Person: ERBARUT SEVEN, İPEK
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ERBARUT SEVEN
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İPEK
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Publication Open Access A gaucher patient with bilateral total femoral lytic lesions mimicking malignancy: a case report(2022-01-01) AKGÜLLE, AHMET HAMDİ; BUĞDAYCI, ONUR; ERBARUT SEVEN, İPEK; KESKİN ÖZTÜRK, BEYZA; ŞAHBAT Y., AKGÜLLE A. H. , BUĞDAYCI O., ERBARUT SEVEN İ., KESKİN ÖZTÜRK B.Bone involvement in Gaucher disease can afect quality of life. Bone lesions of Gaucher disease can be confused with hematological diseases, infections, and malignancy. Our patient with bilateral femur involvement presented to us with a pathological fracture. After the fracture was treated with a long leg splint and healed, we performed a biopsy because of suspicious radiological fndings. The pathology results confrmed Gaucher disease with bone infltration during the time in which conservative follow-up was taking place, eventually leading to the patient’s mobilization again. Bone fndings of Gaucher disease indicate a difcult process requiring follow-up and treatment. It is crucial to scan patients periodically for possible vertebral and extremity symptoms. Vertebral and extremity fractures undoubtedly require experience on the part of the clinician as they can imitate malignant masses.Publication Open Access The effect of HPV analysis on the ASC/SIL ratio which is one of the quality control criteria for PAP smears(MARMARA UNIV, FAC MEDICINE, 2021-01-27) ERBARUT SEVEN, İPEK; Erbarut Seven, IpekObjective: The high number of smear tests has a workload on pathologists/cytopathologists, which raises the concern for the quality of diagnoses. The application of high-risk human papillonfavirus (hr-HPV) analyses with the PAP smear has begun to contribute to the clinical practice. In this study, we aimed to show the effect of hr-HPV analysis on the results of PAP smear via atypical squamous cell/squamous intraepithelial lesion (ASC/SIL) ratio on the quality standards. Materials and Methods: A total of 12799 cervical cytology reports, between 2014-2016, from the Pathology Department of Marmara University Hospital, were included. Between November 2014 and May 2016, hr-HPV analysis was performed on a total of 4307 cases with Hologic Aptima HPV (TM), USA. Smear diagnoses before and after the start of the HPV test application were recorded. Results: The cytology diagnoses, during when hr-HPV screening was not performed, were negative for intraepithelial lesion or malignancy (NILM) 99.4%, atypical squamous cells of undetermined significance (ASCUS) 0.6%, low-grade squamous intraepithelial lesion (LSIL) 0.2%, ASC-H 0.04%, and high-grade squamous intraepithelial lesion (HSIL) 0.13%. The cytology diagnoses that were evaluated with HPV test were as follows: NILM 93.67%, ASCUS 2.31%, LSIL 2.82%, ASC-H 0.3%, and HSIL 0.91%. ASC/SIL ratio has been dropped from 1.9 to 0.7 after the initiation of hr-HPV use. Conclusion: During the period without hr-HPV analysis, the ASC/SIL ratio was 1.9. Later with the initiation of hr-HPV screening this ratio decreased to 0.7. This shows that knowing HPV test results affects and improves the quality of the laboratory diagnoses.Publication Open Access A retrospective evaluation of the epithelial changes/lesions and neoplasms of the gallbladder in turkey and a review of the existing sampling methods: a multicentre study(2013) ERBARUT SEVEN, İPEK; Esendagli, Guldal; Akarca, F. Goknur; Balci, Serdar; Argon, Asuman; Erhan, Selma Sengiz; Turhan, Nesrin; Zengin, Neslihan Ince; Keser, Sevinc Hallac; Celik, Betul; Bulut, Tangul; Abdullazade, Samir; Erden, Esra; Savas, Berna; Bostan, Temmuz; Sagol, Ozgul; Agalar, Anil Aysal; Kepil, Nuray; Karslioglu, Yildirim; Gunal, Armagan; Markoc, Fatma; Saka, Burcu; Ozgun, Gonca; Ozdamar, Sukru Oguz; Bahadir, Burak; Kaymaz, Esin; Isik, Emre; Ayhan, Semin; Tuncel, Deniz; Yilmaz, Banu Ozguven; Celik, Sevinc; Karabacak, Tuba; Seven, Ipek Erbarut; Celikel, Cigdem Ataizi; Gucin, Zuhal; Ekinci, Ozgur; Akyol, GulenPublication Metadata only Follicular Cholecystitis: Reappraisal of Incidence, Definition, and Clinicopathologic Associations in an Analysis of 2550 Cholecystectomies(SAGE PUBLICATIONS INC, 2020) ERBARUT SEVEN, İPEK; Saka, Burcu; Memis, Bahar; Seven, Ipek Erbarut; Pehlivanoglu, Burcin; Balci, Serdar; Bagci, Pelin; Reid, Michelle; Dursun, Nevra; Tapia Escalano, Oscar; Carlos Roa, Juan; Carlos Araya, Juan; Kong, So Yeon; Basturk, Olca; Koshiol, Jill; Adsay, N. VolkanContext. Follicular cholecystitis (FC) is a poorly characterized entity. Objective. To determine its frequency/clinicopathologic associations. Design. A total of 2550 cholecystectomy specimens were examined. Two hundred three of these were consecutive routine cholecystectomies submitted entirely for microscopic examination to determine the relative frequency of incidental pathologies in gallbladders (GBs). The remainder had representative sampling. Underlying conditions were nonobstructive pathologies (1270 nonspecific cholecystitis), obstructive (62 distal biliary tract tumors, 35 primary sclerosing cholangitis, and 31 autoimmune pancreatitis), and neoplastic (n = 949). FC was defined as 3 distinct lymphoid follicles (LFs)/centimeter. Results. In the GBs totally submitted for microscopic examination, the true frequency of FC was found to be 2.5% (5/203), and in the representatively sampled group, it was 1.9%, with similar frequencies in nonobstructive, obstructive, and neoplastic cases (2.3%, 3.1%, and 1.3%, respectively, P = .77). When the 39 FC in nonneoplastic GBs contrasted with ordinary chronic cholecystitis, they were associated with older age (68 vs 49 years, P < .0001), similar gallstone frequency (68 vs 81%), female/male ratio (2.7 vs 2.6), and wall thickness (4 mm for both). None had lymphoma/parasites/Salmonella infection. Of 17 cases who had undergone gastric biopsy, 5 had chronic gastritis (2 with Helicobacter pylori). Microscopically, the LFs were the main inflammatory process often with minimal intervening inflammation. IgG4-positive plasma cell density was low (<10/high-power field) in 21/24(87.5%) cases. Conclusions. Follicular cholecystitis is seen in 2% of cholecystectomies, typically in significantly older patients, suggesting a deranged immune response. A third of the patients reveal biopsy-proven gastritis. FC does not seem to be associated with autoimmunity, lymphoma, or obstructive pathologies.Publication Open Access Minimally invasive thyroid anaplastic carcinoma with long survival(TURKISH SURGICAL ASSOC, 2018-01-15) ERBARUT SEVEN, İPEK; Ugurlu, Mustafa Umit; Seven, Ipek Erbarut; Eren, Funda; Yegen, Cumhur; Gulluoglu, Bahadir MahmutAnaplastic thyroid carcinoma is a highly lethal malignancy. Previously, only five cases of a noninvasive form of anaplastic thyroid carcinoma with excellent prognosis were reported, We report a case of a 68-year-old man who presented with a 3,8 cm thyroid nodule diagnosed by fine needle aspiration biopsy as poorly differentiated spindled and epithelial malignant cells, Lobectomy and isthmusectomy were performed, and the final diagnosis was micro-invasive anaplastic thyroid carcinoma arising in a poorly differentiated carcinoma, The patient remains disease-free after six years, even after hemithyroidectomy and radiation treatment. Noninvasive/micromvasive anaplastic thyroid carcinoma appears to be a different disease entity from classical anaplastic thyroid carcinoma, with favorable prognosis and long disease-free survival.Publication Open Access Laparoscopic approach for removing a coin trapped in Meckel's diverticulum(TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2017) KIYAN, GÜRSU; Karadeniz, Kivilcim; Kalyoncu, Aybegm; Erbarut, Ipek; Kiyan, Gursu; Dagli, Tolga EmrullahForeign body ingestion is a common problem in children. Most of these foreign bodies spontaneously pass through the gastrointestinal tract. When there is a persistent foreign body in the abdomen, it is impossible to make a diagnosis without exploration. We herein present the case of a child who was admitted to our hospital with a coin trapped in Meckel's diverticulum and our laparoscopic approach in this case. The diagnosis of Meckel's diverticulum should be considered when there is a prolonged lodgment of a foreign body in the right lower quadrant, and the laparoscopic approach is the preferred choice in these cases.Publication Metadata only Pathologic classification of pancreatic cancers: current concepts and challenges(AME PUBL CO, 2017) ERBARUT SEVEN, İPEK; Mostafa, Mohamed E.; Erbarut-Seven, Ipek; Pehlivanoglu, Burcin; Adsay, VolkanAs the most common and most important cancer of the pancreas, with rapid mortality and now also as the third leading cause of cancer-related deaths in the United States, pancreatic ductal adenocarcinoma (PDAC) has become synonymous with pancreas cancer. PDAC is also the prototype of the pancreatobiliary-type adenocarcinomas, along the biliary tract, ampullary and gallbladder cancers with the similar morphology and behavior. Recent molecular profiling studies have identified distinct subsets of PDAC, potentially with different behaviors and targetability. Moreover, while PDAC is by far the most common cancer of the pancreas, there are various other types that occur in this organ and are erroneously classified together with PDAC. Many of these have different molecular and biologic characteristics that warrant their management separately although they are also technically pancreatic cancers. While some are closely related to PDAC and have as aggressive behavior (such as adenosquamous carcinomas which are recently recognized under basal like category in profiling studies, which are actually even worse prognostically than PDACs), in the meantime, others such as colloid carcinoma has a much better behavior than PDAC, and as a carcinoma with intestinal lineage (MUC2/CDX2) colloid carcinoma may require an entirely different treatment approach as well. Similarly, medullary carcinomas also appear to have different biology. Additionally, non-ductal cancers such as acinar, neuroendocrine, solid-pseudopapillary neoplasms and pancreatoblastoma have their respective clinicopathologic and molecular associations and warrant careful elimination in the management and study protocols. Another very problematic aspect in the classification of pancreas cancer is its delineation from the cancers of neighboring organs, in particular, ampullary/duodenal and common bile duct (CBD) cancers, for which recently more refined criteria have been provided. Additionally, the possibility of metastasis from another site and lymphomas also need to be considered. In summary, there is a whole host of cancers that occur in the pancreas that ought to be considered carefully before a case is classified as an ordinary pancreas cancer (PDAC).Publication Metadata only Tumor cell seeding in the biopsy tract and its clinical significance in osteosarcomas(WILEY, 2018) EROL, BÜLENT; Turkoz, Kemal H.; Erol, Bulent; Seven, Ipek E.Background and objectives Methods The reasons behind the removal of the biopsy tract in osteosarcomas are not well known, and studies about tumor seeding in the biopsy tract have generated conflicting results. This study is designed to evaluate the presence and possible clinical significance of tumor cell seeding in the biopsy tract of osteosarcomas. We prospectively evaluated 55 cases of osteosarcomas for tumor cell seeding and other clinical and pathologic prognostic parameters. Results Conclusions Eleven cases (20%) involved microscopic tumor foci in the biopsy tract. The higher local recurrence rates (P = 0.005) and worse recurrence-free survivals (P = 0.009) were observed in patients with tumor cell foci in the biopsy tract. Mitotic rate, tumor cell pleomorphism, and matrix production in main tumor foci were higher in cases with tumor seeding (P = 0.047, P = 0.012, and P = 0.005, respectively) Tumor seeding in the biopsy tract is a fact in osteosarcomas. The higher local recurrence rates are more likely to occur in cases with tumor seeding.Publication Open Access Production of 3D-printed ribs with a novel material (Nylon 680 Co-Polymer) for chest wall reconstruction on a pig model: Preliminary results of an experimental study(2023-09-01) ERMERAK, NEZİH ONUR; LAÇİN, TUNÇ; ERBARUT SEVEN, İPEK; ERMERAK N. O., YÜKSEL M., Yüksel B., LAÇİN T., ERBARUT SEVEN İ., LAÇİN B.Aim: Three-dimensional (3D) printing has gained popularity among all fields of science in recent years. New research studies about the utilization of 3D printing in the medical field, in terms of medical devices and implants, have been published recently. We tried to adapt this technology into thoracic surgery by implanting 3D produced ribs following chest wall resection with a novel material called Nylon 680 Co-Polymer. We, hereby, present the preliminary results of this experimental study. Materials and Methods: We ordered multi detector computerized tomography of the chest for 2 pigs. We measured the area that we planned to resect on chest wall and used the data for printing custom-made rib for the reconstruction of the resected area. Then, we produced ribs with a USA Food and Drug Administration approved material called Nylon 680 Co-polymer (Taulman 3D, Saint Peters, MO, USA) by using 3D printer (Afinia H480, Chanhassen, MO, USA). Pigs were operated under general anesthesia and the resected areas were reconstructed with custom-made 3D printed ribs. Results: One of the pigs passed away due to myocardial infarction while waking up from anesthesia. We followed up the other pig for 45 days. Then, we sacrificed the animal and resected the operated part for histopathological evaluation. Histopathologic evaluation revealed moderate chronic inflammation with few giant cells containing pigmented foreign bodies. Conclusion: Although we need more studies, it is an important step for adapting 3D-printing into thoracic surgery. Additionally, it is important to identify a potential new material (Nylon 680 Co-polymer) for the future studies. We can use this new material for 3D-printed implant and mesh production, which enables us to produce custom-made products with lower cost in shorter timePublication Metadata only Apocrine carcinomas of the breast in Turkish women: Hormone receptors, c-erbB-2 and p53 immunoexpression(ELSEVIER GMBH, 2008) KAYA, HANDAN; Kaya, Handan; Bozkurt, Sueheyla Uyar; Erbarut, Ipek; Djamgoz, Mustafa B. A.The aims of this study were twofold: (i) to determine the occurrence frequency of apocrine carcinoma of the breast (ApBCa) in Turkish breast cancer (BCa) patients; and (ii) to evaluate the expression of estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR), gross cystic disease protein-15 (GCDFP-15), c-erbB-2, and p53 in these cases. Six hundred and twenty-six cases of BCa were studied immunohistochemically (streptoavidin-biotin horseradish peroxidase method). The results of ApBCa were compared with those of invasive ductal carcinoma not otherwise specified type (IDC-NOS) cases of similar grade. Thirteen cases of ApBCa were encountered, accounting for 2.1% of all BCa cases. Immunohistochemically, ApBCa positivity was as follows: GCDFP-15 (100%), ER (39%), PR (8%), AR (54%), p53 (39%), and c-erbB-2 (85%). In the IDC-NOS group, GCDFP-15* was expressed in less than 50% of the tumors. The occurrence frequencies of the other markers were as follows: ER (69%), PR (69%)*, AR (46%), c-erbB-2 (0%)*, and p53 (31%), (*) indicating significant differences between the two groups. For Turkish BCa patients, (i) the occurrence rate of ApBCa (2.1%) was high; and (ii) the following combination would allow for an immunohistochemical identification of ApBCa: GCDFP-15(+), c-erbB-2(+), and PR-. (C) 2008 Elsevier GmbH. All rights reserved.