Person: BİLĞİÇ ALKAYA, DİLEK
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BİLĞİÇ ALKAYA
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DİLEK
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Publication Metadata only Fabrication and characterization of pla/sa/ha composite nanofiber by electrospinning for bone tissue engineering applications(2018-07-18) CESUR, SÜMEYYE; EKREN, NAZMİ; KILIÇ, OSMAN; OKTAR, FAİK NÜZHET; BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; GÜNDÜZ, OĞUZHAN; Cesur S., Ekren N., Kılıç O., Oktar F. N., Bilğiç Alkaya D., Ayaz Seyhan S., Ege Z. R., Gündüz O.Publication Metadata only Loading of tuberculosis drugs to nanofiber structures, fiber optimization(2019-06-28) BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Onurlu H. İ., Bilğiç Alkaya D., Ayaz Seyhan S., Cesur S., Gündüz O.uberculosis is a disease caused by a bacillus called mycobacterium tuberculosis which can be seen in other organs, especially in the lungs. Tuberculosis is an infectious, infectious, inflammatory, acute or chronic-trending bacterial infection. Since the treatment is insufficient with a single drug and the bacilli are resistant to this antibiotic, various antituberculosis drugs are used side by side during the treatment. Side-by-side use of the drugs breaks the resistance of the bacteria but creates a lot of side effects for the patient. We aim to reduce the existing side effects by loading the active agents of rifampicin, isoniazid, pyrazinamide and ethambutol, which are used as antituberculosis drugs, to a biodegradable nanofib. Primarily, PCL polymer material was dissolved in DMF: THF (v / v). After preparing PCL solution in 3%, 6%, 9%, 12% and 15% concentrations, optimization studies were performed by using electrospin device at various voltages. The SEM images of the obtained PCL fibers were examined and drug loading was performed at the suitable PCL concentration. In the planned study, FTIR images of the fibers loaded with the drug will be examined and controlled drug oscillations will be provided at the stomach and intestinal pH as an in vitro trial and spectrophotometric measurements will be taken. The release of drugs loaded into nanofibers are slower due to the wide surface area of the nanofibers, which offers a more controlled drug release.Publication Metadata only Preparation and characterization of silver-doped hydroxyapatite from seashell by different methods(2018-09-08) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; , Ayaz Seyhan S., Bilğiç Alkaya D., Öztürk B. N., Cesur S., Topsakal A., Oktar F. N., Gündüz O.Publication Metadata only Hydroxyapatıte is bıomaterıals: its chemıcal synthesıs characterızatıon shell of cypaea annulus(2018-09-08) BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; Bilğiç Alkaya D., Ayaz Seyhan S., Öztürk B. N., Cesur S., Topsakal A., Oktar F. N., Gündüz O.Publication Metadata only Preparatıon of hydroxyapatıte biomaterıals for benzoic acid delıvery from scotch bonnets seashell by microwave processing(2018-09-08) BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; Öztürk B. N., Bilğiç Alkaya D., Ayaz Seyhan S., Cesur S., Topsakal A., Oktar F. N., Gündüz O.Publication Metadata only The relation between blood and tissue magnesium levels and development of atrial fibrillation after coronary artery bypass surgery(TURKISH SOC CARDIOLOGY, 2010) BİLĞİÇ ALKAYA, DİLEK; Sahin, Veysel; Kaplan, Mehmet; Bilsel, Serpil; Filizcan, Ugur; Cetemen, Sebnem; Bayserke, Olgar; Alkaya, Dilek Bilgic; Eren, ErginObjective: Atrial fibrillation (AF) is a common complication of cardiovascular surgery and its mechanisms are not well understood. The aim of our study was a prospective investigation of the relationship between AF development and tissue or blood magnesium levels. Methods: This prospective observational study evaluated 20 patients undergoing elective initial coronary artery bypass graft (CABG) surgery. Right atrial appendage and skeletal muscle samples were obtained for tissue magnesium level analysis before, during (at 60(th) minute) and 30 minutes after cardiopulmonary bypass (CPB) with simultaneous blood samples. Daily measurements of blood Mg levels and continuous monitoring for AF were performed for 7 postoperative days. Statistical analyses were performed using ANOVA, independent samples t and Chi-square tests. Results: AF developed in 5 out of 20 patients during postoperative period (25%). Patients with or without AF did not differ in terms of tissue and blood magnesium levels during and early after CPB and during 7 days after the operation. Blood magnesium levels were significantly higher in the whole study population on postoperative days 3 through 7 (day 3 - 1.13 +/- 0.11 mmol/L; day 4-, 1.18 +/- 0.07 mmol/L; day 5-1.15 +/- 0.10 mmol/L; day 6-1.17 +/- 0.08 mmol/L; and day 7, 1.22 +/- 0.08 mmol/L) compared to day 1 and day 2 (day 1-0.96 +/- 0.13 mmol/L and day 2-1.02 +/- 0.12 mmol/L; p<0.002 for all comparisons). Conclusion: Although patients with and without AF did not significantly differ with regard to blood and tissue magnesium levels, the coincidence of an early postoperative reduction in magnesium levels in all patients and occurrence of all AF incidences at this time period suggests a potential association deserving further investigation. (Anadolu Kardiyol Derg 2010; 10: 446-51)Publication Metadata only Investıgatıon of chıtosan / trıcalcıum phosphate (Tcp) composıte powders from scotch bonnets ( Semıcassıs Granulata) as a drug controlled release matrıces(2018-07-18) BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; OKTAR, FAİK NÜZHET; Bilğiç Alkaya D., Ayaz Seyhan S., Cesur S., Gündüz O., Oktar F. N.Publication Unknown Productıon of hydroxyapatite/poly(vinyl alcohol) based scaffold for drug delıvery from orange spıny oyster seashell (spondylus barbatus)(2018-07-18) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; Ayaz Seyhan S., Bilğiç Alkaya D., Cesur S., Oktar F. N., Gündüz O.