Person: TARCAN, TUFAN
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TARCAN
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TUFAN
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Publication Open Access Evaluation of new treatments for benign prostatic obstruction: ICI-RS 2023(2023-12-11) TARCAN, TUFAN; Hashim H., Tarcan T., Acar O., Malde S., Wein A., Abrams P.Aims: To address how invasive therapies for benign prostatic obstruction (BPO) have been evaluated, what their effect is on BPO, if they can prevent progression to BPO and how new therapies need to be evaluated before implementation into clinical practice. Methods: The think tank conducted a literature review and looked at the previous and current American Urological Association, European Association of Urology and the International Consultation on Urological Diseases guidelines to see what procedures have been used to treat BPO. They then assessed whether trials have been conducted before implementation of the procedures and whether they have been compared to a “gold” standard treatment. The use of urodynamics has also been addressed in the think tank in relation the clinical trials as well as terminology. Results: Guidelines vary in the use of terminology when it comes to BPO with some continuing to use the term benign prostatic hyperplasia (BPH). There are several procedures for example, TUNA, which have become obsolete although continues to be mentioned in the guidelines until recently. Majority of procedures have been introduced without comparing to “gold” standard treatment and without any long‐term data. There continues to be many unknowns with regard to the success of some of the BPO procedures and why some of the adverse events develop. Conclusion: There needs to be more robust long‐term clinical trials conducted of new BPO therapies, with men who have both lower urinary tract symptoms and urinary retention, before introduction into clinical practice.Publication Metadata only The effect of using a standard Illustrated consent form on anxiety levels in the urodynamic investigation: A prospective clinical study(2022-09-07) ŞAHİN, BAHADIR; ŞEKERCİ, ÇAĞRI AKIN; ONUR, AHMET RAHMİ; ÇAM, HAYDAR KAMİL; TARCAN, TUFAN; Özkan O., Güçtaş A. Ö. , Şahin B., Şekerci Ç. A. , Onur A. R. , Çam H. K. , Tarcan T.Publication Open Access Consistency of uroflowmetry analysis in children among observers(2023-01-01) ŞEKERCİ, ÇAĞRI AKIN; TANIDIR, YILÖREN; TARCAN, TUFAN; YÜCEL, SELÇUK; ŞEKERCİ Ç. A., TANIDIR Y., TARCAN T., YÜCEL S.© 2023 Wiley Periodicals LLC.Aim: The aim of the study is to compare the intra- and inter-observer interpretations of the same uroflowmetry study at two different times. Materials and Methods: Two-hundred children with a voided volume of 50% above the expected bladder capacity were included. All traces were asked to be evaluated by 11 observers two times in a time span of 1 month. These observers consist of pediatric urologists (n = 2), pediatric urology fellows (n = 2), urology residents (n = 5), and certified urodynamics nurses (n = 2). Each uroflowmetry was asked to be assessed for three domains: voided volume (VV), detrusor sphincter dyssynergia (DSD), and flow curve pattern (FCP). Results: Of the 200 patients with a median age of 10 (4–18) years, 128 (64%) were girls and 72 (36%) boys. The maximum flow rate and the median voided volume were found to be 20 (4–61) mL/s and 232 (116–781) mL. The Fleiss\" kappa coefficient of VV, DSD, and FCP in the first assessment was 0.510, 0.501, and 0.346. In the second assessment, κ values were 0.530, 0.422, and 0.373. The best-agreed findings were similar at both times. These were found to be low VV (0.602 and 0.626) and intermittent pattern (0.500 and 0.553). Interpreters were found to have a statistically significant difference in agreement with their own interpretation at different times. Conclusion: Both inter- and intra-observer reliability of the agreement point out the problem in the standardization of uroflowmetry. Inter- and intra-observer reliability of uroflowmetry interpretation can be increased by defining precise numbers and numerical algorithms.Publication Metadata only The comparison of anxiety levels in children who underwent invasive or non-invasive urodynamic studies(2022-05-13) ŞEKERCİ, ÇAĞRI AKIN; TARCAN, TUFAN; YÜCEL, SELÇUK; TANIDIR, YILÖREN; Sekerci C. A., Can Ozkan O., Tanidir Y., Tarcan T., Yucel S.INTRODUCTION AND OBJECTIVE: Urodynamic studies play an important role in the evaluation of children with lower urinary tract dysfunction. In this study, we aimed to examine the effects of invasive and non-invasive urodynamic studies on the anxiety levels of children with the help of an anxiety scale. METHODS: Children aged 8-17 years who were scheduled for uroflowmetry (UF) or filling cystometry (FC) and who agreed to fill out an anxiety scale were included in the study. It was the first UF or FC of all children. “The Screen for Child Anxiety Related Disorders (SCARED)” form consisting of 41 questions was used in the evaluation. All children included in the study filled the form themselves. The SCARED results of children who underwent UF and FC were compared. RESULTS: A total of 56 children with a mean age of 10.85þ/- 2.98 years were included in the study. 31 (55.4%) of the children were females and 25 (44.6%) were males. The number of children who had UF was 26 (46.4%; 8.5 (8-14) years), and 30 (53.6%; 11.5 (8-17) years) had FC. The total SCARED scores of the children who underwent UF and FC were 26.5 (5-75) and 27 (2-57), respectively, and there was no statistical difference (p[0.980) (Table 1). A significant difference was found only in "Separation Anxiety Disorder" among sub-score evaluations (p[0.049) (Table 1). In children who underwent filling cystometry, there was no statistical difference in the total SCARED score between those who did and did not do clean intermittent catheterization (28 (3-41); 27 (2-57), respectively) (p[0.860). CONCLUSIONS: The SCARED scores above 25 indicate an anxiety disorder, and interestingly, in this study, both the invasive and noninvasive urodynamic study groups scored over 25. We consider that non-invasive urodynamic tests may cause stress on children as much as invasive ones.Publication Metadata only Predictive factors of full response to desmopressin treatment in children with primary monosymptomatic enuresis nocturna(2023-02-01) ÖZGÜR, GÜNAL; TANIDIR, YILÖREN; TARCAN, TUFAN; YÜCEL, SELÇUK; Ozgur G., Sekerci C. A., TANIDIR Y., Tarcan T., YÜCEL S.Publication Open Access The association of urinary BDNF, ATP, and MMP-2 with bladder compliance in children with myelodysplasia(2023-01-01) ŞEKERCİ, ÇAĞRI AKIN; KÜTÜKOĞLU, MEHMET UMUT; YÜCEL, SELÇUK; TARCAN, TUFAN; ŞEKERCİ Ç. A., KÜTÜKOĞLU M. U., Basok B. I., Fidan M., ÇAM S., YÜCEL S., TARCAN T.Aim: The purpose of our study was to evaluate the relationship of urinary brain-derived neurotrophic factor (BDNF), adenosine triphosphate (ATP), matrix metallopreteinase-2 (MMP-2) with urodynamic findings and upper urinary tract deterioration (UUTD) in children with myelodysplasia. Materials and Methods: Children with myelodysplasia evaluated in outpatient clinic between 2022 and 2023 were included. All patients underwent urinary ultrasonography, voiding cystourethrography, urodynamics, and DMSA scintigraphy. Urine samples were collected before urodynamics. Control urine was collected from 10 healthy children. Urinary biomarker values of patients and controls were compared, and subgroup analysis was performed. Results: The median age of 40 children (26 girls) included in the study was 108 (8–216) months, and the control group (six girls) was 120 (60–154) (p = 0.981). Urinary BDNF, MMP-2, and ATP were found to be significantly higher in children with myelodysplasia compared to the control (p = 0.007, p = 0.027, p = 0.014, respectively). The three biomarker values were similar in children with bladder compliance below or above 10 cmH2O/mL (p = 0.750, p = 0.844, p = 0.575). No difference was found in terms of UUTD in all three biomarkers (p = 0.387, p = 0.892, p = 0.705). A negative correlation was found between urinary ATP and compliance (p < 0.05). Conclusion: In this study, all three biomarkers were found to be higher in children with myelodysplasia than in controls. There was a negative correlation between urinary ATP and compliance. Urinary biomarkers may contribute the follow-up of children with neurogenic lower urinary tract deterioration in future with their noninvasive features. However, the lack of standardization and the inability to reliably predict risky groups are important shortcomings of urinary biomarkers.Publication Open Access Primer monosemptomatik enürezis nokturnası olan çocuklarda desmopressin tedavisine tam yanıtın prediktif faktörleri(2023-10-04) ŞEKERCİ, ÇAĞRI AKIN; TARCAN, TUFAN; YÜCEL, SELÇUK; Özgür G., Şekerci Ç. A., Tanıdır Y., Tarcan T., Yücel S.AMAÇ: Primer monosemptomatik enürezis nokturna (PMEN), pediatrik ürolojide sık görülen bir problemdir ve medikal tedavide ilk tercih desmopressindir. Bu çalışmada, desmopressine tam yanıt alınan PMEN'li çocuklarda prediktif faktörleri ve desmopressinin idrar elektrolit düzeyleri (sodyum, potasyum ve kalsiyum) üzerindeki etkisini değerlendirmeyi amaçladık. MATERYAL-METOD: Çalışmaya çocuk ürolojisi polikliniğine başvurup PMEN tanısı alan ve desmopressin tedavisi başlanan çocuklar dahil edildi. Gündüz semptomları olan veya sekonder enürezisi bulunan çocuklar çalışmaya alınmadı. Hastalar fizik muayene, idrar tahlili, semptom skoru ve işeme günlüğü ile değerlendirildi. Tüm hastalara 120 mcg desmopressin başlandı. Hastalardan tedavi öncesinde, tedavi sonrası ise 1. ve 3. aylarda elektrolit değerlendirmesi için 24 saatlik idrar toplandı. Üçüncü aydaki semptomlarına göre tedaviye tam yanıt veren grup ve diğer (tedaviye dirençli veya kısmi yanıtlı) grup olarak hastalar ikiye ayrıldı. Hastaların tedavi öncesi ve tedavi sonrası elektrolit değerleri karşılaştırıldı ve tam yanıtlı grupta yanıtı öngörebilecek olası prediktif faktörler değerlendirildi. BULGULAR: Çalışmaya 34 çocuk (23 erkek, 11 kız) dahil edildi. Ortanca yaş 8 (5-15) idi. Tedavi öncesi ve sonrasındaki (1. ve 3. ay) idrar dansitesi, 24 saatlik idrar sodyum, potasyum ve kalsiyum değerleri arasında fark yoktu (p=0,432, 0,822, 0,970, 0,970, sırasıyla). Cinsiyet, bir aydaki ıslak gece sayısı ve bir gecede olan idrar kaçırma sayısı desmopressine tam yanıtı öngören faktörler olarak bulundu (p=0,015, 0,022, p=0,001, sırasıyla) (Tablo 1). Yaşın, aile öyküsünün, işeme günlüğündeki mesane kapasitesi/beklenen mesane kapasitesinin ve tedavi öncesi idrar sodyum seviyesinin tam yanıtı öngörme üzerinde etkisinin olmadığı gösterildi (p=0,230, p=0,547, p=0,763, p=0.060, sırasıyla) (Tablo 1). SONUÇ: PMEN'li çocuklarda erkek cinsiyet olması, bir ayda çok sayıda ıslak gece olması ve bir gecede çoklu idrar kaçırma olması desmopressin tedavisine tam yanıt alınmasında olumsuz faktörler olarak bulundu.Publication Metadata only Alt üriner sistem disfonksiyonu olan çocuklarda üç günlük işeme günlüğündeki işeme hacimleri ve sıklıkları farklı mıdır(2023-10-25) ŞEKERCİ, ÇAĞRI AKIN; YÜCEL, SELÇUK; TARCAN, TUFAN; Ergün R., Şekerci Ç. A., Çetin M., Sahak M. Y., Yücel S., Tarcan T.Publication Metadata only Editorial comments(2023-04-01) TARCAN, TUFAN; TARCAN T.Publication Metadata only Predictive factors of full response to desmopressin treatment in children with primary monosymptomatic enuresis nocturna(2023-03-10) ŞEKERCİ, ÇAĞRI AKIN; TARCAN, TUFAN; YÜCEL, SELÇUK; Özgür G., Şekerci Ç. A., Tanıdır Y., Tarcan T., Yücel S.