Publication: Fabrication and characterization of electrospun ellagic acid-loaded Poly (lactic acid)-polyethylene glycol nanofibers for biomedical application
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Date
2022-11-25
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Abstract
Ellagic acid (dilactone of hexahydroxydiphenic acid, 2,3,7,8-tetrahydroxy-1-benzopyran-5,4,3-cde-1-benzopyran-5,10-
dione, EA) is one of the natural polyphenolic antioxidants present in numerous fruits (pomegranate, persimmon,
raspberry, black raspberry, strawberry, blueberry, peach, plumes, almonds, walnuts, mango kernel), vegetables and nuts
to the tune of 100–1900 mg/kg and contributes significantly to the dietary consumption as nutraceuticals or functional
foods. EA demonstrates a broad array of biological roles including anti-inflammatory, anti-carcinogenic, anti-fibrosis,
anti-diabetic, anti-ulcer, anti-viral, anti-microbial, anti- apoptotic, anti-mutagenic and cardio-, hepato-renal and neuroprotective together with defense against oxidative stress, lipid peroxidation and free radical damage. Because of its multitarget pharmacological properties endowed with multiple mechanisms of action, can serve as an innovative option for
several applications, such as the treatment of bacterial infections and diabet.
The use of natural compounds without undesired side effects, in tissue engineering applications, is highly preferred
compared to chemical drugs. In recent years, many studies have been carried out to produce nanofibrous materials by
electrospinning method. Electrospun nanofibers have very large surface area, controllable pore size and tunable drug
release profiles. Several biocompatible polymers with excellent biocompatibility and biodegradability including poly
ethylenglycol (PEG) and poly lactic acid (PLA) have been widely used for the synthesis of nanofibers using the
electrospun technique.
In this study, nanofibers were obtained by adding of EA at different concentration into PLA by electrospinning technique.
Morphological (SEM), molecular interaction (FT-IR), thermal analysis (DSC), antioxidant activity and physical analysis
were carried out after production process. The resulting structures of nanofibers are suitable for biomedical applications.
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Sağlık Bilimleri, Mühendislik ve Teknoloji, Health Sciences, Engineering and Technology, Klinik Tıp (MED), Mühendislik, Bilişim ve Teknoloji (ENG), Clinical Medicine (MED), Engineering, Computing & Technology (ENG), Polylactic acid (PLA), nanofiber, ellagic acid, electrospinning
Citation
Yaşar K., Yamlı R., Bilğiç Alkaya D., Ayaz Seyhan S., Cesur S., Gündüz O., \"Fabrication and characterization of electrospun ellagic acid-loaded Poly (lactic acid)-polyethylene glycol nanofibers for biomedical application\", 5th International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2022), Ankara, Türkiye, 23 - 25 Kasım 2022, ss.1351-1355