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YALÇIN, BAHATTİN

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Fen - Edebiyat Fakültesi

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YALÇIN

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BAHATTİN

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Now showing 1 - 10 of 12

Open Access
TQ-Ox, a novel synthetic derivative of thymoquinone on ovarian cancer cells in vitro
(2022-01-01) ÖZDEMİR, MÜCAHİT; YALÇIN, BAHATTİN; Kale E., Kale A., Bozali K., Gulgec A. S. , ÖZDEMİR M., YALÇIN B., Guler E. M.
© 2022 Informa UK Limited, trading as Taylor & Francis Group.There are many studies in the literature on thymoquinone (TQ)-related cancer cells and models, and there is no relevant study investigating the efficacy of the oxime derivative of TQ (TQ-Ox). This study synthesized TQ-Ox and examined its cytotoxic, genotoxic and apoptotic properties in ovarian cancer cells. The structure TQ-Ox was confirmed with NMR. The cytotoxicity by luminometric ATP, intracellular reactive oxygen species (iROS) by fluorometric, intracellular calcium (iCa2+) by fluorometric, mitochondrial membrane potential (MMP) by flow cytometry, glutathione (GSH) levels with GSH/GSSG-Glo assay, DNA damage by comet assay, and apoptosis by acridine orange/ethidium bromide dye were determined. Concentrations of TQ-Ox were statistically increased cytotoxicity, DNA damage, apoptosis, iROS, and iCa2+ in a concentration-dependent manner (p < 0.001). Besides, MMP and GSH levels also decreased statistically significantly (p < 0.001) with increasing concentrations. TQ-Ox would be an effective treatment option by increasing cytotoxicity, genotoxicity, and apoptosis in ovarian carcinoma.
Open Access
New metallophthalocyanines including benzylphenoxy groups and investigation of their organic-field effect transistor (OFET) features
(2022-04-01) ÖZDEMİR, MÜCAHİT; YALÇIN, BAHATTİN; ÖZDEMİR M., ALTINIŞIK S., Koksoy B., Canimkurbey B., KOYUNCU S., Durmus M., Bulut M., YALÇIN B.
In this study, metal and metal-free novel phthalocyanines containing peripheral and non-peripheral tetra 2-ben-zylphenoxy groups were synthesized. The compounds were characterized by UV-Vis, FT-IR, H-1 NMR, and MALDI-TOF mass spectrometry as well as elemental analysis. These new phthalocyanines exhibited excellent solubility in most organic solvents, and their redox behavior was investigated in different solvents such as dimethyl sulfoxide (DMSO) and dichloromethane (DCM). The redox behavior of the peripheral and non-peripheral phthalocyanine compounds 1a -c and 2a -c was determined by cyclic voltammetry and in situ spec-troelectrochemistry. According to organic field-effect transistors (OFETs) measurements, the peripheral and non-peripheral phthalocyanine-cobalt complexes which have higher mobility than others were utilized top-gate bottom-contact OFETs fabrication. The output characteristics of the device show that its mobility is approximately 5 x 10(-2) cm(2)/Vs with p-type accumulation.
Metadata only
Sars-cov-2 omicron varyantinin spi̇ke protei̇ni̇ne karşı doğal kumari̇nleri̇n taranması: in silico bi̇r hesaplama yaklaşımı
(2022-02-27) ÖZDEMİR, MÜCAHİT; YALÇIN, BAHATTİN; Özdemir M., Yalçın B., Öztürkkan F. E., Akbaba G. B., Sertçelik M., Necefoğlu H.
In this study, the interactions of coumarin derivatives with the spike protein of the coronavirus Omicron variant were investigated with the help of Molecular Docking studies. When the substrate effects of the compounds against the SARS-CoV-2 Omicron variant Spike protein are examined in silico, it has been determined that the compounds exhibit moderate antagonistic effect. There are some interactions such as hydrogen bonding, carbon-hydrogen bonding, π-π stacking, π-anion, π cation, π-alkyl and alkyl interactions between coumarin derivatives and against Omicron variant’s spike protein of Sars-CoV-2.
Open Access
The role of electron-donating subunits in cross-linked BODIPY polymer films
(2023-01-01) ÖZDEMİR, MÜCAHİT; YALÇIN, BAHATTİN; ÖZDEMİR M., Köksoy B., YALÇIN B., KOYUNCU S.
A new method for synthesizing cross-linked 4,4-difluoro-4-bora-3a,4a-diaza-s-indacenes (BODIPYs) using a radical-based thiol-ene click reaction is developed. This method is simple, efficient, and cost-effective, and it produces polymers with unique optical, electrochemical, and surface morphology properties. Significant blue shifts in absorption and photoinduced electron transfer in emissions are observed in the cross-linked BODIPY thin films. Cross-linking also leads to the restriction of conjugation, which results in the breakage of the terminal vinyl group, an increase in the oxidation potential, and a slight upshift in the HOMO position. As a result, the electrochemical band gap is widened from 1.88 to 1.94 eV for polymer bearing N,N-dimethylamino-BODIPY and from 1.97 to 2.02 eV for polymer bearing N,N-diphenylamino-BODIPY moieties. Monomer thin films form planar surfaces due to crystallinity, while amorphous cross-linked BODIPY polymers form more rough surfaces. Additionally, photopatterning on the film surface is successfully performed using different patterned masks. This new method for synthesizing cross-linked BODIPYs has the potential to be used in a variety of applications, including organic electronics, bioimaging, and photocatalysis.
Open Access
Direct photopatterning of BODIPY-based small Molecules via thiol-ene click chemistry
(2022-01-01) ÖZDEMİR, MÜCAHİT; YALÇIN, BAHATTİN; ÖZDEMİR M., ALTINIŞIK S., Ömeroğlu İ., Köksoy B., Durmuş M., YALÇIN B., KOYUNCU S.
© 2022 Wiley-VCH GmbH.We demonstrate a BODIPY-based small molecule photopatterned surface by thiol-ene click chemistry at room temperature utilizing only 366 nm UV light. The resulting cross-linked polymer exhibits porous surfaces according to AFM and TEM results. A dramatic blue shift occurred in absorption spectra and the photoluminescence was also intensified as a result of crosslinking. Optical and electrochemical results are compatible with the DFT calculations. The obtained results prove that the photopatterned BODIPY-based material can be easily and inexpensively applied in multilayer optoelectronic devices.
Open Access
Electron-Donating and Electron-Withdrawing Subunit Effects on Coumarin-BODIPY Dyads: Optical and Electrochemical Properties and Molecular Interactions
(2023-01-01) ÖZDEMİR, MÜCAHİT; YALÇIN, BAHATTİN; Köksoy B., ÖZDEMİR M., ALTINIŞIK S., Zorlu Y., YALÇIN B., Durmuş M., KOYUNCU S.
In this study, a series of coumarin-BODIPY molecules were synthesized using a Sonogashira cross-linking reaction. The effects of electron withdrawing and electron donating moieties on electrochemical and optical properties were supported by results of density functional theory calculations, and energy transfer mechanisms were investigated. The band gap value decreased from 2.0 eV to 1.6 eV due to reversible oxidation of the extra dimethylamino subunit at lower potential. Besides, characteristics of the crystal structures were investigated with single-crystal X-ray diffraction, and crystallinity was supported by differential scanning calorimetry. In addition, when the thin film surface morphologies were examined, it was clearly observed that the N,N-dimethylamino group on the coumarin-BODIPY dyad (B3) formed large-scale domains due to its crystalline behavior. As a result, Förster-type energy transfer was observed for coumarin-BODIPY dyads containing different electron withdrawing and donating subunits.
Open Access
7,8-Dihydroxycoumarin derivatives: In silico molecular docking and in vitro anticholinesterase activity
(2023-02-15) ÖZDEMİR, MÜCAHİT; TAŞKIN, TURGUT; YALÇIN, BAHATTİN; ÖZDEMİR M., Taşkın D., Ceyhan D., Köksoy B., TAŞKIN T., Bulut M., YALÇIN B.
© 2022In this study, acetylcholinesterase enzyme (AChE) inhibition potential and antioxidant activity of eight different coumarin derivatives together with two (5 and 8) newly synthesized coumarins were investigated. The results showed that all compounds exhibited inhibitory activity on AChE. Compounds 1 (96.83%), 3 (96.72%), and 2 (95.48%) showed the highest inhibitory activity and the results were more significant than that of galantamine (93.14%). Compound 7 displayed the most potent inhibition of AChE (92.12%), close to galantamine. Molecular docking studies of AChE were carried out to support in vitro testing. In addition, the antioxidant activities of coumarins were performed with DPPH, FRAP, and CUPRAC methods. Among them, compound 7 had the highest results in all the assays. The pharmacokinetic properties of compounds were determined using ADMET estimates; target coumarins may be drug candidates for Alzheimer\"s disease, especially compound 7 may be used as an antioxidant agent in the future after detailed analysis.
Open Access
Photophysical and photochemical properties and comparison of tolyl and tosyl coumarin-bearing phthalocyanines
(2023-02-15) ÖZDEMİR, MÜCAHİT; YALÇIN, BAHATTİN; SALAN, ÜMİT; Kazancıçok Z., Güler H. E., ÖZDEMİR M., PİŞKİN M., Bulut M., YALÇIN B., SALAN Ü.
© 2022In this study, peripheral and non-peripherally substituted Zn(II) phthalocyanine complexes were synthesized from 7‑hydroxy-3-(p-tolyl)coumarin and 7‑hydroxy-3-(p-tosyl)coumarin compounds. The synthesized new compounds were characterized using elemental analysis, FT-IR, UV–Vis, Fluorescence 1HNMR spectroscopy and MALDI-TOF mass spectrometry. All the synthesized phthalocyanine complexes showed good solubility in organic solvents such as acetone, dichloromethane, chloroform, pyridine, and ethyl acetate. Fluorescent quenching behavior was investigated using 1,4-benzoquinone and potassium iodide as a quencher. The photophysical (fluorescent quantum yields and lifetimes) and photochemical (single oxygen and photodegradation quantum yields) properties of these new phthalocyanines were examined in dimethyl sulfoxide. Phthalocyanine complexes containing 7‑hydroxy-3-(p-tolyl)coumarin had higher singlet oxygen quantum yields than phthalocyanine complexes containing 7‑hydroxy-3-(p-tosyl)coumarin. Phthalocyanines to which coumarins are peripherally bound were more advantageous than their non-peripherally bound derivatives. As a result of their photophysical and photochemical properties, coumarin-phthalocyanine complexes containing tolyl-/tosyl- groups can be used as photosensitizing candidates in photodynamic therapy and can be developed with targeted modifications.
Open Access
Bioactivity, crystal and molecular structure of vanadyl(III) complex with N-salicyloyl − N’(3,5-ditertbutyl-2-hydroxy)benzylidene hydrazine
(2024-07-15) YALÇIN, BAHATTİN; Amrulla Fatullayeva P., Akper Medjidov A., Gennadievna Safronenko M., Nikolaevic Khrustalev V., Huseyn Ismayilov R., Allahverdi Bayramov M., YALÇIN B., Sadeghian N., Taslimi P., TÜZÜN B.
N-salicyloyl-N’-(3,5-ditertbutyl-2-hydroxy)benzylidene hydrazine (H3sahz) and its complex with VO(III) have been synthesized. The molecular and crystal structure of the [(VO)2(sahz)2(C2H5O)2(C2H5OH)] complex by X-ray diffraction, as well as IR and electronic spectra, EPR spectrum etc., have been studied. The structure of the investigated VO(III) complex consists of binuclear units in which the monomeric complex molecules are linked to each other through vanadyl oxygen atom. Monomeric complexes differ between themselves in the character of coordination. Both vanadium atoms have a distorted octahedral environment. The biological activity of this compound has been studied. Lastly, the activities of the studied ligand against various enzyme proteins including acetylcholinesterase (AChE), butrylcholinesterase (BChE) and α-glycosidase (α-Gly) enzyme were compared. ChE inhibitory activities of the new complex against α-Gly, AChE and BChE were determined by Tao and Ellman\"s methods. The new complex was shown to have IC50 values of 42.60 µM for BChE, 91.43 µM for AChE, and 196.49 µM for α-glycosidase.
Open Access
Pyridine derivatives complexes of Co(II) and Ni(II) 3-bromobenzoates: Crystal structure, in silico anti-SARS-CoV-2 potential, serum albumin binding properties and cytotoxicity
(2023-01-01) ÖZDEMİR, MÜCAHİT; YALÇIN, BAHATTİN; Öztürkkan F. E., ÖZDEMİR M., Akbaba G. B., Sertçelik M., YALÇIN B., ŞAHİN E.
© 2023 John Wiley & Sons, Ltd.Two mononuclear [Co(3-BrBA)2(NA)2(H2O)2] (1) and [Ni(3-BrBA)2(3-CNPY)2(H2O)2] (2) (3-BrBA = 3-bromobenzoate, NA = pyridine-3-carboxylic acid, and 3-CNPy = 3-cyanopyridine) were synthesized and characterized by single crystal X-ray diffraction, elemental analysis, and FT-IR spectroscopy. In both complexes, the metal atom is coordinated by two oxygen atoms of two carboxylate anions, two nitrogen atoms of two pyridine rings, and two oxygen atoms of two water molecules in the distorted octahedral environment. Intermolecular interactions were examined with the help of the 3D Hirshfeld surfaces and 2D fingerprint plots. With the help of density functional theory (DFT) studies, besides verifying the experimentally obtained structural properties, the electronic energies, polarizability, dipole moments, ionization potentials, electron affinities, electronegativity, chemical hardness, global softness, electrophilic indexes, HOMO-LUMO orbitals, and band gaps were also calculated. In vitro cytotoxic activity of the complexes on primary peripheral blood mononuclear cells were evaluated using the MTT assay. Fluorescence quenching techniques and molecular docking studies were used to investigate the interaction between bovine serum albumin (BSA) and the complexes. The molecular docking study has been used to explain the interaction of complexes with spike proteins of beta variant (B.1.351), gamma variant (P.1), delta variant (B.1.617.2), kappa variant (B.1.617.1), and omicron variant (B.1.1.529) of coronavirus. Additionally, the pharmacokinetic and toxicological properties of the complexes have been computed using the SwissADME and ProTox-II online databases, respectively.