Person: ERYÜKSEL, SEMİHA EMEL
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ERYÜKSEL
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SEMİHA EMEL
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Publication Metadata only Usage of NEWS for prediction of mortality and in-hospital cardiac arrest rates in a Turkish university hospital(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2018) ARIKAN, HÜSEYİN; Atmaca, Ozgur; Turan, Can; Guven, Pinar; Arikan, Huseyin; Eryuksel, S. Emel; Karakurt, SaitBackground/aim: Early warning scores (EWS), widely used around the world but not yet in Turkey, are composed of physiological parameters designed to determine potentially worsening patients to perform necessary interventions in time. The aim is to determine the national EWS (NEWS) of the patients to assess the relation between this score and length of hospital stay (LOHS), transfer to the ICU, 24-h and 28-day mortality rates, and the frequency of in-hospital cardiac arrest (IHCA). Materials and methods: NEWS of all the patients in the internal medicine clinics were calculated via a point prevalence study. The LOHS, transfer to the ICU, rates of mortality in the 24-h and 28-day period, IHCA rate, and the period of the stay in the ICU parameters were determined. Results: Out of 104 patients, 84 of them had low scores (<5), while 20 had mid/high scores. In mid/high-score group (score>5), transfer to the ICU, IHCA rate, and mortality rates within 24 h and 28 days were significantly higher. Conclusion: In this, the first prospective study about EWS in Turkey, 24-h and 28-day mortality rates, transfer to the ICU, and IHCA frequency of the patients with mid/high NEWS were higher.Publication Open Access Outcome of solid and cavitary pulmonary nodules in rheumatoid arthritis patients— case series(2022-01-01) AKSOY, AYSUN; BOZKURTLAR, EMİNE; KARAKURT, SAİT; ERYÜKSEL, SEMİHA EMEL; İNANÇ, GÜZİDE NEVSUN; KOCAKAYA, DERYA; AKSOY A., KOCAKAYA D., Yalçinkaya Y., BOZKURTLAR E., KARAKURT S., Eryüksel E., İnanç N.© TÜBİTAK.Background/aim: Rheumatoid pulmonary nodule can be detected in up to 32% of rheumatoid arthritis (RA) patients and approximately one-third of nodules may cavitate. We aimed to evaluate characteristics of patients with RA developing cavitary pulmonary nodular (CPN) lesions under disease-modifying antirheumatic drugs (DMARDs), follow-up of both cavitary and solid nodules, and their outcome with the treatment. Materials and methods: RA patients who presented with CPN lesions during follow-up were recruited retrospectively in this case series analysis. Total numbers and mean diameters of cavitary and solid nodules in each thorax computed tomography (CT) have been determined and followed up by two experienced pulmonary physicians. Moreover, changes in treatment after the development of the CPN lesions and characteristics of cavitary nodules were collected. Results: Eleven patients with CPN lesions were reported. At the time of CPN diagnosis, more patients were taking leflunomide than methotrexate (81% vs 19%). Half of the patients were receiving biologic therapy and only 18% were taking anti-TNF drugs. After a median of 24 (3–65) months of follow-up, the regression of CPN lesions was determined in 45% (5/11) of patients. Four of these 5 (80%) patients were switched to a treatment regimen without leflunomide and three of them to nonanti-TNF biologic treatment or targeted synthetic DMARDs (tocilizumab, tofacitinib, and rituximab). Conclusion: CPN lesions seen in RA patients are often pulmonary manifestations of the underlying disease; however, one must rule out malignancies or infections. If lesions progress under DMARDs, it is advised to discontinue synthetic DMARDs (LEF/MTX) and switch to another biological DMARD with different modes of action.Publication Metadata only İlerı ve son evre akciğer hastalığına ikincil solunum yetmezliği olan hastaların bakım verenlerinde bakım verici yükü ve depresyon ilişkisi(2018-04-18) OLGUN YILDIZELİ, ŞEHNAZ; KASAPOĞLU, UMUT SABRİ; KOCAKAYA, DERYA; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; KARAKURT, SAİT; ARIKAN, HÜSEYİN; OLGUN YILDIZELİ Ş., ARIKAN H., KASAPOĞLU U. S., KOCAKAYA D., ERYÜKSEL S. E., CEYHAN B., KARAKURT S.Publication Open Access The role of procalcitonin as a biomarker for acute pulmonary exacerbation in subjects with cystic fibrosis and non-cystic fibrosis bronchiectasis(2022-01-01) KOCAKAYA, DERYA; ARIKAN, HÜSEYİN; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; Mammadov F., Olgun Yildizel S., Kocakaya D., ARIKAN H., Cinar C., Eryuksel E., CEYHAN B.Objective: Patients with cystic fibrosis (CF) and non-CF bronchiectasis are prone to exacerbations of pulmonary infections. C-reactive protein (CRP) and procalcitonin (PCT) are inflammatory markers. The aim of this study is to evaluate the role of CRP and PCT on exacerbations of CF and non-CF bronchiectasis. Patients and Methods: The medical records of 18 CF (52 hospitalizations) and 20 non-CF bronchiectasis patients (51 hospitalizations) were reviewed retrospectively. CRP, PCT levels and, white blood cell (WBC) counts on admission and follow-up were evaluated. Results: C-reactive protein levels correlated with PCT levels on admission in all patients. Baseline PCT levels were markedly higher (>0.5µg/L) in 12% of CF and 10% of non-CF bronchiectasis patients, however, baseline CRP values were markedly higher (>5mg/L) in 96% of CF and non-CF bronchiectasis patients (p=0.760 and p=0.100, respectively). Baseline CRP and PCT levels were positively correlated with hospitalization length (r=0.501, p=0.001 and r=0.289, p=0.04, respectively) in CF patients, but not in non-CF bronchiectasis. Conclusion: Our study shows the potential utility of these biomarkers to determine the severity of the exacerbation particularly predicting hospitalization length in CF patients. Both biomarkers could be able to guide antibiotic treatment of infective exacerbations in CF and non-CF bronchiectasis patients.Publication Open Access Tuberculosis menengitis during pregnancy: a case report(2019-05-17) KORTEN, VOLKAN; ESİM BÜYÜKBAYRAK, ESRA; KARAKURT, SAİT; ERYÜKSEL, SEMİHA EMEL; Saçar Kübüç K., Nazlı İ., Korten V., Esim Büyükbayrak E., Karakurt S., Eryüksel S. E.Publication Open Access Reliability and validity of the Turkish translation of the beliefs about medicines questionnaire (bmq-t) in patients with behçet’s disease(2018-10-01) ARIKAN, HÜSEYİN; KARAKURT, SAİT; ERYÜKSEL, SEMİHA EMEL; ARIKAN H., Duman D., Kargın F., ERGİN G., Horne R., KARAKURT S., ERYÜKSEL S. E.Publication Metadata only The predictive role of psychological status and disease severity indexes on quality of life among patients with non-CF bronchiectasis(2022-01-01) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; CEYHAN B., Bekir M., KOCAKAYA D., OLGUN YILDIZELİ Ş., ERYÜKSEL S. E.OBJECTIVE: Bronchiectasis is a chronic suppurative lung disease that significantly impacts the patients\" quality of life. The aim of this study is to evaluate the relationship between quality of life and patient\"s psychological status and bronchiectasis disease severity indexes in patients with non-cystic fibrosis bronchiectasis. We also aimed to investigate the validity and reliability of Turkish version of Quality of Life Questionnaire-Bronchiectasis (V3.1) in Turkish adult bronchiectatic patients.Publication Metadata only Akut hipoksemik solunum yetmezliğinde yüksek akım oksijen tedavisinin başarısını etkileyen faktörler(2018-05-15) ERYÜKSEL, SEMİHA EMEL; ARIKAN, HÜSEYİN; KASAPOĞLU, UMUT SABRİ; YALÇINKAYA, ERDEM; OLGUN YILDIZELİ, ŞEHNAZ; KARAKURT, SAİT; ERYÜKSEL S. E., ARIKAN H., KASAPOĞLU U. S., YALÇINKAYA E., ERER A., OLGUN YILDIZELİ Ş., KARAKURT S.Publication Metadata only Impact of body composition and nutritional status on health outcomes in adultcystic fibrosis patients(2019-04-18) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; USLU N. Z. , KOCAKAYA D., OLGUN YILDIZELİ Ş., ERYÜKSEL S. E. , GÖRÇİN KARATEKİR Ş., CEYHAN B.AIM: Cystic fibrosis (CF) is a multi-systemic disease. Chronic inflammation and malabsorption may affect body composition, respiratory function and health outcomes. Our aim was to examine anthropometric measures, microbiologic data, spirometric data, comorbidities and how body composition may impact health outcomes in adult CF patients. METHODS: 31 adult CF patients (15 female, 16 male) with mean age 25 (18-42) and 23 controls were enrolled. The modified Medical Research Council (mMRC) scale, 6 minute-walk-test and pulmonary function test were performed. Anthropometric data including body mass index (BMI), fat-free mass index (FFMI) and total body fat percentiles were measured. Clinical indices, presence/absence of pancreatic insufficiency and method of nutrition were recorded. RESULTS: Mean duration of disease was 18.6±7.5 years. 24 of the patients (77%) were below targeted BMI. Mean BMI of the patients was 20.6±3.1 kg/m2 and mean FFMI was 16.4±1.6 kg/m2. When compared to control group, both BMI and FFMI were lower in CF patients (p<0.05 and 0.00) and both were correlated with age ( p: 0.008, r: 0.468 and p: 0.036, r:0.377). Female patients had lower FFMI (15.7±1.3 vs17.1±1.6, p:0.01) and higher fat percentile (22.7% vs 12.5%, p:0.00) than male patients. FFMI was found to be positively correlated with FEV1L and FVC L (p:0.017, r: 0.025 and p:0.05 and r: 0.490, respectively). 20 patients (65%) had pancreatic insufficiency and all were under pancreatic enzyme replacement medication. This group of patients had lower fat percentile then the group without pancreatic insufficiency (15.0±6.7% vs 23.2±9.0%; p:0.011) 16 patients (52%) had anemia and FFMI positively correlated with hemoglobin values (p:0.03, r: 0.390). 17 patients (55%) were receiving oral nutritional support and these patients had lower BMI then those who were not receiving (19.4±2.6 vs 22.1±2.9, p: 0.013). CONCLUSION: The prevalence of malnutrition was high in adult CF patients and lung function is correlated with nutritional status. Periodic measurement of anthropometrics and close monitoring of nutritional status may improve respiratory function and health outcomes in adult CF patientsPublication Metadata only Yoğun bakımda kurutlu uyuz salgını(2017-10-07) KASAPOĞLU, UMUT SABRİ; ERYÜKSEL, SEMİHA EMEL; KARAKURT, SAİT; ARIKAN, HÜSEYİN; DEMİRCİ A. F., KASAPOĞLU U. S., ÇİFTÇİ M., ARIKAN H., ERER A., KOÇOĞLU KINAL A. G., YALÇINKAYA E., ERYÜKSEL S. E., KARAKURT S.