Person: OLGUN YILDIZELİ, ŞEHNAZ
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OLGUN YILDIZELİ
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ŞEHNAZ
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Publication Metadata only İlerı ve son evre akciğer hastalığına ikincil solunum yetmezliği olan hastaların bakım verenlerinde bakım verici yükü ve depresyon ilişkisi(2018-04-18) OLGUN YILDIZELİ, ŞEHNAZ; KASAPOĞLU, UMUT SABRİ; KOCAKAYA, DERYA; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; KARAKURT, SAİT; ARIKAN, HÜSEYİN; OLGUN YILDIZELİ Ş., ARIKAN H., KASAPOĞLU U. S., KOCAKAYA D., ERYÜKSEL S. E., CEYHAN B., KARAKURT S.Publication Metadata only Eri̇şki̇n ki̇sti̇k fi̇brozi̇s hastalarinda İlaç uyumu ve anksi̇yete/depresyonu etki̇leyen faktörler(2018-05-18) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; CEYHAN, BERRİN; USLU N. Z. , KOCAKAYA D., OLGUN YILDIZELİ Ş., CEYHAN B.Publication Metadata only Aktif kanaması olan vena cava superior sendromuna yol açan venöz tromboz olgusunda antikoagülan tedavi yaklaşımı(2015-04-01) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; CEYHAN, BERRİN; BEKIR KULAH M., KOCAKAYA D., OLGUN YILDIZELİ Ş., CEYHAN B.Publication Open Access Anxiety and depression in patients with chronic obstructive pulmonary disease and their relation to serum vitamin D levels(MARMARA UNIV, FAC MEDICINE, 2018-02-26) CEYHAN, BERRİN; Kocakaya, Derya; Olgun Yildizeli, Sehnaz; Kocakaya, Ozan; Arikan, Huseyin; Eryuksel, Emel; Ceyhan, BerrinObjectives: To determine whether serum vitamin D levels were related to the risk of anxiety and depression among patients with chronic obstructive pulmonary disease (COPD), as well as their spirometry parameters, disease severity, and other clinical findings. Materials and Methods: Ninety-two stable patients with COPD aged over 18 years with no exacerbations in the previous month were included. Symptom severity was assessed using the modified Medical Research Council (mMRC) dyspnea scale and COPD Assessment Test (CAT) scores. Spirometry tests were performed and previous hospitalization histories were recorded to determine ABCD groups of the patients according to their combined COPD assessments. Their Body mass index, airflow Obstruction, Dyspnea and Exercise capacity (BODE) indices were calculated and the Hospital Anxiety and Depression Scale (HADS) was administered. Serum vitamin D levels were determined using immune electrochemiluminescence. Results: According to the HADS scores, 16 patients (17.4%) had the risk of anxiety and 29 (31.5%) had the risk of depression. The risk of anxiety differed significantly (P=0.016 Fischer's exact test) between the ABCD groups. Anxiety scores were positively correlated with both mMRC (r=0.315; P=0.002) and CAT (r=0.445; P=0.000) scores. Similarly, depression scores correlated positively with mMRC (r= 0.249; P=0.017) and CAT (r=0.373; P=0.000) scores. Neither anxiety nor depression scores were significantly correlated with % of predicted FEV1. Serum vitamin D levels were inversely correlated with anxiety (r=-0.215; P=0.039) and depression (r=-0.244; P=0.019) scores. Anxiety scores were positively correlated with BODE although not statistically significantly (r=0.199; P=0.058). Conclusion: A negative correlation was revealed between serum vitamin D levels and HADS scores, and symptom scores were positively correlated to HADS scores, independent of % of predicted FEV1.Publication Metadata only KF ve KF dışı bronşektazi hastalarında obstrüktif uyku apnesinin depresyon üzerine etkisi(2022-06-28) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; CEYHAN, BERRİN; VEZİR D., BALCAN M. B. , KOCAKAYA D., ÇINAR C., OLGUN YILDIZELİ Ş., CEYHAN B.AMAÇ: Erişkin kistik fibrozis (KF) ve KF dışı bronşektazi hastalarında obstrüktif uyku apnesi (OUA) sıklığını belirlemek ve bu hastaların demografik, klinik, mikrobiyolojik, spirometrik özelliklerinin uyku apnesi ile ilişkisini ortaya koymaktır. YÖNTEM: 35 KF ( ortalama yaş: 27(18-38)) ve 35 KF dışı bronşektazi (ortalama yaş: 24 (19-75)) hastası dahil edilmiştir. Hastaların demografik özellikleri, kullandığı ilaçlar, komorbiditeleri, vücut kitle indeksleri (VKI), Modified Medical Research Center (mMRC) dispne skalası değerleri, balgam kültür üremeleri, son bir yıl içindeki atak ve hastaneye yatışları kaydedildi. Solunum fonksiyon testleri (SFT) yapıldı. Her hastaya Epworth Uykululuk Skorlaması (ESS) anketi dolduruldu ve Polisomnografi (PSG) uygulandı. BULGULAR: Hastalarımızın ESS’leri karşılaştırıldığında KF ve KF dışı bronşektazi hastalarında istatistiksel olarak anlamlı fark görülmemiştir. PSG bulguları karşılaştırıldığında toplam uyku süresi, uyku etkinliği, uykuya dalma süresi, uykuya daldıktan sonra uyanık geçen süre, ODI, AHI, supin pozisyondaki AHI değerleri, REM evresinde geçirdikleri zaman değerlendirildiğinde iki grup arasında istatistiksel olarak anlamlı fark bulunmadı. KF hastalarının Non-REM Evre 2 uykuda geçirdikleri süre KF dışı bronşektazi hastalarına göre daha kısaydı (%47’ye karşın %52 (p:0.034)). KF hastalarının uyku boyunca ortalama oksijen saturasyonları (p:0.001) ve en düşük oksijen saturasyon değerlerinin (p:0.024) daha düşük, ortalama kalp hızının daha yüksek olduğu bulundu (p:0.02). Tüm hastaların uyku test sonuçları değerlendirildiğinde toplamda 37 (%53) kişide OUA saptandı. Gruplar ayrı ayrı değerlendirildiğinde ise KF bronşektazili hastaların 19’unda (%54) KF dışı bronşektazi hastalarının da 18’inde (%51) OUA saptanması nedeniyle hastalık tipinin uyku apnesi için bir risk oluşturmadığı görüldü. Hastaların multipl logistik regresyon analizi değerlendirildiğinde erkek cinsiyet ile hastalık süresinin (p:0.023 ve p:0.041) uyku apnesi geliştirmelerinde risk faktörü olduğu görüldü. SONUÇ: Çalışmamızda erişkin KF ve KF dışı bronşektazi hastalarının yarısından fazlasında obstrüktif uyku apnesi saptanması dikkat çekici bir bulgudur. Erkek cinsiyet ile hastalık süresinin riski artırdığı saptanmıştır. Çalışmamızda bronşiektazi hastalarımızı takip ederken gündüz uykululuk sorgulamalarının ve PSG uygulamasının yaygınlaştırılmasının gerekli olduğunun önemi gösterilmiştir.Publication Metadata only The predictive role of psychological status and disease severity indexes on quality of life among patients with non-CF bronchiectasis(2022-01-01) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; CEYHAN B., Bekir M., KOCAKAYA D., OLGUN YILDIZELİ Ş., ERYÜKSEL S. E.OBJECTIVE: Bronchiectasis is a chronic suppurative lung disease that significantly impacts the patients\" quality of life. The aim of this study is to evaluate the relationship between quality of life and patient\"s psychological status and bronchiectasis disease severity indexes in patients with non-cystic fibrosis bronchiectasis. We also aimed to investigate the validity and reliability of Turkish version of Quality of Life Questionnaire-Bronchiectasis (V3.1) in Turkish adult bronchiectatic patients.Publication Open Access The angiogenic gene profile of pulmonary endarterectomy specimens: Initial study(2023-01-01) ERMERAK, NEZİH ONUR; YILMAZ, BETÜL; BATIREL, SAİME; OLGUN YILDIZELİ, ŞEHNAZ; KOCAKAYA, DERYA; MUTLU, BÜLENT; YILDIZELİ, BEDRETTİN; ERMERAK N. O., YILMAZ B., BATIREL S., OLGUN YILDIZELİ Ş., KOCAKAYA D., MUTLU B., Tas S., YILDIZELİ B.© 2023 The Author(s)Objectives: The underlying mechanisms for the development of chronic thromboembolic pulmonary hypertension and prognostic biomarkers are not clear yet. Thus, our aim is to assess and identify new biomarkers for the expression of 84 key genes linked to angiogenesis. Methods: Patients who had levels more than 1000 dynes·sec·cm−5 were included in the test group, and the other patients were included in the control group. Twelve specimens were taken from the patients. RT2 Profiler PCR Array (Qiagen) was used to quantify the expression of the 84 key genes. Results: Eight patients (6 male, 2 female, median age 54.4 ± 13.1 years) who underwent pulmonary endarterectomy were included. Pulmonary vascular resistance improved significantly from 811 ± 390 dyn/s/cm−5 to 413.3 ± 144.9 dyn/s/cm−5 (P .005) after surgery. Median length of hospital stay was 11.62 ± 2.97 days. The test group had a distinct pattern of impaired angiogenic and antiangiogenic genes. The expression levels of TGFA, TGFB1, THBS2, THBS1, TGFBR1, SERPINE1, SERPINF1, TGFB2, TIMP2, VEGFC, IFNA1, TNF, CXCL10, NOS3, IGF1, and MMP14 were downregulated in the specimens from the patients who had higher pulmonary vascular resistance values, whereas some genes, including PDGFA, showed upregulation that was statistically nonsignificant in the same group. Conclusions: These results can lead to the development of new markers that could predict adverse outcomes of patients with CTEPH. Identification of new markers that are related to worse outcomes would enable screening patients for early diagnosis and treatment.Publication Metadata only Risk factors for bronchoscopic complications in patients over 75 years of age(ELSEVIER MASSON, CORPORATION OFFICE, 2018) TUFAN ÇİNÇİN, ASLI; Yildizeli, Sehnaz Olgun; Tufan, Asli; Arikan, Huseyin; Cinar, Caner; Kocakaya, Derya; Eryuksel, EmelAim Bronchoscopy is a widely used, well-tolerated diagnostic and therapeutic intervention and has a low complication rate. The aim of this study was to describe the rates of bronchoscopic complications and risk factors in a group of patients 75 years' old and above. Methods To investigate the rate of complications and risk factors in the older patients, we carried out a retrospective cohort study of 240 patients above 75 years of age who had bronchoscopy for various reasons. Results Complication rate was found to be 3.7% in the older patients group which was not different from the control group (1.2%, p > 0.05). No significant relationship was found between age group and complication development (p > 0.05). The type of procedures did not show any effect on complication development between age groups and individually. We found that anemia (OR 7.2, 95% CI 1.2-41.2), percutaneous gastrostomy (OR 9.9, 95% CI 1.6-58), immobility (OR 11.9, 95% CI 2.6-33.5) and procedures performed in the intensive care unit (OR 7.4, 95% CI 1.4-37.5) were significant risk factors for complication. Conclusions In the older patients group, bronchoscopy is a safe procedure regardless of the type of procedures performed and age. It has been shown that anemia, PEG presence, immobility and intensive care patients are associated with increased complication.Publication Metadata only Impact of body composition and nutritional status on health outcomes in adultcystic fibrosis patients(2019-04-18) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; USLU N. Z. , KOCAKAYA D., OLGUN YILDIZELİ Ş., ERYÜKSEL S. E. , GÖRÇİN KARATEKİR Ş., CEYHAN B.AIM: Cystic fibrosis (CF) is a multi-systemic disease. Chronic inflammation and malabsorption may affect body composition, respiratory function and health outcomes. Our aim was to examine anthropometric measures, microbiologic data, spirometric data, comorbidities and how body composition may impact health outcomes in adult CF patients. METHODS: 31 adult CF patients (15 female, 16 male) with mean age 25 (18-42) and 23 controls were enrolled. The modified Medical Research Council (mMRC) scale, 6 minute-walk-test and pulmonary function test were performed. Anthropometric data including body mass index (BMI), fat-free mass index (FFMI) and total body fat percentiles were measured. Clinical indices, presence/absence of pancreatic insufficiency and method of nutrition were recorded. RESULTS: Mean duration of disease was 18.6±7.5 years. 24 of the patients (77%) were below targeted BMI. Mean BMI of the patients was 20.6±3.1 kg/m2 and mean FFMI was 16.4±1.6 kg/m2. When compared to control group, both BMI and FFMI were lower in CF patients (p<0.05 and 0.00) and both were correlated with age ( p: 0.008, r: 0.468 and p: 0.036, r:0.377). Female patients had lower FFMI (15.7±1.3 vs17.1±1.6, p:0.01) and higher fat percentile (22.7% vs 12.5%, p:0.00) than male patients. FFMI was found to be positively correlated with FEV1L and FVC L (p:0.017, r: 0.025 and p:0.05 and r: 0.490, respectively). 20 patients (65%) had pancreatic insufficiency and all were under pancreatic enzyme replacement medication. This group of patients had lower fat percentile then the group without pancreatic insufficiency (15.0±6.7% vs 23.2±9.0%; p:0.011) 16 patients (52%) had anemia and FFMI positively correlated with hemoglobin values (p:0.03, r: 0.390). 17 patients (55%) were receiving oral nutritional support and these patients had lower BMI then those who were not receiving (19.4±2.6 vs 22.1±2.9, p: 0.013). CONCLUSION: The prevalence of malnutrition was high in adult CF patients and lung function is correlated with nutritional status. Periodic measurement of anthropometrics and close monitoring of nutritional status may improve respiratory function and health outcomes in adult CF patientsPublication Metadata only Endobronchial ultrasound transbronchial needle aspiration in elderly patients: safety and performance outcomes EBUS-TBNA in elderly(TAYLOR & FRANCIS LTD, 2020) TUFAN ÇİNÇİN, ASLI; Yildizeli, Sehnaz Olgun; Tufan, Asli; Bozkurtlar, Emine; Arikan, Huseyin; Kocakaya, Derya; Eryuksel, Emel; Ceyhan, Berrin; Karakurt, SaitAim Complication rates are low and endobronchial ultrasound guided needle aspiration (EBUS-TBNA) is generally regarded as a safe procedure, but there is a very limited number of studies evaluating the efficacy and safety of the procedure in advanced ages. The aim of this study is to assess the safety and performance outcomes of EBUS-TBNA in elderly. Methods It was a retrospective observational study; patients who received EBUS-TBNA between September 2016 and January 2018 were evaluated. We analyzed patient's characteristics, doses of midazolam, and lidocaine used, regions of lymph node biopsies, and complications. Also, functionality and general physical status of patients over 65 years of age were evaluated. Results During study period 132 cases of EBUS-TBNA were evaluated. 39 (29.5%) cases were aged 70 years, and over. There were more comorbidities in older group. Performance status of older group was worse. Furthermore, when evaluated according to American College of Cardiology (ACC)/American Heart Association (AHA) and American Society of Anesthesiologists (ASA), the older group was found to be composed of the riskier patients. When patients aged between 65 and 69, and over 70 compared, older patient's Barthel, EQ 5-D, SGA, and G8 scores were found to be worse. Despite that, there was no difference in the frequency, and types of complications between both groups. Diagnostic performance was not different between age groups. Conclusions Independent from comorbidities, general health status, and functionality EBUS-TBNA procedure in 70-year-old and over patients is a safe minimally invasive procedure.