Person: ULAĞ, SONGÜL
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ULAĞ
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SONGÜL
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Publication Open Access Investigation of the properties of encapsulated hydrophilic and hydrophobic drugs in whey protein microparticles(2022-10-01) ULAĞ, SONGÜL; GÜNDÜZ, OĞUZHAN; Irem Deniz K., Ulağ S., Gündüz O.© 2022 Elsevier B.V.In this study, the amoxicillin (AMX) and rifampicin (RIF) were loaded into the whey protein (WP) to form the hydrophilic and hydrophobic drugs loaded whey protein microparticles. Scanning electron microscopy (SEM) images demonstrated that AMX addition increased the particle size, but RIF addition decreased the dimensions of the particles. The Fourier-transformed infrared spectroscopy (FTIR) results showed that both drugs were successfully loaded into the protein. AMX and RIF were ultimately released from the WP microparticles after 1440 min, according to the drug release test. Two drugs exhibited the same behaviour, but in the first hour, AMX had more release than the RIF.Publication Metadata only Characterizations of ethosuximide-loaded bismuth ferrite nanoparticles for the potential treatment of epilepsy(2023-07-15) ULAĞ, SONGÜL; Ulağ S.Epilepsy is the most common neurological disease that affected people of all ages, races, social classes, and geographical locations. According to the 2019 World Health Organization (WHO) data, about 0.7 % of the population is struggling with epilepsy. In addition, nearly 5 million people are diagnosed every year. The basic characteristic of epilepsy is aberrant electrical activity in several brain regions. About %70 patients with epilepsy can be treated successfully with antiepileptic drugs to control the patient's seizures. 20–30% of patients exhibit pharmacoresistance, and only a small portion of these patients will benefit from surgical intervention. Therefore, developing a successful treatment for the disease is still quite difficult. To accomplish this objective, antiepileptic drug-loaded carrier nanoparticles can be an alternative treatment for epilepsy.Recent developments to improve the release of drugs from smart materials include Near Infrared Light (NIR) radiation (NIR), ultraviolet (UV) and visible wavelength light, magnetic fields, ultrasound, and electrical stimulation. Compared to drug delivery systems based on stable passive delivery, these strategies offer more effective control over the delivery of drugs. Nanoparticle drug carriers are being studied further for controlled drug delivery due to their benefits including good structure and tunable characteristics. Multiferroic materials due to their controllable possession, have drawn interest in recent years to develop new materials or structures. Bismuth ferrite (BiFeO3, BFO) is a single-phase multiferroic material with a polar R3c space group and rhombohedral distorted cell, has the ability to be both ferroelectric and antiferromagnetic.In this study, bare and drug loaded bismuth ferrite nanoparticles were synthesized by coprecipitation method. Bare and drug loaded nanoparticles were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray diffraction analysis (XRD), and scanning electron microscopy (SEM). Ethosuximide is an FDA-approved, made available as an efficient and generally well-tolerated medication to treat absence seizures. It prevents clonic seizures generated on by bicuculline or pentylenetetrazole when administered subcutaneously. Also, biological test was done by using microglia cells.Publication Metadata only Characterization of scaffolds for neural tissue engineering(Elsevier Science, Oxford/Amsterdam , 2023-05-01) ULAĞ, SONGÜL; Ulağ S.Publication Metadata only Fabrication, characterization and investigation of antibacterial activity of propolis substituted sodium alginate tissue scaffolds using three-dimensional (3d) printing technology(2021-06-05) UZUN, MUHAMMET; SU TORUN, SENA; ULAĞ, SONGÜL; AKSU, MEHMET BURAK; GÜNDÜZ, OĞUZHAN; CESUR, SÜMEYYE; Aarancı K., Uzun M., Su Torun S., Cesur S., Ulağ S., Amin A., Güncü M. M., Aksu M. B., Kolaylı S., Silva J., et al.Publication Metadata only Ethosuximide-loaded alginate/polyethylene oxide 3d-printed scaffolds for epilepsy treatment(2023-01-17) ULAĞ, SONGÜL; Ulağ S.A chronic medical disease known as epilepsy typically causes spontaneous, unprovoked repeated seizures that have an impact on a variety of mental and physical activities. The majority of epilepsy patients can manage their seizures with medical treatment. More than one-third of patients who do not receive adequate benefit from oral antiepileptic drug therapy continue to have seizures. It is considered as a proper option to design local drug release to the focal area of the brain where the seizure occurs in order to reduce side effects of antiepileptic drugs and to increase therapeutic efficacy by providing higher and more effective doses to the seizure focus. This study concentrates on polymer-based implants, which are polymeric devices loaded with AED and designed for implantation at the seizure focus to provide gradual, prolonged release of AED directly into the area of the brain responsible for seizures. Ethosuximide, an antiepileptic drug used in the treatment of absence seizures, was chosen as the active ingredient in this study. With 3D printing, implantable scaffolds consisting of Alginate and polyethylene oxide polymers and containing the active substance ethosuximide were produced. The properties of drug-containing polymeric scaffolds were investigated by SEM analysis, and their chemical and thermal properties were analyzed using DSC and FTIR, respectively. The drug release of the scaffolds was tested in vitro. In this study, human neuroblastoma cell line, SH-SY5Y (CRL-2266™, ATCC) was used for toxicity analysis.Publication Open Access Fabrication of gentamicin sulfate-loaded 3d-printed polyvinyl alcohol/sodium alginate/gelatin-methacryloyl hybrid scaffolds for skin tissue replacement(2023-01-01) ULAĞ, SONGÜL; ŞAHİN, ALİ; AKSU, MEHMET BURAK; GÜNDÜZ, OĞUZHAN; Izgordu M. S., Ayran M., ULAĞ S., Yildirim R., Bulut B., ŞAHİN A., Guncu M. M., AKSU M. B., GÜNDÜZ O.3D-printed scaffolds can better mimic the function of human skin, both biologically and mechanically. Within the scope of this study, the effect of the addition of different amounts (10, 15, 20 mg) of gentamicin sulfate (GS) to a 10 mL solution of natural and synthetic polymers is investigated. Sodium alginate (SA), gelatin-methacryloyl (GelMA), and polyvinyl alcohol (PVA) are chosen as bioactive materials. The surface morphology and pore structures are visualized by scanning electron microscopy (SEM). According to the results, it is observed that the pore sizes of all scaffolds are smaller than 270 µm, the lowest value (130 µm) is obtained in the scaffold loaded with 15 mg GS, and it also has the highest tensile strength value (12.5 ± 7.6 MPa). Similarly, it is observed that the tensile strength (9.7 ± 4.5 MPa) is high in scaffold loaded with 20 mg GS. The biocompatibility test is performed with fibroblast cells, and the results show that the scaffolds are biocompatible with cells. The antibacterial test is carried out against the S.aureous and E. coli and the results indicate that all GS-loaded scaffolds demonstrate antibacterial activity.Publication Open Access Fabrication of Amphotericin-B-loaded Sodium Alginate Nanoparticles for Biomedical Applications(2022-12-01) ULAĞ, SONGÜL; ŞENGÖR, MUSTAFA; GÜNDÜZ, OĞUZHAN; ULAĞ S., Celik S. E., ŞENGÖR M., GÜNDÜZ O.In this study, amphotericin-B (AMB)-loaded sodium alginate (SA) nanoparticles were fabricated using the electrospraying technique for biomedical applications. AMB is an antifungal agent and is poorly absorbed from the gastrointestinal tract due to its low aqueous solubility. Therefore, it should be given parenterally to treat systemic fungal infections. This study aims to transport it with nanoparticle formulations and observe the nanoparticle release behaviours. Scanning electron microscopy (SEM) images showed that nanoparticles of 0.5% SA fabricated at 37 kV had the most suitable particle diameter (93.36±24.386 nm) for loading 0.5, 1, and 3 ml of AMB. Fourier transform infrared spectroscopy (FTIR) results demonstrated that AMB successfully loaded into 0.5% SA nanoparticles. Drug release behaviours of the AMB-loaded particles indicated that AMB was released with a burst at the beginning, and release behaviour became sustainable after half an hour. The encapsulation efciencies of the diferent amounts of drug were calculated, and the results showed that the highest encapsulation efciency belonged to the 0.5% SA/1 AMB nanoparticles (42±1.23%).Publication Metadata only Development of microparticles containing polylactic acid/bioactive glass/caffeic acid(2023-07-15) ULAĞ, SONGÜL; Ulağ S.Bone diseases or defects cause significant problems for people around the world, both in terms of the economy and their health. The deficiencies in traditional methods have led researchers to focus on bone tissue engineering (BTE) and explore new and improved methods. In this study, the production and characterization of microparticles (MPs) for BTE are emphasized. By using the polylactic acid (PLA), bioactive glass (BG), and caffeic acid (CA) electrospray (ES) method with optimum parameters, four different types of MPs (3% PLA, 3% PLA/0.1% BGs, 3% PLA/0.1% CA, and 3% PLA/0.1% BGs/0.1% CA) were produced. Scanning electron microscopy (SEM) analysis revealed an increase in the mean diameter with the addition of substances. Fourier transform infrared spectroscopy (FTIR) analysis confirmed the presence of the main material, PLA. Differential scanning calorimetry (DSC) analysis demonstrated that the added substances affected the thermal properties of PLA. X-ray diffraction (XRD) analysis showed that the substances had minimal impact on the PLA pattern. In addition, in the in vitro drug release test, the release characteristics of CA from MPs were examined, and as a result, different compositions at different rates (180 min and 720 min) were determined. Moreover, the 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay results showed that the MPs did not show toxicity against human fetal osteoblastic (hFOB) 1.19 cell lines. In conclusion, this study provides comprehensive information about the production and characterization of MPs and will be a promising study for use in BTE studies thanks to the results obtained.Publication Open Access Microfluidic systems for neural tissue engineering(Elsevier Science, Oxford/Amsterdam , 2023-01-01) CESUR, SÜMEYYE; ULAĞ, SONGÜL; GÜNDÜZ, OĞUZHAN; Cesur S., Ulağ S., Gündüz O.Damage to the nervous system due to illness or injury can cause serious and lasting loss of function or even fatal consequences. It is necessary to develop new treatment strategies to restore the function of the damaged nervous system.The optimal environment for nerve cell proliferation and differentiation is provided by neural tissue engineering. It aims to improve a new approximation for the therapy of nervous system diseases. Compared to 2D cell culture techniques, 3D cell culture systems ensure a more biomimetic environment and encourage more differentiation of cells. However, certain cell culture parameters have limitations in spatio-temporal control. With the advent of microfluidic systems, it can control the spatio-temporal dispersion of physical and chemical signals at the cellular level. In this section, microfluidic systems are explored as a tool to target both physical and chemical injury and recreate the post-injury environment, to study nerve injury at the cellular grade.Publication Open Access Gentamicin and fluconazole loaded electrospun polymethylmethacrylate (PMMA) fibers as a novel platform for the treatment of corneal keratitis(2022-05-01) GÜNDÜZ, OĞUZHAN; ULAĞ, SONGÜL; GÜNDÜZ O., ULAĞ S.In this study, 10 mg fluconazole (10 FCZ) and 10 mg gentamicin (10 GEN) loaded with 40% polymethylmethacrylate (40% PMMA) fibers were fabricated by electrospinning and the performance of the formulations (40% PMMA, 40% PMMA/10 FCZ, 40% PMMA/10 GEN, and 40% PMMA/10 FCZ/10 GEN) was tested. 10 mg Gentamicin-loaded 40% PMMA fiber mat showed a more significant zone of inhibition against the S. aureus compared to the zone of 40% PMMA/10 GEN/10 FCZ fiber. The biocompatibility test using a human adipose-derived mesenchymal stem cell (MSCs) as a cell model proved that the amount of loaded and released GEN has no toxic effects on the MSCs.