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GÜNDÜZ, OĞUZHAN

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GÜNDÜZ

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OĞUZHAN

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2020 - 202410
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    A study on hemp seed oil/polycaprolactone based wound dressing structures by making use of additive manufacturing methods
    (2022-12-07) UZUN, MUHAMMET; ALTAN, ERAY; GÜNDÜZ, OĞUZHAN; Ertaş İ. F., Kabir M. H., UZUN M., ALTAN E., GÜNDÜZ O.
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    Tissue engineering applications of bacterial cellulose based nanofibers
    (Springer, 2020-01-01) ÜNAL YILDIRIM, SEMRA; GÜNDÜZ, OĞUZHAN; UZUN, MUHAMMET; ÜNAL S., GÜNDÜZ O., UZUN M.
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    PublicationOpen Access
    Production and characterization of PLA/HA/GO nanocomposite scaffold
    (2022-08-12) ŞAHİN, ALİ; GÜNDÜZ, OĞUZHAN; Oktay B., Ahlatcıoğlu Özerol E., Şahin A., Gunduz O., Ustundag C. B.
    © 2022 Wiley-VCH GmbH.Polylactic acid (PLA) composite nanofibers combined with hydroxyapatite (HA) and graphene oxide (GO) nanoparticles were produced by electrospinning to create excellent biodegradable and durable scaffolds to be used in tissue engineering. The properties of the pure PLA, PLA/HA, PLA/GO, and PLA/HA/GO nanocomposite scaffolds were analyzed in chemical, morphological, mechanical, and biocompatibility. Morphology and composition were investigated by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), respectively. To predict the cytocompatibility of these scaffolds, HFF-1 cells were cultured and the respective cell adhesion and proliferation were investigated by fluorescence microscopy, SEM, and MTT assay. FTIR results showed the successful synthesis of HA and GO nanoparticles. SEM images showed that the PLA/HA/GO scaffold is ideal for cell attachment and proliferation in tissue regeneration. Mechanical test results showed that the tensile strength and elastic modulus of PLA nanofibers could be increased by adding 0,8 wt % HA and 0,4 wt % GO. The PLA/HA/GO scaffold exhibited the highest tensile strength of other scaffolds. MTT assay revealed that the PLA/HA/GO scaffold showed significantly high biocompatibility with 105 % cell viability. Therefore, PLA/HA/GO scaffold with 0,8 wt %HA and 0,4 wt %GO possessing high tensile strength as well as good cell proliferation is an excellent and versatile biomaterial for tissue engineering applications.
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    Production of nanofiber for combination with anticancer tragopon porrifolius L. Naringenin
    (2023-06-30) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Yeşil E., Ayaz Seyhan S., Bilğiç Alkaya D., Cesur S., Gündüz O.
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    PublicationOpen Access
    3D-printed polylactic acid (PLA)/polymethyl silsesquioxane (PMSQ)-based scaffolds coated with vitamin E microparticles for the application of wound healing
    (2024-05-01) ULAĞ, SONGÜL; GÜNDÜZ, OĞUZHAN; Anjrini N., Karabulut H., Ulağ S., Ege H., Noberi C., Dogan E., Sahin A., Gündüz O.
    Skin is part of the integumentary and excretory system, which helps protect the body against infections. The skin should be properly treated when it gets injured, which requires a long healing process. In this study, 15% (w/v) polylactic acid (PLA) and 1 and 2% (w/v) polymethylsilsesquioxane (PMSQ) scafolds were fabricated using 3D printing technology, and the surfaces of each scafold were coated with 5% ethylcellulose (EC)/vitamin E microparticles using the electrospray method. The morphologies of the scafolds were characterized using a scanning electron microscope (SEM), and results showed that the pore sizes of the scafolds ranged from 136 to 265μm. The vitamin E was completely released from the scafolds within 5h. MTT test was performed with fbroblast cells and results proved the biocompatibility of the scafolds. These fndings showed that the scafolds may have good potential as a wound dressing material. The biodegradation test was performed in invitro conditions and results showed that the surface coating with 5% EC/vitamin E microparticles on the 15% PLA/2% PMSQ scafolds increased the degradation rate of the scafolds.
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    PublicationOpen Access
    Effects of temperature and pH on the synthesis of nanohydroxyapatite powders by chemical precipitation
    (2023-01-01) ALTAN, ERAY; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; Mahmutoglu G., Topsakal A., ALTAN E., KUŞKONMAZ N., DAĞLILAR S., OKTAR F. N., Erdemir G., Kuruca S. E., AKYOL S., GÜNDÜZ O., et al.
    Bone tissue engineering is based on a comprehensive understanding of bone structure, bone mechanics, and biology. In order to create nanostructured hydroxyapatite powders with customized properties, many synthesis strategies such as wet chemical precipitation, sol-gel, hydrothermal, and biomimetic approaches have been intensively researched through the years. Calcium phosphate (CaP)-based ceramic nanoparticles, including hydroxyapatite (HAp), were synthesized by the chemical precipitation technique at pH ranges of 7 to 11 and different calcination temperatures of 600 to 1100 °C. The synthesized powders were characterized by several techniques, including scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), energy dispersive X-ray analysis (EDX), and in vitro cell culture assays. The particle size analysis and zeta potential of these powders were also carried out using the dynamic light scattering (DLS) and laser Doppler electrophoresis methods. The results showed that the pH levels of 9 to 11 range and calcination temperatures of 600 to 800 °C were adequate for appropriate nanohydroxyapatite powder production using this method. The particle size of the nanohydroxyapatite was approximately 55 nm, although they were agglomerated after calcination. The biocompatibility tests demonstrated that these nanohydroxyapatite (nHAp) powders produced have appropriate cytocompatibility and can be used for bone graft production and other biomedical applications.
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    PublicationOpen Access
    Recent advances in health biotechnology during pandemic
    (2023-06-01) GÜNDÜZ, OĞUZHAN; ULAĞ, SONGÜL; ARI Yuka S., Akpek A., Özarslan A., Vural A., Koçer A. T., ASLAN A., Karaaltin A. B., Gök B., Yilmaz B. B., İNAN B., et al.
    The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in 2019, cut the epoch that will make profound fluctuates in the history of the world in social, economic, and scientific fields. Urgent needs in public health have brought with them innovative approaches, including diagnosis, prevention, and treatment. To exceed the coronavirus disease 2019 (COVID-19) pandemic, various scientific authorities in the world have procreated advances in real time polymerase chain reaction (RT-PCR) based diagnostic tests, rapid diagnostic kits, the development of vaccines for immunization, and the purposing pharmaceuticals for treatment. Diagnosis, treatment, and immunization approaches put forward by scientific communities are cross-fed from the accrued knowledge of multidisciplinary sciences in health biotechnology. So much so that the pandemic, urgently prioritized in the world, is not only viral infections but also has been the pulsion in the development of novel approaches in many fields such as diagnosis, treatment, translational medicine, virology, microbiology, immunology, functional nano- and bio-materials, bioinformatics, molecular biology, genetics, tissue engineering, biomedical devices, and artificial intelligence technologies. In this review, the effects of the COVID-19 pandemic on the development of various scientific areas of health biotechnology are discussed.
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    Bioceramics
    (Springer, London/Berlin , 2023-09-01) ALTAN, ERAY; GÜNDÜZ, OĞUZHAN; Bedir T., Altan E., Arancı Çiftçi K., Gündüz O. (Editör); Gunduz, Oğuzhan; Egles, Christophe; Pérez, Roman A.; Ficai, Denisa; Üstündağ, Cem Bulent
    Bioceramics commonly employed materials for the restoration, replacement and recovery of unhealthy and impaired pieces of the muscle and skeletal system, as well as periodontal anomalies. According to the host tissue interactions, bioceramics can be graded as nearly bioinert, bioactive, and bioresorbable. Most of the clinical applications of bioceramics comprise orthopedic and dental surgery and also have potential in the field of tissue engineering. This chapter aims to introduce a concise and accessible overview of the past of bioceramics to the present. From bioinert to bioactive and bioabsorbable bioceramics, the classification of materials is discussed and bioceramics characteristics such as biodegradability, bioactivity, biocompatibility, porosity, mechanical and surface properties, as well as osteoconductivity and osteoinductivity emphasized in depth. Production processes of bioceramics are also considered herein. At the end of this chapter, the biomedical applications of bioceramics including orthopedic, dental, surface coatings, and bone tissue engineering, challenges, and future research expectations in the area of bioceramics are also highlighted.
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    PublicationOpen Access
    Comparative studies of GelMA hydrogels: investigating the effect of different source on mechanical, physical and biological properties
    (2024-07-01) YILMAZ, HİLAL; GÜNDÜZ, OĞUZHAN; YILMAZ H., Gursoy S., ÇALIK H., Kazancioglu Y., Yildirim R., ÇAKIR R., GÜNDÜZ O., Ahmed A., ÜSTÜNDAĞ C. B.
    GelMA hydrogels are prominent in biomedical applications due to their innate extracellular matrix mimicking properties. They exhibit favorable properties for cell proliferation and formation of light-induced hydrophilic cross-linked structures. However, there is limited research on the effect of variations in the starting material (gelatin) on the physical, mechanical and biological properties. In this study, Gelatin Methacrylic Anhydride (GelMA) hydrogels were synthesized from two different products of type B gelatin and loaded with polyvinylpyrrolidone (PVP) nanoparticles by electrospray method. Chemical and structural analyses were performed by FTIR, 1HNMR, TNBS and SEM, respectively. Mechanical properties were evaluated by compression tests. Cytocompatibility was evaluated by XTT analysis. GelMA hydrogels obtained from two brands have suitable pore size, mechanical strength, swelling properties and cytocompatibility, making them suitable for various biomedical applications. In addition, the addition of PVP nanoparticles can make them useful for drug delivery applications.
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    PublicationOpen Access
    Development of bilayer tissue-engineered scaffolds: combination of 3D printing and electrospinning methodologies
    (2024-07-01) YILMAZ, HİLAL; GÜNDÜZ, OĞUZHAN; YILMAZ H., Bedir T., Gursoy S., Kaya E., ŞENEL İ., Tinaz G. B., GÜNDÜZ O., ÜSTÜNDAĞ C. B.
    Although different fabrication methods and biomaterials are used in scaffold development, hydrogels and electrospun materials that provide the closest environment to the extracellular matrix have recently attracted considerable interest in tissue engineering applications. However, some of the limitations encountered in the application of these methods alone in scaffold fabrication have increased the tendency to use these methods together. In this study, a bilayer scaffold was developed using 3D-printed gelatin methacryloyl (GelMA) hydrogel containing ciprofloxacin (CIP) and electrospun polycaprolactone (PCL)-collagen (COL) patches. The bilayer scaffolds were characterized in terms of chemical, morphological, mechanical, swelling, and degradation properties; drug release, antibacterial properties, and cytocompatibility of the scaffolds were also studied. In conclusion, bilayer GelMA-CIP/PCL-COL scaffolds, which exhibit sufficient porosity, mechanical strength, and antibacterial properties and also support cell growth, are promising potential substitutes in tissue engineering applications.