Person: GÜNDÜZ, OĞUZHAN
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Publication Metadata only Biomaterials and tissue engineering(Springer, London/Berlin , 2023-08-01) GÜNDÜZ, OĞUZHAN; Gündüz O. (Editör)Publication Open Access Fabrication of gentamicin sulfate-loaded 3d-printed polyvinyl alcohol/sodium alginate/gelatin-methacryloyl hybrid scaffolds for skin tissue replacement(2023-01-01) ULAĞ, SONGÜL; ŞAHİN, ALİ; AKSU, MEHMET BURAK; GÜNDÜZ, OĞUZHAN; Izgordu M. S., Ayran M., ULAĞ S., Yildirim R., Bulut B., ŞAHİN A., Guncu M. M., AKSU M. B., GÜNDÜZ O.3D-printed scaffolds can better mimic the function of human skin, both biologically and mechanically. Within the scope of this study, the effect of the addition of different amounts (10, 15, 20 mg) of gentamicin sulfate (GS) to a 10 mL solution of natural and synthetic polymers is investigated. Sodium alginate (SA), gelatin-methacryloyl (GelMA), and polyvinyl alcohol (PVA) are chosen as bioactive materials. The surface morphology and pore structures are visualized by scanning electron microscopy (SEM). According to the results, it is observed that the pore sizes of all scaffolds are smaller than 270 µm, the lowest value (130 µm) is obtained in the scaffold loaded with 15 mg GS, and it also has the highest tensile strength value (12.5 ± 7.6 MPa). Similarly, it is observed that the tensile strength (9.7 ± 4.5 MPa) is high in scaffold loaded with 20 mg GS. The biocompatibility test is performed with fibroblast cells, and the results show that the scaffolds are biocompatible with cells. The antibacterial test is carried out against the S.aureous and E. coli and the results indicate that all GS-loaded scaffolds demonstrate antibacterial activity.Publication Metadata only Production and Characterization of a Dual Drug Delivery System of Memantine and Naringenin by Electrospinning Method(2023-06-30) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Birinci A., Ayaz Seyhan S., Bilğiç Alkaya D., Cesur S., Gündüz O.Publication Metadata only Production and characterization of calcium phosphates from marine structures: The fundamentals basics(Springer, 2019-01-01) ÜNAL YILDIRIM, SEMRA; GÜNDÜZ, OĞUZHAN; OKTAR, FAİK NÜZHET; ÜNAL S., GÜNDÜZ O., AKYOL S., Ben Nissan B., OKTAR F. N.Publication Open Access Light-Processed 3D Bioprinting of Symblepharon Rings Fortified with l-Ascorbic Acid for Ocular Tissue Engineering(2024-01-01) ULAĞ, SONGÜL; GÜNDÜZ, OĞUZHAN; Ayran M., Goyuk Y., Tiryaki A., ULAĞ S., Koyuncu A. C. C., Turhan S. A., GÜNDÜZ O.This study aims to develop gelatin methacryloyl (GelMA)-based symblepharonrings fortified with l-ascorbic acid (lAA), aiming for controlled release ofvitamins for the treatment of the ocular surface, corneal healing, andacceleration of epithelial growth, while concurrently preventing potentialinflammation. The human tears contain abundant IAA, which serves aprotective role for ocular tissues. The utilization of 3D printing digital lightprocessing technology not only navigating the manufacturing process ofsymblepharon rings, addressing challenges related to commercial productionand expedited delivery to patients but also imparts enhanced flexibilitycompared to commercial products. This innovative approach also facilitatesthe production of rings that exhibit superior softness and are amenable tomechanical movements for ocular tissue engineering. The morphological,chemical, rheological, biological, thermal, and drug-release characteristics of3D-printed lAA-loaded symblepharon rings are investigated. In themorphological characterization, it is observed that the rings exhibit a porousstructure. In biocompatibility tests, Gelas and Gelas-low rings achieve over75% viability. Following the cell test, scanning electron microscope imagesreveal fibroblasts adhering to Gelas and Gelas-low rings, spreading acrosstheir surfaces. Drug release studies conducted in phosphate-buffered saline atpH 7.4 reveal the complete release of lAA from Gelas-low within a 5-dincubation period.Publication Open Access Fabrication of ethosuximide loaded alginate/polyethylene oxide scaffolds for epilepsy research using 3D-printing method(2023-01-01) ULAĞ, SONGÜL; GÜLHAN, REZZAN; US, ZEYNEP; GÜNDÜZ, OĞUZHAN; Karabulut H., Dutta A., Moukbil Y., Cisen Akyol A., ULAĞ S., Aydin B., GÜLHAN R., US Z., Kalaskar D. M., GÜNDÜZ O.Epilepsy is a medical condition that causes seizures and impairs the mental and physical activities of patients. Unfortunately, over one-third of patients do not receive adequate relief from oral Antiepileptic Drugs (AEDs) and continue to experience seizures. In addition to that, long term usage of Antiepileptic Drugs can cause a range of side effects. To overcome this problem, the precision of 3D printing technology is combined with the controlled release capabilities of biodegradable polymers, allowing for tailored and localized AED delivery to specific seizure sites. As a result of this novel technique, therapeutic outcomes can be enhanced, side effects of AEDs are minimized, and patient-specific dosage forms can be created. This study focused on the use of ethosuximide, an antiepileptic drug, at different concentrations (10, 13, and 15 mg) loaded into 3D-printed sodium alginate and polyethylene oxide scaffolds. The scaffolds contained varying concentrations (0.25%, 0.50%, and 0.75% w/v) and had varying pores created by 3D patterning sizes from 159.86 ± 19.9 µm to 240.29 ± 10.7 µm to optimize the releasing system for an intracranial administration. The addition of PEO changed the Tg and Tm temperatures from 65°C to 69°C and from 262°C to 267°C, respectively. Cytotoxicity assays using the human neuroblastoma cell line (SH-SY5Y) showed that cell metabolic activity reached 130% after 168 h, allowing the cells to develop into mature neural cells. In vitro testing demonstrated sustained ethosuximide release lasting 2 hours despite crosslinking with 3% CaCl2. The workpaves the way for the use of ethosuximide -loaded scaffolds for treating epilepsy.Publication Metadata only Additive manufacturing of microneedles for sensing and drug delivery(2024-01-01) GÜNDÜZ, OĞUZHAN; Bedir T., Kadian S., Shukla S., GÜNDÜZ O., Narayan R.Introduction: Microneedles (MNs) are miniaturized, painless, and minimally invasive platforms that have attracted significant attention over recent decades across multiple fields, such as drug delivery, disease monitoring, disease diagnosis, and cosmetics. Several manufacturing methods have been employed to create MNs; however, these approaches come with drawbacks related to complicated, costly, and time-consuming fabrication processes. In this context, employing additive manufacturing (AM) technology for MN fabrication allows for the quick production of intricate MN prototypes with exceptional precision, providing the flexibility to customize MNs according to the desired shape and dimensions. Furthermore, AM demonstrates significant promise in the fabrication of sophisticated transdermal drug delivery systems and medical devices through the integration of MNs with various technologies. Areas covered: This review offers an extensive overview of various AM technologies with great potential for the fabrication of MNs. Different types of MNs and the materials utilized in their fabrication are also discussed. Recent applications of 3D-printed MNs in the fields of transdermal drug delivery and biosensing are highlighted. Expert opinion: This review also mentions the critical obstacles, including drug loading, biocompatibility, and regulatory requirements, which must be resolved to enable the mass-scale adoption of AM methods for MN production, and future trends.