Person: TEZCAN, SONGÜL
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
TEZCAN
First Name
SONGÜL
Name
26 results
Search Results
Now showing 1 - 10 of 26
Publication Metadata only Aprepitant in the Treatment of Subacute Sclerosing Panencephalitis: A Randomized, Double-Blind, Placebo-Controlled Study(ELSEVIER SCIENCE INC, 2020) ARMAN KANDIRMAZ, EMİNE; Oncel, Ibrahim; Sancar, Mesut; Konuskan, Bahadir; Arioz, Filiz; Tezcan, Songul; Arman-Kandirmaz, Emine; Parlak, Safak; Gumeler, Ekim; Anlar, BanuBackground: Aprepitant is a neurokinin-1 receptor antagonist approved for the treatment of chemotherapy-induced nausea. We aimed to investigate the safety and efficacy of aprepitant in patients with subacute sclerosing panencephalitis. Methods: A randomized, double-blind, placebo-controlled study was conducted in patients with subacute sclerosing panencephalitis assigned to receive two courses of aprepitant 250 mg/day orally or placebo for 15 days with an interval of two months between courses. Primary end points were safety and tolerability, and secondary end point was clinical improvement or stabilization assessed by subacute sclerosing panencephalitis scoring system. Electroencephalography (EEG), brain magnetic resonance imaging, and cerebrospinal fluid measles-specific immunoglobulin G index were evaluated before and after treatment. Results: Sixty-two patients with subacute sclerosing panencephalitis were allocated to aprepitant (n = 31, median age 18 years) or placebo (n = 31, median age 22 years) group. Fifteen patients left the study within the first six months and 12 patients left between six and 12 months. Aprepitant was well tolerated and treatment-associated adverse events were similar to those described in the treatment of nausea. Clinical status at six and 12 months' follow-up did not differ between aprepitant and placebo groups. Post-treatment EEG scores at 12 months were better in the aprepitant group (P = 0.015). Cerebral atrophy on magnetic resonance imaging increased in both groups, whereas measles-specific immunoglobulin G index decreased in the placebo group. Conclusions: In this first clinical trial of aprepitant treatment in patients with subacute sclerosing pan encephalitis, the drug was safe and well tolerated. No clinical effect was observed. A modest improvement in EEG findings might justify trials for longer periods because EEG changes can precede clinical findings in subacute sclerosing panencephalitis. (C) 2020 Elsevier Inc. All rights reserved.Publication Metadata only Knowledge, awareness, and attitudes of pharmacists about dermocosmetic products - adescriptive study(2023-11-02) TEZCAN, SONGÜL; BİLİCİ B., TEZCAN S., İLERİ Y., FARBOUİDİ A.Publication Metadata only The effect of pharmaceutical care practices on clinical competencies and professional preparednessof students(2023-06-04) TEZCAN, SONGÜL; YÜRÜK F. U., AY Z. Y., UÇAR YAMAN N., TEZCAN S., YÜKSEL H. G., MERCANOĞLU H. G.Publication Open Access The role of the clinical pharmacist in patient education and monitoring of patients under warfarin treatment(MARMARA UNIV, 2019-11-15) SANCAR, MESUT; Izzettin, Fikret Vehbi; Celik, Sevda; Acar, Rezzan Deniz; Tezcan, Songul; Aksoy, Nilay; Bektay, Muhammed Yunus; Sancar, MesutThis study was carried out on patients who were under anticoagulation treatment with warfarin, at the outpatient cardiology clinic. The aim was to determine the effectiveness of pharmacist consultation, education, and intervention on each patient's therapeutic results. A cross-sectional randomized trial has been done. Twenty-five patients were included in the study. The Oral Anticoagulation Knowledge (OAK) Test, Short Form-36 (SF-36) and Duke Anticoagulation Satisfaction Scale (DASS) were applied. Patients resumed their routine anticoagulation treatment and INR and complications were recorded during the study. Additionally, patients received patient education, consultation on lifestyle and anticoagulant usage issues from a pharmacist. The same tests were applied again to the patients on the 90th day of the study and the results were compared with the initial test. Maintenance of INR within the target range and complication rates were compared before and after the intervention. Pre-test and post-test results of the patients revealed statistically significant improvements on the physical and mental score components of the SF-36 (p = 0.001; p = 0.001), OAK test scores (p <= 0.001) and the (negative) limitations and burdens and positive effects components of the DASS (p = 0.005; p < 0.001; p = 0.001). The successful maintenance of INR within target range was significantly higher (p = 0.027). The positive effects of pharmacist consultation and education on therapeutic results were demonstrated.Publication Metadata only Factors affecting the career preference of pharmacystudents(2023-08-11) TEZCAN, SONGÜL; AY Z. Y., TEZCAN S., Akar M. C., KALE E.Diabetes is a global health concern. Pharmacists contribute to improving health outcomes by providing pharmaceutical care to patients with Diabetes Mellitus (DM). There are studies showing that pharmacy students need more knowledge in order to competently contribute to diabetes management. The aim of this study is to determine the level of diabetes knowledge of the undergraduate students of Health Sciences University Hamidiye Faculty of Pharmacy. A cross sectional study using online self-administered survey was conducted during 2 weeks among the 4th and 5th year pharmacy students. Sociodemographic characteristics of the students were collected. A structured questionnaire about the definition, causes and symptoms of diabetes (40 items) [1] were applied. The response options were “yes; no; or I do not know”. Each correct answer was scored as 1 point, incorrect or I don't know answers are scores as 0 point. The maximum possible score was 40. Diabetes Knowledge Scale scores and the correlation of the scores with students’ sociodemographic characteristics are main outcome measures. Of the 196 students 77% were female and 43.4% of them had diabetes family history. Forty-one percent of the participants stated that they were involved in the care of at least one diabetes patient. The mean knowledge score was found to be as 34.07 ± 4.13. The subscale scores were found to be as follows; diabetes general knowledge 7.04 ± 1.15 (8 items), diabetes risk factor 2.88 ± 0.37 (3 items), diabetes symptoms 2.70 ± 0.53 (3 items), diabetes diagnosis 3.46 ± 0.91 (4 items), diabetes treatment 7.64 ± 1.62 (10 items), diabetes complications 3.81 ± 0.58 (4 items), and diabetes diet and exercise 3.78 ± 1.19 (5 items), and diabetes control 2.76 ± 0.48 (3 items). The Cronbach's alpha value of the scale was found to be 0.767. Students were found to have adequate background knowledge regarding diabetes diagnosis, symptoms, and risk factors. However, knowledge deficits in areas such as diet in diabetes and treatment in gestational diabetes have been identified among participants.Publication Open Access Erişkin kemik iliği transplantasyon ünitesinde potansiyel ilaç etkileşimlerinin belirlenmesi - prospektif çalışma(2023-01-01) TEZCAN, SONGÜL; Öztürk G. S., Ratip S., TEZCAN S.Objective: Bone marrow treatment (BMT) is a long and complicated process with multiple drug use can lead to drug-drug interactions. The aim of our study is to evaluate potential drug interactions (PDIs) in patients hospitalized in the adult bone marrow transplantation unit. Material and Method: This was a prospective and descriptive study conducted in an adult BMT unit in a private hospital in Turkey between January-June 2021. Sociodemogphrapics of the patients were recorded. PDIs were analyzed via Medscape and Lexicomp drug interaction checker. SPSS 15 was used for analysis. Result and Discussion: Of 40 patients 22 (55%) were male and the mean age was 46. Most of the patients were diagnosed with multiple myeloma (35%) and 58% of the patients had at least one comorbid disease. The number of PDIs detected in the Lexicomp database was statistically higher than in the Medscape database (299 vs 244; p<0.05). More PDIS were found in patients with concomitant disease than in patients without (p<0.05). The number of comorbid diseases was found to be higher in this population. Additionally, the number of PDIs was found to be high. We think that clinical pharmacists have an important role in patient monitoring and management of PDIs in BMT unitsPublication Open Access Role of clinical oncology pharmacist in determination of pharmaceutical care needs in patients with colorectal cancer(BMJ PUBLISHING GROUP, 2018-03) SANCAR, MESUT; Tezcan, Songul; Izzettin, Fikret Vehbi; Sancar, Mesut; Turhal, Nazim Serdar; Yumuk, Perran FuldenObjective To determine and evaluate the pharmaceutical care needs and quality of life of patients with colorectal cancer. Methods 36 Patients with colorectal cancer eligible for chemotherapy after surgery were included in the study. The patients were followed up during 3 courses of chemotherapy and individual pharmaceutical care plans were developed. The quality of life of patients was evaluated before and after the third course of chemotherapy. Results The incidence of drug-related problems (DRPs) in chemotherapy-treated patients was reduced in the 3rd course as compared with 1st course (63.9% vs 75%, respectively; n = 36; p > 0.05). The clinical oncology pharmacist gave 147 recommendations to patients, which were followed in 98% (n = 144) of cases. 91.7% (n = 132) of the recommendations of clinical oncology pharmacists solved the drug-related problems; however, the remaining 8.3% (n = 12) did not solve the problems and the patients were referred to a doctor for further investigations. The symptom-related quality of life of patients related to anaemia, diarrhoea and neurotoxicity was reduced after the third course of chemotherapy (p < 0.05). Conclusions The pharmaceutical care provided by the clinical oncology pharmacist has an important role in the identification and resolution of DRPs. Evaluation of symptom-related quality of life is important for the monitoring of patients receiving chemotherapy.Publication Metadata only Therapeutic drug monitoring of aprepitant with liquid chromatography–massspectrometry(2023-10-31) TEZCAN, SONGÜL; ARMAN KANDIRMAZ, EMİNE; SANCAR, MESUT; TEZCAN S., Kunal G., ÖZDEMİR F., ARMAN KANDIRMAZ E., SANCAR M.Publication Metadata only Evaluation of diabetes knowledge of pharmacy students(2023-08-11) TEZCAN, SONGÜL; RABUŞ, ŞULE; AY Z. Y., TEZCAN S., APİKOĞLU Ş.Diabetes is a global health concern. Pharmacists contribute to improving health outcomes by providing pharmaceutical care to patients with Diabetes Mellitus (DM). There are studies showing that pharmacy students need more knowledge in order to competently contribute to diabetes management. The aim of this study is to determine the level of diabetes knowledge of the undergraduate students of Health Sciences University Hamidiye Faculty of Pharmacy. A cross sectional study using online self-administered survey was conducted during 2 weeks among the 4th and 5th year pharmacy students. Sociodemographic characteristics of the students were collected. A structured questionnaire about the definition, causes and symptoms of diabetes (40 items) [1] were applied. The response options were “yes; no; or I do not know”. Each correct answer was scored as 1 point, incorrect or I don't know answers are scores as 0 point. The maximum possible score was 40. Diabetes Knowledge Scale scores and the correlation of the scores with students’ sociodemographic characteristics are main outcome measures. Of the 196 students 77% were female and 43.4% of them had diabetes family history. Forty-one percent of the participants stated that they were involved in the care of at least one diabetes patient. The mean knowledge score was found to be as 34.07 ± 4.13. The subscale scores were found to be as follows; diabetes general knowledge 7.04 ± 1.15 (8 items), diabetes risk factor 2.88 ± 0.37 (3 items), diabetes symptoms 2.70 ± 0.53 (3 items), diabetes diagnosis 3.46 ± 0.91 (4 items), diabetes treatment 7.64 ± 1.62 (10 items), diabetes complications 3.81 ± 0.58 (4 items), and diabetes diet and exercise 3.78 ± 1.19 (5 items), and diabetes control 2.76 ± 0.48 (3 items). The Cronbach's alpha value of the scale was found to be 0.767. Students were found to have adequate background knowledge regarding diabetes diagnosis, symptoms, and risk factors. However, knowledge deficits in areas such as diet in diabetes and treatment in gestational diabetes have been identified among participants.Publication Metadata only Community Pharmacists' Knowledge on Cancer and Screening Methods(SAGE PUBLICATIONS LTD, 2022) TEZCAN, SONGÜL; Uygun, Aysen; Caliskan, Nazli Dilek; Tezcan, SongulBackground and Objective The aim of the study is to evaluate the knowledge of community pharmacists on cancer and screening methods. Setting and Method This study was a descriptive cross-sectional study and was conducted between January-June 2020 in Istanbul/Turkey. a structured questionnaire was applied to pharmacists as online. The questionnaire was prepared by the researchers and consisted of 49 questions; basic information about cancer (15 items), signs and symptoms (11 items), causes and risk factors (14 items), cancer screening methods (9 items). Results It was determined that the majority (>90%) of the pharmacists did not receive any education on cancer and/or cancer screening methods after graduation. The sufficient knowledge level of the pharmacists about cancer basics, signs and symptoms, and risk factors were found to be as 80%, 77%, and 67%, respectively. The internal consistency level of the questionnaire was calculated (Cronbach's alpha = 0.814). The item Every woman should perform breast self-examination and notify a health professional when there is a change in breast appearance or feeling, was answered correctly by 98% of the pharmacists. It was determined that 71% of the pharmacists gave the correct answer to the item Women aged 21-30 years should have a PAP smear every 3 years. Conclusion According to the results of the study, while the rate of sufficient knowledge level on cancer was found to be low, knowledge on cancer screening was found to be sufficient. We think that pharmacists should receive training on cancer and screening methods and to follow the guidelines closely.
- «
- 1 (current)
- 2
- 3
- »