Person: OLGUN YILDIZELİ, ŞEHNAZ
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OLGUN YILDIZELİ
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ŞEHNAZ
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Publication Metadata only İlerı ve son evre akciğer hastalığına ikincil solunum yetmezliği olan hastaların bakım verenlerinde bakım verici yükü ve depresyon ilişkisi(2018-04-18) OLGUN YILDIZELİ, ŞEHNAZ; KASAPOĞLU, UMUT SABRİ; KOCAKAYA, DERYA; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; KARAKURT, SAİT; ARIKAN, HÜSEYİN; OLGUN YILDIZELİ Ş., ARIKAN H., KASAPOĞLU U. S., KOCAKAYA D., ERYÜKSEL S. E., CEYHAN B., KARAKURT S.Publication Metadata only Protective effect of cysteinyl leukotriene receptor antagonist montelukast in bleomycin-induced pulmonary fibrosis(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2018) CEYHAN, BERRİN; Topaloglu, Nurhayat; Yildizeli, Sehnaz Olgun; Sener, Goksel; Lacin, Tunc; Sehirli, Ozer; Bozkurtlar, Emine; Celikel, Cigdem; Ceyhan, BerrinBackground: This study aims to investigate the early- and late-term effects of pharmacological inhibition of cysteinyl leukotriene activity by using montelukast in bleomycin-induced inflammatory and oxidative lung injury in an animal model. Methods: The study included 48 male Wistar albino rats (weighing 250 g to 300 g). Rats were administered intratracheal bleomycin or saline and assigned into groups to receive montelukast or saline. Bronchoalveolar lavage fluid and lung tissue samples were collected four and 15 days after bleomycin administration. Results: Bleomycin resulted in significant increases in tumor necrosis factor-alpha levels (4.0 +/- 1.4 pg/mL in controls vs. 44.1 +/- 14.5 pg/mL in early-term vs. 30.3 +/- 5.7 pg/mL in late-term, p<0.001 and p<0.001, respectively), transforming growth factor beta 1 levels (28.6 +/- 6.6 pg/mL vs. 82.3 +/- 14.1 pg/mL in early-term vs. 60.1 +/- 2.9 pg/mL in late-term, p<0.001 and p<0.001, respectively), and fibrosis score (1.85 +/- 0.89 in early-term vs. 5.60 +/- 1.14 in late-term, p<0.001 and p<0.01, respectively). In bleomycin exposed rats, collagen content increased only in the late-term (15.3 +/- 3.0 mu g/mg in controls vs. 29.6 +/- 9.1 mu g/mg in late-term, p<0.001). Montelukast treatment reversed all these biochemical indices as well as histopathological alterations induced by bleomycin. Conclusion: Montelukast attenuates bleomycin-induced inflammatory and oxidative lung injury and prevents lung collagen deposition and fibrotic response. Thus, cysteinyl leukotriene receptor antagonists might be regarded as new therapeutic agents for idiopathic pulmonary fibrosis.Publication Metadata only Eri̇şki̇n ki̇sti̇k fi̇brozi̇s hastalarinda İlaç uyumu ve anksi̇yete/depresyonu etki̇leyen faktörler(2018-05-18) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; CEYHAN, BERRİN; USLU N. Z. , KOCAKAYA D., OLGUN YILDIZELİ Ş., CEYHAN B.Publication Metadata only Aktif kanaması olan vena cava superior sendromuna yol açan venöz tromboz olgusunda antikoagülan tedavi yaklaşımı(2015-04-01) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; CEYHAN, BERRİN; BEKIR KULAH M., KOCAKAYA D., OLGUN YILDIZELİ Ş., CEYHAN B.Publication Metadata only KF ve KF dışı bronşektazi hastalarında obstrüktif uyku apnesinin depresyon üzerine etkisi(2022-06-28) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; CEYHAN, BERRİN; VEZİR D., BALCAN M. B. , KOCAKAYA D., ÇINAR C., OLGUN YILDIZELİ Ş., CEYHAN B.AMAÇ: Erişkin kistik fibrozis (KF) ve KF dışı bronşektazi hastalarında obstrüktif uyku apnesi (OUA) sıklığını belirlemek ve bu hastaların demografik, klinik, mikrobiyolojik, spirometrik özelliklerinin uyku apnesi ile ilişkisini ortaya koymaktır. YÖNTEM: 35 KF ( ortalama yaş: 27(18-38)) ve 35 KF dışı bronşektazi (ortalama yaş: 24 (19-75)) hastası dahil edilmiştir. Hastaların demografik özellikleri, kullandığı ilaçlar, komorbiditeleri, vücut kitle indeksleri (VKI), Modified Medical Research Center (mMRC) dispne skalası değerleri, balgam kültür üremeleri, son bir yıl içindeki atak ve hastaneye yatışları kaydedildi. Solunum fonksiyon testleri (SFT) yapıldı. Her hastaya Epworth Uykululuk Skorlaması (ESS) anketi dolduruldu ve Polisomnografi (PSG) uygulandı. BULGULAR: Hastalarımızın ESS’leri karşılaştırıldığında KF ve KF dışı bronşektazi hastalarında istatistiksel olarak anlamlı fark görülmemiştir. PSG bulguları karşılaştırıldığında toplam uyku süresi, uyku etkinliği, uykuya dalma süresi, uykuya daldıktan sonra uyanık geçen süre, ODI, AHI, supin pozisyondaki AHI değerleri, REM evresinde geçirdikleri zaman değerlendirildiğinde iki grup arasında istatistiksel olarak anlamlı fark bulunmadı. KF hastalarının Non-REM Evre 2 uykuda geçirdikleri süre KF dışı bronşektazi hastalarına göre daha kısaydı (%47’ye karşın %52 (p:0.034)). KF hastalarının uyku boyunca ortalama oksijen saturasyonları (p:0.001) ve en düşük oksijen saturasyon değerlerinin (p:0.024) daha düşük, ortalama kalp hızının daha yüksek olduğu bulundu (p:0.02). Tüm hastaların uyku test sonuçları değerlendirildiğinde toplamda 37 (%53) kişide OUA saptandı. Gruplar ayrı ayrı değerlendirildiğinde ise KF bronşektazili hastaların 19’unda (%54) KF dışı bronşektazi hastalarının da 18’inde (%51) OUA saptanması nedeniyle hastalık tipinin uyku apnesi için bir risk oluşturmadığı görüldü. Hastaların multipl logistik regresyon analizi değerlendirildiğinde erkek cinsiyet ile hastalık süresinin (p:0.023 ve p:0.041) uyku apnesi geliştirmelerinde risk faktörü olduğu görüldü. SONUÇ: Çalışmamızda erişkin KF ve KF dışı bronşektazi hastalarının yarısından fazlasında obstrüktif uyku apnesi saptanması dikkat çekici bir bulgudur. Erkek cinsiyet ile hastalık süresinin riski artırdığı saptanmıştır. Çalışmamızda bronşiektazi hastalarımızı takip ederken gündüz uykululuk sorgulamalarının ve PSG uygulamasının yaygınlaştırılmasının gerekli olduğunun önemi gösterilmiştir.Publication Metadata only The predictive role of psychological status and disease severity indexes on quality of life among patients with non-CF bronchiectasis(2022-01-01) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; CEYHAN B., Bekir M., KOCAKAYA D., OLGUN YILDIZELİ Ş., ERYÜKSEL S. E.OBJECTIVE: Bronchiectasis is a chronic suppurative lung disease that significantly impacts the patients\" quality of life. The aim of this study is to evaluate the relationship between quality of life and patient\"s psychological status and bronchiectasis disease severity indexes in patients with non-cystic fibrosis bronchiectasis. We also aimed to investigate the validity and reliability of Turkish version of Quality of Life Questionnaire-Bronchiectasis (V3.1) in Turkish adult bronchiectatic patients.Publication Metadata only Impact of body composition and nutritional status on health outcomes in adultcystic fibrosis patients(2019-04-18) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; USLU N. Z. , KOCAKAYA D., OLGUN YILDIZELİ Ş., ERYÜKSEL S. E. , GÖRÇİN KARATEKİR Ş., CEYHAN B.AIM: Cystic fibrosis (CF) is a multi-systemic disease. Chronic inflammation and malabsorption may affect body composition, respiratory function and health outcomes. Our aim was to examine anthropometric measures, microbiologic data, spirometric data, comorbidities and how body composition may impact health outcomes in adult CF patients. METHODS: 31 adult CF patients (15 female, 16 male) with mean age 25 (18-42) and 23 controls were enrolled. The modified Medical Research Council (mMRC) scale, 6 minute-walk-test and pulmonary function test were performed. Anthropometric data including body mass index (BMI), fat-free mass index (FFMI) and total body fat percentiles were measured. Clinical indices, presence/absence of pancreatic insufficiency and method of nutrition were recorded. RESULTS: Mean duration of disease was 18.6±7.5 years. 24 of the patients (77%) were below targeted BMI. Mean BMI of the patients was 20.6±3.1 kg/m2 and mean FFMI was 16.4±1.6 kg/m2. When compared to control group, both BMI and FFMI were lower in CF patients (p<0.05 and 0.00) and both were correlated with age ( p: 0.008, r: 0.468 and p: 0.036, r:0.377). Female patients had lower FFMI (15.7±1.3 vs17.1±1.6, p:0.01) and higher fat percentile (22.7% vs 12.5%, p:0.00) than male patients. FFMI was found to be positively correlated with FEV1L and FVC L (p:0.017, r: 0.025 and p:0.05 and r: 0.490, respectively). 20 patients (65%) had pancreatic insufficiency and all were under pancreatic enzyme replacement medication. This group of patients had lower fat percentile then the group without pancreatic insufficiency (15.0±6.7% vs 23.2±9.0%; p:0.011) 16 patients (52%) had anemia and FFMI positively correlated with hemoglobin values (p:0.03, r: 0.390). 17 patients (55%) were receiving oral nutritional support and these patients had lower BMI then those who were not receiving (19.4±2.6 vs 22.1±2.9, p: 0.013). CONCLUSION: The prevalence of malnutrition was high in adult CF patients and lung function is correlated with nutritional status. Periodic measurement of anthropometrics and close monitoring of nutritional status may improve respiratory function and health outcomes in adult CF patientsPublication Metadata only Endobronchial ultrasound transbronchial needle aspiration in elderly patients: safety and performance outcomes EBUS-TBNA in elderly(TAYLOR & FRANCIS LTD, 2020) TUFAN ÇİNÇİN, ASLI; Yildizeli, Sehnaz Olgun; Tufan, Asli; Bozkurtlar, Emine; Arikan, Huseyin; Kocakaya, Derya; Eryuksel, Emel; Ceyhan, Berrin; Karakurt, SaitAim Complication rates are low and endobronchial ultrasound guided needle aspiration (EBUS-TBNA) is generally regarded as a safe procedure, but there is a very limited number of studies evaluating the efficacy and safety of the procedure in advanced ages. The aim of this study is to assess the safety and performance outcomes of EBUS-TBNA in elderly. Methods It was a retrospective observational study; patients who received EBUS-TBNA between September 2016 and January 2018 were evaluated. We analyzed patient's characteristics, doses of midazolam, and lidocaine used, regions of lymph node biopsies, and complications. Also, functionality and general physical status of patients over 65 years of age were evaluated. Results During study period 132 cases of EBUS-TBNA were evaluated. 39 (29.5%) cases were aged 70 years, and over. There were more comorbidities in older group. Performance status of older group was worse. Furthermore, when evaluated according to American College of Cardiology (ACC)/American Heart Association (AHA) and American Society of Anesthesiologists (ASA), the older group was found to be composed of the riskier patients. When patients aged between 65 and 69, and over 70 compared, older patient's Barthel, EQ 5-D, SGA, and G8 scores were found to be worse. Despite that, there was no difference in the frequency, and types of complications between both groups. Diagnostic performance was not different between age groups. Conclusions Independent from comorbidities, general health status, and functionality EBUS-TBNA procedure in 70-year-old and over patients is a safe minimally invasive procedure.Publication Metadata only Kistik Fibrozis ve KF Dışı Bronşektazi Hastalarında Obstrüktif Uyku Apne Sıklığı VeKlinik Bulgularla İlişkisi(2022-06-28) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; CEYHAN, BERRİN; VEZİR D., BALCAN M. B. , KOCAKAYA D., ÇINAR C., OLGUN YILDIZELİ Ş., CEYHAN B.Publication Metadata only Clinical impact of depression and anxiety in patients with non-cystic fibrosis bronchiectasis(TURKISH ASSOC TUBERCULOSIS & THORAX, 2020) CEYHAN, BERRİN; Bekir, Melahat; Kocakaya, Derya; Balcan, Baran; Olgun Yildizeli, Sehnaz; Eryuksel, Emel; Ceyhan, BerrinIntroduction: Bronchiectasis is a chronic suppurative disease characterized by abnormal bronchial dilatation. The nature of bronchiectasis may have negative impact on psychological status, however it is poorly studied in relation to clinical indices, particularly the severity of disease. Primary aim of this study is to detect depression and anxiety in patients with non-cystic fibrosis bronchiectasis and to evaluate its relationship with disease severity indexes. Materials and Methods: Ninety (male/female= 37/53; median age 45 years) stable non-cystic fibrosis bronchiectatic adult patients were enrolled into this study. Dyspnea scores, number of exacerbations and hospital admissions within the last year, body-mass index, pulmonary function tests, sputum cultures, bronchiectasis disease severity indexes (BSI and FACED) were assessed. Anxiety and depression were evaluated by using the Turkish version of the hospital anxiety and depression scale questionaire. Results: Anxiety was diagnosed in 30% of patients and depression was diagnosed in 41% of the participants. Female participants had significantly higher rates of depression (55% vs. 22%; p= 0.002). Exacerbation rates within the last year were higher among the subjects with anxiety, moreover, patients with depression had shorter duration of disease. 851 and FACED severity indexes increased with longer duration of disease (5.6 +/- 5.0 yrs in mild group vs. 10.1 +/- 9.2 yrs in moderate-to-severe group, p= 0.035 and 5.7 +/- 5.4 yrs in mild group vs. 12.1 +/- 9.7 yrs in moderate-to-severe group, p= 0.001, respectively), however, anxiety and depression were not related with BSI and FACED severity indexes. Conclusion: Patients with non-cystic fibrosis bronchiectasis have an increased risk for depression and anxiety. Duration of disease and higher exacerbation rate are related with psychological status and indexes increased with longer duration of disease. Lady detection and taking the necessary measures to improve the psychological state is necessary for the overall management of these patients.