Person: KADİR, TANJU
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KADİR
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TANJU
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Publication Metadata only In vitro effects of clarithromycin on human polymorphonuclear leukocyte functions(KARGER, 2000) KADİR, TANJU; Kadir, T; Izzetin, FV; Cevikbas, A; Johansson, CB; Clark, PBackground: It has been shown that antibacterial agents affect polymorphonuclear leukocytes (PMNs), which are active in the body's first line of defense, in different ways. However, few studies have investigated the effects of tablet dosage forms as opposed to pure powder forms. There is a need to demonstrate the clinical relevance of previous results with commercially available products. Methods: We examined the effects of clarithromycin solutions, prepared separately from either pure powder or commercially available tablets (250 mg), on human PMNs. The in vitro effects of each solution, adjusted to therapeutic concentration (1 mg/l), on PMN adherence, chemotaxis, phagocytosis, candidacidal capacity and superoxide production were studied. Results: Solutions prepared from pure clarithromycin powder did not affect the adherence, phagocytosis or superoxide production of PMNs, but did inhibit (p < 0.05) chemotaxis and candidacidal capacity. By contrast, a decrease (p < 0.05) in all functions except phagocytosis was observed with solutions prepared from the tablet dosage form of clarithromycin. Conclusion: The results of this study suggest that the tablet dosage form of clarithromycin may have a more pronounced inhibitory effect on human PMN functions than solutions prepared from the pure powder form. Copyright (C) 2000 S. Karger AG, Basel.Publication Metadata only Postmenopozal Osteoporözlü ve Kronik Periodontitisli Kadınlarda Periodontal Tedavi ile Birlikte Kullanılan Alendronatın Klinik ve Mikrobiyolojik Bulgular Üzerine Etkisi.(2008-05-22) KURU, LEYLA; KADİR, TANJU; TOPRAKSEVEN R. E., KURU L., NOYAN F. Ü., KURU B., KADİR T.Publication Metadata only COMPARISON OF DIFFERENT TREATMENT METHODS FOR LOCALIZED AND GENERALIZED SIMPLE DENTURE STOMATITIS(BLACKWELL SCIENCE LTD, 1995) KADİR, TANJU; ARIKAN, A; KULAK, Y; KADIR, TThe purpose of this study was to compare the treatment effects of fluconazole, fluconazole plus chlorhexidine and the fitting of new dentures upon the treatment of denture stomatitis and 15 subjects with clinical evidence of localized simple denture stomatitis were investigated clinically and mycologically. Patients with clinical evidence of generalized simple denture stomatitis were divided into three treatment groups. The first group was given 50 mg of fluconazole tablets daily for 2 weeks. The second group were instructed to apply chlorhexidine solution to the inner surface of the denture twice a day in addition to fluconazole treatment for 2 weeks. New dentures were constructed for the third group. Patients with clinical evidence of localized simple denture stomatitis were fitted new dentures without antifungal therapy. Palatal swabs were taken from each subject before, immediately after, and 2 weeks after the end of treatment, and the samples were examined mycologically in order to identify yeast colonies. It was found that for generalized simple denture stomatitis, treatment with fluconazole plus chlorhexidine resulted in better improvement of palatal inflammation than that by either fluconazole or the fitting of new dentures without medication, Whereas fitting new dentures did not reduce inflammation in patients with generalized simple denture stomatitis, the beneficial effects of prosthetic treatment were seen in patients with localized simple denture stomatitis.Publication Metadata only Evaluation of the Effectiveness of Er:YAG Laser and Conventional Periodontal Treatment in a Patient with Acute Streptococcal Gingivitis: A 2-Year Follow-Up(MARY ANN LIEBERT, INC, 2010) KADİR, TANJU; Gursoy-Mert, H.; Altan-Koran, M.; Noyan, U.; Kadir, T.; Cologlu, S.; Yilmaz, S.Objective:The aim of this study was to evaluate the effectiveness of Er:YAG laser and conventional periodontal therapy in the treatment of acute streptococcal gingivitis both clinically and microbiologically. Background Data:This case report describes a 2-year follow-up of a 30-year-old, female, chronic periodontitis patient, presenting severe gingival inflammation, sensitivity, pain, and acute gingival lesions that were treated with Er:YAG laser and conventional hand and ultrasonic instruments. Materials and Methods:Before the initial periodontal treatment, microbiological samples were taken from the lesion sites with sterile paper points from the sulcuses bilaterally, and excisional biopsies were obtained from the lesions. Following diagnostic tests, the lesions were identified as acute streptococcal gingivitis. Following the measurement of clinical indices, initial periodontal therapy was performed with Er:YAG laser on the right side and conventional hand and ultrasonic instruments on the left side, which were performed as two sessions at weekly intervals. As an adjunct to mechanical periodontal therapy, 500 mg amoxicillin was prescribed t.i.d. for a week. Results:Microbiological samples grew mostly Streptococcus sp. and black pigmented obligate anaerobic bacteria. The histopathological examination revealed acanthosis, papillomatosis, and spongiotic lesions in the keratinized stratified squamous epithelium; infiltration of polymorphonuclear neutrophils, lymphocytes, and macrophages and plasma cells in the connective tissue; infiltration and accumulation of polymorphonuclear neutrophils in the epithelium, especially in the spongiotic lesions; and formation of microabscess-like clusters. After the initial periodontal treatment, clinical and microbiological measurements were repeated and reductions in clinical indices and the number of microorganisms were observed. Both treatment modalities gave similar results, and no recurrences were observed during the 2-year follow-up. Conclusion:Er:YAG laser seems to be promising and as effective as conventional periodontal therapy in the treatment of acute streptococcal gingivitis.Publication Metadata only Er:YAG Laser Versus Systemic Metronidazole as an Adjunct to Nonsurgical Periodontal Therapy: A Clinical and Microbiological Study(MARY ANN LIEBERT INC, 2012) KADİR, TANJU; Yilmaz, Selcuk; Kut, Burak; Gursoy, Hare; Eren-Kuru, Bahar; Noyan, Ulku; Kadir, TanjuObjective: The objective of this randomized clinical trial was to describe the clinical and microbiological results obtained by treatment with Er:YAG laser and systemic metronidazole used as adjuncts to mechanical subgingival debridement in chronic periodontitis. Methods: Twenty-seven chronic periodontitis (CP) patients were randomly divided into three parallel groups each comprising nine individuals with at least four teeth having at least one approximal site with a probing depth (PD) of >= 5 mm and gingival index (GI) of >= 2 in each quadrant. Groups of patients received: (1) Scaling and root planing (SRP) + Er:YAG laser (10 hz, 30 mJ/pulse, 1 min per pocket, apico-coronal direction in parallel paths with 30 degree angle tips, under water irrigation), (2) SRP + systemic metronidazole, or (3) SRP alone. In all treatment groups, SRP was performed at 1 week intervals in two sessions. The microbiological and clinical effects of the treatments were evaluated after 90 days. Results: At the end of the experimental period, statistically significant improvements in plaque index, GI, PD and attachment level, as well as reductions in the number of total bacteria and proportions of obligately anaerobic microorganisms were observed within each group. Although intergroup comparisons revealed no significant microbiological differences, clinical parameters as attachment gain and PD reduction were found significantly higher in Group 1 compared with the other groups. Conclusions: Within its limits, this study demonstrated the possibility of better resolution of infection with combined SRP + Er: YAG laser treatment. However, microbiological results failed to demonstrate significant advantages of this combination in comparison with SRP alone or SRP + systemic metronidazole.Publication Metadata only Effect of oral antiseptic agents on phospholipase and proteinase enzymes of Candida albicans(PERGAMON-ELSEVIER SCIENCE LTD, 2016) GÜMRÜ TARÇIN, BİRSAY; Uygun-Can, Banu; Kadir, Tanju; Gumru, BirsayObjective: Candida-associated denture stomatitis is the most prevalent form of oral candida infections among the denture wearers. Generally, antiseptic oral rinses used in the treatment of these infections are considered as an adjunct or alternative antifungal treatment. Studies have suggested that the intraoral concentrations of antiseptics decrease substantially to the sub-therapeutic levels on account of the dynamics of the oral cavity. This condition yields the question about the minimum antiseptic concentration that effect the character or pathogenesis of Candida during treatment. The extracellular phospholipase and proteinase enzymes of Candida albicans are regarded to have a crucial role in the pathogenesis of human fungal infections. Therefore, the aim of this study was to investigate the effect of different sub-therapeutic concentrations of chlorhexidine gluconate, hexetidine and triclosan on the production of these enzymes by C. albicans strains isolated from 20 patients with denture stomatitis. Methods: Phospholipase test was done by using Sabouraud dextrose agar with egg yolk, proteinase test was done by using bovine serum albumin agar. Methods: Phospholipase test was done by using Sabouraud dextrose agar with egg yolk, proteinase test was done by using bovine serum albumin agar. Results: Exoenzyme production of 20 strains which were brief exposured to sub-therapeutic concentrations of three antiseptic agents decreased significantly compared with the strains that were not exposured with antiseptic values (p < 0.05). There was significant difference between the sub therapeutic concentrations of each of three antiseptics (p < 0.05). When the same concentrations of each antiseptic was compared, there were no significant differences between enzymatic activities (p > 0.05). Conclusions: The results of this study show that sub-therapeutic levels of each antiseptic may modulate candidal exoenzyme production, consequently suppressing pathogenicity of C albicans. (C) 2015 Elsevier Ltd. All rights reserved.Publication Metadata only Effectiveness of Photoactivated Disinfection in Experimentally Infected Root Canals(2014-04-24) PEKER, MEHMET SERTAÇ; KADİR, TANJU; GERNİ P. M., UYGUN CAN B., PEKER M. S., KADİR T., GÜNDAY M.Publication Metadata only The antibacterial effects of ornidazole on primary molars with infected pulps(KARGER, 2001) KARGÜL, BETÜL; Kargul, B; Kadir, TThe purpose of this study was to investigate the antibacterial effects of a short-term topical application of ornidazole on anaerobic microorganisms, The antibacterial properties of such materials against organisms at infected primary root canals have not been well documented. Twenty infected primary molars in this study were treated using ornidazole (Biteral, Roche), The bacterial contents of the roots were collected with sterile paper points before the application. Freshly mixed ornidazole and sterile saline were placed into the root canals, After 1 week, the bacterial contents of the root canals were collected again. Microbiological analyses were made, Based on our results, it appears that the antibacterial activity of ornidazole caused significant changes in rates of microorganisms (94.53% reduction), Copyright (C) 2001 S. Karger AG, Basel.Publication Metadata only Candida Albicans’ların Nazoalveoler şekillendirme (NAŞ) aygıtlarına yapışma sıklığı(2014-10-29) YILMAZ, HANİFE NURAY; CAN, BANU; KADİR, TANJU; NEVZATOĞLU Ş., YILMAZ H. N., CAN B., KADİR T.Publication Metadata only The relation of microbiologic data to aspartate aminotransferase enzyme activity in gingival crevicular fluid(1996-01-01) YILMAZ, SEBİHA NİHAL; KADİR, TANJU; Kuru B., Noyan U., YILMAZ S. N., KADİR T., Acar O., Büget E.Gingival crevicular fluid (GCF), reflects the immune and inflammatory reactions and is itself a location for specific host-microbe interactions that lead to periodontal diseases. Aspartate aminotransferase (AST) is one of the components of GCF that is released as a result of cell death. In this study, 40 periodontal sites in 10 early onset periodontitis patients before and after nonsurgical periodontal therapy, with and without local metronidazole administration, were first examined for the AST enzyme levels in GCF and then evaluated for microbiological and clinical variables. In each patient, 4 sites (one site/quadrant) with a probing depth of > or = 5 mm were selected and treated with separate treatment protocols. Certain microbial species including Prevotella intermedia, Porphyromonas gingivalis, and Actinobacillus actinomycetemcomitans(A. a.) were found more often and/or in higher levels in AST active sites (36/40 first measurement--9/36 second measurement), while other species (Streptococcus and Actinomyces) were found more often and/or in higher levels in AST inactive sites (4/40 first measurement--8/36 second measurement). Eight post-treatment AST active sites revealed 1.5 mm of attachment loss, whereas 8 post-treatment AST inactive sites showed 1.37 mm of attachment gain. AST activity and microbiological-clinical data presenting such an agreement suggests that, AST level assessment would be beneficial as an adjunctive method alongside other clinical criteria, in guiding the clinician in periodontal treatment.