Person: KARAKURT, SAİT
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
KARAKURT
First Name
SAİT
Name
78 results
Search Results
Now showing 1 - 10 of 78
Publication Metadata only Induced sputum as a method for detection of systemic sclerosis-related interstitial lung disease(SPRINGER HEIDELBERG, 2012) ÇELİKEL, ÇİĞDEM; Yilmaz, Neslihan; Abul, Yasin; Bicakcigil, Muge; Golabi, Pejman; Celikel, Cigdem; Karakurt, Sait; Yavuz, SuleInducted sputum (IS) is a non-invasive procedure that can be used for collection of airway secretions. The aim of our study is to evaluate the clinical usefulness of IS for detection of airway inflammation in systemic sclerosis (SSc). Bronchoalveolar lavage and IS were performed to 20 patients with SSc. Eighteen patients who were referred to pulmonary medicine for bronchoalveolar lavage due to other reasons were also recruited for cell counts comparisons. Spirometry, echocardiography and thorax CT (HRCT) imaging were also performed to all patients. Mean macrophage and lymphocyte counts were found to be increased in IS of SSc patients compared with that of control (58.4 +/- A 14.5% vs. 31.3 +/- A 16.3%, 30.2 +/- A 15.4% vs. 15.0 +/- A 11.5% P < 0.001), whereas mean neutrophil count was lower in the SSc patients (4.1 +/- A 4.5% vs. 17.2 +/- A 13.1%, P < 0.05). Significant correlations were noted between BAL and IS findings for macrophage (r = 0.55, P = 0.02) lymphocyte (r = 0.65, P < 0.01) and total cell counts (r = 0.45, P = 0.06). IS is an easy and reliable method for the detection of alveolitis and can be used for early detection of lung involvement in scleroderma.Publication Metadata only Evaluation of Airway Resistance in Children with Juvenile Idiopathic Arthritis(MARY ANN LIEBERT, INC, 2014) KARAKURT, SAİT; Abul, Mehtap Haktanir; Abul, Yasin; Erguven, Muferet; Karatoprak, Elif Yuksel; Karakurt, Sait; Celikel, TurgayBackground: Pneumonitis, pleuritis, and pulmonary interstitial infiltration have been described in patients with juvenile idiopathic arthritis (JIA). However, the pulmonary involvement of JIA is not often clinically apparent. There are few studies based on pulmonary function in children having only a diagnosis of JIA. The aim of the present study is to determine whether children with JIA have airway resistance and flow impairments measured by easily applied interrupter technique. Method: We performed interrupter resistance (Rint) measurements in children with JIA and in healthy control subjects who had no respiratory symptoms or diseases. Results: Fifty-eight children with the diagnosis of JIA (Mean age = 12.5 +/- 2.75 years; range 7-17 years) and 33 healthy subjects (Mean age = 11.8 +/- 2.62 years; range 6-16 years) were included in the study. The mean value of tidal peak flow during expiration measured by the interrupter technique was significantly lower in the JIA study group (0.73 +/- 0.11 L/s) compared to the healthy control group (0.79 +/- 0.08 L/s; p = 0.01). Rint values measured during inspiration (Rint(insp)) and during expiration (Rint(exp)) were higher in the JIA study group (Rint(insp) = 0.28 +/- 0.16 Kpa/L/s; Rint(exp) = 0.30 +/- 0.50 Kpa/L/s) compared to the healthy control group (Rint(insp) = 0.26 +/- 0.11 Kpa/L/s; Rint(exp) = 0.23 +/- 0.08 Kpa/L/s; p > 0.05). There was also a positive correlation between C-reactive protein level and median expiratory interrupter resistance (Rint(exp); r = 0.50, p = 0.005). Conclusion: The interrupter technique is a noninvasive and feasible technique and can be used to assess airway abnormalities in children with JIA who cannot successfully complete spirometry.Publication Metadata only The Endocrinologic Changes in Critically III Chronic Obstructive Pulmonary Disease Patients(TAYLOR & FRANCIS INC, 2010) KARAKURT, SAİT; Akbas, Turkay; Karakurt, Sait; Unluguzel, Goksenin; Celikel, Turgay; Akalin, SemaBackground: Alterations in the neuroendocrine system occur during critical illness. Chronic obstructive pulmonary disease (COPD) itself causes hormonal changes. The aim of this study was to determine neu roendocrine hormones of COPD patients with acute respiratory failure and to investigate the relationship between hormonal changes, mortality, and morbidity. Methods: We enrolled 21 patients (13 F/8 M) with COPD exacerbation requiring artificial airway support. Blood samples were collected on admission to the ICU, and on the day of hospital discharge. Eighteen healthy people were included as controls. Results: Female patients had lower luteinizing hormone (LH), follicle stimulating hormone (FSH), and free triiodothyronine (fT3), and higher prolactin (PRL) levels than controls on admission to the ICU (FSH: 70.3 vs. 29.3 mIU/mL; LH: 26.6 vs. 6.8 mIU/mL; fT3: 2.9 vs. 2.0 pg/mL; PRL: 12.4 vs. 21.3 ng/mL). Male patients had low testosterone and TSH and high PRL but only changes in TSH and PRL reached statistical significance (testosterone: 3.5 vs. 1.5 ng/mL, TSH: 1.1 vs. 0.5 uIU/mL, PRL: 9.7 vs. 14.2 ng/mL). Female patients had lower fT3 than males (fT3(female): 2.7 vs. fT3(male): 2.0 pg/mL). On follow-up, significantly elevated FSH and fT3 and decreased estradiol concentrations were documented among recovered women (FSH: 28.4 vs. 46.6 mIU/mL, fT3,: 2.0 vs. 2.6 pg/mL, E-2: 27.7 vs. 19.0 pg/mL). Patients had high C-reactive protein levels and acute physiologic and chronic health evaluation II scores. Mortality rate was 9.5% and a negative correlation between E-2 and duration of noninvasive mechanical ventilation and length of hospital stay was found in male patients. Conclusion: Men and women with acute respiratory failure in the presence of COPD develop significant changes in the neuroendocrine axis. Hormonal suppression vanishes with disease improvement.Publication Metadata only Usage of NEWS for prediction of mortality and in-hospital cardiac arrest rates in a Turkish university hospital(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2018) ARIKAN, HÜSEYİN; Atmaca, Ozgur; Turan, Can; Guven, Pinar; Arikan, Huseyin; Eryuksel, S. Emel; Karakurt, SaitBackground/aim: Early warning scores (EWS), widely used around the world but not yet in Turkey, are composed of physiological parameters designed to determine potentially worsening patients to perform necessary interventions in time. The aim is to determine the national EWS (NEWS) of the patients to assess the relation between this score and length of hospital stay (LOHS), transfer to the ICU, 24-h and 28-day mortality rates, and the frequency of in-hospital cardiac arrest (IHCA). Materials and methods: NEWS of all the patients in the internal medicine clinics were calculated via a point prevalence study. The LOHS, transfer to the ICU, rates of mortality in the 24-h and 28-day period, IHCA rate, and the period of the stay in the ICU parameters were determined. Results: Out of 104 patients, 84 of them had low scores (<5), while 20 had mid/high scores. In mid/high-score group (score>5), transfer to the ICU, IHCA rate, and mortality rates within 24 h and 28 days were significantly higher. Conclusion: In this, the first prospective study about EWS in Turkey, 24-h and 28-day mortality rates, transfer to the ICU, and IHCA frequency of the patients with mid/high NEWS were higher.Publication Metadata only Does preexisting immuncompromised status prevent mortality in COVID-19 patients: friend or foe?(2022-09-01) VEZİR, DUYGU; KOCAKAYA, DERYA; MERCANCI, ZEYNEP; KARAKURT, SAİT; Vezir D., Yildizeli S. O., KOCAKAYA D., Mercanci Z., Balcan B., Cinar C., Eryuksel E., KARAKURT S.Publication Open Access Outcome of solid and cavitary pulmonary nodules in rheumatoid arthritis patients— case series(2022-01-01) AKSOY, AYSUN; BOZKURTLAR, EMİNE; KARAKURT, SAİT; ERYÜKSEL, SEMİHA EMEL; İNANÇ, GÜZİDE NEVSUN; KOCAKAYA, DERYA; AKSOY A., KOCAKAYA D., Yalçinkaya Y., BOZKURTLAR E., KARAKURT S., Eryüksel E., İnanç N.© TÜBİTAK.Background/aim: Rheumatoid pulmonary nodule can be detected in up to 32% of rheumatoid arthritis (RA) patients and approximately one-third of nodules may cavitate. We aimed to evaluate characteristics of patients with RA developing cavitary pulmonary nodular (CPN) lesions under disease-modifying antirheumatic drugs (DMARDs), follow-up of both cavitary and solid nodules, and their outcome with the treatment. Materials and methods: RA patients who presented with CPN lesions during follow-up were recruited retrospectively in this case series analysis. Total numbers and mean diameters of cavitary and solid nodules in each thorax computed tomography (CT) have been determined and followed up by two experienced pulmonary physicians. Moreover, changes in treatment after the development of the CPN lesions and characteristics of cavitary nodules were collected. Results: Eleven patients with CPN lesions were reported. At the time of CPN diagnosis, more patients were taking leflunomide than methotrexate (81% vs 19%). Half of the patients were receiving biologic therapy and only 18% were taking anti-TNF drugs. After a median of 24 (3–65) months of follow-up, the regression of CPN lesions was determined in 45% (5/11) of patients. Four of these 5 (80%) patients were switched to a treatment regimen without leflunomide and three of them to nonanti-TNF biologic treatment or targeted synthetic DMARDs (tocilizumab, tofacitinib, and rituximab). Conclusion: CPN lesions seen in RA patients are often pulmonary manifestations of the underlying disease; however, one must rule out malignancies or infections. If lesions progress under DMARDs, it is advised to discontinue synthetic DMARDs (LEF/MTX) and switch to another biological DMARD with different modes of action.Publication Metadata only İlerı ve son evre akciğer hastalığına ikincil solunum yetmezliği olan hastaların bakım verenlerinde bakım verici yükü ve depresyon ilişkisi(2018-04-18) OLGUN YILDIZELİ, ŞEHNAZ; KASAPOĞLU, UMUT SABRİ; KOCAKAYA, DERYA; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; KARAKURT, SAİT; ARIKAN, HÜSEYİN; OLGUN YILDIZELİ Ş., ARIKAN H., KASAPOĞLU U. S., KOCAKAYA D., ERYÜKSEL S. E., CEYHAN B., KARAKURT S.Publication Metadata only Histopathological evaluation of post-mortem pulmonary specimens excised from ICU patients with COVID-19: Do we know what we do not know(2023-05-06) ERMERAK, NEZİH ONUR; BOZKURTLAR, EMİNE; KOCAKAYA, DERYA; GÜL, FETHİ; KARAKURT, SAİT; ERMERAK N. O., BOZKURTLAR E., KOCAKAYA D., GÜL F., KARAKURT S., Cinel I.Publication Metadata only Clinical Experience Receiving ECMO for Acute Respiratory Distress Syndrome(AVES, 2017) AK, KORAY; Eryuksel, Emel; Yalcin, Aslihan; Guven, Pinar; Turan, Can; Yildizeli, Sehnaz Olgun; Ispir, Selim; Ak, Koray; Karakurt, SaitAcute respiratory distress syndrome (ARDS) is characterized by pulmonary edema caused by sudden increase in alveolocapillary membrane permeability, hypoxemia, and bilateral lung infiltration. Despite improvement in ICU treatment modalities, the mortality rate among ARDS patients is still considerably high. In the treatment of ARDS, in addition to the treatment of underlying cause, low-tidal volume, lung-protective mechanical ventilation is recommended. However, in patients who cannot attain target oxygen level or develop high plateau pressure despite low-tidal volume ventilation and who cannot tolerate high carbon dioxide and low pH levels, extracorporeal membrane oxygenation (ECMO) may be considered as a good treatment option. In this article, cases of ARDS patients treated with ECMO in our clinic during 2013-14 have been retrospectively documented and discussed in line with the literature.Publication Metadata only Severe respiratory failure secondary to Varicella zoster pneumonia(2010-01-01) KARAKURT, SAİT; DURMUŞOĞLU, LÜTFİYE; ÇELİKEL, TURGAY HÜSEYİN; ERYÜKSEL E., ABUL Y., KARAKURT S., AKBAŞ T., DURMUŞOĞLU L., ÇELİKEL T. H.Varicella is one of the most contagious diseases of childhood. Whenever varicella is seen in adults, it can cause serious complications. Pneumonia is one of the most serious complications of varicella during adulthood and it has a high mortality rate. Cases of varicella pneumonia which need mechanical ventilation in intensive care unit, have %50 of mortality rate. This report presents a patient who was diagnosed as varicella pneumonia in our intensive care unit. Our treatment and diagnostic approach is presented together with actual literature. J Clin Exp Invest 2010; 1(2): 113-116