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YALÇIN, BAHATTİN

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Fen - Edebiyat Fakültesi

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YALÇIN

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BAHATTİN

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Open Access
TQ-Ox, a novel synthetic derivative of thymoquinone on ovarian cancer cells in vitro
(2022-01-01) ÖZDEMİR, MÜCAHİT; YALÇIN, BAHATTİN; Kale E., Kale A., Bozali K., Gulgec A. S. , ÖZDEMİR M., YALÇIN B., Guler E. M.
© 2022 Informa UK Limited, trading as Taylor & Francis Group.There are many studies in the literature on thymoquinone (TQ)-related cancer cells and models, and there is no relevant study investigating the efficacy of the oxime derivative of TQ (TQ-Ox). This study synthesized TQ-Ox and examined its cytotoxic, genotoxic and apoptotic properties in ovarian cancer cells. The structure TQ-Ox was confirmed with NMR. The cytotoxicity by luminometric ATP, intracellular reactive oxygen species (iROS) by fluorometric, intracellular calcium (iCa2+) by fluorometric, mitochondrial membrane potential (MMP) by flow cytometry, glutathione (GSH) levels with GSH/GSSG-Glo assay, DNA damage by comet assay, and apoptosis by acridine orange/ethidium bromide dye were determined. Concentrations of TQ-Ox were statistically increased cytotoxicity, DNA damage, apoptosis, iROS, and iCa2+ in a concentration-dependent manner (p < 0.001). Besides, MMP and GSH levels also decreased statistically significantly (p < 0.001) with increasing concentrations. TQ-Ox would be an effective treatment option by increasing cytotoxicity, genotoxicity, and apoptosis in ovarian carcinoma.
Open Access
Preliminary assessment of microfibers amount in textile wastewater
(2022-05-20) AKYILDIZ, SİNEM HAZAL; YALÇIN, BAHATTİN; Akyildiz S. H. , Yalçın Eniş I., Sezgin H., Yalçin B.
Textile wastewater is a complex mixture of inorganic compounds, polymers, organic products, dyes, and microfibers (MFs), including microplastics (MPs) and natural fibers. The treatment of textile wastewater, which contains a significant share of MFs, is of great importance to prevent the release of MPs in the environment. MPs analysis requires multiple phases of pretreatment (to eliminate the organic compounds), separation of the MFs from the water, and identification of the MPs among the MFs. This work presents the preliminary results of a research aimed at exploring two issues. Firstly, the pretreatment (through Fenton,H2O2, HCl, KOH and NaOH, applied at 25 °C for 5 days and 60 °C for 6 hours) of artificial textile wastewater, evaluating the effect of the different conditions on the MFs and the MPs. Secondly, the separation of MFs from a real textile wastewater sample through different processes (centrifugation, sink-float & filtration, filtration). The results of the pretreatment tests revealed Fenton, HCl, andH2O2at 25 °C for 5 days as the best performing chemicals and conditions. Considering the results of the separation tests, filtration gave back the best removal of the MFs from wastewater compared to centrifugation and sink-float and filtration, which left some MFs in the supernatant/float and in the sediment/sink. In conclusion, these preliminary results may be useful to further explore the detection of MFs and MPs in textile wastewater.
Open Access
New metallophthalocyanines including benzylphenoxy groups and investigation of their organic-field effect transistor (OFET) features
(2022-04-01) ÖZDEMİR, MÜCAHİT; YALÇIN, BAHATTİN; ÖZDEMİR M., ALTINIŞIK S., Koksoy B., Canimkurbey B., KOYUNCU S., Durmus M., Bulut M., YALÇIN B.
In this study, metal and metal-free novel phthalocyanines containing peripheral and non-peripheral tetra 2-ben-zylphenoxy groups were synthesized. The compounds were characterized by UV-Vis, FT-IR, H-1 NMR, and MALDI-TOF mass spectrometry as well as elemental analysis. These new phthalocyanines exhibited excellent solubility in most organic solvents, and their redox behavior was investigated in different solvents such as dimethyl sulfoxide (DMSO) and dichloromethane (DCM). The redox behavior of the peripheral and non-peripheral phthalocyanine compounds 1a -c and 2a -c was determined by cyclic voltammetry and in situ spec-troelectrochemistry. According to organic field-effect transistors (OFETs) measurements, the peripheral and non-peripheral phthalocyanine-cobalt complexes which have higher mobility than others were utilized top-gate bottom-contact OFETs fabrication. The output characteristics of the device show that its mobility is approximately 5 x 10(-2) cm(2)/Vs with p-type accumulation.
Open Access
Detection and analysis of microfibers and microplastics in wastewater from a textile company
(2022-10-01) YALÇIN, BAHATTİN; AKYILDIZ, SİNEM HAZAL; Akyildiz S. H. , Yalçın Eniş I., Sezgin H., Yalçin B.
Textile wastewater is polluted by inorganic/organic substances, polymers, dyes, and microfibers (MFs), which are microplastics (MPs) and natural fibers. This work is aimed at the preliminary investigation of MFs and MPs in textile industrial wastewater, and at evaluating the removal efficiency of an on-site wastewater treatment plant (WWTP). Ten samples of inflows and outflows of the WWTP of a textile company (applying a physic-chemical process) have been analyzed. Firstly, the samples underwent a pretreatment with 15% hydrogen peroxide at 25◦C for 5 days to remove organic compounds. Secondly, the MFs were recovered from the aqueous phase by pre- screening centrifugation, density separation, and filtration as alternative options. Filtration obtained the best performances, compared to the other recovery processes. Thirdly, the MFs were counted through optical microscopy and the MPs were identified through micro-FTIR. The MFs amount in the inflow samples was in the range of 893–4452 MFs/L. The outflow samples (310–2404 MFs/L) exhibited a 38–65% reduction compared to the inflows, demonstrating that up to 62% of residual MFs can enter the sewer network or the receiving water body. Cotton and wool, and numerous MPs (acrylic, polyester, polypropylene, polyamide, and viscose/rayon) were identified in the inflow and outflow samples (with the only exception of \"dense\" viscose (rayon), not detected in the out- flows, and probably retained by the WWTP with the sludge). This study, even if just preliminary, offers interesting hints for future research on MFs/MPs detection in textile wastewater, and on the performance of a full-scale WWT process for their removal.
Open Access
Trace metal levels in edible wild fungi
(SPRINGER, 2013-03) YALÇIN, BAHATTİN; Severoglu, Z.; Sumer, S.; Yalcin, B.; Leblebici, Z.; Aksoy, A.
Metal levels (cadmium, cobalt, chromium, copper, iron, nickel, lead and zinc) of seventeen different edible wild fungi species (Agaricus campestris, Calocybe gambosa, Coprinus comatus, Hericium coralloides, Hydnum repandum, H. repandum var. rufescens, Lactarius deliciosus, L. salminocolor, Macrolepiota procera, Pleurotus ostreatus, P. ostreatus var. columbinus, Ramaria aurea, R. stricta, Rhizopogon luteolus, Sparassis crispa, Suillus bovinus, Tricholoma terreum) growing in Bolu-Turkey were measured by inductively coupled plasma optical emission spectrocopy. The obtained data were analyzed with statistical package for the social sciences statistics program. In addition, relation between metal concentrations in both soil and fungi samples were investigated. The highest metal concentrations in Bolu District, Turkey were measured in A. campestris (cadmium 0.270, chromium 2.735 and zinc 7.683), C. comatus (iron 160.12), M. procera (copper 15.990, cobalt 0.352 and nickel 3.645), R. luteolus (Pb 4.756) mg/kg dw (dry weight). As a result of the measurements, it was observed that metal uptake is related with the species of fungi and is also affected by pH and organic contents of the soil.
Open Access
The role of electron-donating subunits in cross-linked BODIPY polymer films
(2023-01-01) ÖZDEMİR, MÜCAHİT; YALÇIN, BAHATTİN; ÖZDEMİR M., Köksoy B., YALÇIN B., KOYUNCU S.
A new method for synthesizing cross-linked 4,4-difluoro-4-bora-3a,4a-diaza-s-indacenes (BODIPYs) using a radical-based thiol-ene click reaction is developed. This method is simple, efficient, and cost-effective, and it produces polymers with unique optical, electrochemical, and surface morphology properties. Significant blue shifts in absorption and photoinduced electron transfer in emissions are observed in the cross-linked BODIPY thin films. Cross-linking also leads to the restriction of conjugation, which results in the breakage of the terminal vinyl group, an increase in the oxidation potential, and a slight upshift in the HOMO position. As a result, the electrochemical band gap is widened from 1.88 to 1.94 eV for polymer bearing N,N-dimethylamino-BODIPY and from 1.97 to 2.02 eV for polymer bearing N,N-diphenylamino-BODIPY moieties. Monomer thin films form planar surfaces due to crystallinity, while amorphous cross-linked BODIPY polymers form more rough surfaces. Additionally, photopatterning on the film surface is successfully performed using different patterned masks. This new method for synthesizing cross-linked BODIPYs has the potential to be used in a variety of applications, including organic electronics, bioimaging, and photocatalysis.
Open Access
Design and in silico study of the novel coumarin derivatives against SARS-CoV-2 main enzymes
(TAYLOR & FRANCIS INC, 2020-12-27) YALÇIN, BAHATTİN; Ozdemir, Mucahit; Koksoy, Baybars; Ceyhan, Deniz; Sayin, Koray; Ercag, Erol; Bulut, Mustafa; Yalcin, Bahattin
The novel coronavirus (SARS-CoV-2) causes severe acute respiratory syndrome and can be fatal. In particular, antiviral drugs that are currently available to treat infection in the respiratory tract have been experienced, but there is a need for new antiviral drugs that are targeted and inhibit coronavirus. The antiviral properties of organic compounds found in nature, especially coumarins, are known and widely studied. Coumarins, which are also metabolites in many medicinal drugs, should be investigated as inhibitors against coronavirus due to their pharmacophore properties (low toxicity and high pharmacokinetic properties). The easy addition of substituents to the chemical structures of coumarins makes these structures unique for the drug design. This study focuses on factors that increase the molecular binding and antiviral properties of coumarins. Molecular docking studies have been carried out to five different proteins (Spike S1-subunit, NSP5, NSP12, NSP15, and NSP16) of the SARS-CoV-2 and two proteins (ACE2 and VKORC1) of human. The best binding scores for 17 coumarins were determined for NSP12 (NonStructural Protein-12). The highest score (-10.01 kcal/mol) in the coumarin group is 2-morpholinoethan-1-amine substituted coumarin. Molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) analyses of selected ligand-protein complexes were performed. The binding energies in each 5 ns were calculated and it was found that the interaction between ligand and target protein were stable. Communicated by Ramaswamy H. Sarma
Open Access
Determination of carbohydrate amounts of various cheese species presented to sale in the market
(2018-11-30) CEBECİ, AYBİKE; YALÇIN, BAHATTİN; GÜNEŞ, FATMA ESRA; Aybike Cebeci, Mustafa Yaman, Bahattin Yalcin, Fatma Esra Gunes
The aim of this study is to determine the amounts of lactose, glucose, galactose, starch and total carbohydrates in cheese types presented to sale in the market. In the study, from different points of sale in Istanbul province 15 different types of cheese were investigated. Carbohydrate amounts of the cheeses examined were determined in two ways as theoretically (by difference method) and analytically (by HPLC). The amount of analytically determined carbohydrate of white cheese types was lower than the theoretically calculated amount (P<0.05). However, there was no statistically significant difference between the theoretical and analytically calculated carbohydrate amounts of kashar and other cheese types (P>0.05). In addition, it was determined that the amount of carbohydrates of ripened cheeses was lower than carbohydrate amounts in fresh cheeses. Consequently, analytical calculation of carbohydrate amount gives more accurate results. This should be taken into account when evaluating the macronutrient content of cheese.
Open Access
Nasal sprays containing mometasone furoate can be used prophylactically in covid-19 infection and related smell disorders
(2023-09-01) ÖZDEMİR, MÜCAHİT; YALÇIN, BAHATTİN; ENÖZ M., ÖZDEMİR M., YALÇIN B.
Objective: We aimed to emphasize the possible beneficial effects of intranasal sprays containing mometasone furoate, especially for preventive treatment or supportive treatment in patients with olfactory disorders due to damage to the olfactory area, or for regular use in healthcare workers with a high risk of close contact. Methods: Preventive and therapeutic scientific studies are continuing around the world for viral spread and viral damage associated with the Coronavirus disease 2019 (COVID-19) pandemic. We investigated the attachment of the COVID-19 virus in the nose and entry into the body with the crystal structure of the spike and Angiotensin-Converting Enzyme 2 (ACE-2) proteins, a molecular docking study. This scientific study is the first in-silico study to investigate the possible antiviral effects of Mometasone furoate molecules on spike protein and to show the antiviral effect of mometasone furoate on COVID-19. Results: We think that nasal sprays containing mometasone furoate can be used prophylactically in patients with COVID-19 infection due to its antiviral effect, and it may be beneficial to use sprays containing mometasone furoate before the symptoms of upper respiratory tract infection begin in patients. Conclusions: The role of these molecules in the treatment of acute smell disorders associated with COVID-19 infection and their antiviral effects on coronavirus should be investigated by conducting extensive scientific studies on the subject.
Open Access
Direct photopatterning of BODIPY-based small Molecules via thiol-ene click chemistry
(2022-01-01) ÖZDEMİR, MÜCAHİT; YALÇIN, BAHATTİN; ÖZDEMİR M., ALTINIŞIK S., Ömeroğlu İ., Köksoy B., Durmuş M., YALÇIN B., KOYUNCU S.
© 2022 Wiley-VCH GmbH.We demonstrate a BODIPY-based small molecule photopatterned surface by thiol-ene click chemistry at room temperature utilizing only 366 nm UV light. The resulting cross-linked polymer exhibits porous surfaces according to AFM and TEM results. A dramatic blue shift occurred in absorption spectra and the photoluminescence was also intensified as a result of crosslinking. Optical and electrochemical results are compatible with the DFT calculations. The obtained results prove that the photopatterned BODIPY-based material can be easily and inexpensively applied in multilayer optoelectronic devices.