Person: ALTAN, ERAY
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ALTAN
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ERAY
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Publication Open Access Investigation of 3D-printed chitosan-xanthan gum patches(2022-07-01) ALTAN, ERAY; GÜNDÜZ, OĞUZHAN; BİNGÖL ÖZAKPINAR, ÖZLEM; ALTAN E., Turker N., Hindy O. A., Dirican Z., Ozakpinar Ö., Demir A. U., Kalaskar D., Thakur S., GÜNDÜZ O.In this study, using a new polymer combination of Chitosan(CH)/Xanthan Gum(XG) has been exhibited for wound dressing implementation by the 3D-Printing method, which was fabricated due to its biocompatible, biodegradable, improved mechanical strength, low degradation rate, and hydrophilic nature to develop cell-mimicking, cell adhesion, proliferation, and differentiation. Different concentrations of XG were added to the CH solution as 0.25, 0.50, 0.75, 1, and 2 wt% respectively in the formic acid/distilled water (1.5:8.5) solution and rheologically characterized to evaluate their printability. The results demonstrated that high mechanical strength, hydrophilic properties, and slow degradation rate were observed with the presence and increment of XG concentration within the 3D-Printed patches. Moreover, in vitro cell culture research was conducted by seeding NIH 3T3 fibroblast cells on the patches, proving the cell proliferation rate, viability, and adhesion. Finally, 1% XG and 4% CH containing 3D-Printed patches were great potential for wound dressing applications.Publication Metadata only A study on hemp seed oil/polycaprolactone based wound dressing structures by making use of additive manufacturing methods(2022-12-07) UZUN, MUHAMMET; ALTAN, ERAY; GÜNDÜZ, OĞUZHAN; Ertaş İ. F., Kabir M. H., UZUN M., ALTAN E., GÜNDÜZ O.Publication Open Access Marine-derived bioceramics for orthopedic, reconstructive and dental surgery applications(2022-11-01) OKTAR, FAİK NÜZHET; ÜNAL YILDIRIM, SEMRA; GÜNDÜZ, OĞUZHAN; EKREN, NAZMİ; ALTAN, ERAY; OKTAR F. N. , Unal S., GÜNDÜZ O., Ben Nissan B., Macha I. J. , Akyol S., Duta L., EKREN N., ALTAN E., YETMEZ M.Bioceramics are a fast-growing materials group, which are widely used in orthopedics, maxillofacial, dental, and reconstructive surgeries. They are produced using raw materials either from synthetic or natural sources. As naturally originated resources, the bones of sheep and cows are used after converting to calcium phosphates. Human-originated sources in the past were obtained from human cadaver bones, however now-a-days this has been discontinued. On the other hand, the \"golden standard\" in the reconstruction surgery has been using patients own bones, -i.e., autogenous bones, which heal better than other alternatives. Besides natural products, synthetic materials are produced from a range of inorganic raw and natural materials based on marine sources, such as corals, and other marine-derived materials (i.e., seashells, nacre). These are used to produce bioceramics and hence implants, devices, and bone grafts. Although during the last four decades a number of excellent books and book chapters have been published, no comprehensive review has been yet reported to cover the available marine materials and to indicate the related work and corresponding references to allow for both medical and ceramic scientists to access directly and open new avenues for further research on marine structures and their applications in orthopedic, maxillofacial, and reconstructive surgery areas. Hence, this review covers the general marine structures, their locations and availability in different countries and, current research on production methods of these unique structures that are difficult to fabricate synthetically. The authors are confident that this comprehensive review will be an excellent source not only for the ceramists, but also for the medical scientists.Publication Metadata only Study on potential of additive manufactured wound dressing from hemp seed oil/polycaprolactone(2022-11-06) UZUN, MUHAMMET; ALTAN, ERAY; TINAZ, GÜLGÜN; GÜNDÜZ, OĞUZHAN; Ertaş İ. F., UZUN M., ALTAN E., Kabir M. H., TINAZ G., GÜNDÜZ O.Publication Open Access Fabrication of electrospun juglans regia (juglone) loaded poly(lactic acid) scaffolds as a potential wound dressing material(2022-05-01) ALTAN, ERAY; ŞAHİN, ALİ; GÜNDÜZ, OĞUZHAN; ULAĞ, SONGÜL; ALTAN E., Karacelebi Y., Saatcioglu E., ULAĞ S., ŞAHİN A., AKSU M. B., Croitoru A., Codrea C. I., Ficai D., GÜNDÜZ O., et al.Juglone (5-hydroxy-1,4-naphthoquinone) (J) is a naphthoquinone structured allelochemical that is mostly found in the roots, leaves, nut-hulls, bark, and wood of walnut (Juglans regia). In this study, the biocompatibility, mechanical, thermal, chemical, morphological, and antimicrobial properties of the poly(lactic acid) (PLA) (w/v)/J (10, 20, 30 mg) electrospun scaffolds were investigated. Based on the results of the study, it was shown that juglone addition increased the antimicrobial properties of the scaffolds against the Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), compared to the neat PLA film after 24 h of contact time. According to the tensile test results, the addition of J made the scaffolds more flexible but decreased the mechanical strength. The cytotoxicity properties of the J-added scaffolds demonstrated a toxic behavior on the first day of incubation. However, with an increase in the J ratio, the fibroblast cell metabolic activity increased for all incubation periods.Publication Open Access Electrically Triggered Drug Delivery from Novel Electrospun Poly(Lactic Acid)/Graphene Oxide/Quercetin Fibrous Scaffolds for Wound Dressing Applications(MDPI, 2021-06-25) ŞAHİN, ALİ; Croitoru, Alexa-Maria; Karacelebi, Yasin; Saatcioglu, Elif; Altan, Eray; Ulag, Songul; Aydogan, Huseyin Kivanc; Sahin, Ali; Motelica, Ludmila; Oprea, Ovidiu; Tihauan, Bianca-Maria; Popescu, Roxana-Cristina; Savu, Diana; Trusca, Roxana; Ficai, Denisa; Gunduz, Oguzhan; Ficai, AntonThe novel controlled and localized delivery of drug molecules to target tissues using an external electric stimulus makes electro-responsive drug delivery systems both feasible and desirable, as well as entailing a reduction in the side effects. Novel micro-scaffold matrices were designed based on poly(lactic acid) (PLA) and graphene oxide (GO) via electrospinning. Quercetin (Q), a natural flavonoid, was loaded into the fiber matrices in order to investigate the potential as a model drug for wound dressing applications. The physico-chemical properties, electrical triggering capacity, antimicrobial assay and biocompatibility were also investigated. The newly fabricated PLA/GO/Q scaffolds showed uniform and smooth surface morphologies, without any beads, and with diameters ranging from 1107 nm (10%PLA/0.1GO/Q) to 1243 nm (10%PLA). The in vitro release tests of Q from the scaffolds showed that Q can be released much faster (up to 8640 times) when an appropriate electric field is applied compared to traditional drug-release approaches. For instance, 10 s of electric stimulation is enough to ensure the full delivery of the loaded Q from the 10%PLA/1%GO/Q microfiber scaffold at both 10 Hz and at 50 Hz. The antimicrobial tests showed the inhibition of bacterial film growth. Certainly, these materials could be loaded with more potent agents for anti-cancer, anti-infection, and anti-osteoporotic therapies. The L929 fibroblast cells cultured on these scaffolds were distributed homogeneously on the scaffolds, and the highest viability value of 82.3% was obtained for the 10%PLA/0.5%GO/Q microfiber scaffold. Moreover, the addition of Q in the PLA/GO matrix stimulated the production of IL-6 at 24 h, which could be linked to an acute inflammatory response in the exposed fibroblast cells, as a potential effect of wound healing. As a general conclusion, these results demonstrate the possibility of developing graphene oxide-based supports for the electrically triggered delivery of biological active agents, with the delivery rate being externally controlled in order to ensure personalized release.Publication Open Access Effects of temperature and pH on the synthesis of nanohydroxyapatite powders by chemical precipitation(2023-01-01) ALTAN, ERAY; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; Mahmutoglu G., Topsakal A., ALTAN E., KUŞKONMAZ N., DAĞLILAR S., OKTAR F. N., Erdemir G., Kuruca S. E., AKYOL S., GÜNDÜZ O., et al.Bone tissue engineering is based on a comprehensive understanding of bone structure, bone mechanics, and biology. In order to create nanostructured hydroxyapatite powders with customized properties, many synthesis strategies such as wet chemical precipitation, sol-gel, hydrothermal, and biomimetic approaches have been intensively researched through the years. Calcium phosphate (CaP)-based ceramic nanoparticles, including hydroxyapatite (HAp), were synthesized by the chemical precipitation technique at pH ranges of 7 to 11 and different calcination temperatures of 600 to 1100 °C. The synthesized powders were characterized by several techniques, including scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), energy dispersive X-ray analysis (EDX), and in vitro cell culture assays. The particle size analysis and zeta potential of these powders were also carried out using the dynamic light scattering (DLS) and laser Doppler electrophoresis methods. The results showed that the pH levels of 9 to 11 range and calcination temperatures of 600 to 800 °C were adequate for appropriate nanohydroxyapatite powder production using this method. The particle size of the nanohydroxyapatite was approximately 55 nm, although they were agglomerated after calcination. The biocompatibility tests demonstrated that these nanohydroxyapatite (nHAp) powders produced have appropriate cytocompatibility and can be used for bone graft production and other biomedical applications.Publication Metadata only Bioceramics(Springer, London/Berlin , 2023-09-01) ALTAN, ERAY; GÜNDÜZ, OĞUZHAN; Bedir T., Altan E., Arancı Çiftçi K., Gündüz O. (Editör); Gunduz, Oğuzhan; Egles, Christophe; Pérez, Roman A.; Ficai, Denisa; Üstündağ, Cem BulentBioceramics commonly employed materials for the restoration, replacement and recovery of unhealthy and impaired pieces of the muscle and skeletal system, as well as periodontal anomalies. According to the host tissue interactions, bioceramics can be graded as nearly bioinert, bioactive, and bioresorbable. Most of the clinical applications of bioceramics comprise orthopedic and dental surgery and also have potential in the field of tissue engineering. This chapter aims to introduce a concise and accessible overview of the past of bioceramics to the present. From bioinert to bioactive and bioabsorbable bioceramics, the classification of materials is discussed and bioceramics characteristics such as biodegradability, bioactivity, biocompatibility, porosity, mechanical and surface properties, as well as osteoconductivity and osteoinductivity emphasized in depth. Production processes of bioceramics are also considered herein. At the end of this chapter, the biomedical applications of bioceramics including orthopedic, dental, surface coatings, and bone tissue engineering, challenges, and future research expectations in the area of bioceramics are also highlighted.