Person: BEKİROĞLU, GÜLNAZ NURAL
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BEKİROĞLU
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GÜLNAZ NURAL
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Publication Metadata only Knowledge and attitudes concerning diet and dental health in a group Turkish students(2006-09-07) BEKİROĞLU, GÜLNAZ NURAL; KARGÜL, BETÜL; Erzengin Ö. U., Kargül B., Alyan M., Öktem S. N., Bekiroğlu G. N.Publication Metadata only Screening athletes with Down syndrome for ocular disease(2010) BEKİROĞLU, GÜLNAZ NURAL; Gutstein W., Sinclair S.H., North R.V., Bekiroglu N.Background: Persons with Down syndrome are well known to have a high prevalence of vision and eye health problems, many of which are undetected or untreated primarily because of infrequent ocular examinations. Public screening programs, directed toward the pediatric population, have become more popular and commonly use letter or symbol charts. This study compares 2 vision screening methods, the Lea Symbol chart and a newly developed interactive computer program, the Vimetrics Central Vision Analyzer (CVA), in their ability to identify ocular disease in the Down syndrome population. Methods: Athletes with Down syndrome participating in the European Special Olympics underwent an ocular screening including history, auto-refraction, colour vision assessment, stereopsis assessment, motility assessment, pupil reactivity, and tonometry testing, as well as anterior segment and fundus examinations to evaluate for ocular disease. Visual acuity was tested with the Lea chart and CVA to evaluate these as screening tests for detecting ocular disease as well as significant, uncorrected refractive errors. Results: Among the 91 athletes that presented to the screening, 79 (158 eyes) were sufficiently cooperative for the examination to be completed. Mean age was 26 years ±10.8 SD. Significant, uncorrected refractive errors (≥1.00 spherical equivalent) were detected in 28 (18%) eyes and ocular pathology in 51 (32%) eyes. The Lea chart sensitivity and specificity were 43% and 74%, respectively, for detecting ocular pathology and 58% and 100% for detecting uncorrected refractive errors. The CVA sensitivity and specificity were 70% and 86% for detecting pathology and 71% and 100% for detecting uncorrected refractive errors. Conclusion: This study confirmed the findings of prior studies in identifying a significant presence of uncorrected refractive errors and ocular pathology in the Down syndrome population. Screening with the Lea symbol chart found borderline sufficient sensitivity and specificity for the test to be used for screening in this population. The better sensitivity and specificity of the CVA, if adjusted normative values are utilized, appear to make this test sufficient for testing Down syndrome children for identifying both refractive errors and ocular pathology. © 2010 American Optometric Association.Publication Metadata only The importance of biostatistics and scientific research in evidence- based medicine(2022-12-16) BEKİROĞLU, GÜLNAZ NURAL; Özgür E. G. , Bekiroğlu G. N.ÖZETKanıta Dayalı Tıp terimi 1990’ların başında ilk kez Guyatt ve arkadaşlarının çalışmasında yayınlanmıştır. Daha sonra ise Kanada Ontorio McMaster Üniversitesinden Sackett ve arkadaşları yeni bilgiye ulaşmak için klinik deneyim ve hastaya ait tercihlerin önemini vurgulamıştır.Kanıta Dayalı Tıp, sistematik araştırmalardan elde edilen klinik dışı kanıtların, klinik tecrübe, mesleksel deneyim ve olgunun özellikleri ile birleştirilmesi ve bunun tıp etiği çerçevesinde yapılmasıdır. Hekimlerin hastaların tedavi sürecinde en iyi kararı vermesi için kanıtların dikkatli, açık ve akıllıca kullanılması gerekir. Bireysel klinik deneyime dayanan karar verme yaklaşımının yaratmış olduğu değişkenlikler ve tutarsızlıklar ile sağlık alanında sürekli olarak yeni kanıtların ortaya çıkması ve büyüyen literatürü takip etmenin zorlaşması ile klinik uygulama ve tıbbi araştırmalar arasında kopukluğun artmasından dolayı Kanıta Dayalı Tıp yaklaşımı önemli hale gelmiştir. Kanıta dayalı tıp yaklaşımında en iyi kanıtı belirlemek epidemiyolojik ve biyoistatistiksel düşünme yollarını kullanmak anlamına gelir. Bununla birlikte elde edilen kanıtların geçerliliği ve güvenilirliği test edilir. Randomize kontrollü çalışmalar, sistematik derleme ve meta analizler en iyi araştırma kanıtlarıdır. Yine biyoistatistiksel yöntemlerden tanı testleri, çok değişkenli modeller ve uzunlamasına modeller ile en iyi tanı yöntemleri, ilgili araştırmadaki risk faktörleri ve yapılan müdahalelerin uzun dönem etkileri elde edilir.Sağlık alanında tanı ve tedavinin gelişmesi insan sağlığı açısından çok önemlidir. Bunun için yapılan çalışmalarda da bir biyoistatistik uzmanı ile çalışmak ve biyoistatistiksel yöntemlerin kullanılması hem çalışmanın geçerlilik ve güvenirliğini arttıracaktır hem de zaman açısından önemli kazançlar sağlayacaktır.Anahtar Kelimeler: Kanıta Dayalı Tıp, Biyoistatistik, Bilimsel Araştırma,Publication Metadata only An approach to clinical decision making(2003-01-12) BEKİROĞLU, GÜLNAZ NURAL; Bekiroğlu G. N., Yıldızeli B., Mergen O.Publication Metadata only Where is the place of biostatistics in education and in medical sciences(1997-08-12) BEKİROĞLU, GÜLNAZ NURAL; Bekiroğlu G. N., Şahin Ş.Publication Open Access Sleep assessment in preterm infants: Use of actigraphy and aEEG(2022-11-01) BEKİROĞLU, GÜLNAZ NURAL; Ülgen Ö., Barış H. E. , Özbörü Aşkan Ö., Küçük Akdere S., Ilgın C., Özdemir H., Bekiroğlu G. N. , Gücüyener K., Özek E., Boran P.Objective: Objective methods to monitor the sleep of preterm infants at the neonatal intensive care unit (NICU) are required to prevent potentially adverse neurodevelopmental outcomes. This study aimed to determine the concordance of actigraphy and amplitude-integrated electroencephalogram (aEEG) against gold standard direct observation (DO) in assessing sleep/wake states of typically developing preterm infants. Methods: This prospective observational study was conducted in a single center level III NICU. Sleep variables were measured using Philips Respironics Mini-Mitter® Actiwatch-2 for 24 h and compared with 8-h matched data of aEEG and DO. Sensitivity-specificity analysis, Cohen's kappa, prevalenceadjusted and bias-adjusted kappa (PABAK), and Bland Altman plots were generated. Results: Seventeen preterm infants were recruited. A total of 11252 epochs were studied. Sensitivity (86.4%), agreement rate (67.9%), and predictive value for wake (47.9%) for the actigraphy were highest at the automatic activity threshold whereas specificity (54.5%) and predictive value for sleep (75.5%) were highest at low threshold. The sensitivity of aEEG was 79.3% and the specificity was 54.3%. At all thresholds, the agreement was largely equivalent with low kappas (0.14e0.17) and PABAK coefficients (0.22e0.35) for actigraphy and DO. Moderate agreement was observed between aEEG and DO according to the PABAK coefficient (0.44). Mean differences in sleep parameters were not different between DO and aEEG as well as DO/aEEG and actigraphy at medium threshold (p > 0.05). Conclusions: Actigraphy at medium threshold can be used in depicting sleep in typically developing preterm infants at NICU. aEEG may be an alternative adjunctive method to actigraphy for the evaluation of sleep/wake states in the NICU settingPublication Open Access Açık ve laparoskopik kolesistektominin erken postoperatif dönem sıvı faz mide boşalmasına etkileri (ön çalışma)(1996-06-01) BEKİROĞLU, GÜLNAZ NURAL; Günal Ö., Değirmencioğlu L., Çaşkurlu U., Akkaya L., Bekiroğlu G. N.Today, laparoscopic cholecystectomy (LC) as a gold standard operation in the treatment of the gallbladder stones, has not been known enough how it does effect to earty postoperative period (EPP) liquid phase gastric emptying, comparing with the open cholecystectomy (OC). Gastric empyting scintigraphy (Tc 99m-DPTA) has been done to 12 laparoscopically, 6 conventionally treated cholecystectomy patients in prospective, randomized manner. Pre-operative, postoperative 1st and 7th day scintigraphic gastric empyting values (GEVs) were compared with each other. As compared with OC, decreasing GEV in LC at post-op 1st day 60.min was found to be increased at 7th day 0. and 30. min. significantly (p<0.05). However, both LC and OC groups GEVs were found to be statistically the similar levels at 7th day 60. min. We could not find a clinically reasonable difference between the effects of LC and OC on the liquid phase gastric empyting.Publication Metadata only Statistical evaluation of the relationship between house dust mold and mould comtaminations of non-sealed opened and used medicaments(1994-07-03) BEKİROĞLU, GÜLNAZ NURAL; Özyaral O., Johansson C. B., Bekiroğlu G. N.Publication Metadata only Meta-analiz yönteminin tıp teknolojisindeki önemi ve bir uygulaması(1997-11-24) BEKİROĞLU, GÜLNAZ NURAL; Bekiroğlu G. N.Publication Metadata only Validity and reliability of Child Perception Questionnaire (CPQ(11-14)) by Rasch Analysis in Turkish children(ELSEVIER SCIENCE BV, 2017) KARGÜL, BETÜL; Bekiroglu, Nural; Bakkal, Meltem; Ozbay, Gizem; Karadeniz, Pinar Gunel; Kargul, BetulAssessment for the reproducibility of the answers to the Child Perception Questionnaire (CPQ(11-14)) in different languages with test-retest exercises have importance to be acceptable in other populations. The present study is to evaluate the validity and reliability of Child Perception Questionnaire for ages 11-14 (CPQ(11-14)) with 37 items by means of Rasch Analysis in a group of Turkish population. 133 children aged 11-14 years old were included to the study. CPQ11-14 was administered at their first visit, as well as Facial Image Scale questions. After two weeks, CPQ11-14 was re-applied to a subgroup (n = 25) of the children. The construct validity of the CPQ11-14 data was assessed by using Rasch Analysis. Intra-class Correlation Coefficient was calculated with the CPQ11-14 scores of first and second visits. Cronbach's alpha coefficient was obtained for evaluating internal consistency. According to Rasch Analysis, mean item infit +/- sd was 0.98 +/- 0.25; mean item outfit +/- sd was 1.08 +/- 0.91. Item and person separation indices and reliabilities were calculated as 3.34 and 2.42; 0.92 and 0.85, respectively. The Pearson's correlation coefficient between the total scores of CPQ(11-14) and the Facial Image Scale was found as 0.74 (p < 0.001). Cronbach's alpha coefficient was 0.93 and ICC was 0.90 for the total scale. The findings of the present study showed that the Turkish version of CPQ(11-14) with 37 items is valid and has excellent reliability. (C) 2016 Japanese Society of Pediatric Dentistry. Published by Elsevier Ltd. All rights reserved.