Publication: Fabrication of Amphotericin-B-loaded Sodium Alginate Nanoparticles for Biomedical Applications
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Date
2022-12-01
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Abstract
In this study, amphotericin-B (AMB)-loaded sodium alginate (SA) nanoparticles were fabricated using the electrospraying technique for biomedical applications. AMB is an antifungal agent and is poorly absorbed from the gastrointestinal
tract due to its low aqueous solubility. Therefore, it should be given parenterally to treat systemic fungal infections. This
study aims to transport it with nanoparticle formulations and observe the nanoparticle release behaviours. Scanning electron microscopy (SEM) images showed that nanoparticles of 0.5% SA fabricated at 37 kV had the most suitable particle
diameter (93.36±24.386 nm) for loading 0.5, 1, and 3 ml of AMB. Fourier transform infrared spectroscopy (FTIR) results
demonstrated that AMB successfully loaded into 0.5% SA nanoparticles. Drug release behaviours of the AMB-loaded
particles indicated that AMB was released with a burst at the beginning, and release behaviour became sustainable after
half an hour. The encapsulation efciencies of the diferent amounts of drug were calculated, and the results showed that
the highest encapsulation efciency belonged to the 0.5% SA/1 AMB nanoparticles (42±1.23%).
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Mühendislik ve Teknoloji, Engineering and Technology, MALZEME BİLİMİ, BİYOMATERYAL, Malzeme Bilimi, Mühendislik, Bilişim ve Teknoloji (ENG), MATERIALS SCIENCE, BIOMATERIALS, MATERIALS SCIENCE, Engineering, Computing & Technology (ENG), Biyomalzemeler, Malzeme Bilimi (çeşitli), Genel Malzeme Bilimi, Fizik Bilimleri, Biomaterials, Materials Science (miscellaneous), General Materials Science, Physical Sciences, Amphotericin-B, Biomedical, Drug release, Electrospraying, Nanoparticle, Sodium alginate
Citation
ULAĞ S., Celik S. E., ŞENGÖR M., GÜNDÜZ O., "Fabrication of Amphotericin-B-loaded Sodium Alginate Nanoparticles for Biomedical Applications", BIONANOSCIENCE, cilt.12, sa.4, ss.1230-1237, 2022