Person: YALÇIN, BAHATTİN
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YALÇIN
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BAHATTİN
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Publication Open Access TQ-Ox, a novel synthetic derivative of thymoquinone on ovarian cancer cells in vitro(2022-01-01) ÖZDEMİR, MÜCAHİT; YALÇIN, BAHATTİN; Kale E., Kale A., Bozali K., Gulgec A. S. , ÖZDEMİR M., YALÇIN B., Guler E. M.© 2022 Informa UK Limited, trading as Taylor & Francis Group.There are many studies in the literature on thymoquinone (TQ)-related cancer cells and models, and there is no relevant study investigating the efficacy of the oxime derivative of TQ (TQ-Ox). This study synthesized TQ-Ox and examined its cytotoxic, genotoxic and apoptotic properties in ovarian cancer cells. The structure TQ-Ox was confirmed with NMR. The cytotoxicity by luminometric ATP, intracellular reactive oxygen species (iROS) by fluorometric, intracellular calcium (iCa2+) by fluorometric, mitochondrial membrane potential (MMP) by flow cytometry, glutathione (GSH) levels with GSH/GSSG-Glo assay, DNA damage by comet assay, and apoptosis by acridine orange/ethidium bromide dye were determined. Concentrations of TQ-Ox were statistically increased cytotoxicity, DNA damage, apoptosis, iROS, and iCa2+ in a concentration-dependent manner (p < 0.001). Besides, MMP and GSH levels also decreased statistically significantly (p < 0.001) with increasing concentrations. TQ-Ox would be an effective treatment option by increasing cytotoxicity, genotoxicity, and apoptosis in ovarian carcinoma.Publication Metadata only 4-Fenil-2H-Kromen-2-On içeren periferal ve nonperiferal Cu ve Zn ftalosiyaninlerin sentezi ve fotostabilitelerinin incelenmesi(2021-12-20) GÖRGÜLÜ, AHMET ORHAN; YALÇIN, BAHATTİN; DİCLE C., ÖZDEMİR M., GÖRGÜLÜ A. O., YALÇIN B.Publication Open Access Preliminary assessment of microfibers amount in textile wastewater(2022-05-20) AKYILDIZ, SİNEM HAZAL; YALÇIN, BAHATTİN; Akyildiz S. H. , Yalçın Eniş I., Sezgin H., Yalçin B.Textile wastewater is a complex mixture of inorganic compounds, polymers, organic products, dyes, and microfibers (MFs), including microplastics (MPs) and natural fibers. The treatment of textile wastewater, which contains a significant share of MFs, is of great importance to prevent the release of MPs in the environment. MPs analysis requires multiple phases of pretreatment (to eliminate the organic compounds), separation of the MFs from the water, and identification of the MPs among the MFs. This work presents the preliminary results of a research aimed at exploring two issues. Firstly, the pretreatment (through Fenton,H2O2, HCl, KOH and NaOH, applied at 25 °C for 5 days and 60 °C for 6 hours) of artificial textile wastewater, evaluating the effect of the different conditions on the MFs and the MPs. Secondly, the separation of MFs from a real textile wastewater sample through different processes (centrifugation, sink-float & filtration, filtration). The results of the pretreatment tests revealed Fenton, HCl, andH2O2at 25 °C for 5 days as the best performing chemicals and conditions. Considering the results of the separation tests, filtration gave back the best removal of the MFs from wastewater compared to centrifugation and sink-float and filtration, which left some MFs in the supernatant/float and in the sediment/sink. In conclusion, these preliminary results may be useful to further explore the detection of MFs and MPs in textile wastewater.Publication Metadata only Yeni metil (7-Hidroksi-8-Metil-2-Okso-2HBenzopiran-4-Yl) asetat kumarin içeren ftalosiyaninin kimyasal özelliklerinin incelenmesi(2022-09-28) DİCLE, CANSU; GÖRGÜLÜ, AHMET ORHAN; YALÇIN, BAHATTİN; ÖZDEMİR, MÜCAHİT; DOĞAN Y., DİCLE C., GÖRGÜLÜ A. O., YALÇIN B., BULUT M., ÖZDEMİR M.Halkasında karbon dışında atomlar olan ve oksijen bileşiklerinden meydana gelen büyük heterosiklik aromatik yapılar Kumarin (Coumarine) olarak tanımlar. Kumarin, adını 1820 yılında August Vogel tarafından izole edildiği tonka fasulyesinin (Dipteryx odorata Willd, Fabaceae) sınıf adı olan “coumarou” kelimesinden almıştır. IUPAC adı, 2H-kromen-2-on veya 2H-1-benzopiron-2-on’dur [1,2]. Kumarin ve türevleri doğada yaygın olarak; lavanta, tatlı yonca otu ve meyan kökü gibi bitkilerde; çilek, kiraz, kayısı ve tarçın gibi yiyeceklerde bulunmaktadır [3]. Kapalı formülü C9H6O2’dir. Mol kütlesi 146,14 g/mol, erime noktası 69- 71 °C ve kaynama noktası 301 °C’dir [4]. Kumarinler, absorbsiyon spektrumu ile iyi tanımlanırlar ve ultraviyole ışıkla uyarılınca karakteristik bir floresans gösterir. Ayrıca geniş bir fizyolojik aktiviteye sahiptirler [5]. Kumarin türevleri; yüksek floresans kuantum verimi, büyük kayma, mükemmel ışık stabilitesi ve düşük toksisite gibi birçok avantaja sahiptir [6]. Kumarin sentezlemede kullanılan metodlardan en yaygın olanları; Perkin, Pechmann, Knoevenagel, Reformatsky ve Witting Kondenzasyon reaksiyonlarıdır [7]. Yüksek simetriye sahip dört iminoizoindol ünitesi içeren 18 π elektronlu aromatik makrosiklik yapılar olan ftalosiyaninler, sahip oldukları bu π-elektron delokalizasyonu özelliği nedeni ile olağanüstü optik ve elektriksel davranışlar gösteren kimyasal ve termal olarak dayanıklı bileşiklerdir. İlk sentezlenen bakır ftalosiyanin molekülü merkez metale bağlı klor atomu sayısının arttırılması ile maviden yeşile doğru giden bir renk değişimi göstermiştir. Çoğu ftalosiyanin bileşiği yüksek vakumda buharlaştırılabilip, süblimleştirilebilen bileşiklerdir. Öte yandan termal kararlılıkları sebebiyle çoğunun erime noktası yoktur [8]. Bugüne kadar ftalosiyaninlerde merkez atom olarak 70‘den fazla farklı element kullanılmıştır. Ftalosiyanin ligandı metallerin hemen hepsiyle koordine edilebilir.Publication Open Access New metallophthalocyanines including benzylphenoxy groups and investigation of their organic-field effect transistor (OFET) features(2022-04-01) ÖZDEMİR, MÜCAHİT; YALÇIN, BAHATTİN; ÖZDEMİR M., ALTINIŞIK S., Koksoy B., Canimkurbey B., KOYUNCU S., Durmus M., Bulut M., YALÇIN B.In this study, metal and metal-free novel phthalocyanines containing peripheral and non-peripheral tetra 2-ben-zylphenoxy groups were synthesized. The compounds were characterized by UV-Vis, FT-IR, H-1 NMR, and MALDI-TOF mass spectrometry as well as elemental analysis. These new phthalocyanines exhibited excellent solubility in most organic solvents, and their redox behavior was investigated in different solvents such as dimethyl sulfoxide (DMSO) and dichloromethane (DCM). The redox behavior of the peripheral and non-peripheral phthalocyanine compounds 1a -c and 2a -c was determined by cyclic voltammetry and in situ spec-troelectrochemistry. According to organic field-effect transistors (OFETs) measurements, the peripheral and non-peripheral phthalocyanine-cobalt complexes which have higher mobility than others were utilized top-gate bottom-contact OFETs fabrication. The output characteristics of the device show that its mobility is approximately 5 x 10(-2) cm(2)/Vs with p-type accumulation.Publication Metadata only Novel lutetium(III) phthalocyanine-coumarin dyads; synthesis, characterization, photochemical, theoretical and antioxidant properties(ELSEVIER SCIENCE SA, 2021) YALÇIN, BAHATTİN; Ozdemir, Mucahit; Koksoy, Baybars; Yalcin, Bahattin; Taskin, Turgut; Selcuki, Nursel Acar; Salan, Umit; Durmus, Mahmut; Bulut, MustafaIn this study, novel 7-oxy-3-ethyl-6-hexyl-4-methylcoumarin substituted lutetium(III) phthalocyanine compounds were synthesized, characterized and their photochemical, theoretical, and antioxidant properties were examined. All complexes were characterized by common spectroscopic methods such as FT-IR, UV?vis, 1H NMR, MALDI-TOF-MS and elemental analysis as well. Geometry optimization of phthalocyanine compounds was calculated in the B3LYP functional using 6-31G (d, p) + SDD basis set of the Density Functional Theory. Aggregation, singlet oxygen generation, and photodegradation behavior under light irradiation of the complexes (1?4) were investigated in dimethylformamide. The three phthalocyanine compounds (1, 2, and 4) showed a high level of singlet oxygen efficiency were compared with the unsubstituted zinc(II) and lutetium(III) phthalocyanine compounds because their quantum yield values were found to be over 0.80. The radical cation scavenging activities of the compounds 3 (120.344 mM trolox/mg) and 4 (188.733 mM trolox/mg) are quite remarkable in 2,2?-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid analysis according to butylated hydroxyanisole (52.63 mM trolox/mg).Publication Metadata only Sars-cov-2 omicron varyantinin spi̇ke protei̇ni̇ne karşı doğal kumari̇nleri̇n taranması: in silico bi̇r hesaplama yaklaşımı(2022-02-27) ÖZDEMİR, MÜCAHİT; YALÇIN, BAHATTİN; Özdemir M., Yalçın B., Öztürkkan F. E., Akbaba G. B., Sertçelik M., Necefoğlu H.In this study, the interactions of coumarin derivatives with the spike protein of the coronavirus Omicron variant were investigated with the help of Molecular Docking studies. When the substrate effects of the compounds against the SARS-CoV-2 Omicron variant Spike protein are examined in silico, it has been determined that the compounds exhibit moderate antagonistic effect. There are some interactions such as hydrogen bonding, carbon-hydrogen bonding, π-π stacking, π-anion, π cation, π-alkyl and alkyl interactions between coumarin derivatives and against Omicron variant’s spike protein of Sars-CoV-2.Publication Metadata only Nutrient dynamics and eutrophication in the Sea of Marmara: Data from recent oceanographic research(ELSEVIER SCIENCE BV, 2017) YALÇIN, BAHATTİN; Yalcin, Bahattin; Artuz, M. Levent; Pavlidou, Alexandra; Cubuk, Soner; Dassenakis, ManosThis work was implemented to study the physicochemical and biological characteristics of the Sea of Marmara and the Turkish straits (TSS: Bosporus and Dardanelles straits) for the period 2010-2013 and to calculate winter and summer fluxes of nutrients (nitrates, phosphates) between the Aegean and Black Seas through the TSS. The brackish Black Sea waters reach the Dardanelles Strait with modified biochemical properties. The salinity and phosphates of the surface waters increased westwards. Biologically labile nutrients of Black Sea origin are utilized through biological processes in the Marmara Sea. On the other hand, increase of nutrients due to land based sources has led to eutrophication problems in the area. The sub surface water layer of Mediterranean origin is oxygen depleted (saturation < 30%) and rich in nutrients. Higher oxygen values indicated water mixing of the Sea of Marmara during winter 2012. Ammonium was the predominant form of inorganic nitrogen. The study area has been classified from Moderate to Bad trophic status. Izmit Bay also faced serious eutrophication problems together with hypoxic conditions below the halocline. Nutrient fluxes through the TSS showed temporal variation in the upper and lower layers related to changes in both nutrient concentrations and the water mass volume fluxes. Surface nitrates and phosphates outflux from the Sea of Marmara to the Aegean Sea was higher than the influx from the Black Sea through Bosporus strait, indicating high enrichment of nutrients in the Sea of Marmara from anthropogenic sources. (C) 2017 Elsevier B.V. All rights reserved.Publication Open Access Detection and analysis of microfibers and microplastics in wastewater from a textile company(2022-10-01) YALÇIN, BAHATTİN; AKYILDIZ, SİNEM HAZAL; Akyildiz S. H. , Yalçın Eniş I., Sezgin H., Yalçin B.Textile wastewater is polluted by inorganic/organic substances, polymers, dyes, and microfibers (MFs), which are microplastics (MPs) and natural fibers. This work is aimed at the preliminary investigation of MFs and MPs in textile industrial wastewater, and at evaluating the removal efficiency of an on-site wastewater treatment plant (WWTP). Ten samples of inflows and outflows of the WWTP of a textile company (applying a physic-chemical process) have been analyzed. Firstly, the samples underwent a pretreatment with 15% hydrogen peroxide at 25◦C for 5 days to remove organic compounds. Secondly, the MFs were recovered from the aqueous phase by pre- screening centrifugation, density separation, and filtration as alternative options. Filtration obtained the best performances, compared to the other recovery processes. Thirdly, the MFs were counted through optical microscopy and the MPs were identified through micro-FTIR. The MFs amount in the inflow samples was in the range of 893–4452 MFs/L. The outflow samples (310–2404 MFs/L) exhibited a 38–65% reduction compared to the inflows, demonstrating that up to 62% of residual MFs can enter the sewer network or the receiving water body. Cotton and wool, and numerous MPs (acrylic, polyester, polypropylene, polyamide, and viscose/rayon) were identified in the inflow and outflow samples (with the only exception of \"dense\" viscose (rayon), not detected in the out- flows, and probably retained by the WWTP with the sludge). This study, even if just preliminary, offers interesting hints for future research on MFs/MPs detection in textile wastewater, and on the performance of a full-scale WWT process for their removal.Publication Metadata only Keto-Kumarin grubu içeren ftalosiyaninlerin sentezi ve elektrokimyasal özelliklerinin incelenmesi(2021-10-08) YALÇIN, BAHATTİN; ABLİATİPOVA A., ÖZDEMİR M., YALÇIN B., BULUT M.