Person: ŞAHBAZ, SEVİNÇ
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ŞAHBAZ
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SEVİNÇ
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Publication Metadata only İmhası istenilen ürünler(2015-12-01) CÜCÜ, AYŞEN; BİTİŞ, LEYLA; RAYAMAN, ERKAN; ŞAHBAZ, SEVİNÇ; AKGÜN ÖLMEZ, SEVCAN GÜL; Cücü A., Bitiş L., Rayaman E., Şahbaz S., Akgün Ölmez S. G.Publication Open Access Synthesis and characterization of chitosan-PVA hydrogel containing PEGylated recombinant epidermal growth factor on cell culture for wound healing substitute(2022-08-01) SEZER, ALİ DEMİR; UĞURLU, TİMUÇİN; ŞAHBAZ, SEVİNÇ; Doğan M., Şahbaz S., Uğurlu T., Sezer A. D.The aim of the current study was to assess the physicochemical characteristics and wound healing activity of chitosan-polyvinyl alcohol (PVA) crosslinked hydrogel containing recombinant human epidermal growth factor (rh-EGF) or recombinant mouse epidermal growth factor (rm-EGF). The hydrogels were prepared and analyses were made of the morphological properties, viscosity, water absorption capacity, mechanical and bio-adhesive properties. The viscosity of the formulations varied between 14.400 - 48.500 cPs, with the greatest viscosity values determined in K2 formulation. F2 formulation showed the highest water absorption capacity. According to the studies of the mechanical properties, H2 formulation (0.153±0.018 N.mm) showed the greatest adhesiveness and E2 (0.245±0.001 mj/cm2 ) formulation, the highest bio-adhesion values. Hydrogels were cytocompatible considering in vitro cell viability values of over 76% on human keratinocyte cells (HaCaT, CVCL-0038) and of over 84% on human fibroblast cells (NIH 3T3, CRL-1658) used as a model cell line. According to the BrdU cell proliferation results, B1 (197.82±2.48%) formulation showed the greatest NIH 3T3 and C1 (167.43±5.89%) formulation exhibited the highest HaCaT cell proliferation ability. In addition, the scratch closure assay was performed to assess the wound healing efficiency of formulation and the results obtained in the study showed that F2 formulation including PEGylated rh-EGF had a highly effective role. Keywords: Chitosan. rh-EGF. Hydrogel. Texture analyzer. Cell culture.Publication Metadata only Bebeklerde pişik önleyici amaçla, biodegradable fiber kumaş içeren bitkisel içerikli ıslak mendillerin geliştirilmesi(2022-02-18) KAYMAKÇIOĞLU, BEDİA; ŞAHBAZ, SEVİNÇ; Akgil M., Aktı M., Şahbaz S., Kaymakçıoğlu B.Publication Metadata only Aseklofenak içeren ağızda dağılan tablet formülasyonlarının hazırlanması ve in-vitro değerlendirilmesi(2021-01-12) UĞURLU, TİMUÇİN; ŞAHBAZ, SEVİNÇ; Erdoğan K. O., Uğurlu T., Şahbaz S.Publication Metadata only Probiyotik tablet formülasyonlarında kullanılan yardımcı maddelerin bakteri sağ kalımına etkisinin değerlendirilmesi(2023-03-19) ŞAHBAZ, SEVİNÇ; RAYAMAN, ERKAN; UĞURLU, TİMUÇİN; Kandur B., Şahbaz S., Rayaman E., Uğurlu T.