Person: CİNEL, ZELİHA LEYLA
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CİNEL
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ZELİHA LEYLA
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Publication Open Access Nodular mucinosis of the breast: A rare entity(MARMARA UNIV, FAC MEDICINE, 2018-06-05) SALMAN, ANDAÇ; Salman, Andac; Cinel, Leyla; Turkoz, Huseyin Kemal; Akbas, Gamze; Ergun, TulinNodular mucinosis of the breast (NMB) is an uncommon disease involving the nipple-areolar region. It usually presents with asymptomatic, subcutaneous masses with indolent growth in women. Here, we report a 43-year-old man presented with a subcutaneous growth on the left nipple. Histopathological examination confirmed the diagnosis of NMB. We report our patient in order to point out this rare disease and think that the recognition of this entity is important for both clinicians and pathologists.Publication Open Access An unusual presentation of ocular rosacea(CONSEL BRASIL OFTALMOLOGIA, 2017) ÇELİKER ATABERK, HANDE; Celiker, Hande; Toker, Ebru; Ergun, Tulin; Cinel, LeylaRosacea is a chronic, progressive disease of unknown cause affecting the eye and the facial skin. Ocular rosacea is often underdiagnosed if the ophthalmologist does not inspect the patient's face adequately during the ocular examination. Severe ocular complications and blindness can occur if the treatment is delayed because of non-diagnosis of the rosacea. Here, we present a case of ocular rosacea in a 78-year-old Caucasian woman. Based on the ocular lesions, which preceded cutaneous involvement, she was misdiagnosed as having ocular cicatricial pemphigoid initially. This case emphasizes the difficulty in diagnosis when ocular findings precede those of skin manifestations, and rosacea should be kept in mind in the differential diagnosis of chronic cicatrizing conjunctivitis.Publication Metadata only Expanding the differential diagnosis of raccoon eyes: sweet syndrome(2019) SALMAN, ANDAÇ; Salman, A.; Demir, G.; Cinel, L.; Oguzsoy, T.; Yıldızhan, G.; Ergun, T.Publication Open Access Adenoid ‘ameloblastoma: Clinicopathological description of 4 additional BRAF-negative cases(2023-12-01) CİNEL, ZELİHA LEYLA; Khalaj F., CİNEL Z. L., Aminishakib P., Mosavat F., SOLUK TEKKEŞİN M.Objective: Adenoid ameloblastoma (AA) is an epithelial odontogenic tumor that was recognized as a separate entity in the last odontogenic classification of WHO in 2022. The etiology is unknown, and the pathogenesis remains controversial. The objective of this study is to contribute the clinicopathological features of 4 additional BRAF-negative cases to the existing literature, aiming to enhance the molecular understanding of this unique tumor in the forthcoming classification. Materials and methods: This study consists of a case series of four patients diagnosed with AA. The patients’ demographic and clinical information were collected from the universities’ medical achieves. Histopathologically, all cases were reexamined according to the latest update of the WHO odontogenic tumor classification. In addition to H&E and immunohistochemical stains, cytogenetics was also evaluated. Results: Well-defined unilocular radiolucent lesions were observed in all cases. Ameloblastoma-like components exhibited reserved nuclear polarity, suprabasal stellate reticulum-like epithelium, duct-like structure, whorls/morules, and cribriform architecture were common features. Variable immunoreactivity to CK7, CK19, CK14, p63, and p40 were determined, and proliferative activity was greater than 15%. The BRAF molecular study revealed no mutations. Conclusions: When diagnosing AA, the essential histopathological characteristics must be rigorously applied, and a significant portion of the lesion should contain these features. Additionally, despite limited molecular data, since the BRAF mutation commonly observed in ameloblastomas is not present in the majority of AA cases, we propose changing the term \"ameloblastoma\" to \"ameloblastic\" and referring to it as \"adenoid ameloblastic tumor\" in the forthcoming classification.Publication Metadata only Acquired progressive lymphangioma: Case report with partial response to imiquimod 5% cream(WILEY, 2017) SALMAN, ANDAÇ; Salman, Andac; Sarac, Gonca; Kuru, Burce Can; Cinel, Leyla; Yucelten, Ayse Deniz; Ergun, TulinAcquired progressive lymphangioma (APL), or benign lymphangioendothelioma, is an unusual entity derived from vascular structures. Clinically and histopathologically it may resemble Kaposi's sarcoma and well-differentiated angiosarcoma, causing a diagnostic problem. We report an individual with APL initially diagnosed with Kaposi's sarcoma who underwent unnecessary laboratory testing. Imiquimod 5% cream stopped the progression of the lesion. Awareness of this rare entity may prevent patients from undergoing excessive testing. Imiquimod may be used as a safe, effective treatment option.Publication Metadata only Schneiderian type papilloma of the middle ear(2020-12-01) CİNEL, ZELİHA LEYLA; Keskin B., CİNEL Z. L.Publication Open Access The promising role of Gelsolin expression to predict survival in patients with squamous cell carcinoma of the larynx(2021-06) BATMAN, ABDULLAH ÇAĞLAR; Şahin, Akın; Enver, Necati; Erçetin, Selim Yiğit; Cinel, Zeliha Leyla; Batman, Abdullah ÇağlarPublication Metadata only Calretinin immunohistochemistry for the diagnosis of Hirschprung disease in rectal biopsies(ELSEVIER GMBH, 2015) CİNEL, ZELİHA LEYLA; Cinel, Leyla; Ceyran, Bahar; Gucluer, BerrinIn this study we aimed to evaluate the usability of calretinin staining in the diagnosis and exclusion of HD in 36 rectal biopsies. Through immunohistochemical examination, in of a total of 21 pediatric patients in whom ganglion cells were detected in first rectal biopsies and in re-biopsies, ganglion cells were seen through nuclear and cytoplasmic staining. In the lamina propria and superficial submucosa, staining of nerve fibers was detected in a granular pattern in varying intensities. Out of a total of 5 biopsies (including one re-biopsy) of non-HD patients, where ganglion cells could not be seen, the nerve fibers were all stained. On the other hand, in 10 HD patients, diagnosed by a colon pull through operation, calretinin staining was not detected in any area of the rectal biopsies except for the mast cells. We conclude that calretinin immunostaining for the diagnosis of HD is an easy and reliable method for use in daily practice. (C) 2014 Published by Elsevier GmbH.Publication Metadata only Baş-boyun spesimenleri patolojik değerlendirme ve raporlama rehberi(buluş, 2021-03-01) CİNEL, ZELİHA LEYLA; Cinel Z. L., Gökcan M. K., Veral A., Çomunoğlu N., Soluk Tekkeşin M.Publication Metadata only Immunomodulatory and Tissue-preserving Effects of Human Dental Follicle Stem Cells in a Rat Cecal Ligation and Perforation Sepsis Model(ELSEVIER SCIENCE INC, 2020) GÜL, FETHİ; Sarica, Leyla Topcu; Zibandeh, Noushin; Genc, Deniz; Gul, Fethi; Akkoc, Tolga; Kombak, Erdem Faruk; Cinel, Leyla; Akkoc, Tunc; Cinel, IsmailBackground. Mesenchymal stem cells may be used for the treatment of sepsis. Dental follicle stem cells (DFSCs) are easily accessible but have not been studied in vivo or in clinical trials in sepsis models. Aim of the study. We aim to elucidate DFSC effects on host immunological functions in a rat cecal ligation and perforation (CLP) sepsis model. Methods. Adult male rats were categorized into group 1 (sham procedure SP), group 2 (SP + 1 x 10(6) DFSCs administered 0 h after SP), group 3 (CLP + saline), group 4 (CLP 1 x 10(6) DFSCs administered 0 h after CLP), and group 5 (CLP + 1 x 10(6) DFSCs administered 4 h after CLP). Green fluorescent protein-labeled cells were used for imaging. Histopathological examination of ileal tissues was performed. Results. A significant increase in the percentage of CD4+/CD25+/Foxp3+ Treg cells in groups 4 and 5 occurred compared with that in group 3. No significant changes in CD3+/CD4+ helper T-cells and CD3+/CD8+ cytotoxic T-cells were observed. Treatment with DFSCs at 4 h significantly decreased the level of TNF-alpha compared with that in group 3. No significant changes in IL-10 levels and lymphocyte proliferation suppression were observed. During histopathological examination, no high scoring (Chiu scores: 3 or 4) rats were observed in the curative treatment group (group 5). Conclusions. Treatment with DFSC after 4 h of sepsis induction downregulates tissue inflammatory responses by decreasing TNF-alpha levels and increasing Treg cell ratio. This also has a protective effect on intestinal tissues during sepsis. (C) 2020 IMSS. Published by Elsevier Inc.
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