Person: FİLİNTE, DENİZ
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FİLİNTE
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DENİZ
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Publication Open Access Atypical Cell'' Parameter in Automated Urine Analysis for the Diagnosis of Bladder Cancer: A Retrospective Pilot Study(GALENOS YAYINCILIK, 2020-04-01) FİLİNTE, DENİZ; Tinay, Ilker; Sahin, Bahadir; Saracoglu, Sertac; Yanilmaz, Ozgur; Aksu, Mehmet Burak; Ayas, Ramazan; Filinte, Deniz; Cam, Haydar Kamil; Ilki, ArzuObjective: To evaluate the application of an automated urine analyzer (AUA) for the diagnosis of bladder cancer (BC) Materials and Methods: A retrospective data analysis of 2365 urine specimens from the department of urology has been performed and matched with those patients, who have undergone cystoscopic evaluation or surgical treatment for different urological pathologies during 2018. After matching, clinical records of the patients has been further evaluated in order to select patients with recent or previous BC diagnosis. To assess the diagnostic efficacy of AUA, patients were divided into five groups according to the patient history of BC and healthy controls. Results: A total of 106 patients are included in this study and the majority (69.8%) of the patients are follow-up patients with previous diagnosis and treatment of non-muscle invasive BC (NMIBC). For patients with low-risk NMIBC (n=27), the sensitivity and specificity were calculated as 75% and 100%. For patients with high-risk NMIBC (n=47), who were previously treated with intravesical BCG, the sensitivity and specificity were calculated as 54.5% and 83.3%. All patients in radical cystectomy group (n=7) with muscle invasive BC had positive urine analyses results for atypical cells. And none of the patients in the control group (n=8) had positive AUA results and cystoscopic evaluation also did not show any bladder mass suspicious for BC. Conclusion: The results of this retrospective pilot study showed acceptable sensitivity and specificity rates of the fluorescence flow cytometry based AUA and the results of the low-risk group are especially valuable regarding its potential use to decide on performing a follow-up cystoscopy or not. A prospective study is currently on progress to validate the findings of the current study.Publication Open Access Risk factors of patients with prostate cancer upgrading for international society of urological pathology grade group I after radical prostatectomy(2022-01-01) ÖZGÜR, GÜNAL; FİLİNTE, DENİZ; ÇAM, HAYDAR KAMİL; ÖZGÜR A., ÖZGÜR G., ŞAHİN B., FİLİNTE D., TİNAY İ., ÇAM H. K., TÜRKERİ N. L.Objective: This study aimed to determine the predictive factors for patients whose International Society of Urological Pathology (ISUP) score was upgraded in radical prostatectomy (RP) pathologies with a prostate biopsy pathology of ISUP grade group 1. Materials and Methods: Among patients who underwent RP in our clinic within 10 years, 158 patients with prostate biopsy pathology of ISUP grade group 1 were examined retrospectively. Age, serum prostate-specific antigen (PSA) level, prostate biopsy ISUP grade group, number of cores taken in the prostate biopsy, number of tumor-positive cores, RP pathology ISUP grade group, and pathological stage were evaluated. Results: The mean age (± standard) of the 158 patients whose prostate biopsy pathology was ISUP grade group 1 were 64.07 (±6.6). ISUP group upgrading was detected in 47 patients (29.7%). The mean PSA value of these patients was 10.6 ng/mL (±6.9). The mean PSA value of the other 111 patients without ISUP group upgrading was 7.98 ng/mL (±4.9). The serum PSA level was significantly higher in patients with upgraded ISUP in the RP pathology (p=0.02). The percentage of tumor-positive cores in the group with ISUP group upgrading (37%) was significantly higher than that in the group without ISUP group upgrading (27%) (p=0.01). The detection rates of surgical margin positivity (42.6% vs. 18%), capsule invasion (55.3% vs. 19.8%), and seminal vesicle invasion (23.6% vs. 3.6%) were also significantly higher in the upgraded ISUP group after RP (p<0.05). Conclusion: The results of this trial suggest that active surveillance may not be an appropriate option for patients with biopsy ISUP grade group 1 with PSA level >10 ng/mL. Moreover, the presence of a higher number and percentage of tumor-positive cores constituted risks of ISUP group upgrading with concomitant poor pathological outcomes such as surgical margin positivity, capsule invasion, and seminal vesicle invasion.Publication Open Access The Intensity of PLA2R and C4d_x000D_ Immunoexpression in Primary_x000D_ Membranous Nephropathy(2019) FİLİNTE, DENİZ; Deniz FİLİNTE;Hakkı ARIKAN;Mehmet KOÇ;Handan KAYA;İshak Çetin ÖZENER;Gamze AKBAŞObjective: Antibodies against the phospholipase A2 receptor (PLA2R) on podocyte membranes result in the formation of immune complexes that cause loss of function of theglomerular basement membrane in primary membranous nephropathy (PMN). It has alsobeen demonstrated that there is a deposition of complement 4d (C4d) in the glomeruli inPMN. The present study aims to evaluate PLA2R and C4d immunoexpressions in PMN casesand search the correlation with the clinical parameters.Methods: In this study, clinicopathological data and paraffin-embedded specimens werecollected from 51 patients. The formalin-fixed paraffin-embedded tissues were stained usingroutine hematoxylin-eosin, periodic acid-Schiff, and silver methenamine stains and immunostained for anti-PLA2R and C4d. Ten normal kidney tissues and 10 focal segmental glomerulosclerosis (FSGS) cases were selected as controls for PLA2R and C4d immunoexpression.Results: Of the PMN cases, 51 (100%) cases were positive for PLA2R, including 15 (29%)cases that scored 2+, and 36 (71%) cases that scored 3+. Forty of the 51 cases (78%) werepositive for C4d. The percentages of cases staining positively for C4d, per scoring group,were as follows: 31 (61%) cases faintly (1+) positive and 9 (18%) cases moderately (2+)positive. No strong positivity was observed. All of the control cases (100%) were negativefor PLA2R and C4d. There was no statistically significant difference between the intensity ofthe staining of PLA2R and the staining of C4d, proteinuria levels, creatinine levels, and complement 3 (C3) positivity. Similarly, there was no statistically significant difference betweenthe intensity of the staining of C4d and proteinuria levels, creatinine levels, and C3 positivity.Conclusion: Immunohistochemical detection of PLA2R and C4d is a safe and easy methodfor the diagnosis of PMN. In cases where fresh tissue is not available for the detection of IgGand C3 using the immunofluorescence method, positivity for PLA2R and C4d with immunohistochemistry may be beneficial for the diagnosis of PMN.Publication Open Access Histopathologic and spectrometric evaluation of bony components of synostotic suture and parietal bone in children with sagittal synostosis(2023-01-01) FİLİNTE, DENİZ; CICEK C., FILINTE G., HICDONMEZ T., AMUTKAN MUTLU D., FİLİNTE D., SULUDERE Z.AIM: To understand the characterization of the ossification process both in the synostotic suture, and the adjacent parietal bone. MATERIAL and METHODS: The surgical procedure for the 28 patients diagnosed with sagittal synostosis consisted of removing the synostotic bone as a whole, if possible, \"Barrel–Stave\" relaxation osteotomies, and strip osteotomies to the parietal and temporal bones perpendicular to the synostotic suture. The synostotic (group I) and parietal (group II) bone segments are obtained during osteotomies. Atomic absorption spectrometry was used to determine the amount of calcium in both groups, which is an indicator of ossification. Scanning electron microscopy and immunohistochemistry were employed to assess trabecular bone formation, osteoblastic density, and osteopontin, which is one of the in vivo indicators of new bone formation. RESULTS: Histopathologically, trabecular bone formation scores did not indicate any significant difference between the groups. However, the osteoblastic density and calcium accumulation in group I were higher than those in group II, and the difference was significant. Osteopontin staining scores in cells showing membranous and cytoplasmic staining with osteopontin antibodies significantly increased in group II. CONCLUSION: In this study, we found reduced differentiation of osteoblasts despite their increase in number. Moreover, the osteoblastic maturation rate was low in synostotic sutures, bone resorption becomes slower than new bone formation, and the remodeling rate is low in sagittal synostosis.Publication Open Access Catastrophic antiphospholipid syndrome accompanied by complement regulatory gene mutation(2023-03-01) GÖKCE, İBRAHİM; DEMİRCİ BODUR, ECE; ÇİÇEK DENİZ, NESLİHAN; SAK, MEHTAP; FİLİNTE, DENİZ; ALPAY, HARİKA; Pul S., GÖKCE İ., DEMİRCİ BODUR E., Guven S., ÇİÇEK N., SAK M., Turkkan O. N., FİLİNTE D., Pehlivanoglu C., Sozeri B., et al.Background. Antiphospholipid syndrome (APS), particularly the catastrophic antiphospholipid syndrome (CAPS), is one of the rare causes of thrombotic microangiopathy (TMA). CAPS is the most severe form of APS, especially when accompanied by complement dysregulation, causes progressive microvascular thrombosis and failure in multiple organs. In this report, a case of CAPS with TMA accompanied by a genetic defect in the complement system is presented.Case. A 13-year-old girl was admitted to the hospital with oliguric acute kidney injury, nephrotic range proteinuria, Coombs positive hemolysis, refractory thrombocytopenia, a low serum complement C3 level and anti-nuclear antibody (ANA) positivity. The kidney biopsy was consistent with TMA. She was first diagnosed with primary APS with clinical and pathological findings and double antibody positivity. As initial treatments, plasmapheresis (PE) was performed and eculizumab was also administered following pulse -steroid and intravenous immunoglobulin treatments. Her renal functions recovered and she was followed up with mycophenolate mofetil, hydroxychloroquine, low dose prednisolone and low molecular weight heparin treatments. The patient presented with severe chest pain, vomiting and acute deterioration of renal functions a few months after the diagnosis of TMA. A CAPS attack was considered due to radiological findings consistent with multiple organ thrombosis and intravenous cyclophosphamide (CYC) was given subsequent to PE. After pulse CYC and PE treatments, her renal functions recovered, she is still being followed for stage-3 chronic kidney disease. Complement factor H-related protein I gene deletion was detected in the genetic study.Conclusions. The clinical course of complement mediated CAPS tends to be worse. Complement system dysregulation should be investigated in all CAPS patients, and eculizumab treatment should be kept in mind if detected.Publication Open Access The Determination of Normal Percentages of Syncytiotrophoblastic Knots in Various Regions of Placenta: Where to Count the Syncytial Knots(DE GRUYTER POLAND SP ZOO, 2014) FİLİNTE, DENİZ; Cigercuigykkaru, Engin; Filinte, Deniz; Toz, Emrah; Avci, Ibrahim; Erdem, Baki; Eminli, Itibar; Ozgur, TanerObjective: The marginal, basal and subchorial regions of the placenta are considered to be more hypoxic than other regions. Therefore, it is not recommended to determine the increase in syncytiotrophoblast knots, based on the major morphological change in placental hypoxia, from the samples taken from these regions. However, the normal count of knots at various regions of placenta is not investigated. Material and Method: In this study we have sampled morphologically and clinically normal placenta with eccentric cord insertion from various sites, either close to cord entrance or away from it (marginal, non-marginal basal, non-marginal subchorial, and nonmarginal midparanchymal). The number of knots was calculated on a total of at least 100 villi for each placental sample. The normal amount of knots in different regions and comparison between them were investigated. Twenty-eight placentas with eccentric cord insertion were sampled in the same manner. Hot spots from the above mentioned regions were counted in a total of 100 villi. Results: No significant difference was found between the dual comparison of the mean percentages of different regions (p: 0.148). The variety of hypoxia in different regions of the placenta could not be demonstrated in this study. Conclusion: It is found that there is no difference in perfusion that can be morphologically demonstrated with increase in syncytiotrophoblast knot, between different regions of placenta.Publication Open Access Polyarteritis nodosa in case of familial Mediterranean fever(TURKISH J PEDIATRICS, 2018) FİLİNTE, DENİZ; Gokce, Ibrahim; Altuntas, Ulger; Filinte, Deniz; Alpay, HarikaFamilial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent self-limited attacks of fever accompanied by peritonitis, pleuritis, and arthritis. Protracted febrile myalgia syndrome (PFMS) is a rare form of vasculitic disease which is an uncommon dramatic manifestation of FMF, characterized by severe crippling myalgia and high fever. Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis affecting medium or small arteries. It is rarely observed in children, but its incidence increases in the presence of FMF. In this article we described a 14-yea-old child diagnosed with FMF associated with PAN. Physicians should be aware of this possible association.Publication Open Access Renal Amyloidosis Secondary to Dystrophic Epidermolysis Bullosa: A Case Report and Review of Literature(2020-10-20) VELİOĞLU, ARZU; Division of Nephrology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey; Barutcu Atas, Dilek; Aykent, Mahmut Basar; Division of Nephrology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey; Arikan, Izzet Hakki; Division of Nephrology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey; Asicioglu, Ebru; Division of Nephrology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey; Velioglu, Arzu; Division of Nephrology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey; Filinte, Deniz; Department of Pathology, Marmara University School of Medicine, Istanbul, Turkey; Koc, Mehmet; Division of Nephrology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey; Serhan Tuglular, Zubeyde; Division of Nephrology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey; Ozener, Ishak Cetin; Division of Nephrology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, TurkeyPublication Open Access Multilocular Cystic Renal Neoplasm of Low Malignant Potential: Alterations in the 2016 Renal Tumor Classification of World Health Organization(GALENOS YAYINCILIK) FİLİNTE, DENİZ; Filinte, Deniz; Tinay, Ilker