Publication: Synthesis of new hydrazide-hydrazone derived from etophenamate and investigation of their antimicrobial activity
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Date
2023-10-22
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Abstract
Recently since the emerging resistant strains to antimicrobial agents, the development of original antimicrobial
agents in pharmaceutical chemistry has gained great importance. Antibiotic resistance is accepted as one of
the greatest threatens against health worldwide. Since 1950s to now it is known that hydrazide-hydrazones
have antimicrobial, anticancer, antitubercular, anticonvulsant etc., biological spectrum and biological activity
(Polovic et al., 2019). Hydrazone derivatives are used in treatment and involved in the structure of many drugs
such as nifuroxazide, nitrofurazone, bisanthren, budralazine, and levosimendan. Etophenamate was chosen as
the starting compound to synthesis of 16 novel hydrazide-hydrazones. All of these derivatives were
investigated in order to determine their antimicrobial activities. The structures of the synthesized compounds
were characterized by IR, 1H-NMR, 13C-NMR, mass spectroscopy and elemental analysis. In this study, the
antimicrobial activity of 16 hydrazide-hydrazone derivatives to 4 standard bacterial strains (Staphylococcus
aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Enterococcus
faecalis ATCC 29212) and 4 standard yeast strains (Candida albicans ATCC 90028, Candida glabrata ATCC
90030, Candida parapsilosis ATCC 90018, Candida tropicalis KUEN 1021) was examined by the
microdilution method in accordance with the Clinical and Laboratory Standards Institute (CLSI) standards,
and the Minimal Inhibitory Concentration (MIC) values of these derivatives were determined. It was found
that among these derivatives, 2c (725-0.35µg/ml) and 2p (1000-0.5µg/ml) possed antimicrobial activity
against all of the 8 standard microorganism strains.
Description
Keywords
Hydrazid-Hydrazone, Synthesis, Characterization, Antimicrobial activity
Citation
Saral Çakmak S., GÜRBÜZ B., RAYAMAN P., KARAKUŞ S., \"Synthesis of New Hydrazide-Hydrazone Derived from Etophenamate and Investigation of Their Antimicrobial Activity\", 6th International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2023), Ankara, Türkiye, 11 Ekim 2023