Person: ERDİL, TANJU YUSUF
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ERDİL
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TANJU YUSUF
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Publication Open Access Langerhans Hucreli Histiyositoz Tanili Hastada Soliter Kemik Lezyonunun Takibinde Kemik Sintigrafi ve SPECT/BT'nin Rolu(GALENOS YAYINCILIK, 2021-10-01) TUROĞLU, HALİL TURGUT; Kesim, Selin; Turoglu, Halil Turgut; Inanir, Sabahat; Ozguven, Salih; Erdil, Tanju YusufLangerhans' cell histiocytosis (LCH) is a rare disease observed in childhood characterized by the proliferation of Langerhans' cells resulting in focal or systemic manifestations (including the bones). Here, we present a pediatric case with a localized biopsy-proven LCH, who underwent progression from solitary to multifocal form detected on bone scintigraphy and single photon emission computerized tomography/computed tomography (SPECT/CT) performed within four months. Emphasizing on localized bone pain (predictive of osseous LCH) and local tenderness and swelling usually guides the nuclear physician to perform additional SPECT/CT with presumably an improvement of the diagnostic accuracy as demonstrated in our case.Publication Metadata only Simple provocative maneuvers in renal transplant scintigraphy for detecting urine leak(SPRINGER, 2007) DEDE, FUAT; Dede, Fuat; Ones, Tunc; Caliskan, Billur; Civen, Huseyin; Erdil, Tanju Y.; Inanir, Sabahat; Tuglular, Zubeyde S.; Yegen, Cumhur; Akoglu, Emel; Turoglu, Halil T.Urine leak in the early postoperative period following renal transplantation is a serious complication requiring early identification and aggressive intervention, which significantly reduces the morbidity and mortality. Renal transplant scintigraphy is a noninvasive method to evaluate the perfusion and function of a transplanted kidney and urinary drainage including urine leak. Here, we reported two cases in which the standard transplant renogram failed to demonstrate urine leak. The cases were referred for a diethylenetriaminepentaacetic acid renogram following the transplantation to evaluate the cause of symptoms or elevated serum creatinine level. In both the cases, urine leak was successfully detected following simple maneuvers such as diuretic administration or Foley catheter irrigation. Renal transplant scintigraphy is an effective and safe technique and the use of these simple maneuvers can enhance the diagnostic sensitivity of the transplant renogram in the detection of urine leak.Publication Metadata only FDG PET/CT Appearance of Multi-Regional Elastofibroma: Original Image(ORTADOGU AD PRES & PUBL CO, 2012) DEDE, FUAT; Gungor, Serkan; Ones, Tunc; Aras, Mustafa; Dede, Fuat; Inanir, Sabahat; Erdil, T. Yusuf; Turoglu, H. TurgutPublication Metadata only Ektopik Paratiroid Bezlerini Saptamada Dual Faz MIBI Sintigrafisi ve SPECT/BT Görüntülemesinin Rolü Tek Merkezli Çalışma(2023-04-26) KESİM, SELİN; TUROĞLU, HALİL TURGUT; FİLİZOĞLU, NUH; ÖZGÜVEN, SALİH; İNANIR, SABAHAT; DEDE, FUAT; ÖNEŞ, TUNÇ; ERDİL, TANJU YUSUF; BALABAN GENÇ, ZEYNEP CEREN; Kesim S., Turoğlu H. T., Balaban Genç Z. C., Filizoğlu N., Niftaliyeva K., Kıssa T. N., Öksüzoğlu K., Özgüven S., Şen F., İnanır S., et al.Amaç: Primer hiperparatiroidisi olan hastalardan, daha önce hiç araştırılmamış hasta popülasyonunda ektopik paratiroid adenomu (EPA) prevalansı yaklaşık %20 iken; tekrar ameliyat edilen popülasyonda EPA prevalansın %66’ya kadar yükselebildiği literatürde bildirilmiştir. Ektopik bezler karotis bifurkasyonundan aortopulmoner pencereye kadar herhangi bir yerde olabilir. Bu çalışmada, hastanemize gelip, primer hiperparatiroidi nedeniyle paratiroid sintigrafisi çekilen hastalarda ektopik paratiroid bezi sıklığı ve tek foton emisyon bilgisayarlı tomografi/bilgisayarlı tomografi (SPECT/BT) tekniğinin katkısı retrospektif olarak araştırıldı.Yöntem: Haziran 2015-Ocak 2023 tarihleri arasında Nükleer Tıp Kliniğine refere edilen 300 primer hiperparatiroidi tanılı olguya preoperatif lokalizasyon amacıyla anterior mediasten dahil, dual faz Tc-99m-MIBI planar sintigrafileriyle SPECT/BT tomografik görüntüleme yapıldı. Renal kalkül veya kemik mineral yoğunluğunda azalma gibi son organ hasarı bulunan, ciddi hiperkalsemisi bulunan, semptomatik hastalar, 50 yaş ve altında tanı alan olgular ile klinik veya biyokimyasal kanıtların paratiroid karsinomu ile uyumlu olduğu olgular paratiroidektomiye yönlendirildi. Hastaların korele eden ameliyat bulguları ve postop patoloji sonuçları retrospektif olarak incelendi. Postop PTH düzeylerinin düşmesi, hiperkalseminin, hasta semptomlarının kaybolması ve renal kalkül gibi klinik bulguların nüks etmemesi, primer paratiroid adenomu lokalizasyonu ve tedavisinin başarılı olması olarak değerlendirildi. Bulgular: MIBI sintigrafisinde 300 hastadan 24 olguda (%8) ektopik yerleşimli paratiroid bezi saptandı bunların 7 tanesi ameliyat ile konfirme edildi. Histopatolojik olarak bu ektopik bezlerden 5 tanesi paratiroit adenomu, 2 tanesi paratiroid hiperplazisi olarak raporlandı. Yirmi dört hastanın 4 tanesi erkek, 20 tanesi kadın olup; hasta yaşları 45 ile 82 arasında değişmekteydi (ortalama yaş; 64,2). Hastaların ortalama kalsiyum değeri 11,3±0,9 mg/dL iken, ortalama parathormon değeri 258±469 ng/L olarak hesaplandı. Adenom boyutları ortalama 10,5±4,8 mm olarak ölçüldü. Ektopik paratiroidlerin yerleşim yerleri en sık görülme yerlerinden başlayarak azalan sıklık sayısına göre, mediastinal, paraözofageal, intratiroidal, submandibular, jugulum düzeyi, trakeoözofageal ve karotis kılıfı idi. Sonuç: Ektopik paratiroit bezlerine, tiroit bezi içerisinde veya angulus mandibuladan aşağı anterior mediastene kadar uzanan, timofarengeal kanal boyunca rastlanabilir. Süperior paratiroid bezleri, embriyolojik olarak 4. Yutak kesesinden kaynaklanır ve posterolateral loblarına yakın yerleşim gösterdikleri tiroit beziyle birlikte aşağı inerler. İnferior paratiroit bezleri ise, embriyolojik olarak 3. yutak kesesinden kaynaklanır ve timusla birlikte kaudale doğru göç ederler. Alt paratiroid bezlerinin yerleşimi tiroit bezinin içinde ve yakınında, karotis bifurkasyonunda, alt boyunda veya mediastende olabilir.Ektopik yerleşime, inferior paratiroit bezlerinde daha sık rastlanmaktadır. Ektopik adenomlar hem Tc-99m-MIBI görüntülemesi ile lokalize etmekte hem de cerrahi rezeksiyonda zorluk çıkarmaktadır. Hibrid SPECT/BT görüntüleme tekniğininin kullanılması, deneyim ve multidisipliner işbirliği ile optimal sonuç elde edilebilir. Anahtar Kelimeler: Primer hiperparatiroidi, ektopik paratiroid adenomu, dual faz MIBI sintigrafisi, SPECT/BTPublication Metadata only Invasive urothelial carcinoma detected in bladder diverticulum with FDG PET/CT: A rare case with negative cystoscopy(ELSEVIER DOYMA SL, 2014) TUROĞLU, HALİL TURGUT; Ozguven, Salih; Maleki, Reza; Ones, Tunc; Inanir, Sabahat; Erdil, Tanju Yusuf; Turoglu, Halil TurgutPublication Open Access Long-Term Results of Fixed High-Dose I-131 Treatment for Toxic Nodular Goiter: Higher Euthyroidism Rates in Geriatric Patients(GALENOS YAYINCILIK, 2015-10-05) DEDE, FUAT; Aktas, Gul Ege; Turoglu, Halil Turgut; Erdil, Tanju Yusuf; Inanir, Sabahat; Dede, FuatObjective: Geriatric patient population has special importance due to particular challenges. In addition to the increase in incidence of toxic nodular goiter (TNG) with age, it has a high incidence in the regions of low-medium iodine intake such as in our country. The aim of this study was to evaluate the overall outcome of high fixed dose radioiodine (RAI) therapy, and investigate the particular differences in the geriatric patient population. Methods: One hundred and three TNG patients treated with high dose I-131 (370-740 MBq) were retrospectively reviewed. The baseline characteristics; age, gender, scintigraphic patterns and thyroid function tests before and after treatment, as well as follow-up, duration of antithyroid drug (ATD) medication and achievement of euthyroid or hypothyroid state were evaluated. The patient population was divided into two groups as those=>65 years and those who were younger, in order to assess the effect of age. Results: Treatment success was 90% with single dose RAI therapy. Hyperthyroidism was treated in 7 +/- 7, 2 months after RAI administration. At the end of the first year, overall hypothyroidism rate was 30% and euthyroid state was achieved in 70% of patients. Age was found to be the only statistically significant variable effecting outcome. A higher ratio of euthyroidism was achieved in the geriatric patient population. Conclusion: High fixed dose I-131 treatment should be preferred in geriatric TNG patients in order to treat persistent hyperthyroidism rapidly. The result of this study suggests that high fixed dose RAI therapy is a successful modality in treatni g TNG, and high rates of euthyroidism can be achieved in geriatric patients.Publication Open Access False Positive FDG PET/CT Resulting from Fibrous Dysplasia of the Bone in the Work-Up of a Patient with Bladder Cancer: Case Report and Review of the Literature(KOWSAR PUBL, 2012-12-27) DANE, FAYSAL; Aras, Mustafa; Ones, Tunc; Dane, Faysal; Nosheri, Omid; Inanir, Sabahat; Erdil, Tanju Yusuf; Turoglu, Halil TurgutFibrous dysplasia of the bone (FDB) is a common, genetic, developmental disorder with a benign course. FDB can be seen anywhere throughout the skeleton. It is usually asymptomatic and found incidentally on imaging studies that are performed for other purposes. Although whole body 18 F-flourodeoxyglucose PET/CT (FDG PET/CT) is widely used in tumor imaging, infections and benign pathologies like FDB may cause false positive results. Herein we report the case of a 48-year-old FDB patient with transitional cell carcinoma of the urinary bladder. Restaging FDG PET/CT showed multiple mild to moderate hypermetabolic bone lesions which were initially misinterpreted as bone metastases. In this case report, we aimed to guide physicians in evaluating bone lesions in cancer patients with FDB in the light of the literature.Publication Metadata only The clinical utility of 99(m)Tc-HMPAO SPECT in Fahr's disease(SPRINGER, 2008) GÜNAL, DİLEK; Ones, Tunc; Dede, Fuat; Gunal, Dilek; Ekinci, Gazanfer; Memis, Hatice; Erdil, Tanju Y.; Inanir, Sabahat; Turoglu, Halil T.Fahr's disease is a rare neurodegenerative syndrome, characterized by massive symmetrical intracerebral calcifications of the basal ganglia, dentate nuclei of the cerebellum, and the adjacent parenchyma. Computerized tomography (CT) is considerably more sensitive to detect these intracranial calcifications than other imaging modalities. The clinical, CT scan, and 99(m)Tc-D,L-hexamethylpropylene amine oxime (99(m)Tc-HMPAO) brain perfusion single-photon emission computerized tomography (SPECT) findings in a 42-year-old woman with Fahr's disease are reported, and the clinical utility of 99(m)Tc-HMPAO SPECT findings in Fahr's disease is discussed in this article. In conclusion, 99(m)Tc-HMPAO brain perfusion SPECT seems to be useful in the clinical approach to Fahr's disease, and may provide more specific and clinically relevant information when compared with anatomical imaging.Publication Metadata only Quantitative shunt imaging in the evaluation of therapeutic surgery in a patient with pulmonary arteriovenous malformation(ELSEVIER SCIENCE INC, 2008) DEDE, FUAT; Ones, Tunc; Dede, Fuat; Erdim, Refik; Erdil, Tanju Yusuf; Inanir, Sabahat; Yuksel, Mustafa; Turoglu, Halil TurgutA case of pulmonary arteriovenous malformation (PAVM) in a 32-year-old woman who underwent successful left upper lobectomy is presented. A whole-body technetium-99m-labeled macro-aggregated albumin scan was used to demonstrate intrapulmonary right-to-left shunt, and shunt fraction was calculated as 39%. The patient underwent a follow-up scan after the operationPublication Open Access 2-(fluorine-18)-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography after breast conserving surgery: Correlation with molecular markers of breast cancer(MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2016) TUROĞLU, HALİL TURGUT; Ozguven, Salih; Inanir, Sabahat; Turoglu, Halil Turgut; Erdil, Tanju Yusuf; Ugurlu, Mustafa Umit; Gulluoglu, BahadirAim: To investigate the role of 2-(fluorine-18)-fluoro-2-deoxy-D-glucose (F-18-FDG) positron emission tomography/computed tomography (PET/CT) early after breast-conserving surgery (BCS) in patients with breast cancer (BC) and whether we can determine which molecular biomarkers of breast carcinoma put the patients at risk. Materials and Methods: This retrospective study involved 88 patients with histologically proven T1 or T2 BC, who were treated with BCS and underwent F-18-FDG PET/CT study. The correlation between biological markers (estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 [HER2], and Ki-67) of the primary tumor and F-18-FDG PET/CT findings was analyzed. Results: F-18-FDG PET/CT demonstrated the presence of BC disease (locoregional disease [LRD], distant metastases, or contralateral BC) in 26 of 88 patients (29.5%). Regarding immunohistochemical profiles, BC expressing high levels of Ki-67 were associated with an increased percentage of LRD, which was the major recurrence pattern on F-18-FDG PET/CT. Although the BC disease was observed more commonly in patients with HER2 positivity compared to those of HER2 negative, the difference did not reach statistical significance. The patients with T2 tumor or a higher histopathological grade had a higher percentage of BC disease. Conclusions: This study demonstrated that patients with early stage BC treated with BCS have a remarkable risk of the presence of BC even early after surgery, and there was a clinically important relationship between F-18-FDG PET/CT findings and biological markers of BC. These findings suggest that high-risk molecular biomarkers (Ki-67, HER2) can be taken into account in the decision-making the process for both preoperative imaging and planning of the surgical approach.