Person: OLGUN YILDIZELİ, ŞEHNAZ
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OLGUN YILDIZELİ
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ŞEHNAZ
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Publication Metadata only KF ve KF dışı bronşektazi hastalarında obstrüktif uyku apnesinin depresyon üzerine etkisi(2022-06-28) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; CEYHAN, BERRİN; VEZİR D., BALCAN M. B. , KOCAKAYA D., ÇINAR C., OLGUN YILDIZELİ Ş., CEYHAN B.AMAÇ: Erişkin kistik fibrozis (KF) ve KF dışı bronşektazi hastalarında obstrüktif uyku apnesi (OUA) sıklığını belirlemek ve bu hastaların demografik, klinik, mikrobiyolojik, spirometrik özelliklerinin uyku apnesi ile ilişkisini ortaya koymaktır. YÖNTEM: 35 KF ( ortalama yaş: 27(18-38)) ve 35 KF dışı bronşektazi (ortalama yaş: 24 (19-75)) hastası dahil edilmiştir. Hastaların demografik özellikleri, kullandığı ilaçlar, komorbiditeleri, vücut kitle indeksleri (VKI), Modified Medical Research Center (mMRC) dispne skalası değerleri, balgam kültür üremeleri, son bir yıl içindeki atak ve hastaneye yatışları kaydedildi. Solunum fonksiyon testleri (SFT) yapıldı. Her hastaya Epworth Uykululuk Skorlaması (ESS) anketi dolduruldu ve Polisomnografi (PSG) uygulandı. BULGULAR: Hastalarımızın ESS’leri karşılaştırıldığında KF ve KF dışı bronşektazi hastalarında istatistiksel olarak anlamlı fark görülmemiştir. PSG bulguları karşılaştırıldığında toplam uyku süresi, uyku etkinliği, uykuya dalma süresi, uykuya daldıktan sonra uyanık geçen süre, ODI, AHI, supin pozisyondaki AHI değerleri, REM evresinde geçirdikleri zaman değerlendirildiğinde iki grup arasında istatistiksel olarak anlamlı fark bulunmadı. KF hastalarının Non-REM Evre 2 uykuda geçirdikleri süre KF dışı bronşektazi hastalarına göre daha kısaydı (%47’ye karşın %52 (p:0.034)). KF hastalarının uyku boyunca ortalama oksijen saturasyonları (p:0.001) ve en düşük oksijen saturasyon değerlerinin (p:0.024) daha düşük, ortalama kalp hızının daha yüksek olduğu bulundu (p:0.02). Tüm hastaların uyku test sonuçları değerlendirildiğinde toplamda 37 (%53) kişide OUA saptandı. Gruplar ayrı ayrı değerlendirildiğinde ise KF bronşektazili hastaların 19’unda (%54) KF dışı bronşektazi hastalarının da 18’inde (%51) OUA saptanması nedeniyle hastalık tipinin uyku apnesi için bir risk oluşturmadığı görüldü. Hastaların multipl logistik regresyon analizi değerlendirildiğinde erkek cinsiyet ile hastalık süresinin (p:0.023 ve p:0.041) uyku apnesi geliştirmelerinde risk faktörü olduğu görüldü. SONUÇ: Çalışmamızda erişkin KF ve KF dışı bronşektazi hastalarının yarısından fazlasında obstrüktif uyku apnesi saptanması dikkat çekici bir bulgudur. Erkek cinsiyet ile hastalık süresinin riski artırdığı saptanmıştır. Çalışmamızda bronşiektazi hastalarımızı takip ederken gündüz uykululuk sorgulamalarının ve PSG uygulamasının yaygınlaştırılmasının gerekli olduğunun önemi gösterilmiştir.Publication Metadata only The predictive role of psychological status and disease severity indexes on quality of life among patients with non-CF bronchiectasis(2022-01-01) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; CEYHAN B., Bekir M., KOCAKAYA D., OLGUN YILDIZELİ Ş., ERYÜKSEL S. E.OBJECTIVE: Bronchiectasis is a chronic suppurative lung disease that significantly impacts the patients\" quality of life. The aim of this study is to evaluate the relationship between quality of life and patient\"s psychological status and bronchiectasis disease severity indexes in patients with non-cystic fibrosis bronchiectasis. We also aimed to investigate the validity and reliability of Turkish version of Quality of Life Questionnaire-Bronchiectasis (V3.1) in Turkish adult bronchiectatic patients.Publication Open Access The angiogenic gene profile of pulmonary endarterectomy specimens: Initial study(2023-01-01) ERMERAK, NEZİH ONUR; YILMAZ, BETÜL; BATIREL, SAİME; OLGUN YILDIZELİ, ŞEHNAZ; KOCAKAYA, DERYA; MUTLU, BÜLENT; YILDIZELİ, BEDRETTİN; ERMERAK N. O., YILMAZ B., BATIREL S., OLGUN YILDIZELİ Ş., KOCAKAYA D., MUTLU B., Tas S., YILDIZELİ B.© 2023 The Author(s)Objectives: The underlying mechanisms for the development of chronic thromboembolic pulmonary hypertension and prognostic biomarkers are not clear yet. Thus, our aim is to assess and identify new biomarkers for the expression of 84 key genes linked to angiogenesis. Methods: Patients who had levels more than 1000 dynes·sec·cm−5 were included in the test group, and the other patients were included in the control group. Twelve specimens were taken from the patients. RT2 Profiler PCR Array (Qiagen) was used to quantify the expression of the 84 key genes. Results: Eight patients (6 male, 2 female, median age 54.4 ± 13.1 years) who underwent pulmonary endarterectomy were included. Pulmonary vascular resistance improved significantly from 811 ± 390 dyn/s/cm−5 to 413.3 ± 144.9 dyn/s/cm−5 (P .005) after surgery. Median length of hospital stay was 11.62 ± 2.97 days. The test group had a distinct pattern of impaired angiogenic and antiangiogenic genes. The expression levels of TGFA, TGFB1, THBS2, THBS1, TGFBR1, SERPINE1, SERPINF1, TGFB2, TIMP2, VEGFC, IFNA1, TNF, CXCL10, NOS3, IGF1, and MMP14 were downregulated in the specimens from the patients who had higher pulmonary vascular resistance values, whereas some genes, including PDGFA, showed upregulation that was statistically nonsignificant in the same group. Conclusions: These results can lead to the development of new markers that could predict adverse outcomes of patients with CTEPH. Identification of new markers that are related to worse outcomes would enable screening patients for early diagnosis and treatment.Publication Metadata only Endobronchial ultrasound transbronchial needle aspiration in elderly patients: safety and performance outcomes EBUS-TBNA in elderly(TAYLOR & FRANCIS LTD, 2020) TUFAN ÇİNÇİN, ASLI; Yildizeli, Sehnaz Olgun; Tufan, Asli; Bozkurtlar, Emine; Arikan, Huseyin; Kocakaya, Derya; Eryuksel, Emel; Ceyhan, Berrin; Karakurt, SaitAim Complication rates are low and endobronchial ultrasound guided needle aspiration (EBUS-TBNA) is generally regarded as a safe procedure, but there is a very limited number of studies evaluating the efficacy and safety of the procedure in advanced ages. The aim of this study is to assess the safety and performance outcomes of EBUS-TBNA in elderly. Methods It was a retrospective observational study; patients who received EBUS-TBNA between September 2016 and January 2018 were evaluated. We analyzed patient's characteristics, doses of midazolam, and lidocaine used, regions of lymph node biopsies, and complications. Also, functionality and general physical status of patients over 65 years of age were evaluated. Results During study period 132 cases of EBUS-TBNA were evaluated. 39 (29.5%) cases were aged 70 years, and over. There were more comorbidities in older group. Performance status of older group was worse. Furthermore, when evaluated according to American College of Cardiology (ACC)/American Heart Association (AHA) and American Society of Anesthesiologists (ASA), the older group was found to be composed of the riskier patients. When patients aged between 65 and 69, and over 70 compared, older patient's Barthel, EQ 5-D, SGA, and G8 scores were found to be worse. Despite that, there was no difference in the frequency, and types of complications between both groups. Diagnostic performance was not different between age groups. Conclusions Independent from comorbidities, general health status, and functionality EBUS-TBNA procedure in 70-year-old and over patients is a safe minimally invasive procedure.Publication Open Access Tuberculosis and COVID-19: An overlapping situation during pandemic(J INFECTION DEVELOPING COUNTRIES, 2020-07-31) KARAHASAN, AYŞEGÜL; Sarinoglu, Rabia Can; Sili, Uluhan; Eryuksel, Emel; Yildizeli, Sehnaz Olgun; Cimsit, Cagatay; Yagci, Aysegul KarahasanIntroduction: The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19). First COVID-19 case was detected in March, 10, 2020 in Turkey and as of May, 18, 2020 148,067 cases have been identified and 4096 citizens have died. Tuberculosis (TB) is a worldwide public health concern, incidence of tuberculosis (per 100,000 people) in Turkey was reported at 14, 1 in 2018. During pandemic COVID-19 was the main concern in every clinic and as we discuss here overlapping respiratory diseases may result in delaying of the diagnosis and treatment. Methodology: There were 4605 respiratory samples examined between March 23 and May 18 for COVID-19 and 185 samples for Mycobacterium tuberculosis in our laboratory. The Xpert Ultra assay was performed for the diagnosis of pulmonary tuberculosis; SARS-CoV-2 RNA was determined by real-time PCR (RT-PCR) analysis in combined nasopharyngeal and deep oropharyngeal swabs of suspected cases of COVID-19. Results: Both of SARS-CoV-2 and M. tuberculosis tests were requested on the clinical and radiological grounds in 30 patients. Here we discussed 2 patients who were both COVID-19 and TB positive. One patient already diagnosed with tuberculosis become COVID-19 positive during hospitalization and another patient suspected and treated for COVID-19 received the final diagnosis of pulmonary TB and Human Immunodeficiency Virus infection. Conclusions: We want to emphasize that while considering COVID-19 primarily during these pandemic days, we should not forget one of the great imitators, tuberculosis within differential diagnoses.Publication Metadata only Trombin jenerasyon zamanı ve endotel disfonsiyon belirteçlerinin pulmoner endarterektomi sonuçlarına etkisi(2023-10-19) ERMERAK, NEZİH ONUR; LAÇİN, TUNÇ; TOPTAŞ, TAYFUR; OLGUN YILDIZELİ, ŞEHNAZ; AK, KORAY; YILDIZELİ, BEDRETTİN; TİRYAKİ G. G., Ertan R., Pasayev J., ERMERAK N. O., LAÇİN T., TOPTAŞ T., OLGUN YILDIZELİ Ş., Taş H., AK K., YILDIZELİ B.Publication Metadata only Kistik Fibrozis ve KF Dışı Bronşektazi Hastalarında Obstrüktif Uyku Apne Sıklığı VeKlinik Bulgularla İlişkisi(2022-06-28) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; CEYHAN, BERRİN; VEZİR D., BALCAN M. B. , KOCAKAYA D., ÇINAR C., OLGUN YILDIZELİ Ş., CEYHAN B.Publication Metadata only Clinical impact of depression and anxiety in patients with non-cystic fibrosis bronchiectasis(TURKISH ASSOC TUBERCULOSIS & THORAX, 2020) CEYHAN, BERRİN; Bekir, Melahat; Kocakaya, Derya; Balcan, Baran; Olgun Yildizeli, Sehnaz; Eryuksel, Emel; Ceyhan, BerrinIntroduction: Bronchiectasis is a chronic suppurative disease characterized by abnormal bronchial dilatation. The nature of bronchiectasis may have negative impact on psychological status, however it is poorly studied in relation to clinical indices, particularly the severity of disease. Primary aim of this study is to detect depression and anxiety in patients with non-cystic fibrosis bronchiectasis and to evaluate its relationship with disease severity indexes. Materials and Methods: Ninety (male/female= 37/53; median age 45 years) stable non-cystic fibrosis bronchiectatic adult patients were enrolled into this study. Dyspnea scores, number of exacerbations and hospital admissions within the last year, body-mass index, pulmonary function tests, sputum cultures, bronchiectasis disease severity indexes (BSI and FACED) were assessed. Anxiety and depression were evaluated by using the Turkish version of the hospital anxiety and depression scale questionaire. Results: Anxiety was diagnosed in 30% of patients and depression was diagnosed in 41% of the participants. Female participants had significantly higher rates of depression (55% vs. 22%; p= 0.002). Exacerbation rates within the last year were higher among the subjects with anxiety, moreover, patients with depression had shorter duration of disease. 851 and FACED severity indexes increased with longer duration of disease (5.6 +/- 5.0 yrs in mild group vs. 10.1 +/- 9.2 yrs in moderate-to-severe group, p= 0.035 and 5.7 +/- 5.4 yrs in mild group vs. 12.1 +/- 9.7 yrs in moderate-to-severe group, p= 0.001, respectively), however, anxiety and depression were not related with BSI and FACED severity indexes. Conclusion: Patients with non-cystic fibrosis bronchiectasis have an increased risk for depression and anxiety. Duration of disease and higher exacerbation rate are related with psychological status and indexes increased with longer duration of disease. Lady detection and taking the necessary measures to improve the psychological state is necessary for the overall management of these patients.Publication Metadata only Artmış D-Dimer ve pulmoner arter çapı değerleri, Türk COVID-19 hastalarında hastalık progresyonu ve artmış mortalite ile ilişkilidir(2021-05-18) OLGUN YILDIZELİ, ŞEHNAZ; KOCAKAYA, DERYA; ERTÜRK ŞENGEL, BUKET; KARAKURT, SAİT; ERYÜKSEL, SEMİHA EMEL; MERCANCI Z., ILGIN C., OLGUN YILDIZELİ Ş., KOCAKAYA D., BALCAN M. B. , ERTÜRK ŞENGEL B., KARAKURT S., ERYÜKSEL S. E.Publication Metadata only Associates of mortality with neutrophil/lymphocyte ratio in patients with COVID 19 infection: a single-center experience(2021-05-18) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; ERYÜKSEL, SEMİHA EMEL; KARAKURT, SAİT; TURAN B., BAYSAL E., ÖMÜR C., ABDULRAHMAN Y., ÇINAR C., KOCAKAYA D., OLGUN YILDIZELİ Ş., ERYÜKSEL S. E. , BALCAN M. B. , KARAKURT S.
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