Person: ARICIOĞLU, FEYZA
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ARICIOĞLU
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FEYZA
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Publication Metadata only Investigation of the protective effect of gel incorporating Eugenia jambolana leaf extract on 5-fluorouracil-induced oral mucositis: an animal study(2022-08-01) BİNGÖL ÖZAKPINAR, ÖZLEM; ARICIOĞLU, FEYZA; AKSOY N., Sen E., Sukmasari S., BİNGÖL ÖZAKPINAR Ö., ARICIOĞLU F., YÜCEL Y. Y., Dumlu M. R., Doolaanea A. A., AbdulRahman M. N., OLGAÇ N. V., et al.Purpose The study aimed to evaluate the possible preventive effect of two concentrations (3 and 5% w/w) of Eugenia jambolana (EJ) extract against 5-FU-induced mucositis. Method Sixteen adult rats were separated into four groups: two control and two preventive groups. Animals in Groups 1, 2, and 3 were injected intraperitoneally with 60 mg/kg/day of 5-FU on Day 1 followed by 150 mg/kg/day on Day 5. The rats in Group 4 (negative control) were given physiological saline at the same times and doses. Furthermore, on the fifth day of the study, the cheek and sublingual mucosa were irritated by external superficial scratches using the tip of an 18-G needle, followed by the application 15 mu L of 20% acetic acid, after which 3 and 5% EJ w/w gels were applied topically for animals in Groups 2 and 3, respectively. Results The weight and the mucositis scores were recorded. Antioxidant and anti-inflammatory markers and biochemical tests were analyzed. Significant differences were found between the study groups in weight loss, clinical mucositis scores, mortality rates, and antioxidant and anti-inflammatory parameters. Conclusion The preventive effect of 3% gel was significant, with no mortality rate, making it an option for preventive strategies.Publication Metadata only Anti-inflammatory properties of brilliant blue G on chronic unpredictable mild stress-induced changes in rat hippocampus(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017) ARICIOĞLU, FEYZA; Aricioglu, F.; Bastaskin, T.; Kandemir, C.; Sirvanci, S.; Ozkartal, C.; Utkan, T.Publication Metadata only Harmane induces anxiolysis and antidepressant-like effects in rats(NEW YORK ACAD SCIENCES, 2003) ARICIOĞLU, FEYZA; Aricioglu, F; Altunbas, H; Piletz, JE; Regunathan, S; Ernsberger, PA forced swim test (FST) and an elevated plus maze (EPM) were used to determine antidepressant and anxiolytic effects of harmane in rats in comparison with a known antidepressant, imipramine (30 mg/kg i.p.). Harmane (2.5, 5.0, or 10 mg/kg, i.p.), saline, or imipramine were given 30 minutes before the tests. Administration of harmane decreased the time of immobility in the FST dose-dependently and increased the time spent in open arms in the EPM, as compared with the saline group. As an endogenous substance, harmane therefore has anti-anxiety and antidepressant effects.Publication Metadata only Agmatine reduces only peripheral-related behavioral signs, not the central signs, of morphine withdrawal in nNOS deficient transgenic mice(ELSEVIER IRELAND LTD, 2004) ARICIOĞLU, FEYZA; Aricioglu, F; Paul, IA; Regunathan, SAgmatine inhibits morphine tolerance/dependence and potentiates morphine analgesia. This study was designed to investigate whether neuronal nitric oxide mediates the actions of agmatine in morphine dependence by using mice lacking a functional form of this enzyme. Mice received agmatine just after the morphine pellet implantation for 3 days twice daily or single injection 30 min before naloxone. In both genotypes treated for 3 days with morphine pellets, naloxone administration precipitated clear signs of withdrawal. Both acute and chronic administration of agmatine reduced withdrawal signs in wild type mice and reduced only peripheral signs of morphine dependence in neuronal nitric oxide synthase knockout mice. Withdrawal signs, that are related to central nervous system activity were not affected. These findings indicate that neuronal nitric oxide synthase partly mediates the effects of agmatine in morphine physical dependence. (C) 2003 Elsevier Ireland Ltd. All rights reserved.Publication Metadata only Harmane suppresses microglial neuroinflammatory response and induce antidepressant-like effect in rats(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017) ARICIOĞLU, FEYZA; Aricioglu, F.; Arkan, G.; Kandemir, C.; Sirvanci, S.; Ozkartal, C.; Utkan, T.Publication Metadata only Neuroprotective effects of agmatine in antineoplastic drugs induced neurotoxicity: In vitro study(PERGAMON-ELSEVIER SCIENCE LTD, 2019) ARICIOĞLU, FEYZA; Binnetoglu, Damla; Hacimuftuoglu, Ahmet; Aricioglu, FeyzaAims: The effects of agmatine, an endogenous substance known to have a neuroprotective effect against neurotoxicity has been investigated. Material and methods: The primary neuron culture obtained from neonatal rats was exposed to toxicity with paclitaxel and cisplatin and the effect of agmatine on both acute (1 h) and chronic (24 h) exposure was demonstrated by biochemical and molecular analyses. It was demonstrated that the effect of agmatine before and after agmatine was induced by neurotoxicity before agmatine and the effect of agmatine on the formed and occuring toxicities. In addition to the results of cell viability assay, total oxidant capacity and total antioxidant capacity, we have found the opportunity to elaborate on our molecular mechanisms by elaborating our findings with apoptotic and inflammation markers such as caspase 3, kaspase 9 and TNF alpha. Key findings: The results of our study revealed the effect profile of a protective molecule against pathological neural deaths due to neurodegeneration not only in neurotoxicity due to anticancer drugs. Significance: In this context, we tried to reverse neurotoxicity due to anticancer drugs by using agmatine the duration (1 and 24 h) and dosage (10-5M and 10-6 M) determined.Publication Metadata only Effect of agmatine on long-term changes induced by early developmental stressors in maternal separation model of depression/anxious-like behaviors(ELSEVIER, 2019) ARICIOĞLU, FEYZA; Zortul, H.; Yilmaz, B.; Aricioglu, F.Publication Metadata only Effects of agmatine on Akt/GSK-3beta/betacatenin signaling pathway in SH-SY5Y cell culture: Relevance to schizophrenia(ELSEVIER SCIENCE BV, 2019) ARICIOĞLU, FEYZA; Unal, G.; Aricioglu, F.; Dokumaci, A. H.; Yerer-Aycan, M. B.; Ozkartal-Sahin, C.Publication Metadata only Unmet needs in psychiatry and emerging novel pharmacological agents(KURE ILETISIM GRUBU A S, 2013) ARICIOĞLU, FEYZA; Cetin, Mesut; Aricioglu, FeyzaDespite huge amount of efforts and resources spent to improve the pharmacotherapeutic tools to treat major psychiatric disorders such as depression and schizophrenia, there still exist unmet needs in the field. Treatment resistance, non-adherence, and severe adverse effects such as diabetes mellitus type II, extrapyramidal side effects, etc. are among the unmet needs commonly faced by clinicians, probably due to the fact that the pathophysiology of both schizopherenia and depression have not been fully elucidated. Today, neither the monoamine hypothesis of depression nor the dopamine hypothesis of schizophrenia explains either disorder in full. In spite of its widespread presence throughout the brain, the glutamatergic system has remained almost unexplored with respect to drug discovery for psychiatric illnesses. Recently, the promising outcomes of intravenous use of ketamine to overcome resistance to antidepressant treatment and the administration of a nitroprusside infusion to address resistance to antipsychotics in the treatment of schizophrenia have drawn attention to the glutamatergic system.Publication Metadata only Antipsychotics: Neurobiological Bases for a Therapeutic Approach(KURE ILETISIM GRUBU A S, 2013) ARICIOĞLU, FEYZA; Gumru, Salih; Aricioglu, FeyzaStudies on the pathophysiology of schizophrenia have become an adventure. It started with a simple pathological approach, focusing only on positive symptoms caused by dopaminergic hyperactivity in mesolimbic system and then branched out with contributions of many different components, including many receptors, various intracellular signaling pathways and gene-environment interactions. These new approaches have been useful in treating the negative symptoms and cognitive impairment observed in schizophrenia. Since there is a bulk of information on the mechanisms causing the disease, a proportional increase in the number of possible new treatment options has been proposed.The most challenging approaches in the disease mechanism address the glutamatergic system, neuroinflammation, neuroplasticity and neurotrophic factors, genetic factors and some intracellular signaling pathways. In this review, all of the above listed factors are discussed in detail.