Person: ARICIOĞLU, FEYZA
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
ARICIOĞLU
First Name
FEYZA
Name
16 results
Search Results
Now showing 1 - 10 of 16
Publication Metadata only Harmane induces anxiolysis and antidepressant-like effects in rats(NEW YORK ACAD SCIENCES, 2003) ARICIOĞLU, FEYZA; Aricioglu, F; Altunbas, H; Piletz, JE; Regunathan, S; Ernsberger, PA forced swim test (FST) and an elevated plus maze (EPM) were used to determine antidepressant and anxiolytic effects of harmane in rats in comparison with a known antidepressant, imipramine (30 mg/kg i.p.). Harmane (2.5, 5.0, or 10 mg/kg, i.p.), saline, or imipramine were given 30 minutes before the tests. Administration of harmane decreased the time of immobility in the FST dose-dependently and increased the time spent in open arms in the EPM, as compared with the saline group. As an endogenous substance, harmane therefore has anti-anxiety and antidepressant effects.Publication Metadata only Agmatine reduces only peripheral-related behavioral signs, not the central signs, of morphine withdrawal in nNOS deficient transgenic mice(ELSEVIER IRELAND LTD, 2004) ARICIOĞLU, FEYZA; Aricioglu, F; Paul, IA; Regunathan, SAgmatine inhibits morphine tolerance/dependence and potentiates morphine analgesia. This study was designed to investigate whether neuronal nitric oxide mediates the actions of agmatine in morphine dependence by using mice lacking a functional form of this enzyme. Mice received agmatine just after the morphine pellet implantation for 3 days twice daily or single injection 30 min before naloxone. In both genotypes treated for 3 days with morphine pellets, naloxone administration precipitated clear signs of withdrawal. Both acute and chronic administration of agmatine reduced withdrawal signs in wild type mice and reduced only peripheral signs of morphine dependence in neuronal nitric oxide synthase knockout mice. Withdrawal signs, that are related to central nervous system activity were not affected. These findings indicate that neuronal nitric oxide synthase partly mediates the effects of agmatine in morphine physical dependence. (C) 2003 Elsevier Ireland Ltd. All rights reserved.Publication Open Access Effect of agmatine on the development of morphine dependence in rats: potential role of cAMP system(ELSEVIER, 2004-11) ARICIOĞLU, FEYZA; Aricioglu, F; Means, A; Regunathan, SAgmatine is an endogenous amine derived from arginine that potentiates morphine analgesia and blocks symptoms of naloxone-precipitated morphine withdrawal in rats. In this study, we sought to determine whether treatment with agmatine during the development of morphine dependence inhibits the withdrawal symptoms and that the effect is mediated by cAMP system. Exposure of rats to morphine for 7 days resulted in marked naloxone-induced withdrawal symptoms and agmatine treatment along with morphine significantly decreasing the withdrawal symptoms. The levels of cAMP were markedly increased in morphine-treated rat brain slices when incubated with naloxone and this increase was significantly reduced in rats treated with morphine and agmatine. The induction of tyrosine hydroxylase after morphine exposure was also reduced in locus coeruleus when agmatine was administered along with morphine. We conclude that agmatine reduces the development of dependence to morphine and that this effect is probably mediated by the inhibition of cAMP signaling pathway during chronic morphine exposure. (C) 2004 Elsevier B.V. All rights reserved.Publication Metadata only Effects of harman and harmine on naloxone-precipitated withdrawal syndrome in morphine-dependent rats(2003) ARICIOĞLU, FEYZA; Aricioglu-Kartal, Feyza; Kayir, Hakan; Tayfun Uzbay, I.The effects of the beta-carbolines, harman and harmine, on naloxone-precipitated withdrawal syndrome in morphine-dependent rats were investigated. Two morphine pellets containing 75 mg morphine base were implanted subcutaneously in the scapular area of adult male Wistar rats (200-250 g) under light ether anesthesia. Rats were then assigned to several groups (n = 12 for each group). Seventy-two hours after morphine implantation, harman (5 and 10 mg/kg), harmine (5 and 10 mg/kg) or saline was injected to rats intraperitoneally (ip). After 45 min, a morphine withdrawal syndrome was precipitated by naloxone (2 mg/kg, ip), and morphine withdrawal signs were observed and evaluated for 15 min. Harmine (5 and 10 mg/kg) attenuated significantly the intensity of all signs of morphine withdrawal except for jumping. While jumping behaviour appearing in morphine withdrawal was intensified by harman (5 and 10 mg/kg) treatment, harmine administration did not produce any significant change in the intensity of this sign. Harman attenuated significantly the intensity of wet dog shakes, writhing, defecation, tremor and ptosis. However, it produced no significant changes in the intensity of teeth chattering and diarrhea. Our results suggest that harman and harmine, beta-carbolines, have some beneficial effects on naloxone-precipitated morphine withdrawal syndrome in rats. Findings from the present study also indicated that harmine was more effective than harman on morphine abstinence syndrome.Publication Metadata only Agmatine inhibits naloxone-induced contractions in morphine-dependent guinea pig ileum(NEW YORK ACAD SCIENCES, 2003) ARICIOĞLU, FEYZA; Aricioglu, F; Ercil, E; Dulger, G; Piletz, JE; Regunathan, S; Ernsberger, PThis study investigates the effects of agmatine on naloxone-precipitated withdrawal syndrome in morphine-dependent guinea pig ileum. Male guinea pigs that were starved for 24 hours were decapitated after cervical dislocation, and terminal portions of the ilea were removed. Segments were fixed at a resting tension of 1 g in an organ bath containing 1 x 10(-6) M morphine in Tyrode solution at 37 degreesC, which was bubbled with 95% O-2 and 5% CO2. Tissues were incubated in morphine containing Tyrode solution for 4 hours before agmatine was added. Naloxone and agmatine had no effect on naive ilea. Naloxone (1 X 10-6 M) contracted morphine-dependent ilea. Agmatine significantly inhibited the contractile response to naloxone in a dose-dependent manner (1 X 10(-7) M, 44%; 1 x 10(-6) M, 80%; 1 x 10(-5) M, 95%). This effect of agmatine was partly abolished by pretreatment with yohimbine and was almost completely abolished by idazoxan.Publication Open Access Agmatine attenuates stress- and lipopolysaccharide-induced fever in rats(PERGAMON-ELSEVIER SCIENCE LTD, 2005-06) ARICIOĞLU, FEYZA; Aricioglu, F; Regunathan, SPhysiological stress evokes a number of responses, including a rise in body temperature, which has been suggested to be the result of an elevation in the thermoregulatory set point. This response seems to share similar mechanisms with infectious fever. The aim of the present study was to investigate the effect of agmatine on different models of stressors [(restraint and lipopolysaccaride (LPS)] on body temperature. Rats were either restrained for 4 h or injected with LPS, both of these stressors caused an increase in body temperature. While agmatine itself had no effect on body temperature, treatment with agmatine (20, 40, 80 mg/kg intraperitoneally) dose dependently inhibited stress- and LPS-induced hyperthermia. When agmatine (80 mg/kg) was administered 30 min later than LPS (500 mu g/kg) it also inhibited LPS-induced hyperthermia although the effect became significant only at later time points and lower maximal response compared to simultaneous administration. To determine if the decrease in body temperature is associated with an anti-inflammatory effect of agmatine, the nitrite/nitrate levels in plasma was measured. Agmatine treatment inhibited LPS-induced production of nitrates dose dependently. As an endogenous molecule, agmatine has the capacity to inhibit stress- and LPS-induced increases in body temperature. (c) 2005 Elsevier Inc. All rights reserved.Publication Metadata only Effect of harmane on the convulsive threshold in epilepsy models in mice(NEW YORK ACAD SCIENCES, 2003) ARICIOĞLU, FEYZA; Aricioglu, F; Yillar, O; Korcegez, E; Berkman, K; Piletz, JE; Regunathan, S; Ernsberger, PThe study investigated the activity of harmane on maximal electroshock seizures (MES) and seizures induced by pentilentetrazole (PTZ) in mice. Initial studies established convulsive current 50 (CC50) values or MES and effective dose 50 (ED50) for PTZ to produce seizures. Harmane (2.5, 5.0, or 10 mg/kg intraperitoneally) increased the threshold of seizures in MES dose-dependently. The convulsions produced by PTZ were decreased by the low dose of harmane (2.5 mg/kg), but the high dose of harmane (10 mg/kg) resulted in worse grade V convulsions followed by more lethality compared with PTZ alone. Therefore, harmane seems to be protective against grand mal seizures in the MES model but not against a petit mal seizure model (PTZ) in mice.Publication Metadata only Effect of agmatine on brain L-citrulline production during morphine withdrawal in rats: A microdialysis study in nucleus accumbens(ELSEVIER SCIENCE BV, 2007) ARICIOĞLU, FEYZA; Yananli, Hasan; Goren, M. Zafer; Berkman, Kemal; Aricioglu, FeyzaAgmatine, an endogenous nitric oxide (NO) synthase inhibitor and ligand for imidazoline receptors, has been previously shown to prevent morphine dependence in rats. The present study was designed to investigate No formation in nucleus accumbens core region (NAcc) during naloxone (NL)-precipitated morphine withdrawal in rats treated with agmatine or L-NAME by using intracerebral microdialysis in freely moving rats, through measuring extracellular L-citrulline concentrations, an indirect sign of NO production since equal amounts Of L-citrulline and NO are produced from L-arginine. L-Citrulline levels in the NAcc core did not change following administration of agmatine (40 mg/kg i.p.) or L-NAME (100 mg/kg i.p.) in control rats. Both agmatine and L-NAME attenuated withdrawal symptoms of morphine in NL (2 mg/kg i.p.) -precipitated withdrawal. L-Citrulline levels showing the release of NO increased in morphine-dependent rats during NL-precipitated withdrawal. Agmatine and L-NAME treatments significantly suppressed the increase in L-citrulline levels compared to physiological saline-treated rats in this setting. The results suggest that the release Of L-citrulline in NAcc may be involved in the processes of morphine withdrawal and agmatine as an endogenous inhibitor of NO synthase may be one of the factors involved in the changes in the physiology and behavioral state during opioid withdrawal and may have pharmacological importance. (c) 2006 Elsevier B.V. All rights reserved.Publication Metadata only Effect of harmane on mononeuropathic pain in rats(NEW YORK ACAD SCIENCES, 2003) ARICIOĞLU, FEYZA; Aricioglu, F; Korcegez, E; Ozyalcin, S; Piletz, JE; Regunathan, S; Ernsberger, PThis study was designed to investigate the effect of the endogenous beta-carboline, harmane, on neuropathic pain produced by chronic constriction injury (CCI) of the sciatic nerve. Thermal allodynia evaluations were made preoperatively, postoperatively on the fifteenth day, and after harmane administration. Harmane (1, 2.5, 5, 10, or 20 mg/kg) was administered intraperitoneally for 5 days beginning from postoperative day 15. Treatment with harmane had a profound anti-allodynic effect in a dose-dependent manner. In conclusion, harmane might provide a new approach to treatment of neuropathic pain.Publication Metadata only Effect of agmatine on electrically and chemically induced seizures in mice(NEW YORK ACAD SCIENCES, 2003) ARICIOĞLU, FEYZA; Aricioglu, F; Kan, B; Yillar, O; Korcegez, E; Berkman, K; Piletz, JE; Regunathan, S; Ernsberger, PAgmatine, an amine and organic cation, is formed by the decarboxylation of L-arginine by arginine decarboxylase. It binds to alpha(2)-adrenergic and imidazoline receptors. It blocks N-methyl-D-aspartate (NMDA) subtype of glutamate receptors and inhibits nitric oxide (NO) synthase. Because the importance of NMDA receptors and the NO system are well known in seizure activity, this study was designed to investigate the effect of agmatine on electrically and chemically induced seizures by using maximal electroshock (MES) and pentilentetrazole (PTZ) models in mice. Initial studies established convulsive current 50 (CC50) for MES and effective dose 50 (ED50) for PTZ to produce seizures. Agmatine (20, 40, 80, and 100 mg/kg intraperitoneally) increased the threshold of seizures in MES dose dependently. In PTZ-induced convulsions, the highest dose of agmatine (100 mg/kg) increased the seizure onset time and decreased percent survival. The percentage of grade V seizures was found to be increased by agmatine doses greater than 20 mg/kg.