Person: BOZKURT, SÜHEYLA
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BOZKURT
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SÜHEYLA
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Publication Open Access Mesenchymal stem cells differentiate to retinal ganglion-like cells in rat glaucoma model induced by polystyrene microspheres(2023-10-01) ERASLAN, MUHSİN; ÇERMAN, EREN; BOZKURT, SÜHEYLA; AKKOÇ, TUNÇ; ERASLAN M., ÇERMAN E., BOZKURT S., Genç D., Virlan A. T., Demir C. S., Akkoç T., Karaöz E., AKKOÇ T.Aim: The study aimed to evaluate the differentiation ability of intravitreally injected rat bone marrow-derived mesenchymal stem cells (rBM-MSCs) to retinal ganglion-like cells in a polystyrene microsphere induced rat glaucoma model. Materials and Methods: The glaucoma rat model was generated via intracameral injection of 7 microliter polystyrene microspheres. Green fluorescence protein-labeled (GFP) rBM-MSCs were transplanted intravitreally at or after induction of ocular hypertension (OHT), depending on the groups. By the end of the fourth week, flat-mount retinal dissection was performed, and labeled against Brn3a, CD90, GFAP, CD11b, Vimentin, and localization of GFP positive rBM-MSCs was used for evaluation through immunofluorescence staining and to count differentiated retinal cells by flow cytometry. From 34 male Wistar albino rats, 56 eyes were investigated. Results: Flow cytometry revealed significantly increased CD90 and Brn3a positive cells in glaucoma induced and with rBM-MSC injected groups compared to control(P = 0.006 and P = 0.003 respectively), sham-operated (P = 0.007 and P < 0.001 respectively), and only rBM-MSCs injected groups (P = 0.002 and P = 0.009 respectively). Immunofluorescence microscopy revealed differentiation of GFP labeled stem cells to various retinal cells, including ganglion-like cells. rBM-MSCs were observable in ganglion cells, inner and outer nuclear retinal layers in rBM-MSCs injected eyes. Conclusion: Intravitreally transplanted rBM-MSCs differentiated into retinal cells, including ganglion-like cells, which successfully created a glaucoma model damaged with polystyrene microspheres. Promisingly, MSCs may have a role in neuro-protection and neuro-regeneration treatment of glaucoma in the future.Publication Open Access Langerhans cell histiocytosis located in the spheno-orbital bone and the pons: Illustrative case(2023-07-01) ÇEKİÇ, EFECAN; KARAGÖZ, AHMET; SAKAR, MUSTAFA; KAÇAR, KADRİYE EBRU; BOZKURT, SÜHEYLA; DAĞÇINAR, ADNAN; ÇEKİÇ E., Karagoz A., SAKAR M., Senay R. E., AKAR K. E., BOZKURT S., DAĞÇINAR A.BACKGROUND This is a case of aggressive Langerhans cell histiocytosis (LCH) with an atypical intracranial location. OBSERVATIONS In this report, the authors present the diagnosis and treatment of a 12-year-old male patient diagnosed with LCH. The patient was admitted to the emergency department with left-sided facial palsy, and a solid lesion with mass effect in the pons was found. A biopsy was performed via suboccipital craniotomy, and the diagnosis was LCH. A chemotherapy regimen was started since the LCH sample was the resistant type. The patient showed improvement in his neurological deficit following treatment. LESSONS This rare localized and aggressive case’s diagnosis process and treatment choices may apply to future cases. https://thejns.org/doi/abs/10.3171/CASE22367.Publication Open Access Mass-forming extramedullary hematopoiesis mimicking Hodgkin's lymphoma(MARMARA UNIV, FAC MEDICINE, 2019-01-31) BOZKURT, SÜHEYLA; Kombak, Faruk Erdem; Uyar Bozkurt, Suheyla; Ozgumus, Toluy; Kaygusuz Atagunduz, IsikExtramedullary hematopoiesis (EMH) refers to the proliferation of hematopoietic precursors outside the bone marrow. EMH often presents as a mass lesion in several areas of the body. In this report, we present a case misdiagnosed and explain the cause of the diagnostic error.Publication Open Access A Case of Acute Myeloid Leukemia (FAB M2) with Inversion 16 Who Presented with Pelvic Myeloid Sarcoma(2014) KOÇ, AHMET; Çakan, Mustafa; Koç, Ahmet; Cerit, Kıvılcım; Bozkurt, Süheyla; Ergelen, Rabia; Vural, IrmakAcute leukemias are the most common childhood cancer in all age groups. Acute myeloid leukemias (AML) constitute about 15-20% of acute leukemias. Fatigability, pallor, fever, and bleeding are the most common presenting symptoms of AML. Hepatosplenomegaly and lymphadenopathy are commonly encountered during physical examination. In rare instances eruptions due to skin involvement and localized tumor masses (myeloid sarcoma) may be found. Myeloid sarcoma is especially seen in AML-M2 subtype. By cytogenetic analysis, in AML-M2 subtype t(8;21) is often seen and it is more probable to find inversion 16 in AML-M4Eos subtype. Herein, we present a 15-year-old girl whose initial symptom was abdominal pain for three days and her pathological sign was a large abdominal mass which was verified by imaging studies and diagnosed as myeloid sarcoma by biopsy. On bone marrow examination, she had diagnosis of AML-M2 and by cytogenetic analysis inversion 16 was positive. She was treated with AML-BFM 2004 protocol and she is being followed up in remission on her ninth month of the maintenance therapy.Publication Open Access De novo myeloid sarcoma as a rare cause of small bowel obstruction: CT findings and histopathologic correlation(2019-12) ASLAN, BÜLENT; Aslan, Bülent; Tüney, Davut; Erçetin, Yiğit; Bozkurt, Süheyla Uyar; Uprak, Tevfik KıvılcımPublication Open Access An Astonishing Extrarenal Wilms Localisation; Spinal Cord(2022-06-01) TOKUÇ, AYŞE GÜLNUR; BOZKURT, SÜHEYLA; KAÇAR, KADRİYE EBRU; EKER, NURŞAH; SAKAR, MUSTAFA; TOKUÇ A. G., EKER N., Tas B. T., BOZKURT S., SAKAR M., Aras S., AKAR K. E.Wilms\" tumour is a renal tumour mostly seen during the first 5 years of life and it accounts for 95% of renal malignancies during childhood. Its origin is primitive metanephric cells and, very rarely, it may occur in places other than the kidneys. The estimated rate of nephroblastoma outside the kidneys is approximately 0.5 to 1% of Wilms\" tumour cases. In this article, we report on a 3-year-old female patient who first presented with spinal dysraphism and a mass in the lumbar spinal cord with a histopathological diagnosis of nephrogenic rest, and after one year, a Wilms tumour arose in this location. This is a very rare extrarenal Wilms\" tumour location. Here, we report on a case with immature renal cells located in the lumber spinal cord associated with spinal dysraphism and the development of Wilms\" tumour there after one year.Publication Open Access CNon-Leukemic Granulocytic Sarcoma Presenting with Multiple Lymphadenopathies(GALENOS YAYINCILIK, 2017-05-11) BOZKURT, SÜHEYLA; Geduk, Ayfer; Demirsoy, Esra T.; Bozkurt, Suheyla U.; Gulbas, Zafer; Isgoren, SerkanPublication Open Access Greater presence of receptors for relaxin in the ligamentum teres of female infants who undergo open reduction for developmental dysplasia of the hip(BMC, 2021-12) BOZKURT, SÜHEYLA; Ayanoglu, Semih; Cabuk, Haluk; Cabuk, Fatmagul Kusku; Beng, Kubilay; Yildirim, Timur; Bozkurt, Suheyla UyarBackground: While many factors involved in the etiology of developmental dysplasia of the hip (DDH), one of which is the hormone relaxin. Relaxin concentrations in patients with DDH may lead to pathodynamic changes during hip development by altering the physiological nature of the ligament, as well as by long-term exposure to relaxin during pregnancy. Our objective in this study was to determine the number of relaxin receptors in the ligamentum teres and their role in causing DDH. Methods: We identified 26 infants between birth and 3 years of age who had undergone open reduction for DDH between 2010 and 2012. 12 hips of 12 miss abortus fetus between 20 to 35 weeks of gestation were used as control group. Specimens obtained from two groups were stained with Relaxin-2 antibody, and the amount of staining for relaxin receptors was determined using an ordinal H score. Results: The mean (SD) H scores of infants with DDH were significantly higher than those of controls: 215 (59) versus 52 (48); P = 0.00; 95% CI. Statistically significant difference between the two groups in terms of gender was not found. Conclusion: As a result, increased number of relaxin receptors in the ligamentum teres could be a risk factor for DDH.Publication Open Access Pilocytic Astrocytoma of the Cerebellopontine Angle with cerebrospinal fluid Spread in an Adult: A Case Report(2022-12-01) KURŞUN, MELTEM; OĞUZSOY, TUBA; BOZKURT, SÜHEYLA; BAYRAKLI, FATİH; BIYIKLI, ERHAN; Bıyıklı E., Kurşun M., Oğuzsoy T., Bozkurt S., Bayraklı F.Introduction Pilocytic astrocytoma of the cerebellopontine angle (CPA) is uncommon, and its spread to the cerebrospinal fluid (CSF) at the time of diagnosis has not been reported in the literature. Case Presentation We report the case of a 33-year-old man with multifocal pilocytic astrocytoma diagnosed by magnetic resonance imaging (MRI) and confirmed by histopathological examination, and present the radiological and histopathological findings. Conclusion In the case herein reported, we observed spread of the pilocytic astrocytoma of the CPA to the CSF at the initial diagnosis, and early detection by MRI is very important regarding the treatment modality and prognosis.Publication Open Access Pediatric primary anaplastic ganglioglioma with malignant neuronal component(2018) BOZKURT, SÜHEYLA; Kaymak-Cihan, Meriç; Erdiş, Eda; Bozkurt, Süheyla; Ünver-Korğalı, Elif