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DOĞAN, BAŞAK

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Diş Hekimliği Fakültesi

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DOĞAN

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BAŞAK

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Now showing 1 - 10 of 11

Open Access
Microbial composition and non-surgical periodontal treatment of aggressive periodontitis: Two case reports
(2019) DOĞAN, BAŞAK; Dilek MAMAKLIOĞLU;Bahar EREN KURU;Maribasappa KARCHED;BAŞAK DOĞAN
The objective of this case report was to characterize the subgingival microbiological profiles of two patients with generalized aggressive periodontitis (GAgP) and to evaluatethe clinical outcomes of non-surgical periodontal treatment(NSPT) over a 6-months period. Pooled subgingival samplesof two patients who referred to our clinic and diagnosed withGAgP were collected and analyzed for the presence of 300species/phlotypes using Human Oral Microbe IdentificationMicroarray analysis. NSPT was performed within 3-week period. Clinical parameters were measured at baseline, 3 and6 months after NSPT. Recall visits were performed every 2weeks during the first 3 months and every 4 weeks up to 6months. All samples harboured a total of 61 species and 32species were common in both patients. First patient had 17and the other had 12 distinct species. High levels of Filifactor alocis, Porpyromonas gingivalis, Campylobacter concisusand rectus, Fusobacterium nucleatum and Desulfobulbusspp. were detected in both patients while Aggregatibacter actinomycetemcomitans was found in none of them. Six monthsafter NSPT, all clinical parameters were improved in two A. actinomycetemcomitans-negative GAgP patients. In addition towell-recognized periodontal pathogens the presence of highlevels of Filifactor alocis and Desulfobulbus spp. seem to beassociated with GAgP.
Open Access
Multidisciplinary Treatment Approach in a Patient with History of Nasopharyngeal Carcinoma
(2014) DOĞAN, BAŞAK; Yavuz, Atacan; Ağralı, Omer Birkan; Calışkan, Zeynep Lale; Türkaydın, Dilek; Sertgöz, Atilla; Kuru, Bahar; Doğan, Başak
Radiotherapy in NPC patients has side effects on the dentition, which affects quality of life dramatically. This case report presents multidisciplinary dental treatment approach in a 17-year-old male patient with a history of nasopharyngeal carcinoma (NPC), which was treated with chemotherapy and radiotherapy. The adolescent patient applied to dental hospital 4 years after the radiotherapy with aesthetic and functional problems on dentition affecting psychological, social, and physical aspects of his life. The dentition of the patient demonstrated the severe destruction as a devastating side effect of radiotherapy. With a successful multidisciplinary approach, our patient's aesthetics, function, and self-confidence were obtained. Well-established procedures, which include preventative care and maintenance, can reduce the duration and expenses of the treatment and help in challenging the life-long complications of radiotherapy.
Open Access
Different treatment approaches for the localized gingival overgrowths: Case series
(2018-04) DOĞAN, BAŞAK; Ozener, Hafize Ozturk; Kundak, Kubra; Sipahi, Nimet Gul; Yetis, Ece; Dogan, Basak
ABSTRACT Localized gingival overgrowths belong to a common group of lesions designated as focal reactive overgrowths. They occur in response to chronic, low‑grade irritation caused by plaque or any other irritant. They have multifactorial etiopathology but exhibit similar clinical features with slight variations in patient complaints. Success of the lesions’ management depends on formation of healthy contours of the surgical area after excision of lesion and absence of a recurrence. The purpose of case series is to present 6 different cases of localized gingival overgrowths and their management with the following techniques: nonsurgical periodontal treatment, gingivectomy, flap surgery, free gingival graft, gingival unit, and connective tissue graft.
Open Access
Specified Species in Gingival Crevicular Fluid Predict Bacterial Diversity
(PUBLIC LIBRARY SCIENCE, 2010-10-25) DOĞAN, BAŞAK; Asikainen, Sirkka; Dogan, Basak; Turgut, Zeynep; Paster, Bruce J.; Bodur, Aysen; Oscarsson, Jan
Background: Analysis of gingival crevicular fluid (GCF) samples may give information of unattached (planktonic) subgingival bacteria. Our study represents the first one targeting the identity of bacteria in GCF. Methodology/Principal Findings: We determined bacterial species diversity in GCF samples of a group of periodontitis patients and delineated contributing bacterial and host-associated factors. Subgingival paper point (PP) samples from the same sites were taken for comparison. After DNA extraction, 16S rRNA genes were PCR amplified and DNA-DNA hybridization was performed using a microarray for over 300 bacterial species or groups. Altogether 133 species from 41 genera and 8 phyla were detected with 9 to 62 and 18 to 64 species in GCF and PP samples, respectively, per patient. Projection to latent structures by means of partial least squares (PLS) was applied to the multivariate data analysis. PLS regression analysis showed that species of genera including Campylobacter, Selenomonas, Porphyromonas, Catonella, Tannerella, Dialister, Peptostreptococcus, Streptococcus and Eubacterium had significant positive correlations and the number of teeth with low-grade attachment loss a significant negative correlation to species diversity in GCF samples. OPLS/O2PLS discriminant analysis revealed significant positive correlations to GCF sample group membership for species of genera Campylobacter, Leptotrichia, Prevotella, Dialister, Tannerella, Haemophilus, Fusobacterium, Eubacterium, and Actinomyces. Conclusions/Significance: Among a variety of detected species those traditionally classified as Gram-negative anaerobes growing in mature subgingival biofilms were the main predictors for species diversity in GCF samples as well as responsible for distinguishing GCF samples from PP samples. GCF bacteria may provide new prospects for studying dynamic properties of subgingival biofilms.
Open Access
Effect of non-surgical periodontal therapy on salivary melatonin levels
(2022-04-01) YARAT, AYŞEN; DOĞAN, BAŞAK; KURU, LEYLA; KUNDAK K., YARAT A., DOĞAN B., KURU L.
Objective: Melatonin, a hormone secreted predominantly by pineal gland in a circadian manner, has antioxidant and anti-inflammatory effects. The current research is conducted to explore the influence of non-surgical periodontal therapy (NSPT) on levels of salivary melatonin in subjects with gingivitis and periodontitis. Methods: Sixty systemically healthy participants were included in this study; the groups are as follows: gingivitis (G), chronic periodontitis (CP), generalized aggressive periodontitis (GAP) and periodontally healthy (H). NSPT was applied to G group patients for 2 sessions, to CP and GAP group patients for 4 sessions. Plaque and gingival indices, probing depth (PD), bleeding on probing (BOP), and clinical attachment level (CAL) were documented at baseline and 3 months post – treatment and early morning salivary samples were collected. ELISA was used to detect melatonin levels in saliva. Pittsburgh Sleep Quality Index (PSQI) questionnaire was performed to evaluate of sleep quality of patients. Results: At baseline, significant difference in gingival index, PD, BOP and CAL values was detected among all groups (p<0.05). Following NSPT, clinical measurements improved in G, CP, and GAP groups significantly (p<0.05). While salivary melatonin concentration of all groups was similar at baseline (p>0.05), a significant elevation in the level of salivary melatonin was found only in the G group after NSPT (p<0.05). PSQI scores differed significantly among groups (p<0.05). Conclusion: The salivary melatonin levels in the presence of gingivitis and periodontitis varied at baseline and elevated following NSPT parallel to the improvement in clinical parameters.
Open Access
Occurrence and serotype distribution of Aggregatibacter actinomycetemcomitans in subjects without periodontitis in Turkey
(PERGAMON-ELSEVIER SCIENCE LTD, 2016-01) DOĞAN, BAŞAK; Dogan, Basak; Chen, Jason; Ciftlikli, Sinem Yildiz; Huang, Jonathan; Kadir, Tanju; Alniak, Anil Kinaci; Chen, Casey
Objective: To determine the occurrence and serotype distribution of Aggregatibacter actinomycetemcomitans in subjects without periodontitis. Design: Systemically healthy dental students without periodontitis (n = 94), who had not used antibiotics within the last 3 months or received any form of periodontal therapy within the last 6 months, were included in the study. Pooled subgingival microbiological samples were collected from 4 first molars and 4 central incisors in each subject using sterile paper points. All samples were tested for the presence and the serotype of A. actinomycetemcomitans through PCR analysis of the 16S rRNA genes and the serotype-specific gene clusters in the DNA extracted from the samples. Results: Of the 94 samples that were tested, 43 (46%) were positive for A. actinomycetemcomitans. No statistically significant differences in clinical parameters were found between subgingival sites with or without detectable A. actinomycetemcomitans (t-test, P > 0.01). Among the 43 A. actinomycetemcomitans-positive samples, the serotype was identified in 21 samples. Fifteen were positive for A. actinomycetemcomitans serotype a, 1 for serotype b, 1 for serotype c, and 4 for serotype f, while serotypes d and e were not detected. Conclusion: A. actinomycetemcomitans serotype a is the most commonly found serotype among Turkish dental students without periodontitis. (C) 2015 Elsevier Ltd. All rights reserved.
Open Access
Different scaling and root planing strategies in Turkish patients with aggressive periodontitis: A randomized controlled clinical trial
(2022-05-01) DOĞAN, BAŞAK; Mamaklioglu D., Karched M., KURU L., Kuru B., Asikainen S., DOĞAN B.
Objectives The aim of this study was to compare clinical, cytokine and microbiological responses after quadrant-based scaling and root planing (Q-SRP), full-mouth SRP (FM-SRP) and full-mouth disinfection (FMD) in patients with generalized aggressive periodontitis (GAgP), which is currently termed as generalized stage-III and grade-C periodontitis. Methods Forty-two patients with GAgP were randomly assigned into groups as Q-SRP, FM-SRP or FMD with chlorhexidine. Clinical parameters were recorded, and gingival crevicular fluid (GCF) and subgingival plaque samples were collected at baseline, 3 and 6 months after treatment. GCF levels of interleukin (IL)-1 beta and IL-17 were analysed using ELISA. Quantities of six bacterial species were determined using qPCR. Results Clinical parameters improved significantly in all groups at 3 and 6 months (p 6 mm was lower in the FMD than Q-SRP group at 3 and 6 months (p < 0.05). FMD showed significantly higher percentage of pocket closure compared with Q-SRP and FM-SRP at both 3 and 6 months after treatment (p < 0.05). The IL-1 beta levels decreased only in the FMD group (p < 0.05), whereas no changes were found in IL-17 levels in any group. The levels of five out of six bacterial species decreased at 3 and/or 6 months only in the FMD group (p < 0.05). Conclusions The FMD treatment appears to offer superior outcome than Q-SRP and could be the first choice for patients with GAgP.
Open Access
Awareness, knowledge and attitude toward the relationship between periodontal health and pregnancy outcomes among obstetrician-gynecologist healthcare professionals in Turkey: Results of 11th Turkish-German Gynecological Association Congress based survey
(2022-01-01) AĞRALI, ÖMER BİRKAN; DOĞAN, BAŞAK; Turabi R., AĞRALI Ö. B., DOĞAN B.
© 2022 by the Turkish-German Gynecological Education and Research Foundation.Objective: The aim of this study was to evaluate the knowledge and practice behavior of Turkish obstetrician-gynecologists regarding oral healthcare during pregnancy and the association between periodontal disease and adverse pregnancy outcomes. Material and Methods: A cross-sectional study was conducted on randomly selected Turkish obstetrician-gynecologists using a questionnaire consisting of 26 questions during 11th Turkish-German Gynecological Association Congress. Participation in the survey was voluntary. Results: Out of 435 attendees approached, 382 (88%) of the gynecologists at the Congress participated in the written questionnaire. Most of the participants (96.1%) acknowledged a connection between oral health and pregnancy, and 77.5% agreed that periodontal disease may affect the outcome of pregnancy. Moreover, a high proportion of participants were aware of the clinical signs of periodontal diseases, mainly gingival bleeding (92.1%). However, almost 20% of participants thought that dental treatment could be performed safely in the first or last trimester of pregnancy. Only 36.9% of participants recommended guidance on dental examination for their patients during prenatal care. Conclusion: This study demonstrated that Turkish obstetrician-gynecologists have a relatively high degree of knowledge with respect to the relationship between periodontal disease and pregnancy outcomes, but practice behavior was poorly correlated with their knowledge. (J Turk Ger Gynecol Assoc 2022; 23: 275-86).
Open Access
Evaluation of knowledge, anxiety levels and attitudes of dental students about the COVID-19 outbreak different light sources
(2022-01-01) DOĞAN, BAŞAK; SELMAN A. E., DOĞAN B.
Amaç: Bu çalışmanın amacı, Marmara Üniversitesi Diş Hekimliği Fakültesi 5. sınıf öğrencilerinin COVID-19 ile ilgili bilgilerini, kaygı düzeylerini, tutum ve davranışlarını değerlendirmektir. Gereç ve Yöntem: Çalışma için COVID-19 ile ilgili 5 farklı çalışmadan elde edilen 26 soruluk yeni bir anket kullanıldı. Hazırlanan çevrimiçi anket 18 Mart 2021 tarihinde Marmara Üniversitesi Diş Hekimliği Fakültesi kliniklerinde hasta bakan son sınıf öğrencilerine gönderildi. Elde edilen verilerin analizinde SPSS 23.0 paket programı kullanıldı. Bulgular: Çalışmaya Marmara Üniversitesi Diş Hekimliği Fakültesi’nde 5. sınıfta eğitim gören öğrenciler dahil edildi ve öğrencilerin %92,9’u çalışmaya katıldı. Öğrencilerin %80’inden fazlası COVID-19’un hava ve temas yoluyla bulaştığını belirtti. Kliniklerde çapraz enfeksiyon sebepleri ve hastalığın klinikte yayılmasının önlenmesi için uygulanması gereken ek koruyucu önlemler öğrencilerin büyük çoğunluğu tarafından bilinmekteydi. Öğrencilerin COVID-19 ile ilgili bilgileri ve tutumları genel olarak cinsiyete göre farklılık göstermemekteydi (p>0.05). Katılımcıların %77.8’inin COVID-19 ile ilgili bilgilerini haberler aracılığı ile elde ettiği görüldü. Öğrencilerin çoğunluğunun COVID-19 ile ilgili kaygılarının orta düzeyde olduğu görüldü. Sonuç: Diş hekimliği son sınıf öğrencilerinin az da olsa bir kısmının COVID-19 hakkındaki bilgilerinin ve uygulamalarının yetersiz olması risk oluşturan bir durumdur. Öğrencilerin bilgilerinin sürekli güncellenmesi ve kaygı durumlarının kontrol altına alınması gerekmektedir.
Open Access
Treatment of multiple adjacent gingival recessions using leucocyte- and platelet-rich fibrin with coronally advanced flap: a 12-month split-mouth controlled randomized clinical trial
(2024-05-01) KURU, LEYLA; DOĞAN, BAŞAK; Yavuz A., Güngörmek H. S., Kuru L., Doğan B.
Objective: This split-mouth randomized study aimed to assess efficacy of leucocyte-platelet-rich fibrin (L-PRF) versus connective tissue graft (CTG) in achieving root coverage (RC) for multiple adjacent gingival recessions (MAGRs) throughout 12-month period. Materials and methods: The study enrolled 59 teeth from 12 patients with Miller Class I MAGRs ≥ 2 mm on bilateral or contralateral sides. Patients were randomly assigned to receive coronally advanced flap (CAF) with either CTG (control) or L-PRF (test) treatment. Various parameters, including plaque and gingival index, clinical attachment level, recession depth, probing depth, recession width (RW), papilla width (PW), keratinized tissue width (KTW), gingival thickness (GT), percentage of RC, complete root coverage (CRC), and location of the relative gingival margin concerning the cemento-enamel junctions (GMCEJ) after CAF, were recorded at baseline, 3-, 6-, and 12-months post-surgery. On June 29, 2021 the study was registred to ClinicalTrials.gov (NCT04942821). Results: Except KTW and GT gain, all clinical parameters, RC, and CRC were similar between the groups at all follow-up periods (p > 0.05). The higher GT and KTW gains were detected in the control group compared to test group at 12 months (p < 0.05). Both RC and CRC were positively associated with initial PW and GMCEJ, but negatively with initial RW (p < 0.05). Conclusions: The current study concludes that L-PRF were equally effective as CTG in treating MAGRs in terms of RC and CRC. Additionally, RC and CRC outcomes appeared to be influenced by GMCEJ, PW, and RW. Clinical relevance: L-PRF could represent a feasible substitute for CTG in treating MAGRs.