Person: YILDIZ, MESUT
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YILDIZ
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MESUT
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Publication Open Access Suicide among doctors in Turkey: Differences across gender, medical specialty and the method of suicide(2023-03-01) YILDIZ, MESUT; HIDIROĞLU, SEYHAN; YILDIZ M., Batun K. D., Sahinoglu H., Eryilmaz M. S., Ozel B., Ataoglu B., HIDIROĞLU S.Background. Doctors have higher rates of mental illness and suicide than the general population worldwide. Suicides of doctors are known to be underreported in developing countries. To the best of our knowledge, there are no studies investigating suicides among medical students and doctors in Turkey.Objectives. To investigate the characteristics of suicides in medical school students and doctors in Turkey.Materials and methods. In this retrospective study, newspaper websites and Google search engine were searched for information on medical school student and doctor suicides in Turkey between 2011 and 2021. Cases of suicide attempt, parasuicide or deliberate self-harm were not included in the study.Results. Sixty-one suicides were reported between 2011-2021. There was a male predominance (45 (73.8%)), and more than half of the suicides (32 (52.5%)) occurred among specialist doctors. Self poisoning, jumping from heights and firearms were the most common methods of suicide (18 (29.5%), 17 (27.9%) and 15 (24.6%), respectively). Cardiovascular surgery, family medicine, gynecology, and obstetrics specialties had the highest numbers of suicide deaths. Depression/mental illness was the most common speculated etiology. These results show that suicides among medical students and doctors in Turkey have characteristics that differ from both suicided among the general population in Turkey and doctor suicides in other countries.Conclusions. In this study, we identified the suicidal characteristics of medical students and doctors in Turkey for the first time. The results help us to better understand this understudied topic and provide an avenue for future studies. The data also indicate that it is important to monitor the individual and systemic difficulties experienced by doctors, starting from the medical education stage, and to provide individual and environmental support to help decrease the risk of suicide.Publication Open Access The relationship between psychopathology and cognitive functions with cytokines in clinically stable patients with schizophrenia(TAYLOR & FRANCIS LTD, 2018-01-02) HAKLAR, GONCAGÜL; Ergun, Serhat; Yanartas, Omer; Kandemir, Guler; Yaman, Ali; Yildiz, Mesut; Haklar, Goncagul; Sayar, KemalOBJECTIVES: Inflammation and the cytokine hypotheses have been proposed for schizophrenia. Several proinflammatory and anti-inflammatory cytokines have been studied in drug-naive, first-episode, and/or chronic schizophrenia patients. However, there were limited data on clinical stable outpatients reflecting daily routine. The aim of this study was to compare the serum levels of cytokines, including transforming growth factor-beta (TGF-beta), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha), between clinically stable patients with schizophrenia and healthy controls, as well as to examine the relationship between these inflammation parameters and clinical variables (positive and negative symptom severity and cognitive functions). METHODS: Thirty clinically stable outpatients with schizophrenia and 30 healthy controls with similar sex and age were included in this study. Serum IL-6, TGF-beta, and TNF-alpha levels were assessed by enzyme-linked immunosorbent assay (ELISA) and immunoenzyme microplate measurement, respectively. Illness severity was evaluated using the Positive and Negative Syndrome Scale (PANSS), and the cognitive functions of the participants were assessed using a broad neuropsychological test battery. RESULTS: The serum levels of IL-6 and TGF-beta were significantly higher in patients with schizophrenia compared to healthy controls (p = .048, p = .012). There was no significant difference between groups in terms of TNF-alpha levels (p = .726). Global impairment of cognitive functions was observed in the patient group compared to healthy controls, and PANSS scores and cognitive functions showed no correlation with cytokine levels (IL-6, TNF-alpha, and TGF-beta). CONCLUSIONS: The present study demonstrated an increased inflammatory response in clinically stable patients with schizophrenia compared to healthy controls. However, symptom severity and cognitive functions showed no correlation with cytokine levels. Further research studies are needed to clarify the effects of cytokine levels on schizophrenia symptomatology and etiopathogenesis.Publication Open Access Simple markers for subclinical inflammation in the different phases of bipolar affective disorder(UNIV SAO PAULO, INST PSIQUIATRIA, 2016-12) YILDIZ, MESUT; Yildiz, Mesut; Batmaz, Sedat; Songur, Emrah; Sahin, Safak; Demir, OsmanBackground: Recently, a growing number of publications have suggested that the immune-inflammatory system may be involved in the etiology of bipolar disorder (BD). Objective: The aim of this study was to investigate neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red cell distribution width (RDW) in the three different phases of BD patients compared to each other and controls. Methods: One hundred eighty-seven bipolar patients (78 euthymic, 53 manic/hypomanic and 56 depressed), and 62 age and sex matched controls were enrolled. Sociodemographic variables and complete blood count parameters of the patients and the control group were recorded. Results: The groups did not differ from each other on the hematological parameters, except for NLR and RDW. Post-hoc analyses revealed that NLR values were significantly higher in the euthymic and manic/hypomanic bipolar groups compared to control group. In addition, post-hoc analyses revealed that RDW values were significantly higher in the manic/hypomanic bipolar group relative to the control group. Discussion: Longitudinal studies evaluating the levels of inflammatory markers in the early phases of the disorder, and their relationship with the development of different episodes and medical comorbidities may be useful to understand the role of inflammation in BD.Publication Metadata only Psychiatric morbidity of patients with keratoconus: A cross-sectional study(PERGAMON-ELSEVIER SCIENCE LTD, 2021) TOKER, AYŞE EBRU; Yildiz, Mesut; Turhan, Semra Akkaya; Yargi, Berru; Ergun, Serhat; Ornek, Erdem; Baz, Fatih; Toker, Ayse EbruBackground: This study aimed to determine the prevalence of psychiatric disorders in patients with keratoconus and the effect of clinical parameters and psychiatric morbidity on quality of life in this patient group. Materials and methods: This cross-sectional study enrolled 94 patients with keratoconus. All patients underwent a complete ophthalmic and psychiatric examination and completed the The National Eye Institute Refractive Error Quality of Life Instrument-42 (NEI-RQL-42), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) questionnaires. The current diagnosis of psychiatric disorders was determined using the Structured Clinical Interview for DSM-IV (SCID). The impact of disease severity (binocular BCVA >0.4 logMAR, steep K reading >52, and Amsler-Krumeich grades) on vision-related quality of life was also analyzed. Results: The patients? mean age was 23.9 ? 4.8 (range, 18?40) years. Of the 94 participants 35 (37.2%) had a psychiatric diagnosis, 13 (13.8%) had moderate-severe depression and 20 (21.2%) had moderate-severe anxiety according to the BDI and BAI, respectively. The probability of having a psychiatric disorder was higher if the keratoconus was more severe. Patients with a psychiatric diagnosis scored lower on physical functioning, role limitations due to emotional problems, energy/fatigue; emotional well-being, social functioning and pain subscales of the Short Form-36 (SF-36). Having a SCID-1 psychiatric diagnosis and the presence of a psychiatric disorder did not significantly affect NEI-RQL-42 questionnaire scores. Conclusions: There was high psychiatric morbidity among patients with keratoconus. Having a psychiatric disorder was associated with lower QoL as measured using the SF-36.Publication Open Access Suicide Attempts in Turkish University Students: The Role of Cognitive Style, Hopelessness, Cognitive Reactivity, Rumination, Self-esteem, and Personality Traits(SPRINGER, 2020-12) YILDIZ, MESUT; Akpinar Aslan, Esma; Batmaz, Sedat; Yildiz, Mesut; Songur, EmrahSuicide is one of the major public health problems in young adults. Detecting the risk factors and correlates among university students might help identify students who are under risk and who need early interventions for suicide prevention. The current study aimed to investigate the cognitive style, self-esteem, hopelessness, rumination, cognitive reactivity, and personality characteristics of Turkish university students, who previously attempted suicide and who did not. A total of 355 university students (34 previous suicide attempters) were recruited for this study, and they completed the Ten-Item Personality Inventory (TIPI), the Ruminative Response Scale (RRS), the Leiden Index of Depression Sensitivity-Revised, the Beck Hopelessness Scale (BHS), the Cognitive Style Questionnaire-Short Form (CSQ), the Rosenberg Self-Esteem Scale (RSES), and the Hospital Anxiety and Depression Scale. Higher RRS, BHS, CSQ scores and lower TIPI-A and RSES scores were significantly associated with a previous suicide attempt. Negative cognitive style, hopelessness, and rumination were significant correlates of a previous suicide attempt. These cognitive factors may be targets in psychotherapy to reduce suicide attempts in college-age individuals.Publication Open Access Automatic thoughts, cognitive distortions, dysfunctional attitudes, core beliefs, and ruminative response styles in unipolar major depressive disorder and bipolar disorder: a comparative study(TAYLOR & FRANCIS LTD, 2019-10-02) YILDIZ, MESUT; Yesilyaprak, Nurgul; Batmaz, Sedat; Yildiz, Mesut; Songur, Emrah; Akpinar Aslan, EsmaOBJECTIVES: We aimed to compare patients with bipolar disorder and major depressive disorder, who were either in an acute depressive episode or in remission, and a healthy control group on their cognitions related to depression and mania/hypomania, and on their response styles. METHODS: A total of 300 participants who presented to our outpatient psychiatry department were included in the study (100 participants with unipolar depression (DG), 100 with bipolar disorder, and 100 with no previous or current psychiatric disorder (CG)). The participants completed the Cognition Checklist (CCL), the Cognition Checklist for Mania (CCL-M-R), the Cognitive Distortions Questionnaire (CDQ), the Dysfunctional Attitude Scale (DAS), the Hypomanic Attitudes and Positive Predictions Inventory (HAPPI), the Brief Core Schemas Scale (BCSS), Ruminative Response Scale (RRS), and the Responses to Positive Affect Questionnaire (RPAQ). The groups were compared with each other by one-way analysis of variance, independent samples t-test, and chi-square tests. RESULTS: The DG scored higher than the other groups on the CCL, the frequency and intensity subscales of the CDQ, the DAS, and the negative-self and negative-others subscales of the BCSS, the RRS, and on the dampening subscale of the RPAQ. The clinical groups scored higher than the CG on the scores of the relationships subscale of the CCL-M-R, the total score of the CDQ, and the HAPPI. The CG scored higher than the clinical groups on the positive-self subscale of the BCSS, and on the emotion focused positive rumination subscale. CONCLUSIONS: These findings are important in the differential diagnosis of mood disorders, and for their treatment with cognitive behavioural psychotherapy.Publication Metadata only How are Experiential Avoidance and Cognitive Fusion Associated with Alexithymia?(SPRINGER, 2021) YILDIZ, MESUT; Celikbas, Zekiye; Batmaz, Sedat; Yavuz, Kaasim Fatih; Aslan, Esma Akpinar; Yesilyaprak, Nurgul; Kocakaya, Hanife; Demir, Meral Oran; Songur, Emrah; Yildiz, MesutA transdiagnostic approach to psychiatric disorders presents an opportunity to evaluate the relationship between alexithymia and the concepts of psychopathology according to the psychological flexibility model. This study aimed to investigate the relationship between alexithymia, cognitive fusion and experiential avoidance. A total of 133 outpatient participants were included in this cross-sectional study. Sociodemographic Data Form, Toronto Alexithymia Scale-20, Acceptance and Action Questionnaire-II, Cognitive Fusion Questionnaire, Hospital Anxiety and Depression Scale, and Ten-Item Personality Inventory were used. The non-alexithymic group consisted of 37 participants while the alexithymic group of 26. The alexithymic group had higher scores in terms of depression, anxiety, experiential avoidance, and cognitive fusion. Difficulty in identifying and differentiating feelings and total alexithymia scores had positive correlations with anxiety, experiential avoidance, and cognitive fusion. In hierarchical regression analysis, the only difficulty in identifying feelings was predicted by both experiential avoidance and cognitive fusion. These results revealed that alexithymia might also be conceptualized adopting the psychological flexibility point of view.Publication Metadata only Massive traumatic events and posttraumatic stress disorder(NOVA Science Publishers Inc., 2021-05-01) YILDIZ, MESUT; Yıldız M.; Turan Yurtsever, NursenPosttraumatic stress disorder (PTSD) is a psychiatric disorder that mayoccur in people who have experienced or witnessed a traumatic event suchas a natural disaster, a serious accident, a terrorist act, war/combat, or rapeor who have been threatened with death, sexual violence, or serious injury.Individuals with PTSD may have impairments in aspects of theirpsychological, physical, interpersonal, and occupational lives. PTSDusually has a chronic course and causes disruptions in the general andsocial functioning of the person. PTSD can be both underdiagnosed andoverdiagnosed in clinical settings. There are clear differences in the clinicalapproach to PTSD cases and the forensic perspective. The medicolegalapproach is different from the clinical viewpoint. Psychiatrists arefrequently asked for evaluations of traumatic events in civil and criminalmatters. Psychiatrists are asked to evaluate if the traumatic event caused orcontributed to a psychiatric disorder or a functional impairment. They arealso asked to make a distinction between causal and contributing factors.In addition, the factors that contribute to the person’s current mental stateand functionality should be well reviewed, and a possible malingeringshould not be overlooked. This chapter will review the clinical and ethical implications in evaluating patients with PTSD in a forensic setting.Publication Open Access Neuropsychological and clinical correlations of optical coherence tomography findings in patients with schizophrenia(2023-10-01) SAKALLI KANİ, AYŞE; ŞAHİN ÇAM, CANSUN; AKKAYA TURHAN, SEMRA; TOKER, AYŞE EBRU; YILDIZ, MESUT; Sakallı Kani A., Şahin Çam C., Çelik E. B., Dural Şenoğuz U., Duran M., Akkaya Turhan S., Toker A. E., Yıldız M.Objective: There are increasing studies examining retinal fiber layer (RNFL) and ganglion cell layer (GCL) thinning in patients with schizophrenia. However, the results are controversial, and clinical and cognitive reflections of these findings remain unclear. With this study, we aim to examine retinal abnormalities and establish correlations with cognitive and clinical parameters. Methods: In this cross-sectional study, we examined 29 patients with schizophrenia and 13 age and gender-matched healthy controls. All participants underwent psychometric assessment, neuropsychological tests, and optical coherence tomography (OCT) measurements. The retinal fiber layer and ganglion cell layer thickness were used as retinal parameters. Results: Five patients dropped out during the OCT measurement process, 24 patients with schizophrenia and nine healthy controls were included in the analysis. There was no statistically significant difference between groups in measuring retinal nerve fiber layer or ganglion cell layer thicknesses. The verbal fluency test score negatively correlated with left RNFL superior (ρ = – .422, p <.05). STROOP response duration positively correlated with right RNFL on average (ρ = .551, p <.05), left RNFL on average (ρ = .498, p <.05), right RNFL superior (ρ = .507, p <.05), left RNFL superior (ρ = .461, p <.05) and right RNFL temporal values (ρ = .434, p <.05). STROOP response error was also positively correlated with right RNFL temporal thickness (ρ = .430, p <.05). STROOP response duration was positively correlated with right GCL total (ρ = .646, p <.01), right GCL superior (ρ = .658, p <.01) and right GCL inferior (ρ = .596, p <.01) thickness. Conclusion: We did not find a significant relationship between reduced RNFL or GCL thickness and cognitive impairment. However, we had several positive correlations between cognitive task scores and RNFL and GCL thicknesses. Additionally, our study did not correlate symptom severity and clinical severity parameters with reduced RNFL or GCL thicknessPublication Open Access Analysis of the psychiatric consultations for inpatients and from the emergency room in a university hospital: A comparison with studies from Turkey(KLINIK PSIKIYATRI DERGISI, 2018) YILDIZ, MESUT; Eser, Burcu; Batmaz, Sedat; Songur, Emrah; Yildiz, Mesut; Aslan, Esma AkpinarObjective: The aim of this research was to assess the characteristics of the consultations required in a psychiatric department of a university hospital, and the distribution of psychiatric disorders in hospitalized patients and patients admitted to the emergency room. Method: In the study, the data of 539 patients 18 years or older (48.67 +/- 20.91 years) (46.8% women) who were hospitalized and who presented to the emergency room between 01/01/2015 and 31/12/2015, and for whom a psychiatric consultation was requested were recorded onto a structured form. Patients' electronic databases were reviewed retrospectively for the specified date range. Descriptive statistical analyzes (frequency of data, distribution, mean, standard deviation) were performed for the data examined in the study. Results: Medical departments (42.9%), surgical departments (31.7%) and the emergency medicine department (25.4%) were the most frequently psychiatric consultation requesting departments. The most frequent requests for consultation were agitation (15.4%), depressive symptoms and signs (14.7%) and suicide attempts (12.2%). The most frequent psychiatric diagnoses were depressive disorders (19.5%), delirium (18.2%) and schizophrenia and other psychotic disorders (7.4%). Musculoskeletal diseases (17.4%), mental disorders (15.0%), oncologic diseases (14.1%) and suicide attempts (12.2%) were the primary diagnoses of patients. Discussion: Consultation and liaison psychiatry services have an important role in our relationship with other departments in medicine. Priority to training of depressive disorders, delirium and suicide attempts should be offered to healthcare providers working in these departments.