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BECEREN, AYFER

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BECEREN

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AYFER

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2010 - 201916
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End date: 2019 × Start date: 2010 ×

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Now showing 1 - 10 of 16
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    Comparison of inhaled and intraperitoneal formaldehyde toxicity in rats and the evaluation of the effects of melatonin
    (ELSEVIER IRELAND LTD, 2016) BECEREN, AYFER; Aydemir, S.; Akgun, S. G.; Ozkan, N.; Yuksel, M.; Beceren, A.; Erdogan, N.; Omurtag, G. Z.
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    PublicationOpen Access
    Evaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugs
    (MARMARA UNIV, INST HEALTH SCIENCES, 2019-06-30) BECEREN, AYFER; Oltulu, Cagatay; Yesil Devecioglu, Tugce; Akinci, Melek; Olmez, Sevcan Gul Akgun; Obeidin, Serra Vildan Akgul; Beceren, Ayfer
    Objective: DNA damage that can be caused by workplace exposure to antineoplastic drugs in health workers has been shown in many scientific studies. It is aimed to evaluate whether the risk of genotoxicity in health workers decreases after the regulations and measures taken by national and international health authorities in our work. Methods: For this purpose, DNA damage was assessed by using alkaline comet technique in lymphocytes isolated from blood samples of health workers (n=29) who were involved in preparing and/or administering antineoplastic agent at Trakya University Health Research and Application Center and compared with the control group (n=30). Also, those who prepare and/or administer antineoplastic agents; (n=16) and manual (n=13) preparations. Results: As a result of the evaluation, there was no statistically significant difference between health personnel and control group in preparing and / or administering antineoplastic agent (p>0,05, Mann-Whitney U) and there was no difference in the genotoxic risk between preparation forms. Furthermore, when the exposed control group was assessed for DNA damage as smokers and nonsmokers, there was no statistically significant difference in terms of DNA damage (p>0.05). Conclusion: At the center where our samples were taken, the resulting measures resulted in the control of the risk of genotoxicity due to occupational exposure to antineoplastic agents.
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    PublicationOpen Access
    Kolorektal kanser tanısı konmuş olgularda ve birinci derece yakınlarında DNA hasarının araştırılması
    (2011-01-01) BECEREN, AYFER; BECEREN A., OMURTAG G. Z., YEĞEN C., ŞARDAŞ S.
    Amaç: Dünyanın pek çok ülkesinde yapılan araştırmalar kalıtımsal duyarlılık ve çevresel faktörlerin etkileri sonucu kolorektal kanserlerin oluştuğuna işaret etmektedir. Kolorektal kanser hastalarının birinci derece yakınlarında kansere yakalanma riskinin diğer bireylere oranla iki kat daha yüksek olduğu yapılan çalışmalar ile gösterilmiştir. Kolorektal kanserin moleküler ve biyolojik özellikleri hakkındaki bilgilerin hızla artması patogenezine ışık tutmaktadır. Artan kanser riskinin belirlenmesi için biyogöstergelerden sıklıkla yararlanılmaktadır. Bu çalışmanın amacı, genotoksisite çalışmalarında DNA hasarının gösterilmesinde oldukça başarılı bir biyogösterge olan comet tekniği ile kolorektal kanser hastaları ve birinci derece yakınlarının lenfositlerindeki muhtemel genotoksik etkilerin sağlıklı gönüllüler ile karşılaştırılmasıdır. Yöntemler: Henüz hiç tedavi görmemiş, yeni teşhis edilmiş kolorektal kanser hastalarından (n=26), birinci derece yakınlarından (n=26) ve kontrol grubundan (n=18) kan örnekleri toplandı. Comet tekniğinde her örnek için incelenen 50 hücrenin (slayt başına) her birinde kuyruktaki DNA yüzdesi oranlarının ortalaması “mean tail DNA %” (%DNAT) görüntüleme analiz sistemi kullanılarak hesaplandı. Yapılan anket değerlendirmelerinde sosyodemografik özellikler ve DNA hasarını etkileyebilecek faktörler göz önünde bulundurulmuştur. Bulgular: Kolorektal kanser hastaları ve birinci derece yakın bireylerin periferal kan lenfositlerinde comet tekniği uygulanması sonucunda elde edilen ortalama %DNAT değerleri (sırasıyla 10.45±1.50 ve 9.83±1.39) olarak saptanmış olup, kontrol grubu (8.59±0.76) ile karşılaştırıldığında istatistiksel olarak anlamlı bir farklılık tespit edilmiştir (sırasıyla p <0.001, p <0.01). Sonuç: Bu çalışmada elde edilen sonuçlar kolorektal kanser teşhisi konmuş hastalarda ve özellikle de birinci derece yakınlarında comet tekniğinin, DNA hasarını belirlemede bir biyogösterge olarak kullanılabileceğini göstermiştir
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    PublicationOpen Access
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    PublicationOpen Access
    Genotoksisite testlerinin yeni ilaç geliştirme sürecindeki önemi
    (2018-03-01) BECEREN, AYFER; ŞEN S., BECEREN A., AKSOY H.
    In the preclinic investigation period at the beginning of the drug development process, it is an obligation to subject candidate drugs to genotoxicty investigations. Genotoxicty data of drugs that are developed with these tests are demanded as a part of the security evaluation process by regulatory authorities in various countries. The demand of these laboring and costly data by regulatory authorities of various countries in different standards prevents potential candidate drugs from being marketed, interrupts the drug development process and causes unnecessary utilization of experimental materials in researches. Therefore, nowadays, it is generally accepted that the researches aimed at achieving these data are implemented with standardized approaches in the guidelines of international harmonisation organizations such as ICH (International Council for Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use) and OECD (Organisation for Economic Cooperation and Development). In this review, it is aimed to provide current information about the various genotoxicity tests which are used commonly in the drug development process, in accordance with ICH, OECD guidelines and literature.
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    Evaluation of incision wound healing activity of Scorzonera veratrifolia in Wistar albino rats
    (ELSEVIER IRELAND LTD, 2017) BECEREN, AYFER; Gecim, Mert; Beceren, Ayfer; Aydemir, Sezgin; Sardas, Semra
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    The wound healing effects of Nerium oleander extract against burn-induced oxidative injury
    (ELSEVIER IRELAND LTD, 2016) BECEREN, AYFER; Akgun, S. G.; Aydemir, S.; Ozkan, N.; Beceren, A.; Sardas, S.
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    Protective role of St. John's Wort on formaldehyde-induced lung tissue injury: Inhibiton of inflammation and oxidative stress mediated apoptosis
    (ELSEVIER IRELAND LTD, 2017) BECEREN, AYFER; Beceren, Ayfer; Aydemir, Sezgin; Ozakpinar, Ozlem Bingol; Sehirli, Ahmet Ozer; Omurtag, Gulden Zehra
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    The role of St. John's Wort against formaldehyde toxicity induced by inhalation in rats
    (ELSEVIER IRELAND LTD, 2017) BECEREN, AYFER; Aydemir, Sezgin; Beceren, Ayfer; Gecim, Mert; Ozakpinar, Ozlem Bingol; Sehirli, Ahmet Ozer; Omurtag, Gulden Zehra
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    Comparision of biocompatibility and cytotoxicity of two new root canal sealers
    (ELSEVIER GMBH, 2010) BECEREN, AYFER; Gencoglu, Nimet; Sener, Goksel; Omurtag, Gulden Z.; Tozan, Ayfer; Uslu, Bahar; Arbak, Serap; Helvacioglu, Dilek
    The aim of this study was to investigate the remote organ toxicity and connective tissue reaction of two new root canal sealers (GuttaFlowa(R) and EndoREZ(R)) and to compare them with zinc oxide eugenol sealer using biochemical and histopatho-logical parameters A total of 60 white albino Wistar rats were used in the study 0 1 ml of GuttaFlow(R), EndoREZ(R) or Kerr Pulp Canal Sealer(R) were administered subcutaneously into the mid dorsal thoracic region of rats (15 in each group) Control rats were given saline only Rats were decapitated after 24 h, on day 7 and on day 30 of the experiment and tissue samples from lung, liver, kidney and skin were removed for the determination of malondialdehyde (MDA) and glutathione (GSH) levels In parallel, tissues were also examined histologically Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels, and creatinine and blood urea nitrogen (BUN), concentrations (BUN) were measured to assess liver and kidney functions, respectively Tumor necrosis factor (TNF) and lactate dehydrogenase (LDH) were also assayed in serum samples No statistical differences were found among the control and EndoREZ(R), GuttaFlow(R) and Kerr Pulp Canal sealers regarding tissue MDA, GSH levels or serum parameters (p>0 05) at all time points examined Both of the new root canal sealers showed good compatibility and acceptable tissue toxicity (C) 2009 Elsevier GmbH All rights reserved