Person: YÜCELTEN, AYŞE DENİZ
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
YÜCELTEN
First Name
AYŞE DENİZ
Name
16 results
Search Results
Now showing 1 - 10 of 16
Publication Metadata only Infantile Bullous Pemphigoid Treated Using Intravenous Immunoglobulin: Case Report and Review of the Literature(WILEY-BLACKWELL, 2015) YÜCELTEN, AYŞE DENİZ; Tekin, Burak; Yucelten, Ayse DenizWe report a 5-month-old girl diagnosed with bullous pemphigoid who initially did not respond to systemic corticosteroids and dapsone but rapidly improved after the addition of intravenous immunoglobulin (IVIG) infusions. A literature search revealed anecdotal cases of infantile bullous pemphigoid treated with IVIG, although variable treatment regimens were used, and some resistant cases required additional medications such as rituximab for clinical remission.Publication Open Access Phacomatosis pigmentokeratotica associated with unilateral toe walking due to short achilles tendon(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2020) SALMAN, ANDAÇ; Salman, Andac; Yucelten, Ayse Deniz; Cakici, Ozlem Akin; Unver, OlcayPhacomatosis pigmentokeratotica (PPK) is characterized by the co-occurrence of speckled lentiginous nevus (nevus spilus) and an organoid nevus with or without extracutaneous involvement. The extracutaneous manifestations may vary widely with musculoskeletal, neurologic, ocular, and vascular findings. The PPK is also associated with an increased risk of cutaneous or extracutaneous tumors. Therefore, the patients with PPK should be followed up regularly for possible malignant transformation. Here, we report a 5-year-old boy with PPK associated with toe walking due to short Achilles tendon, which was not previously reported, to our knowledge.Publication Metadata only Acquired progressive lymphangioma: Case report with partial response to imiquimod 5% cream(WILEY, 2017) SALMAN, ANDAÇ; Salman, Andac; Sarac, Gonca; Kuru, Burce Can; Cinel, Leyla; Yucelten, Ayse Deniz; Ergun, TulinAcquired progressive lymphangioma (APL), or benign lymphangioendothelioma, is an unusual entity derived from vascular structures. Clinically and histopathologically it may resemble Kaposi's sarcoma and well-differentiated angiosarcoma, causing a diagnostic problem. We report an individual with APL initially diagnosed with Kaposi's sarcoma who underwent unnecessary laboratory testing. Imiquimod 5% cream stopped the progression of the lesion. Awareness of this rare entity may prevent patients from undergoing excessive testing. Imiquimod may be used as a safe, effective treatment option.Publication Open Access Atypical presentations of eosinophilic fasciitis(MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2016) SALMAN, ANDAÇ; Ergun, Tulin; Seckin, Dilek; Salman, Andac; Ocak, Esra Sarac; Yucelten, Ayse Deniz; Direskeneli, Haner; Demirkesen, Cuyan; Ekinci, Gazanfer; Bayik, MahmutEosinophilic fasciitis is an uncommon connective tissue disease that may mimic and overlap with other sclerosing disorders such as morphea and lichen sclerosus. Herein, we report four patients (two men and two women, aged 16-64 yeas) with eosinophilic fasciitis. There was overlap with both morphea and lichen sclerosus in 2 patients and with morphoea alone in 1 patient. Magnetic resonance imaging (MRI) was used for diagnosis in three patients and for assessing treatment response in one patient. Eosinophilic fasciitis may co-exist with morhoea and lichen sclerosus. In view of the overlapping clinical and histopathological features of these disorders, MRI may be helful in delineating the conditions by detecting involvement of fascia.Publication Open Access Cutaneous leishmaniasis mimicking verrucous carcinoma: A case with an unusual clinical course(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2015) SALMAN, ANDAÇ; Salman, Andac; Yucelten, Ayse Deniz; Seckin, Dilek; Ergun, Tulin; Demircay, ZeynepPublication Open Access Impact of psoriasis in the quality of life of children, adolescents and their families: a cross-sectional study(SOC BRASILEIRA DERMATOLOGIA, 2018-12) SALMAN, ANDAÇ; Salman, Andac; Yucelten, Ayse Deniz; Sarac, Esra; Saricam, Merve Hatun; Perdahli-Fis, NeseBACKGROUND: Psoriasis is a chronic and inflammatory disease that impairs quality of life and causes psychological symptoms. Despite the high prevalence of psoriasis in pediatric patients, studies investigating the impact of psoriasis in the quality of life of children, adolescents and families are sparse. OBJECTIVE: To investigate the impact of psoriasis in the quality of life of children and adolescents with psoriasis and their families and to determine depression and anxiety levels of the patients. METHODS: A total of 58 patients with psoriasis aged 7-18 years (median age: 11) and a family member of each patient were included in the study. Children's Dermatology Life Quality Index (CDLQI), Family Dermatology Life Quality Index (FDLQI), Children's Depression Inventory (CDI) and State-Trait Anxiety Inventory for Children (STAIC) were used in the study. RESULTS: The median PASI score of the patients included in the study was 1.8. The median CDLQI and FDLQI scores in the study groups were 5 and 10, respectively. The median CDI score, STAIC-state and STAIC-trait scores of the patients were 6,28 and 325, respectively. STUDY LIMITATIONS: Lack of a control group and patient assessment of disease severity. Relatively mild disease severity of the subjects. CONCLUSIONS: Psoriasis has a negative impact in the quality of life of children, adolescents and their families, even in the presence of mild disease. Considering that impairment in quality of life may be associated with psychosocial morbidity, a combined approach with medical therapy, family counseling and quality of life assessment may be beneficial in this patient group.Publication Metadata only Potentially Beneficial Effect of Hydroxychloroquine in a Patient with a Novel Mutation in Protein Kinase C delta Deficiency(SPRINGER/PLENUM PUBLISHERS, 2015) ÖZEN, AHMET OĞUZHAN; Kiykim, Ayca; Ogulur, Ismail; Baris, Safa; Salzer, Elisabeth; Karakoc-Aydiner, Elif; Ozen, Ahmet Oguzhan; Garncarz, Wojciech; Hirschmugl, Tatjana; Krolo, Ana; Yucelten, Ayse Deniz; Boztug, Kaan; Barlan, Isil B.Protein kinase C delta (PRKCD) has essential functions in controlling B-cell proliferation and apoptosis, development of B-cell tolerance and NK-cell cytolitic activity. Human PRKCD deficiency was recently identified to be causative for an autoimmune lymphoproliferative syndrome like disorder with significant B-cell proliferation particularly of immature B cells. Here we report a child with a novel mutation in PRKCD gene who presented with CMV infection and an early onset SLE-like disorder which was successfully treated with hydroxychloroquine.Publication Metadata only Low Density Granulocytes and Dysregulated Neutrophils Driving Autoinflammatory Manifestations in NEMO Deficiency(SPRINGER/PLENUM PUBLISHERS, 2022) ÖZEN, AHMET OĞUZHAN; Yilmaz, Naz Surucu; Eltan, Sevgi Bilgic; Kayaoglu, Basak; Geckin, Busranur; Heredia, Raul Jimenez; Sefer, Asena Pinar; Kiykim, Ayca; Nain, Ercan; Kasap, Nurhan; Dogru, Omer; Yucelten, Ayse Deniz; Cinel, Leyla; Karasu, Gulsun; Yesilipek, Akif; Sozeri, Betul; Kaya, Goksu Gokberk; Yilmaz, Ismail Cem; Baydemir, Ilayda; Aydin, Yagmur; Kahraman, Deniz Cansen; Haimel, Matthias; Boztug, Kaan; Karakoc-Aydiner, Elif; Gursel, Ihsan; Ozen, Ahmet; Baris, Safa; Gursel, MaydaNF-kappa B essential modulator (NEMO, IKK-gamma) deficiency is a rare combined immunodeficiency caused by mutations in the IKBKG gene. Conventionally, patients are afflicted with life threatening recurrent microbial infections. Paradoxically, the spectrum of clinical manifestations includes severe inflammatory disorders. The mechanisms leading to autoinflammation in NEMO deficiency are currently unknown. Herein, we sought to investigate the underlying mechanisms of clinical autoinflammatory manifestations in a 12-years old male NEMO deficiency (EDA-ID, OMIM #300,291) patient by comparing the immune profile of the patient before and after hematopoietic stem cell transplantation (HSCT). Response to NF-kB activators were measured by cytokine ELISA. Neutrophil and low-density granulocyte (LDG) populations were analyzed by flow cytometry. Peripheral blood mononuclear cells (PBMC) transcriptome before and after HSCT and transcriptome of sorted normal-density neutrophils and LDGs were determined using the NanoString nCounter gene expression panels. ISG15 expression and protein ISGylation was based on Immunoblotting. Consistent with the immune deficiency, PBMCs of the patient were unresponsive to toll-like and T cell receptor-activators. Paradoxically, LDGs comprised 35% of patient PBMCs and elevated expression of genes such as MMP9, LTF, and LCN2 in the granulocytic lineage, high levels of IP-10 in the patient's plasma, spontaneous ISG15 expression and protein ISGylation indicative of a spontaneous type I interferon (IFN) signature were observed, all of which normalized after HSCT. Collectively, our results suggest that type I IFN signature observed in the patient, dysregulated LDGs and spontaneously activated neutrophils, potentially contribute to tissue damage in NEMO deficiency.Publication Metadata only Coexistence of Aplasia Cutis and Nevus Psiloliparus-Report of a Novel Case(WILEY-BLACKWELL, 2014) YÜCELTEN, AYŞE DENİZ; Tekin, Burak; Yucelten, Ayse Deniz; Akpinar, Ihsan Nuri; Ekinci, GazanferNevus psiloliparus is a type of mesodermal nevus of the scalp classically seen with encephalocraniocutaneous lipomatosis. The close association between nevus psiloliparus and aplasia cutis congenita is called didymosis aplasticopsilolipara. Although typically associated with neurologic, ocular, and skeletal findings, didymosis aplasticopsilolipara can be seen without the context of encephalocraniocutaneous lipomatosis.Publication Open Access Spina bifidalı hastada ağır nöropatik ülser ve fungal dermatit(2013-10-01) ÇİÇEK DENİZ, NESLİHAN; YILDIZ, NURDAN; YÜCELTEN, AYŞE DENİZ; ALPAY, HARİKA; Aksu Ç., ÇİÇEK DENİZ N., YILDIZ N., YÜCELTEN A. D., ALPAY H.Kaudal nöral açıklığın yanlış kapanması spina bifida (SB) olarak bilinen vertebral ark defektlerini oluşturur. Sıklığı 4-5/10.000 canlı doğumdur. Medulla spinalisin kese şeklinde dışarı çıktığı spina bifida sistika nöral tüp defektinin düzeyi ile uyum gösteren ağır nörolojik kusurlara yol açar. Duyu kaybı, paralizi, barsak ve mesane fonksiyon kaybı sıktır. Hastaların paraliziye bağlı postürlerinden kaynaklanan bası ülserleri ve cilt lezyonları sık rastlanan tıbbi problemlere odaklanıldığında gözden kaçabilir ve önemli sorunlara yol açabilir. Bu yazıda idrar yolu enfeksiyonu ve hipertansiyon nedeni ile başvuran, fizik muayenesinde gluteal bölgelerde yaygın dermatiti ve sağ dizinde derin bası ülseri saptanan SB’li on bir yaşında bir erkek olgu sunulmuş, hastaların uzun dönem izlemlerinde ortaya çıkabilen ve yaşam kalitesini düşüren lokal komplikasyonlara dikkat çekilmek istenmiştir. (Haseki T›p Bülteni 2013; 51: 186-9)