Publication: Harmane induces anxiolysis and antidepressant-like effects in rats
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Date
2003
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NEW YORK ACAD SCIENCES
Abstract
A forced swim test (FST) and an elevated plus maze (EPM) were used to determine antidepressant and anxiolytic effects of harmane in rats in comparison with a known antidepressant, imipramine (30 mg/kg i.p.). Harmane (2.5, 5.0, or 10 mg/kg, i.p.), saline, or imipramine were given 30 minutes before the tests. Administration of harmane decreased the time of immobility in the FST dose-dependently and increased the time spent in open arms in the EPM, as compared with the saline group. As an endogenous substance, harmane therefore has anti-anxiety and antidepressant effects.
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Keywords
harmane, forced swim test, elevated plus maze, imidazoline, benzodiazepine, monoamine oxidase, BETA-CARBOLINE BINDING, OXIDASE SUBTYPE-A, MONOAMINE-OXIDASE, NORHARMAN, INHIBITOR, AFFINITY, URINE