTD, 2018-01-02) HAKLAR, GONCAGÜL; Ergun, Serhat; Yanartas, Omer; Kandemir, Guler; Yaman, Ali; Yildiz, Mesut; Haklar, Goncagul; Sayar, KemalOBJECTIVES: Inflammation and the cytokine hypotheses have been proposed for schizophrenia. Several proinflammatory and anti-inflammatory cytokines have been studied in drug-naive, first-episode, and/or chronic schizophrenia patients. However, there were limited data on clinical stable outpatients reflecting daily routine. The aim of this study was to compare the serum levels of cytokines, including transforming growth factor-beta (TGF-beta), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha), between clinically stable patients with schizophrenia and healthy controls, as well as to examine the relationship between these inflammation parameters and clinical variables (positive and negative symptom severity and cognitive functions). METHODS: Thirty clinically stable outpatients with schizophrenia and 30 healthy controls with similar sex and age were included in this study. Serum IL-6, TGF-beta, and TNF-alpha levels were assessed by enzyme-linked immunosorbent assay (ELISA) and immunoenzyme microplate measurement, respectively. Illness severity was evaluated using the Positive and Negative Syndrome Scale (PANSS), and the cognitive functions of the participants were assessed using a broad neuropsychological test battery. RESULTS: The serum levels of IL-6 and TGF-beta were significantly higher in patients with schizophrenia compared to healthy controls (p = .048, p = .012). There was no significant difference between groups in terms of TNF-alpha levels (p = .726). Global impairment of cognitive functions was observed in the patient group compared to healthy controls, and PANSS scores and cognitive functions showed no correlation with cytokine levels (IL-6, TNF-alpha, and TGF-beta). CONCLUSIONS: The present study demonstrated an increased inflammatory response in clinically stable patients with schizophrenia compared to healthy controls. However, symptom severity and cognitive functions showed no correlation with cytokine levels. Further research studies are needed to clarify the effects of cytokine levels on schizophrenia symptomatology and etiopathogenesis.Publication Metadata only Neuroprotective effect of ebselen against intracerebroventricular streptozotocin-induced neuronal apoptosis and oxidative stress in rats(SAGE PUBLICATIONS INC, 2016) YANARTAŞ, ÖMER; Unsal, Cuneyt; Oran, Mustafa; Albayrak, Yakup; Aktas, Cevat; Erboga, Mustafa; Topcu, Birol; Uygur, Ramazan; Tulubas, Feti; Yanartas, Omer; Ates, Ozkan; Ozen, Oguz AslanThe goal of this study was to examine the neuroprotective effect of ebselen against intracerebroventricular streptozotocin (ICV-STZ)-induced oxidative stress and neuronal apoptosis in rat brain. A total of 30 adult male Sprague-Dawley rats were randomly divided into 3 groups of 10 animals each: control, ICV-STZ, and ICV-STZ treated with ebselen. The ICV-STZ group rats were injected bilaterally with ICV-STZ (3 mg/kg) on days 1 and 3, and ebselen (10 mg/kg/day) was administered for 14 days starting from 1st day of ICV-STZ injection to day 14. Rats were killed at the end of the study and brain tissues were removed for biochemical and histopathological investigation. Our results demonstrated, for the first time, the neuroprotective effect of ebselen on Alzheimer's disease (AD) model in rats. Our present study, in ICV-STZ group, showed significant increase in tissue malondialdehyde levels and significant decrease in enzymatic antioxidants superoxide dismutase and glutathione peroxidase in the frontal cortex tissue. The histopathological studies in the brain of rats also supported that ebselen markedly reduced the ICV-STZ-induced histopathological changes and well preserved the normal histological architecture of the frontal cortex tissue. The number of apoptotic neurons was increased in frontal cortex tissue after ICV-STZ administration. Treatment of ebselen markedly reduced the number of degenerating apoptotic neurons. The study demonstrates the effectiveness of ebselen, as a powerful antioxidant, in preventing the oxidative damage and morphological changes caused by ICV-STZ in rats. Thus, ebselen may have a therapeutic value for the treatment of AD.Publication Metadata only Clinical Correlates of Childhood Trauma and Dissociative Phenomena in Patients with Severe Psychiatric Disorders(SPRINGER, 2014) YANARTAŞ, ÖMER; Zincir, Selma Bozkurt; Yanartas, Omer; Zincir, Serkan; Semiz, Umit BasarIn this present study, we aim to investigate the possibility of a link between psychotic disorders and traumatic experiences in a group of female patients diagnosed with psychotic disorders by comparing childhood trauma exposure with a group of non-psychotic psychiatric disorder attending the same pschiatric clinic. Secondary purpose of this study is to examine the clinical correlates of trauma exposure, dissociative phenomena and psychiatric symptomatology between these two group of patients. Two psychiatric sample groups, those with psychotic disorders-mostly schizophrenic-(n = 54), and those with a non-psychotic severe psychiatric disorders (n = 24), were recruited. Data were collected for demographic, psychiatric and trauma histories and psychiatric symptomatology for all patients. In this study, high prevalance rates of childhood traumatic experiences and dissociative phenomena were found in both groups. Total scores of childhood trauma questionnaire in favor of the non-psychotic group were found to be close to significance (p = 0.052). DES scores of non-psychotic group were also higher although not statistically significant. 54.2 % of nonpsychotic cases had DES scores > 20 on the other hand, that percentage of psychotic cases were found to be as 38.9 %. Furthermore, psychiatric patients who have suffered childhood traumatic experiences are far more likely to try to kill themselves than psychiatric patients who have not experienced such abuse. The high rates of childhood traumatic events in our present samples of both schizophrenia-spectrum patients and nonpsychotic patients confirm the need for clinicans to take trauma histories routinely.Publication Metadata only Dream anxiety, chronotype and dipping pattern in hypertensive patients assessed with 24 h ambulatory blood pressure monitoring(SPRINGER JAPAN KK, 2016) SAKALLI KANİ, AYŞE; Kani, Ayse Sakalli; Sunbul, Murat; Kani, Haluk Tarik; Yanartas, Omer; Tezcan, Neslihan; Emul, MuratThe purpose of the present study was to investigate dream anxiety, impulsivity, and chronotypes in patients with dipper/non-dipper hypertension and to compare with healthy controls. Sixty-two patients diagnosed with hypertension and 33 healthy individuals were recruited in this study. A history of current psychiatric illness or psychotropic drug usage, significant cardiac, medical or neurological disease and pregnancy were the exclusion criterias for the study. All patients and healthy controls underwent 24-h ambulatory blood pressure monitoring. The Van Dream Anxiety Scale, Morningness-Eveningness Questionnaire, Spielberger State-Trait Anxiety Inventory, Beck Depression Inventory, Barratt Impulsivity Scale and Pittsburgh Sleep Quality Index were administered to all participants. There were two groups; patients with hypertension (dipper, n = 26 and non-dipper, n = 36) and healthy controls (n = 33). No differences between groups among gender (chi(2) = 4.42 and p = 0.110) and mean age (F = 0.239 and p = 0.795) were found. In patients with hypertension; dream anxiety, impulsivity, depression and trait anxiety scores were significantly higher than healthy controls. Sleep quality was poorer in patients with hypertension and there was no difference according to chronotype between patients and controls. There were no differences between dipper and non-dipper groups according to dream anxiety, sleep quality, impulsivity, state-trait anxiety, and depressive scores. In conclusion, dream anxiety is a previously unaddressed psychological entity that, in addition to anxiety, depression, impulsivity and poorer sleep quality, appears in hypertensive patients. Longitudinal studies with larger sample sizes would be valuable to elucidate the relationship between dream anxiety and hypertension patterns.Publication Open Access Severity of Depression and Anxiety Symptoms is Associated with Increased Arterial Stiffness in Depressive Disorder Patients Undergoing Psychiatric Treatment(KURE ILETISIM GRUBU A S, 2016-09) SARI, İBRAHİM; Yanartas, Omer; Sunbul, Murat; Durmus, Erdal; Kivrak, Tarik; Senkal, Zeynep; Subasi, Nilufer; Karaer, Gulhan; Ergun, Serhat; Sari, Ibrahim; Sayar, KemalObjective: Depression and anxiety are associated with both subdinical and clinical cardiovascular disease. Endothelial dysfunction, atherosclerosis, and inflammation are some of the underlying mechanisms. Pulse wave velocity (PWV) and augmentation index (Alx) are noninvasive markers for evaluation of arterial stiffness. The aim of this study was to examine the association between arterial stiffness parameters and depression/anxiety scores in depressive patients undergoing psychiatric treatment. Methods: The study population consisted of 30 patients with depression undergoing psychiatric treatment at least 4 weeks, and 25 age and gender matched healthy controls. Depression and anxiety were assessed by self-reported scales, including the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). Measurements of arterial stiffness parameters were performed by using a Mobil-O-Graph arteriograph system, which detects signals from the brachial artery. Results: Baseline characteristics and clinical data were similar between the two groups. BDI and BAI scores were statistically significantly higher in patients with depression (p<0.001, p<0.01). PWV and Alx were statistically significantly higher in patients with depression compared to controls (6.40 +/- 1.31 m/s vs 5.51 +/- 0.41 m/s and 26.9 +/- 12.1 % vs 17.4 +/- 11.3 %, p=0.001, p=0.004, respectively). PWV and Alx positively, mildly and statistically significantly correlated with BDI and BAI scores. Conclusion: Arterial stiffness parameters were statistically significantly higher in depressive patients receiving antidepressant treatment. Moreover, arterial stiffness parameters statistically significantly correlated with BDI and BAI. Assessment of arterial stiffness parameters may be useful for early detection of cardiovascular deterioration in depressive patients undergoing antidepressant treatment.Publication Open Access The psychological determinants of emotional and external eating behavior in a university student sample from Turkey(2023-01-01) ERGÜN, SERHAT; YANARTAŞ, ÖMER; ÖZERCAN, AHMET; SAYAR, MUSTAFA KEMAL; ERGÜN S., Akca E., YANARTAŞ Ö., Akca Z. N. D., ÖZERCAN A., Sayar K.Psychological factors and adverse childhood events at an early age have been poorly investigated in relation to risky eating behavior and obesity. The importance of this relationship grows as these behaviors are becoming public health problems. The main objective of the present study was to examine the effects of interrelated psychological factors such as childhood negative life events, symptoms of depression and anxiety, and impulsivity on eating behaviors in a university student sample in Turkey. A total of 414 undergraduate students (60.4% women) in Turkey, completed the Turkish versions of the Dutch Eating Behavior Questionnaire (DEBQ) to assess emotional eating and external eating and the CDC-Kaiser Permanent Adverse Childhood Experiences (ACE), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Barratt Impulsivity Scale-11 (BSI-11). Structural equation models (SEM) were used to evaluate whether depressive/anxiety symptoms could be a mediator between impulsivity and emotional eating/external eating. Childhood adverse events were both weakly correlated with eating behavior and impulsivity measures (r = .18,r = .275, p <.001, respectively). Depression and anxiety levels were found to be significantly associated with all variables except for the body mass index (BMI; r = .121-.395, p <.001). Body mass index (BMI) was also significantly correlated with emotional eating (r = .231, p <.001) and restrained eating (r = .226, p <.001). Impulsivity was positively and directly associated with symptoms of anxiety and depression and emotional and external eating (respectively 0 = .27, p <.001; 0 = .31, p <.001; 0 = .16, p = .006; 0 = .13, p = .047). The effect of adverse experiences on both emotional eating (0 = .147; 95% CI [.087, .247]) and external eating (0 = .091; 95% CI [.032, .168]) was found to be partially mediated by impulsivity and symptoms of anxiety and depression. The results supported the proposition that symptoms of depression and anxiety levels are mediators between impulsivity and emotional eating/ external eating. This finding suggests that a through psychological assessment should be taken into consideration when evaluating the eating behavior of university students and prevention and treatment strategies applied for disordered eating behaviors in the future.Publication Open Access Depression, anxiety, alexithymia and somatosensory sensitivity in patients with benign palpitation(TAYLOR & FRANCIS LTD, 2017-04-03) ÇİNÇİN, AHMET ALTUĞ; Sayar, Nurten; Yanartas, Omer; Tigen, Kursat; Sadic, Beste Ozben; Ergun, Serhat; Kepez, Alper; Cincin, AltugObjective: The aim of this study is to compare the frequency of depression, anxiety, alexithymia and somatosensory sensitivity in patients with benign palpitation with healthy controls. Method: Sixty-one patients with palpitation and 59 age-and sex-matched control subjects were enrolled. All study subjects were undergone thorough cardiac evaluation, and patients with palpitation also had echocardiography and 24-hour ECG monitoring to rule out significant arrhythmias, coronary artery disease and structural heart disease. All subjects were assessed by Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Toronto Alexithymia scale, Whiteley Index (WI) and Somatosensory Amplification Scale (SAS). Results: Patients with benign palpitation had significantly increased BAI, BDI, WI and SAS scores. Anxiety is the only independent predictor of benign palpitation (odds ratio = 1.12, 95% confidence interval = 1.05-1.19, p < 0.001). Conclusion: This study shows that patients with benign palpitation had increased anxiety levels and somatization disorders. So an integrated psycho-cardiological approach is needed in this special population.Publication Metadata only A cross-sectional analysis of patient characteristics and practice patterns in the management of bipolar disorder across Turkey(CUMHURIYET UNIV TIP FAK PSIKIYATRI ANABILIM DALI, 2014) YANARTAŞ, ÖMER; Bilici, Mustafa; Kesebir, Sermin; Ozkorumak, Evrim; Yanartas, Omer; Isitmez, SemaObjective: Bipolar disorder (BD) is one of the leading causes of disability among medical and psychiatric disorders associated with prevalent, chronic, severe and highly disabling characteristics. This study was designed to identify clinical characteristics and practice patterns in the management of outpatients with BD across Turkey. Method: This multi-center cross-sectional study involving 1001 patients diagnosed with using DSM-IV criteria was conducted prospectively at 31 outpatient psychiatry clinics for 12 months. Patient demographics, clinical features, family history, comorbid psychiatric disorders, and the treatment modalities were assessed by means of semistructured questionnaire. Results: Age at the onset of symptoms was 26.7 +/- 9.8 years, age at diagnosis was 28.9 +/- 10.4 years, and the time interval between them was 2.2 +/- 4.7 years. Misdiagnosis prior to current diagnosis was evident in 40.3% of bipolar patients. The most common type of first episode was mania (57.1%) and depression (34.5%). Comorbid psychiatric illness was identified in 12.0% of patients. Only 10% of patients were receiving monotherapy. The most commonly prescribed drugs for depressive, manic and mixed episodes were lithium, sodium valproate and quetiapine, respectively. Conclusion: The time interval between onset of symptoms and the initial diagnosis in Turkish sample was quite shorter than reported in the literature. The misdiagnosis rate in the present study and recent studies were similar. A low comorbidity rate appears to indicate a lower prevalence of comorbid disorders in BD in Turkish sample. Lithium, sodium valproate and atypical antipsychotics were more commonly used drugs in the treatment of BD in Turkey.
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