Person: ÖZKAN YENAL, NAZİYE
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ÖZKAN YENAL
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NAZİYE
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Publication Metadata only The effect of carnitine against acrylamide-induced toxicity in rat lung and liver tissues(ELSEVIER IRELAND LTD, 2016) GÜÇLÜ, HÜLYA; Aydemir, S.; Guclu, H.; Ozkan, N.; Yuksel, M.; Erdogan, N.; Omurtag, G. Z.Publication Metadata only The protective role of UMCA on bleomycin-induced lung fibrosis in rats(2022-11-05) AYDEMİR, SEZGİN; ÖZKAN YENAL, NAZİYE; GÜÇLÜ, HÜLYA; YÜKSEL, MERAL; ÖZBEYLİ, DİLEK; AYDEMİR S., ÖZKAN YENAL N., GÜÇLÜ H., YÜKSEL M., ÖZBEYLİ D., ERDOĞAN N.Bleomycin (BLM), an antibiotic drug, is used for the treatment of cancers like Hodgkin’s lymphoma, Kaposi’s sarcoma and cervical cancer. The most common adverse effects occurred during BLM treatment is lung toxicity, which manifest as fibrosis. UMCA® (Pelargonium sidoides root extract) is a commercial product to treat acute and chronic upper respiratory tract infections. UMCA® has antiviral, antibacterial, immunomodulatory and cytoprotective properties, which is related to its polyphenol, coumarin, anthocyanidin and flavonoid contents. In the present study, we aimed to investigate the possible protective effects of UMCA® on BLM induced lung fibrosis in rats. Wistar albino rats was included in this study and randomly divided into 4 groups (Control, BLM, BLM+UMCA and UMCA). The control group received physiological saline. UMCA® was orally applied at a dose of 200 mg/kg/day and single intratracheal administration of BLM was conducted at a dose of 10 mg/kg. All animals were decapitated after 10 days and lung tissues was removed for the biochemical and histopathological examinations. Malondialdehyde (MDA) and glutathione (GSH) levels and Myeloperoxidase (MPO) activity were determined. Chemiluminescence (CL) method using luminol and lucigenin probes, additional nitric oxide and peroxynitrite measurements were applied. Histopathological observations were analyzed with H&E and Gomori's one-step trichrome staining. Collagen contents of lung tissue were also determined with a spectrophotometric method in paraffin-embedded tissues. BLM elevated MDA levels and MPO activity and depleted GSH levels in the lung tissues (p<0.001). CL measurement levels were also increased in BLM group respect to the control. Contrary to this, UMCA® treatment reversed these effects, significantly (p<0.001). BLM caused alveolar structural disturbance and inflammatory cell infiltrations and collagen content was also significantly increased in BLM group compared to the control (65.7±10.6, p<0.001). UMCA® administration reduced degenerations and decreased collagen content in the lung tissue. In conclusion, UMCA® has an antioxidant and protective effects on BLM induced lung fibrosis in rats.Publication Metadata only Myrtus communis leaf extract protects against cerulein-induced acute pancreatitis in rats(WILEY, 2020) ŞEN, ALİ; Ozbeyli, Dilek; Sen, Ali; Kaya, Ozlem Tugce Cilingir; Ertas, Busra; Aydemir, Sezgin; Ozkan, Naziye; Yuksel, Meral; Sener, GokselIn this study, the aim was to examine the potential protective effects of Myrtus communis subsp. communis leaf ethanol extract (MC) treatment against acute pancreatitis (AP) in rats. Thirty-two rats were grouped as the saline-pretreated control (C), MC-pretreated control (MC), saline-pretreated AP (AP), and MC-pretreated AP (MC + AP) groups. To induce AP, cerulein was administered (50 mu g/kg) two times. The rats were given MC for 14 days before cerulein injection. Six hours after the final cerulein injection, the rats were sacrificed. Pancreatic damage was associated with an increase in the serum activity of lipase and amylase, the pancreatic activity of myeloperoxidase, and the pancreatic level of malondialdehyde, interleukin-1 beta, and interleukin-6. AP also led to a decrease in the pancreatic level of anti-inflammatory interleukin-10 and glutathione. Pretreatment with MC before the induction of AP significantly reduced the pancreatic damage observed during the histological examination as well as reversed the biochemical changes evoked by AP. Practical applications Acute pancreatitis is characterized by high mortality (average about 5%; severe cases may reach about 30%). The current treatment for acute pancreatitis is mainly symptomatic. The introduction of herbal drugs may lead to the development of a new strategy in the treatment of this disease. This study revealed that MC reduced pancreatic injury by decreasing pro-inflammatory cytokines, increasing antioxidant capacity and anti-inflammatory cytokine, IL-10. To the authors' knowledge, this research is the first report showing that MC inhibits the development of AP. This observation suggests that MC may be useful in the prevention and the treatment of AP in clinical settings.Publication Open Access Evaluation of the wound healing potential of Aloe vera-based extract of Nerium oleander(KARE PUBL, 2017) YÜKSEL, MERAL; Akgun, Sevcan Gul; Aydemir, Sezgin; Ozkan, Naziye; Yuksel, Meral; Sardas, SemraOBJECTIVE: Nerium oleander (Apocynaceae) and Aloe vera (Liliaceae) are among the widely used herbal remedies for treating skin diseases and possess numerous activities such as antibacterial, antiviral, antifungal, and antioxidant. The aim of this study was to investigate the possible wound healing effect of Aloev era-based extract of the N. oleander leaf (NAE-8 (R)) based on its antioxidant, anti-inflammatory, and DNA repair capacity along with histological changes and to compare them with the traditional silver sulfadiazine treatment (SSD). METHODS: Twenty-four Wistar albino rats were randomly grouped as follows: i) control, ii) burn alone (burn), iii) burn with topical NAE-8 (R) (burn+ NAE-8 (R)) treatment, and iv) burn with topical 1% silver sulfadiazine (burn+ SSD) treatment. All groups received their related topical application twice a day for 14 consecutive days. Upon completion of the experimental protocol, trunk blood and skin tissues were collected for measuring malondialdehyde (MDA), glutathione (GSH), myeloperoxidase (MPO), tumor necrosis factor alpha (TNF-a), interleukin-1 beta (IL-1 beta), % DNA in the tail (% DNAT) levels along with histological examinations. RESULTS: Thermal injury-induced alterations in MDA, GSH, MPO, TNF-a, IL-1 beta, and % DNAT levels were significantly reversed by NAE-8 (R) treatment. These ameliorative effects were also supported by histological findings. CONCLUSION: Findings of the present study suggest that NAE-8 (R) is a promising remedy for treating skin burn injury.