Person: UMUROĞLU, TÜMAY
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UMUROĞLU
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TÜMAY
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Publication Open Access The effects of preoperative oral pregabalin and perioperative intravenous lidocaine infusion on postoperative morphine requirement in patients undergoing laparatomy(HINDAWI LTD, 2015) SARAÇOĞLU, AYTEN; Zengin, Senniye Ulgen; Saracoglu, Ayten; Eti, Zeynep; Umuroglu, Tumay; Gogus, Fevzi YilmazOBJECTIVES: To evaluate and compare the effects of preoperative oral pregabalin and perioperative intravenous lidocaine infusion on postoperative morphine requirement, adverse effects, patients' satisfaction, mobilization, time to first defecation and time to discharge in patients undergoing laparotomy. Methods: Eighty patients (18 to 65 years of age) undergoing elective laparotomy were randomly divided into four groups (n=20 in each group): group C, placebo capsules and normal saline infusion perioperatively (control); group L, placebo capsules and lidocaine 1 mg/kg intravenous bolus dose followed by 2 mg/kg/h infusion until skin closure; group P, 150 mg oral pregabalin and normal saline infusion perioperatively; and group PL, 150 mg oral pregabalin and lidocaine 2 mg/kg/h infusion until skin closure. Hemodynamic parameters, visual analogue scale (VAS) scores, analgesic consumption, side effects, time to mobilization, time to first defecation, time to discharge and patients' satisfaction were recorded. Results: VAS scores of group L, group P and group PL were lower than group C (P<0.05). Morphine consumption of group P and group PL was lower than group C (P<0.05). Incidence of nausea in group C was higher than group L and group PL. Time to first defecation and mobilization were shorter in group L and group PL compared with group C (P<0.05). Conclusion: Preoperative oral pregabalin and perioperative intravenous lidocaine infusion decreased postoperative VAS scores. Preoperative oral pregabalin decreased morphine requirement and perioperative intravenous lidocaine infusion hastened gastrointestinal motility and mobilization, and decreased the incidence of nausea in patients undergoing laparotomy. Therefore, preoperative pregabalin with or without lidocaine provides superior pain relief in patients undergoing laparatomy.Publication Open Access Determining the factors affecting the development of perioperative complications according to aging stages(2022-06-01) ZENGİN, SENİYYE ÜLGEN; ORHON ERGÜN, MELİHA; ÇORMAN DİNÇER, PELİN; UMUROĞLU, TÜMAY; ORHON ERGÜN M., ZENGİN S. Ü., ÇORMAN DİNÇER P., UMUROĞLU T., AYKAÇ Z. Z.Objective: This study aimed to examine perioperative complication risks in elderly patients stratified by age. Method: Elderly patients (youngest-old, ages 65 to 74 years; middle-old, 75 to 84 years; and oldest-old, ≥85 years) and controls (20-30 years) who underwent surgical intervention under general anesthesia were included in this prospective observational study. Results: Two-hundred-sixty patients were included. Different age subgroups showed a different course in terms of perioperative complications. For any combined end-point of any perioperative complication, having a body mass index>28 [odds ratio (OR): 2.4; 95% confidence interval (CI): 1.2-4.6; p=0.012] and being on multi-pharmacy regimen at baseline (OR: 1.9; 95% CI: 1.1-3.5; p=0.029) emerged as significant independent predictors. In reference to controls, each elderly age group emerged as a significant independent predictor: youngestolds (OR: 4.9; 95% CI: 2.2-10.8; p<0.001); middle-olds (OR: 2.5; 95% CI: 1.1-5.4; p=0.025); oldest-olds, (OR: 5.6; 95% CI: 2.5-12.6; p<0.001). Conclusion: Elderly patients appear to have higher risk for intraoperative and postoperative complications when compared to the young patients, and each age group appears to have increased risk for different type of complications.Publication Metadata only The comparative effects of local anaesthetics on wound healing in rats: Bupivacaine vs Levobupivacaine(Ondokuz Mayis Universitesi, 2016) BOZKURT, SÜHEYLA; Atalay Y.O., Umuroglu T., Yagmur C., Gogus F.Y., Bozkurt S.The aim of this study is to investigate the effects of local anaesthetic agents (bupivacaine and levobupivacaine) on wound healing in rats. Wistar albino rats were randomly assigned to three groups (n=10 per group); the control group, the bupivacaine group, and the levobupivacaine group. An incision measuring 5 cm in length was made over the dorsum in all groups. The incisions were infiltrated with 3 ml of normal saline in the control group, 3 ml of 0.25%bupivacaine in the bupivacaine group, and 3 ml of 0.25%levobupivacaine in the levobupivacaine group. Histopathological examinations and tensile strength measurements were performed on tissue samples taken from the incision line 14 days after infiltration. Epidermal and dermal regeneration scores were significantly lower in the levobupivacaine group compared with the bupivacaine and control groups (p<0.05). Granulation tissue thickness, angiogenesis, and tensile strength measurements were not significantly different between groups. Even though incomplete epidermal and dermal regeneration scores were attained using levobupivacaine, both bupivacaine and levobupivacaine had no negative effects on the overall clinical wound-healing process. © 2016 OMU.Publication Metadata only Effects of multiple pulmonary aspirations of enteral solutions on lung tissue damage(CHURCHILL LIVINGSTONE, 2006) YILDIZELİ, BEDRETTİN; Umuroglu, T; Takil, A; Irmak, P; Yildizeli, B; Ahiskali, R; Dogan, V; Gogus, FYBackground Et aim: The aim of this study was to compare the pulmonary histopathologic effects of enteral solutions with various lipid content, after multiple aspirations in rats. Methods: Thirty Wistar albino rats were randomly assigned to one of three groups (n = 10). Salinesolution (0.9%) (group C, control), Impact (lipid content, 28g/l; group I), Pulmocare (lipid content, 93.3g/l; group P) were injected into the lung through the trachea, in a volume of 0.8 ml/kg. The aspiration procedure was performed three times in total, in every 2 days. After seven days from the first aspiration, rats were killed, and lungs were examined for histopathologic examination. Results: Alveolar histiocytes were statistically higher in left lungs of the group I than the left ones of the control group(P < 0.05). Lipid-laden alveolar macrophages were significantly higher in left lungs of groups I and, P than left lungs of the control group (P < 0.05). Conclusion: Lung tissue damage occuring after multiple pulmonary aspirations of Impact and Pulmocare, is histopathotogically similar to each other, and is in the form of lipoid pneumonia. In cases of multiple pulmonary aspirations, volume of the aspirate and chronicicity of the aspiration took like major impact factors rather than the amount of the lipid. (c) 2005 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.Publication Open Access Perioperative hypothermia and associated factors: A prospective cohort study(2023-01-01) ABDULLAYEV, RUSLAN; UMUROĞLU, TÜMAY; Kelleci Y., ABDULLAYEV R., Cakmak G., Ozdemir H., UMUROĞLU T., Saracoglu A.Objective: Perioperative hypothermia is deleterious with many consequences, including coagulopathy, decreased immune functions, prolonged drug clearance, and cardiovascular complications. In this study we aimed to demonstrate the incidence of perioperative hypothermia during general anesthesia, its associated risk factors, and outcomes. Methods: For this prospective cohort study patients aged 18-75 years with American Society of Anesthesiologists physical status I-III scheduled for any elective operation under general anesthesia in a one-month period were recruited. The patients’ body temperatures were measured in the preoperative unit, in the operating theatre before induction, at the second hour of the operation, at the end of the operation, at the postoperative recovery unit admission, and discharge using a medical infrared thermometer. The patients’ demographic and hemodynamic characteristics, magnitudes of surgery, surgery and anesthesia durations, warming methods, hospital and Intensive Care Unit (ICU) length of stays were recorded. Results: Sixty five out of 290 enrolled patients (22.4%) developed perioperative hypothermia. Anesthesia and surgery time was longer in patients with hypothermia (p<0.001). Hospital length of stay of the patients was also longer in the patients with hypothermia (p<0.001). Intensive care unit admission of the patients with hypothermia was significantly higher compared with those with normothermia (2.7 vs 9.2%, p=0.030). Conclusion: Perioperative hypothermia continues to be a challenge despite many published clinical application guidelines in this context. Intermediate and major type surgeries resulted in more perioperative hypothermia. Perioperative hypothermia was significantly associated with longer operation and anesthesia durations, hospital length of stays, and higher ICU admissions as well. Routine monitoring and active warming should be performed throughout the perioperative period to prevent hypothermia and current practice guidelines should be followed.Publication Open Access Targeted bleeding management guided by non-invasive haemoglobin measurement in surgical patients(2022-10-01) AKDAĞ, ŞÜKRİYE; ZENGİN, SENİYYE ÜLGEN; UMUROĞLU, TÜMAY; AYKAÇ, ZEYNEP ZUHAL; SARAÇOĞLU, AYTEN; AKDAĞ Ş., ZENGİN S. Ü. , Cakmak G., UMUROĞLU T., AYKAÇ Z. Z. , SARAÇOĞLU A.© 2022 College of Physicians and Surgeons Pakistan. All rights reserved.Objective: To assess blood transfusion decisions in blood losses using a continuous total haemoglobin (SpHb) and non-invasive haemoglobin (Hb) device. Study Design: Double-blinded randomised controlled trial. Place and Duration of Study: Marmara University Hospital, Istanbul, Turkey, from March 2018 to December 2019. Methodology: One hundred and twenty adult patients scheduled for elective major surgery and expected to experience a blood loss greater than 20% of their total blood volume were divided into two groups. These groups were compared for bleeding management with conventional blood gas sampling (Group Hb, the control group) according to Hb monitoring versus SpHb measurement (Group SpHb, the study group). Results: In the postoperative measurement, there were fewer red blood cells (RBC) in the SpHb group than in the Hb group (p=0.020). There was a greater change in the amount of RBC from the perioperative to the postoperative period in the SpHb group compared to the Hb group (p<0.001). Postoperative Hb levels of patients in the intensive care unit (ICU) were higher in the SpHb group than in the Hb group (p<0.05). Conclusion: SpHb can provide effective patient blood management in cases of major surgery. It does not cause a delay in the decision of blood transfusion during surgery.Publication Metadata only Lazer cerrahisi sırasında gelişen trakeobronşial inhalasyon yanığı- olgu sunumu(2017-10-29) KASAPOĞLU, UMUT SABRİ; GÜL, FETHİ; YUMUŞAKHUYLU, ALİ CEMAL; UMUROĞLU, TÜMAY; CİNEL, İSMAİL HAKKI; KASAPOĞLU U. S., GÜL F., ARSLANTAŞ M. K., YUMUŞAKHUYLU A. C., YAMANSAVCI E., UMUROĞLU T., CİNEL İ. H.Publication Open Access Pediatrik hastalarda postoperatif deliryum gelişmesi ile analjezi nosisepsiyon index değerleri arasındaki ilişkinin belirlenmesi(2022-01-01) ORHON ERGÜN, MELİHA; ÇORMAN DİNÇER, PELİN; UMUROĞLU, TÜMAY; ZENGİN, SENİYYE ÜLGEN; ÖZALTUN F., ZENGİN S. Ü., ORHON ERGÜN M., ÇORMAN DİNÇER P., UMUROĞLU T.Publication Open Access Comparative efficacy of finger versus forehead plethysmographic variability index monitoring in pediatric surgical patients(2022-10-01) FİDAN, SEYFULLAH; ZENGİN, SENİYYE ÜLGEN; ORHON ERGÜN, MELİHA; UMUROĞLU, TÜMAY; Fidan S., ZENGİN S. Ü. , ORHON ERGÜN M., UMUROĞLU T.Introduction The Plethysmographic Variability Index can be measured by both finger and forehead probes. Vasoconstriction may jeopardize the reliability of finger PVI measurements in pediatric patients undergoing surgery. However, forehead vasculature exhibits more marked resistance to alterations in the vasomotor tonus. Objective Our aim was to compare the Plethysmographic Variability Index measured via finger or forehead probes in mechanically ventilated pediatric surgery patients in terms of their ability to predict fluid responsiveness as well as to determine the best cut-off values for these two measurements. Materials and Methods A total of 50 pediatric patients undergoing minor elective surgery were included after provision of parental consent and ethics committee approval. Perfusion index measured at the finger or forehead and Plethysmographic Variability Index monitoring comprised the primary assessments. Hemodynamic parameters monitored included perfusion index, Plethysmographic Variability Index, and cardiac output. A >= 15% increase in cardiac output following passive leg raise maneuver was considered to show fluid responsiveness. Two groups were defined based on fluid responsiveness: Group R (responsive) and Group NR (non-responsive). Student\"s t-test, Mann-Whitney U test, DeLong test, and ROC were used for statistical analysis. Results The area under curve for finger and forehead Plethysmographic Variability Index prior to passive leg raise maneuver were 0.699 (p = .011) and 0.847 (p < .001), respectively. The sensitivity for finger and forehead measurements at a cut-off value of <= 14% was 92.9% and 96.4%, and 45.4% and 72.7%, respectively. Conclusion Although forehead and finger Plethysmographic Variability Index monitoring were similarly sensitive in predicting fluid responsiveness in pediatric surgical patients, the former method provided higher specificity. The best cut-off value for PVI measurements with forehead and finger probes was found to be 14%.Publication Metadata only The effect of propofol and alfentanil on the increase in intraocular pressure due to succinylcholine and intubation(WICHTIG EDITORE, 2000) UMUROĞLU, TÜMAY; Eti, Z; Yayci, A; Umuroglu, T; Gogus, FY; Bozkurt, NPURPOSE. The aim of this study was to evaluate the effects of propofol and alfentanil on the increase in intraocular pressure (IOP) due to succinylcholine and intubation, in comparison with thiopental sodium and vecuronium bromide. METHODS. Forty patients aged 20-50 years, scheduled for elective surgery requiring endotracheal intubation, were assigned to four groups of ten. General anesthesia was induced with 2.5 mg/kg propofol in Group 1, 2.5 mg/kg propofol and 10 mu g/kg alfentanil in Group II and 5 mg/kg thiopental in Groups III and IV muscle relaxation was obtained with either 1.5 mg/kg succinylcholine (Group I, II and III) or 0.1 mg/kg vecuronium bromide (Group IV). In all patients mean arterial pressure, heart rate, oxygen saturation and IOP were recorded before (baseline) and after induction, after the muscle relaxant and after endotracheal intubation. RESULTS. Compared with their baseline values in Group I IOP decreased significantly after propofol (p<0.01) and increased significantly after intubation (p<0.01). In Group II IOP decreased significantly after propofol and alfentanyl (p<0.001), remained low after succinylcholine (p<0.01) and did not change after intubation. In Group III IOP decreased significantly after thiopental (p<0.001) and increased significantly after intubation (p<0.001). In Group IV ii decreased significantly after thiopental (p<0.001), remained low after vecuronium (p<0.001) and increased significantly after intubation (p<0.05). CONCLUSIONS. In all Groups, IOP did not increase significantly after succinylcholine, but only anesthesia induced with propofol and alfentanil prevented the increase in IOP due to intubation.
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