Person: AYAZ SEYHAN, SERAP
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
AYAZ SEYHAN
First Name
SERAP
Name
12 results
Search Results
Now showing 1 - 10 of 12
Publication Metadata only Inula helenium loaded nanofibers mat for medical application(2023-06-28) CESUR, SÜMEYYE; AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; GÜNDÜZ, OĞUZHAN; SULUTAŞ R. B., CESUR S., AYAZ SEYHAN S., BİLĞİÇ ALKAYA D., GÜNDÜZ O.Cancer is one of the leading causes of death worldwide. Biomaterials produced with nanotechnological methods for cancer treatment are more effective and complementary than existing treatment strategies. Nanofiber scaffolds are biomaterials that can be used in cancer treatment and can be produced in composites with biocompatible polymers and anti-cancer drugs, plant extracts. The electrospin device used for the production of these materials creates nanofiber networks by providing the electric field between the needle tip and the metal collector, which transmits the polymer solution. PLA is a biodegradable synthetic material preferred in tissue engineering studies and is a biocompatible, high mechanical strength, low cost polymer suitable for use in drug delivery systems. PVP is a polymer with good adhesion, high physiological compatibility, low toxicity and easily soluble in most organic solvents, especially used in the pharmaceutical industry. The extract of the plant Inula helenium, whose main component consists of sesquiterpene lactones, is also used in treatments for cancer. This component, which has various biological activities, has a significant anti-cancer effect. In this study, the polymer ratio used in the production of nanofiber scaffold obtained by adding Inula helenium extract is 75% PLA-chloroform / 25% PVP-ethanol and 1% Tween 80. The surface morphology of the produced fiber material was determined according to the results in the SEM images. The diameters of the fibers were measured and given in the histogram graph. FT-IR for chemical structure between bonds and DSC tests for thermal behavior analysis were applied. Tensile test was performed for mechanical analysis. Swelling-degradation test was performed and drug release kinetic data were calculated by UV spectrophotometer. In addition, its effectiveness on cancerous cells was examined by MTT analysis. In conclusion, Inula helenium extract-loaded nanofibers can reduce the risk of local recurrence of cancer after surgery and can be directly implanted into solid tumor cells for treatmentPublication Metadata only Synthesis of medicinal plant based bioactive electrospun nanofibrous mats and their effect on the antioxidant activity(2022-06-24) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Demirel A. B., Ayaz Seyhan S., Bilğiç Alkaya D., Cesur S., Gündüz O.Publication Metadata only Production and Characterization of a Dual Drug Delivery System of Memantine and Naringenin by Electrospinning Method(2023-06-30) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Birinci A., Ayaz Seyhan S., Bilğiç Alkaya D., Cesur S., Gündüz O.Publication Open Access Preparation and characterization of pure natural hydroxyapatite derived from seashells for controlled drug delivery(2022-09-01) OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; AYAZ SEYHAN S., Alkaya D., Cesur S., OKTAR F. N., GÜNDÜZ O.The marine species are specially used for the fabrication of bioceramic nano-powders with natural methods for their use in controlled drug delivery. However, there are only very limited studies regarding the production and synthesis of hydroxyapatite (HA)-based drug delivery systems from marine structures. In this study, poly (vinyl alcohol) (PVA) containing Rifampicin (RIF)-loaded Orange Spiny Oyster Seashell (Spondylus barbatus) hydroxyapatite (HA) composite is synthesized by an in situ ultrasound-assisted method. All samples were analyzed by X-ray diffraction (XRD), Fourier transforms infrared (FTIR) spectroscopy, and Scanning electron microscope (SEM), respectively. The in vitro drug release tests of the obtained samples were performed in a phosphate-buffered medium (PBS) at 37 degrees C. Drug release was evaluated according to five varying kinetic models. In vitro RIF release from HA/PVA composite in phosphate buffer (pH 7.4) showed prolonged sustained drug release. From the drug release kinetic models, Higuchi and Korsmeyer-Peppas were found to be the best model for the three ratios based on the correlation coefficient. The diffusion component is less than 0.5, which indicates quasi-fickian diffusion. From the kinetic study results, the RIF-loaded marine phase composite has potential use in drug delivery applications as it shows positive sustained drug release behavior.Publication Metadata only Characterization and application of silver nanoparticles decorated electrospun nanofiber loaded with naringenin(2022-06-24) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Birinci A., Ayaz Seyhan S., Bilğiç Alkaya D., Cesur S., Gündüz O.Nanoparticles are an innovative class of functional materials. Silver nanoparticles (AgNPs) are extensively applied in different fields of science, such as biomedical science, including antibacterial, antiviral, anti-inflammatory, and anticancer therapies. Also, AgNPs are being used to produce various biomedical products to prevent infection. The application of AgNPs has been widened due to recent advances in nanotechnology. AgNPs have several important implications including medical diagnostics, therapeutics, antioxidant, antibacterial, and cytotoxic properties. Many natural biomolecules in plants (inactivated plant tissue, plant extracts and living plant) such as proteins/enzymes, amino acids, polysaccharides, alkaloids, alcoholic compounds, and vitamins could be involved in bioreduction, formation and stabilization of AgNPs. Naringenin (4′,5,7-trihydroxyflavanone) (NRG) is a bioflavonoid widely present in fruits; it has been reported to have antioxidant, free radical scavenging, anticancer, anti-inflammatory, immunomodulating and memory enhancing properties. Its antioxidant effects may make NRG a potential drug for treating Alzheimer disease (AD). Recently, NRG was found to exhibit neuroprotective effect in models of Parkinson's disease (PD) and AD, such as the ICV-STZ-induced mode of AD and the 6-OHDA model of PD. Nanocomposite materials consisting of metallic nanoparticles incorporated in or with polymers have attracted much attention because of their distinct optical, electrical and catalytic properties, which have potential applications in the fields of catalysis, bioengineering, photonics, and electronics. Silver nanoparticles have been immobilized into polymer-based nanofibers to introduce hybrid multifunctional substrates for a variety of applications. In this study, nanostructured metal-polymer hybrid (AgNPsNRG-PLA) nanofibers were obtained by electrospinning technique.The nanostructured metal-polymer hybrid (AgNPs-NRG-PLA) nanofibers were characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), thermal analysis (DSC) and tensile strength and physical analyzes such as density, surface tension, particle viscosity were performed.Publication Metadata only Production of nanofiber for combination with anticancer tragopon porrifolius L. Naringenin(2023-06-30) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Yeşil E., Ayaz Seyhan S., Bilğiç Alkaya D., Cesur S., Gündüz O.Publication Metadata only Design and characterization of medicinal plant based nanofibers and their effect on the antioxidant activity(2022-06-24) BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Ekici T., Doğrul E., Bilğiç Alkaya D., Ayaz Seyhan S., Cesur S., Gündüz O.Publication Metadata only Donezepil for the treatment of alzheimer's disease-loaded with curcumin production of sandwich-like 3D PCL/PVA tissue scaffolds(2023-06-30) BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Ekici T., Bilğiç Alkaya D., Ayaz Seyhan S., Cesur S., Gündüz O.Publication Metadata only Fabrication and Characterization of Carbamazepine Loaded Poly(lactic acid) (PLA) Nanofibrous Scaffolds(2021-06-26) BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Bilğiç Alkaya D., Ayaz Seyhan S., Cesur S., Gündüz O.Publication Metadata only Fabrication and characterization of electrospun ellagic acid-loaded Poly (lactic acid)-polyethylene glycol nanofibers for biomedical application(2022-11-25) BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; GÜNDÜZ, OĞUZHAN; CESUR, SÜMEYYE; Yaşar K., Yamlı R., Bilğiç Alkaya D., Ayaz Seyhan S., Cesur S., Gündüz O.Ellagic acid (dilactone of hexahydroxydiphenic acid, 2,3,7,8-tetrahydroxy-1-benzopyran-5,4,3-cde-1-benzopyran-5,10- dione, EA) is one of the natural polyphenolic antioxidants present in numerous fruits (pomegranate, persimmon, raspberry, black raspberry, strawberry, blueberry, peach, plumes, almonds, walnuts, mango kernel), vegetables and nuts to the tune of 100–1900 mg/kg and contributes significantly to the dietary consumption as nutraceuticals or functional foods. EA demonstrates a broad array of biological roles including anti-inflammatory, anti-carcinogenic, anti-fibrosis, anti-diabetic, anti-ulcer, anti-viral, anti-microbial, anti- apoptotic, anti-mutagenic and cardio-, hepato-renal and neuroprotective together with defense against oxidative stress, lipid peroxidation and free radical damage. Because of its multitarget pharmacological properties endowed with multiple mechanisms of action, can serve as an innovative option for several applications, such as the treatment of bacterial infections and diabet. The use of natural compounds without undesired side effects, in tissue engineering applications, is highly preferred compared to chemical drugs. In recent years, many studies have been carried out to produce nanofibrous materials by electrospinning method. Electrospun nanofibers have very large surface area, controllable pore size and tunable drug release profiles. Several biocompatible polymers with excellent biocompatibility and biodegradability including poly ethylenglycol (PEG) and poly lactic acid (PLA) have been widely used for the synthesis of nanofibers using the electrospun technique. In this study, nanofibers were obtained by adding of EA at different concentration into PLA by electrospinning technique. Morphological (SEM), molecular interaction (FT-IR), thermal analysis (DSC), antioxidant activity and physical analysis were carried out after production process. The resulting structures of nanofibers are suitable for biomedical applications.