Person: RAYAMAN, PERVİN
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RAYAMAN
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PERVİN
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Publication Open Access Potential Adjuvant Effects of Nigella sativa Seeds to Improve Specific Immunotherapy in Allergic Rhinitis Patients(KARGER, 2010) GÜRBÜZ, BURÇAK; Isik, Huelya; Cevikbas, Adile; Gurer, Umran Soyogul; Kiran, Bayram; Uresin, Yagiz; Rayaman, Pervin; Rayaman, Erkan; Gurbuz, Burcak; Buyukozturk, SunaObjective: To investigate the effects of Nigella sativa seed supplementation on symptom levels, polymorphonuclear leukocyte (PMN) functions, lymphocyte subsets and hematological parameters of allergic rhinitis. Subjects and Methods: Twenty-four patients randomly selected from an experimental group of 31 (mean age 34 years) sensitive to house dust mites with allergic rhinitis and a control group of 8 healthy volunteers (mean age 23 years) were treated with allergen-specific immunotherapy in conventional doses for 30 days. After a month of immunotherapy, 12 of the 24 patients and the 8 healthy volunteers were given N. sativa seed supplementation (2 g/day orally) for 30 days. The remaining 12 patients continued only on immunotherapy during the same period. The other 7 patients were given 0.1 ml saline solution subcutaneously once a week as a placebo. The symptom scores, PMN functions, lymphocyte subsets and other hematological parameters were evaluated before and after all treatment periods. Results: There was a statistically significant increase in the phagocytic and intracellular killing tivities of PMNs of patients receiving specific immunotherapy, especially after the addition of N. sativa seed. The CD8 counts of patients receiving specific immunotherapy plus N. sativa seed supplementation significantly increased compared to patients receiving only specific immunotherapy. PMN functions of healthy volunteers significantly increased after N. sativa seed supplementation compared to baseline. Conclusion: N. sativa seed supplementation during specific immunotherapy of allergic rhinitis may be considered a potential adjuvant therapy. Copyright (C) 2010 S. Karger AG, BaselPublication Metadata only Synergic potential of Pelargonium endlicherianum Fenzl. Essential oil and antibiotic combinations against Klebsiella pneumoniae(ELSEVIER, 2020) GÜRBÜZ, BURÇAK; Dumlupinar, Berrak; Karatoprak, Gokce Seker; Celik, Damla Damar; Gurer, Umran Soyogul; Demirci, Betul; Gurbuz, Burcak; Rayaman, Pervin; Kurtulus, Eda MerveIn this study we investigated antimicrobial activity against Klebsiella pneumoniae and the phagocytic functions of human leukocyte cells as revealed in an in vitro experimental model combining cefepime and gentamicin with Pelargonium endlicherianum Fenzl. essential oil treatments. The bactericidal effects of this essential oil and antibiotic combinations were dynamically detected by time-kill assay. To examine the function of this essential oil and antibiotics in permeating outer membrane barriers when used singly or in combination, a UV spectrophotometer was used, and morphologic images were captured by scanning electron microscopy. The antibacterial activity of the essential oil and antibiotics was assessed using broth microdilution and agar well diffusion. The combined effects of the essential oils of P. endlicherianum and gentamicin and cefepime were evaluated by means of the checkerboard method against K. pneumoniae. In the assays, fractional inhibitory concentration (FIC) values were calculated to characterize the interactions between the combinations. In the combinations of essential oil and antibiotics, the sensitivity of the bacteria to antibiotics increased and the antibiotics had a synergistic effect, and the antibacterial effect on the microorganisms increased. The cefepime + essential oil pair tested showed a synergistic effect (FIC <= 0.5), but the gentamicin + essential oil pair did not (FIC > 0.5-4.0). Thus, the cefepime + essential oil pair has been found to exhibit a synergistic effect against K. pneumoniae compared to the gentamicin + essential oil pair. According to the results obtained here, the combined use of essential oils with antibiotics can be applied as a treatment strategy to reduce the use of antibiotics, reduce side effects, and possibly reverse antibiotic resistance to these microorganisms in light of the increase in multiple antibiotic resistance. (c) 2020 SAAB. Published by Elsevier B.V. All rights reserved.Publication Metadata only Synthesis of new hydrazide-hydrazone derived from etophenamate and investigation of their antimicrobial activity(2023-10-22) GÜRBÜZ, BURÇAK; RAYAMAN, PERVİN; KARAKUŞ, SEVGİ; Saral Çakmak S., GÜRBÜZ B., RAYAMAN P., KARAKUŞ S.Recently since the emerging resistant strains to antimicrobial agents, the development of original antimicrobial agents in pharmaceutical chemistry has gained great importance. Antibiotic resistance is accepted as one of the greatest threatens against health worldwide. Since 1950s to now it is known that hydrazide-hydrazones have antimicrobial, anticancer, antitubercular, anticonvulsant etc., biological spectrum and biological activity (Polovic et al., 2019). Hydrazone derivatives are used in treatment and involved in the structure of many drugs such as nifuroxazide, nitrofurazone, bisanthren, budralazine, and levosimendan. Etophenamate was chosen as the starting compound to synthesis of 16 novel hydrazide-hydrazones. All of these derivatives were investigated in order to determine their antimicrobial activities. The structures of the synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, mass spectroscopy and elemental analysis. In this study, the antimicrobial activity of 16 hydrazide-hydrazone derivatives to 4 standard bacterial strains (Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Enterococcus faecalis ATCC 29212) and 4 standard yeast strains (Candida albicans ATCC 90028, Candida glabrata ATCC 90030, Candida parapsilosis ATCC 90018, Candida tropicalis KUEN 1021) was examined by the microdilution method in accordance with the Clinical and Laboratory Standards Institute (CLSI) standards, and the Minimal Inhibitory Concentration (MIC) values of these derivatives were determined. It was found that among these derivatives, 2c (725-0.35µg/ml) and 2p (1000-0.5µg/ml) possed antimicrobial activity against all of the 8 standard microorganism strains.