Person: İNANÇ, GÜZİDE NEVSUN
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İNANÇ
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GÜZİDE NEVSUN
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Publication Metadata only The provisional OMERACT ultrasonography score for giant cell arteritis(2023-04-01) İNANÇ, GÜZİDE NEVSUN; Dejaco C., Ponte C., Monti S., Rozza D., Scirè C. A., Terslev L., Bruyn G. A., Boumans D., Hartung W., Hočevar A., et al.Objectives To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. Methods The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima-media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24. Results Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72-0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from -1.19 to -2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corr coeff 0.37-0.48). Conclusion We developed a provisional OGUS for potential use in clinical trials.Publication Metadata only Development of a new ultrasound scoring system to evaluate glandular inflammation in Sjögren's syndrome: an OMERACT reliability exercise(2022-08-03) İNANÇ, GÜZİDE NEVSUN; Hočevar A., Bruyn G. A. , Terslev L., De Agustin J. J. , MacCarter D., Chrysidis S., Collado P., Dejaco C., Fana V., Filippou G., et al.© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.OBJECTIVE: The aim of this exercise from the OMERACT Ultrasound subgroup on Sjögren\"s syndrome was to develop and assess the reliability of a consensus-based semiquantitative colour Doppler US scoring system for pathologic salivary gland vascularization in patients with primary Sjögren\"s syndrome (pSS). METHODS: Using the Delphi method, a colour Doppler semiquantitative scoring system for vascularization of bilateral parotid and submandibular glands was developed and tested in static images and on patients (9 pSS patients and 9 sonographers). Intra-reader and inter-reader reliability of grading the salivary glands were computed by weighted Cohen and Light\"s kappa analysis, respectively. RESULTS: The consensus-based semiquantitative score was: grade 0, no visible vascular signals; grade 1, focal, dispersed vascular signals; grade 2, diffuse vascular signals detected in 50% of the gland. In static images, the intra- and inter-reader reliability showed excellent kappa values (95% CI) of 0.90 (0.87, 0.93) and 0.80 (0.74, 0.84), respectively, for all four salivary glands together. In patients, the intra- and inter-reader reliability for all four salivary glands together was kappa = 0.84 (0.73, 0.92) and 0.70 (0.64, 0.76), respectively. CONCLUSION: The consensus-based colour Doppler US scoring for the evaluation of salivary gland vascularization in pSS showed a good inter-reader reliability and excellent intra-reader reliability in static images and in patients. The clinical application of the developed scoring system should be tested in clinical settings.Publication Metadata only Post-COVID-19 syndrome in patients with primary Sjogren's syndrome after acute SARS-CoV-2 infection(2021-01-01) İNANÇ, GÜZİDE NEVSUN; Brito-Zeron P., Acar-Denizli N., Romao V. C., Armagan B., Seror R., Carubbi F., Melchor S., Priori R., Valim V., Retamozo S., et al.Objective. To analyse the frequency and characteristics of post-COVID-19 syndrome in patients with primary Sjogren\"s syndrome (pSS) affected by acute SARS-CoV-2 infection.Publication Metadata only Validity of the novel omeract ultrasound scoring system for salivary glands target lesions in sjogren's syndrome(2022-12-01) ÇİMŞİT, NURİ ÇAGATAY; İNANÇ, GÜZİDE NEVSUN; ÇİMŞİT, CANAN; İNANÇ G. N., Jousse-Joulin S., Abacar K. Y., ÇİMŞİT C., ÇİMŞİT N. Ç., D'Agostino M., Naredo E., Hocevar A., Finzel S., Terslev L., et al.