Person: ŞAHİN, ÖZLEM
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ŞAHİN
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ÖZLEM
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Publication Metadata only Isolated bilateral optic neuropathy in acute disseminated encephalomyelitis(SLACK INC, 2003) TOKER, AYŞE EBRU; Toker, E; Yenice, O; Yilmaz, YPublication Metadata only Influence of serum levels of sex hormones on intraocular pressure in menopausal women(LIPPINCOTT WILLIAMS & WILKINS, 2003) TOKER, AYŞE EBRU; Toker, E; Yenice, O; Temel, APurpose: The purpose of this study was to assess the effect that changes in sex hormone levels have on intraocular pressure (IOP) in menopausal women. Subjects and Methods: Thirty menopausal women on hormone replacement therapy and 32 menopausal women who had never received hormone replacement therapy (HRT), matched for age and duration of amenorrhea, participated in this study. Intraocular pressures were measured with Goldmann applanation tonometer. Serum levels were measured for estradiol, free testosterone, and follicle stimulating hormone (FSH). The influence of serum hormone levels on IOP was assessed by correlation analysis. Results: The mean IOP of postmenopausal women receiving HRT (13.29 +/- 2.28 mm Hg) was not significantly different from that of menopausal women not receiving HRT (13.56 +/- 2.5 min Hg, P = 0.24). Higher testosterone levels were associated with higher IOPs in women receiving HRT (r = 0.48, P = 0.02) and in those not receiving HRT (r = 0.42, P = 0.003). No significant correlations were observed between IOP and serum levels of estradiol and FSH in either group. Conclusion: Our data provide evidence for a relation between serum testosterone levels and IOP in menopause. Higher testosterone seems to have a tendency to increase IOP in menopausal women.Publication Metadata only Resolution of cystoid macular edema with topical carbonic anhydrase inhibitor in a patient with retinal dystrophy associated with Cohen syndrome(TAYLOR & FRANCIS INC, 2021) SEVİK, MEHMET ORKUN; Sevik, Mehmet Orkun; Aykut, Aslan; Sahin, OzlemBackground: Cohen Syndrome (CS) is an autosomal recessive multisystemic disorder characterized by various ophthalmologic findings, including retinal dystrophy and associated cystoid macular edema (CME), in which there was no known effective treatment approach. Material and Methods: We describe a CS patient with a homozygous c.62 T > G, p.(Leu21*) mutation in the VPS13B gene with a topical carbonic anhydrase inhibitor (CAI; brinzolamide %1, thrice daily) responding CME. Case Description: A seven-year-old girl with an established diagnosis of CS was referred with a primary complaint of nyctalopia. On ophthalmologic examination, bilateral decreased visual acuity and normal-appearing macula with mild optic disc pallor were present. However, the detailed evaluation revealed bilateral blunted foveal reflexes, barely visible foveal pigmentation, and slightly attenuated retinal vessels without any peripheral retinal pigmentary changes in dilated fundus examination, and CME on optical coherence tomography. Bilateral topical brinzolamide thrice daily was initiated for CME. Visual acuity increased, and CME was resolved except for minimal schisis at the inner nuclear layer level at the third-month follow-up visit and remained stable up to one-year follow-up. CME reappeared after five months of self-discontinuation of the patient's therapy but resolved again with treatment resumption. Conclusion: We report the first case of CME secondary to rod-cone dystrophy associated with CS showing improvement in anatomy and visual acuity with a topical CAI.Publication Open Access The influence of sex hormones on ocular blood flow in women(WILEY, 2003-12) TOKER, AYŞE EBRU; Toker, E; Yenice, O; Akpinar, I; Aribal, E; Kazokoglu, HPurpose: To investigate the influence of sex hormones on ocular haemodynamics, blood flow velocities in the ophthalmic and central retinal arteries and serum levels of sex hormones were measured in pre- and postmenopausal women. Methods: Colour Doppler imaging (CDI) was used to determine the flow velocities (peak systolic velocity [PSV] and end-diastolic velocity [EDV]) and the resistive index (RI) in the ophthalmic and central retinal arteries in 22 premenopausal and 32 postmenopausal women, who had never received hormone replacement therapy. Serum levels were measured for oestradiol, free testosterone and follicle-stimulating hormone. The CDI parameters were compared between the two groups and the influence of serum levels of oestradiol and testosterone on blood flow velocities and the resistive indices were analysed. Results: After correcting for age and mean arterial blood pressure, an analysis of covariance disclosed a significantly lower EDV (p = 0.02) and a significantly higher RI (p = 0.01) in the central retinal artery of postmenopausal women compared with premenopausal women. Partial correlation analysis, controlling for age, revealed significant correlations between the CDI parameters and serum levels of oestradiol and testosterone. For premenopausal women, PSV (r = 0.58, p = 0.04) and EDV (r = 0.73, p = 0.006) in the ophthalmic artery correlated positively with serum oestradiol levels. The RI in the central retinal artery decreased with increasing oestradiol levels in both groups (premenopausal r = - 0.40, p = 0.04; postmenopausal r = - 0.32, p = 0.05). Peak systolic velocity in the central retinal artery correlated negatively (r = - 0.49, p = 0.04), whereas the RI correlated positively (r = 0.53, p = 0.02) with testosterone levels in the premenopausal group. Postmenopausal women with higher testosterone levels had lower EDV (r = - 0.53, p = 0.007) in the central retinal artery and higher RI in both vessels (ophthalmic artery r = 0.48, p = 0.01; central retinal artery r = 0.61, p = 0.002). Conclusion: Our data provide evidence of a relationship between serum sex hormone levels and blood flow velocities and resistive indices in retrobulbar arteries. Oestradiol appears to have beneficial effects on ocular haemodynamics, whereas testosterone may act as an antagonistic to the effects of oestrogen.Publication Metadata only Etiopathogenesis of retinopathy of prematurity [Prematüre retinopatisinde etiyopatogenez](2012-12-15) ŞAHİN, ÖZLEM; Balci S.Y., Yenice O.S.In spite of current treatment methods, retinopathy of prematurity (ROP) is one of the most important reasons of blindness. Increased number of newborn intensive care units and technological improvements lead to survival of increased number of immature infants which in turn leads to increased number of premature infants to be screened. Recently, more profound understanding of the specific effects of molecules such as insulin-like growth factor-1 (IGF-1), erythropoietin (EPO), and vascular endothelial growth factor (VEGF) that play a role in the etiopathogenesis of ROP is suggested, and by determining the levels of these factors in the blood of premature infants, screening of infants with definitive blood levels of these factors is recommended. The aim of this review is to evaluate etiopathogenesis of ROP disease and to determine the specific mediators that play a role in the pathogenesis of ROP disease. Understanding the pathogenesis of ROP may induce changes in screening, monitoring, and treatment protocols. © Galenos Yayinevi.Publication Open Access Next generation sequencing identifies mutations in Atonal homolog 7 (ATOH7) in families with global eye developmental defects(OXFORD UNIV PRESS, 2012-02-15) ELÇİOĞLU, HURİYE NURSEL; Khan, Kamron; Logan, Clare V.; McKibbin, Martin; Sheridan, Eamonn; Elcioglu, Nursel H.; Yenice, Ozlem; Parry, David A.; Fernandez-Fuentes, Narcis; Abdelhamed, Zakia I. A.; Al-Maskari, Ahmed; Poulter, James A.; Mohamed, Moin D.; Carr, Ian M.; Morgan, Joanne E.; Jafri, Hussain; Raashid, Yasmin; Taylor, Graham R.; Johnson, Colin A.; Inglehearn, Chris F.; Toomes, Carmel; Ali, ManirThe atonal homolog 7 (ATOH7) gene encodes a transcription factor involved in determining the fate of retinal progenitor cells and is particularly required for optic nerve and ganglion cell development. Using a combination of autozygosity mapping and next generation sequencing, we have identified homozygous mutations in this gene, p.E49V and p.P18RfsX69, in two consanguineous families diagnosed with multiple ocular developmental defects, including severe vitreoretinal dysplasia, optic nerve hypoplasia, persistent fetal vasculature, microphthalmia, congenital cataracts, microcornea, corneal opacity and nystagmus. Most of these clinical features overlap with defects in the Norrin/beta-catenin signalling pathway that is characterized by dysgenesis of the retinal and hyaloid vasculature. Our findings document Mendelian mutations within ATOH7 and imply a role for this molecule in the development of structures at the front as well as the back of the eye. This work also provides further insights into the function of ATOH7, especially its importance in retinal vascular development and hyaloid regression.Publication Metadata only The third family with TAF6-related phenotype: Alazami-Yuan syndrome(2020) ŞAHİN, ÖZLEM; Tuc, Ecenur; Bengur, Fuat Baris; Aykut, Aslan; Sahin, Ozlem; Alanay, YaseminPublication Open Access Comparison of Efficacy and Side Effects of Multispot Lasers and Conventional Lasers for Diabetic Retinopathy Treatment(TURKISH OPHTHALMOLOGICAL SOC, 2017-01-17) ÇELİKER ATABERK, HANDE; Celiker, Hande; Bulut, Azer Erdagi; Sahin, OzlemPanretinal photocoagulation (PRP) is a standard treatment for proliferative diabetic retinopathy. Conventional laser (CL) therapy is performed in one or more sessions in single spot mode. Visual disabilities have been reported after treatment with CL, including central vision loss due to macular edema and peripheral visual field loss resulting from extensive inner retinal scarring. Multispot laser (MSL) photocoagulation has recently been introduced to clinical practice. Studies comparing PRP conducted with MSL and CL have reported that MSLs resulted in less retinal tissue damage and pain, and greater patient comfort compared to CL. The aim of this review was to compare the efficacy and side effects of MSLs and CLs for diabetic retinopathy treatment.Publication Metadata only Visual field analysis in patients with Parkinson's disease(ELSEVIER SCI LTD, 2008) MİDİ, İPEK; Yenice, Ozlem; Onal, Sumru; Midi, Ipek; Ozcan, Eda; Temel, Ahmet; I-Gunal, DilekBackground: To evaluate visual field changes in patients with Parkinson's disease. Methods: Standard automated perimetry of 14 patients (28 eyes) with Parkinson's disease (PD) were compared with controls. PD patients with Unified Parkinson's Disease Rating Scale (UPDRS) score below 25 were included in the study. Results: Visual field indices including mean deviation (-4.69 +/- 2.72 vs. -1.71 +/- 1.30, p = 0.0008), pattern standard deviation (3.94 +/- 1.94 vs. 2.30 +/- 0.41, p = 0.001), and corrected pattern standard deviation (3.23 +/- 2.18 vs. 1.20 +/- 0.91, p = 0.003), were significantly worse in patients with PD when compared with the control group. Bilateral glaucoma-like visual field defects were evident in six patients. Conclusion: Parkinson's patients had worse visual field indices suggesting a common insult in the etiopathogenesis of nerve fiber layer damages observed in glaucoma and PD. (c) 2007 Elsevier Ltd. All rights reserved.Publication Metadata only Colobomatous macrophthalmia with microcornea syndrome: report of a new pedigree(2003) TOKER, AYŞE EBRU; Toker, Ebru; Elcioglu, Nursel; Ozcan, Eda; Yenice, Ozlem; Ogut, MehdiColobomatous macrophthalmia with microcornea syndrome (MIM 602499) is a very rare eye malformation. To date, only two families with a total number of eight patients have been reported. We report on 13 additional cases in a single three-generation family and describe the eye findings and quantitative parameters of corneal curvature and axial ocular dimensions. All affected relatives had bilateral involvement with typical inferonasal iris coloboma, chorioretinal coloboma, microcornea, and varying degrees of axial enlargement associated with myopia. Additional findings included flatter corneal curvatures and shallower anterior chambers. Iridocorneal angle abnormalities associated with elevation of intraocular pressure were detected in three patients. The pedigree confirms the autosomal dominant pattern of inheritance with complete penetrance.