Person: GÜRBÜZ, BURÇAK
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GÜRBÜZ
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BURÇAK
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Publication Metadata only Cinsel yolla bulaşan enfeksiyonlar konusunda ne kadar bilgiliyiz(2016-11-05) GÜRBÜZ, BURÇAK; Yeşil S., Gürbüz B.Cinsel yolla bulaĢan enfeksiyonlar (CYBE) sadece geliĢmekte olan ülkelerde değil tüm dünyada insan sağlığını büyük ölçüde tehdit eden baĢlıca sağlık sorunlarından biridir. Toplumların yanlıĢ bilgilendirilmeleri sonucu bu enfeksiyonların sağaltımında güçlükler yaĢanmaktadır. Bu çalıĢmada; Ġstanbul ili Bağcılar 6 no‟lu Aile Sağlığı Merkezi‟nde 2016 yılı mart ve nisan aylarında, gönüllü 87 kiĢiye yüz yüze anket uygulanmıĢ ve CYBE konusunda gönüllülerin bilgi düzeyleri değerlendirilmiĢtir. Anket sorularına verdikleri cevaplar sonucu çalıĢmamıza katılan gönüllülerin % 55.6‟sının CYBE konusunda bilgi sahibi oldukları belirlenmiĢtir. ÇalıĢmamızın sonucuna göre; CYBE ve cinsel sağlık eğitimi konularında eğitim programları geliĢtirilip yaygınlaĢtırılmalı ve böylece toplumun bilgi düzeyinin arttırılması sağlanmalıdır.Publication Open Access Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity(2022-01-01) TOK, FATİH; GÜRBÜZ, BURÇAK; KAYMAKÇIOĞLU, BEDİA; TOK F., Doğan M. O. , GÜRBÜZ B., Koçyiğit-Kaymakçioğlu B.© 2022 Marmara University Press.In this study, new nine pyrazoline derivatives were synthesized from chalcone derivatives. The antimicrobial activity of nine pyrazoline derivatives to four standard bacterial strains (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis) and four standard yeast strains (Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis) was investigated by the microdilution method for in accordance with the Clinical and Laboratory Standards Institute (CLSI) standard, and the Minimal Inhibitory Concentration (MIC) values of these derivatives were determined. Among these derivatives; compounds 7 and 8 against bacterial strains and compounds 2 and 3 against yeast strains exhibited good antimicrobial activity.Publication Metadata only Synthesis and antimicrobial evaluation of new pyrazoline derivatives(2022-05-28) GÜRBÜZ, BURÇAK; TOK, FATİH; Tok F., Gürbüz B.Publication Metadata only Bazı Sülfonamid Türevlerinin Standart Bakteri Kökenlerine Karşı Antibakteriyel Etkileri(2020-12-20) GÜRBÜZ, BURÇAK; Gürbüz B., Türkmen C.Publication Open Access The cytotoxicity and the antimicrobial activities of arum italicum miller(2022-01-01) GÜRBÜZ, BURÇAK; Ulusoylu M., GÜRBÜZ B.© 2022 Marmara University Press.In this study, the cytotoxicity potential and antibacterial and antifungal activities of two different extracts of fresh leaves of Arum italicum Miller were investigated. The saponin extract and the alkaloid extract were investigated by Brine Shrimp (Artemia salina L.) lethality bioassay method for evaluation of cytotoxic effect. Umbelliferone was used as standard, and both of the extracts showed cytotoxic effect by the Brine Shrimp (Artemia salina L.) lethality bioassay method. According to the LC50 results, saponin extract was found to be the most active extract, and classifiable as moderate to highly toxic (LC50 237.1437 mg/mL-1). Although, the alkaloid extract was showed cytotoxic activity lower than Umbelliferone, LC50 750.1920 mg/mL-1 value was classifiable as mildly cytotoxic. Antibacterial and antifungal activities were tested by the agar well diffusion and tube dilution methods. 6 bacteria and 6 yeasts were used in the methods Meropenem and Fluconazole were the standards of the methods. The saponin extract was found to be effective against Staphylococcus epidermidis and Sthaphylococcus aureus compared with Meropenem. Both of the extracts were not found to be effective against fluconazole as antifungal activity point of view. According to the all studied activity results the saponin contents of the fresh leaves of the plant emphasizing the antimicrobial activity. And, both of the extracts have cytotoxic activity potential.