Person: KESİM, SELİN
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KESİM
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SELİN
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Publication Open Access Langerhans Hucreli Histiyositoz Tanili Hastada Soliter Kemik Lezyonunun Takibinde Kemik Sintigrafi ve SPECT/BT'nin Rolu(GALENOS YAYINCILIK, 2021-10-01) TUROĞLU, HALİL TURGUT; Kesim, Selin; Turoglu, Halil Turgut; Inanir, Sabahat; Ozguven, Salih; Erdil, Tanju YusufLangerhans' cell histiocytosis (LCH) is a rare disease observed in childhood characterized by the proliferation of Langerhans' cells resulting in focal or systemic manifestations (including the bones). Here, we present a pediatric case with a localized biopsy-proven LCH, who underwent progression from solitary to multifocal form detected on bone scintigraphy and single photon emission computerized tomography/computed tomography (SPECT/CT) performed within four months. Emphasizing on localized bone pain (predictive of osseous LCH) and local tenderness and swelling usually guides the nuclear physician to perform additional SPECT/CT with presumably an improvement of the diagnostic accuracy as demonstrated in our case.Publication Open Access Unexpected radiation pneumonitis after SIRT with significant decrease in DLCO with internal radiation exposure: a case report(BMC, 2020-12) TÜRELİ, DERYA; Kesim, Selin; Ones, Tunc; Eryuksel, Emel; Baltacioglu, Feyyaz; Tureli, Derya; Ozguven, Salih; Erdil, Tanju YusufBackground In the last years, Selective Internal Radiation Therapy (SIRT), using biocompatible Yttrium-90 (90Y) labeled microspheres have emerged for the treatment of malignant hepatic tumors. Unfortunately, a significant part of 90Y-labeled microspheres may shunt to the lungs after intraarterial injection. It can be predictable by infusing technetium-99 m-labeled macro-aggregated albumin particles through a catheter placed in the proper hepatic artery depending on the lobe to be treated with performing a quantitative lung scintigraphy. Radiation pneumonitis (RP) can occur 1 to 6 months after the therapy, which is a rare but severe complication of SIRT. Prompt timing of steroid treatment is important due to its high mortality rate. On the other hand, pulmonary diffusion capacity measured by carbon monoxide (DLCO) is an excellent way to measure the diffusing capacity because carbon monoxide is present in minimal amount in venous blood and binds to hemoglobin in the same manner as oxygen. Some authors reported that the most consistent changes after radiation therapy (RT) are recorded with this quantitative reproducible test. The relationship between the proportional reductions in DLCO and the severity of RP developing after this therapy may prove to be clinically significant. Case presentation We herein present a patient who developed RP after SIRT that could be quantified using DLCO. To the best of our knowledge, this case is the first who developed unexpected RP after SIRT with significant decrease in DLCO with internal radiation exposure. Conclusions RP is a very rare complication and may lead to a fatal outcome. Decline in DLCO could be a valuable parameter for follow-up and to identify potential candidates for RP and could be also another trigger for administration of steroid therapy with prompt timing in this patient group.Publication Open Access Lhermitte-duclos disease related with cowden syndrome mimicking metastatic lung cancer on FDG PET/CT(2023-02-01) KESİM, SELİN; KESİM S., Ozguven S., Oksuzoglu K., Erdil T. Y.Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.ABSTRACT: Cowden syndrome is characterized by multiple hamartomatous and neoplastic lesions including Lhermitte-Duclos disease, which is the main criterion for the diagnosis. Herein, we presented a patient with suspected metastatic disease referred to PET/CT, which showed mildly hypermetabolic multinodular thyroid goiter, multiple hamartomatous pulmonary, and breast nodules. Also, intense hypermetabolism was noted on the cerebellar tumor lesion. Lhermitte-Duclos disease was diagnosed based on the characteristic MRI findings, and she was followed up with a diagnosis of Cowden syndrome. Our case indicates that Cowden syndrome should be included as a differential diagnosis of abnormal FDG uptake in the multiple systemic hamartomatous tumors.Publication Open Access Mickey Mouse Sign on Bone Scan in the Monostotic Form of Paget's Disease Mimicking Osseous Metastasis(GALENOS YAYINCILIK, 2020-10-01) TUROĞLU, HALİL TURGUT; Kesim, Selin; Turoglu, Halil Turgut; Ozguven, Salih; Ones, Tunc; Erdil, Tanju YusufPaget's disease is a chronic benign bone disease characterized by excessive and abnormal bone remodeling. Monostotic Paget's disease accounts for only 20% of the cases, and the monostotic form involving the vertebra with the Mickey Mouse sign is very rare. Herein, we report a case of suspected bony metastasis in the second lumbar vertebra that was diagnosed as Paget's disease because of the Mickey Mouse sign on bone scintigraphy, and the diagnosis was confirmed by biopsy. Therefore, bone scintigraphy may provide a positive contribution to the diagnosis, and may help to avoid unnecessary biopsy in cases with specific signs and patterns.Publication Open Access Ga-68-Tetraazacyclododecane Tetraacetic Acid-DPhe1-Tyr3-Octreotate Positron Emission Tomography/Computed Tomographic Findings of Large-Cell Neuroendocrine Carcinoma of the Lung in a Child(2022-10-01) FİLİZOĞLU, NUH; KESİM, SELİN; ÖZGÜVEN, SALİH; Filizoglu N., Kesim S., ÖZGÜVEN S.Primary lung cancers in children are rare, and most children are diagnosed incidentally while being investigated for another medical problem. The diagnosis of primary lung tumors in children is very difficult because many children are asymptomatic until the advanced stages of the disease and nonspecific imaging findings. Although the usage of 68Ga-tetraazacyclododecane tetraacetic acid-DPhe1-Tyr3-octreotate (68Ga-DOTATATE) positron emission tomography/computed tomography (PET/CT) in adult patients is well known, it is a relatively new imaging modality for the pediatric patient group. Herein, we presented a unique case of large-cell neuroendocrine carcinoma of the lung in a child on 68Ga-DOTATATE PET/CT.Publication Open Access 18 F-FDG PET/CT imaging of a Grade 3 lymphomatoid granulomatosis in an immunocompromised pediatric patient(2023-02-01) KESİM, SELİN; ÖZGÜVEN, SALİH; ÖNEŞ, TUNÇ; KESİM S., Şen F., ÖZGÜVEN S., ÖNEŞ T.Lymphomatoid granulomatosis is a rare extranodal Epstein-Barr virus-driven B-cell lymphoproliferative disease, involving predominantly lung, less often skin, kidney, and central nervous system. Here, we present a pediatric case with primary immunodeficiency, diagnosed with pathologically proven pulmonary grade-III lymphomatoid granulomatosis.18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging demonstrated18F-FDG avid pulmonary masses with central air-bronchograms and cavitations. Although the definitive diagnosis depends on biopsy,18F-FDG PET/CT serves as a complementary imaging tool to evaluate the extent of the disease and response to treatment.Publication Open Access Şiddetli kaudal regresyon sendromu olan pediatrik bir hastada tek foton emisyonlu bilgisayarlı tomografi/bilgisayarlı tomografi ile hibrid renal kortikal görüntüleme(2022-02-01) KESİM, SELİN; TUROĞLU, HALİL TURGUT; ÖZGÜVEN, SALİH; ERDİL, TANJU YUSUF; ÖNEŞ, TUNÇ; KESİM S., TUROĞLU H. T., ÖZGÜVEN S., ÖNEŞ T., ERDİL T. Y.© 2022 by Turkish Society of Nuclear Medicine Molecular Imaging and Radionuclide Therapy published by Galenos Yayınevi.Caudal regression syndrome (CRS) or sacral agenesis is a rarely seen malformation with a varying degree of structural abnormalities, including multiorgan system dysfunctions, reported with higher incidence among children of mothers with diabetes, as in this case. Spinal anomalies can range from coccyx hemiagenesis to the total absence of lower lumbar vertebrae and sacrum in most severe cases. Herein, we have presented a 9-year-old patient with CRS who had renal failure. Technetium-99m dimercaptosuccinic acid renal scintigraphy revealed bilaterally non-functioning kidneys with no renal cortical uptake. Renal anomalies in CRS with vertebral, anorectal, cardiac, trachea-esophageal, renal, and limb anomalies association include one-sided renal agenesis, multicystic dysplastic kidneys, and ureter duplications.