Person: OYSU, ÇAĞATAY
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OYSU
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ÇAĞATAY
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Publication Open Access Developing a new model for rhinosinusitis: Animal experiment(2023-09-01) OYSU, ÇAĞATAY; Çaypınar Eser B., Canpolat M. S., Güneş P. G., İrvem ., Zer Toros S., Şahin Yılmaz A., Oysu Ç.Aim: To develop a new model of acute bacterial rhinosinusitis. Method: We divided guinea pigs into four groups in this study. In the primary group of guinea pigs, right nasal cavities of the animals were vaccinated with Streptococcus pneumoniae suspension. In the second group, sponge strips saturated with sterile saline into the right nasal cavities of animals. In the third group, sponge strips saturated with Streptococcus pneumoniae suspension in the right nasal cavities of animals. The fourth group was control group, which was exposed to no intervention. After 7, 14, 28, 35 days from interventions, intranasal cultures were obtained, computed tomography (CT) scans were imaged from all of the guinea pigs, and two randomly selected guinea pigs that were detected as having rhinosinusitis radiologically were killed every week. The sinuses and nasal specimens of sacrificed guinea pigs were prepared for histopathological investigation. Results: Radiological and histopathological examinations of nasal samples were performed to observe the severity of the inflammatory reaction. Acute bacterial rhinosinusitis was induced in all groups of subject animals except the control group. More severe inflammation was seen in the third group of subject animals compared to the first and second groups. No inflammatory reaction was found in the control group. We also evaluated the normal flora of guinea pigs. Conclusion: The guinea pig is certainly a true model for developing rhinosinusitis. Guinea pigs should be considered as an alternative model for further potential studies of genetics and inflammation, even though surgical manipulation is limited.Publication Metadata only Dynamic contrast-enhanced MRI in the differentiation of posttreatment fibrosis from recurrent carcinoma of the head and neck(ELSEVIER SCIENCE INC, 2005) OYSU, ÇAĞATAY; Oysu, AS; Ayanoglu, E; Kodalli, N; Oysu, C; Uneri, C; Erzen, CObjective: The aim of this study was to investigate the value of dynamic contrast-enhanced magnetic resonance imaging (MRI) in the differentiation of posttreatment fibrosis from recurrent carcinoma, by comparing the dynamic contrast-enhancement characteristics of the lesions. Materials and methods: Twenty-six patients with previously treated carcinoma of the head and neck are studied by conventional and dynamic contrast-enhanced MRI at least 6 months after treatment by radiotherapy and/or surgery. Patients are divided into tumor-positive or -negative groups according to the radiological and clinical follow-up and biopsy. Lesion enhancement ratios at each dynamic sequence are calculated. Results: The tumor-positive group consisted of 11 patients, while the tumor-negative group included 15 patients. Between the two groups, lesion enhancement ratios are found to be significantly different (P<.05). Conclusion: Dynamic contrast-enhanced MRI may be a valuable modality in the differentiation of recurrent tumor from posttreatment fibrotic changes of the head and neck. (c) 2005 Elsevier Inc. All rights reserved.Publication Metadata only Correlation of Histopathological Findings in Laryngeal Squamous Cell Carcinoma with Inflammatory Biomarkers(DEOMED PUBL, ISTANBUL, 2019) OYSU, ÇAĞATAY; Deveci, Ildem; Surmeli, Mehmet; Onder, Serap; Karabulut, Burak; Deveci, Hande Senem; Oysu, CagatayObjective: The goal of this research was to investigate how biomarkers, i.e. SII (an index calculated from blood counts of various leucocytes), NLR and MLR correlate with features used in the staging of laryngeal squamous cell carcinoma (LSCC), i.e. perineural infiltration, lymphatic involvement and histological grade. Methods: A retrospective review of clinical records from 146 cases (143 men and 3 women) of LSCC occurring between January 2008 and January 2018 was undertaken. The sample included every stage of LSCC and all biomarker results were found from the full blood count (FBC) results obtained prior to surgery and documented for each case. SII is a newly introduced index of inflammation calculated according to the formula: SII = NxP/L, where N represents neutrophil, P platelet and L lymphocyte counts. Histopathological parameters (presence of perineural or lymphatic involvement, grade of tumour) were evaluated alongside results for NLR, MLR and SII. Results: All three biomarkers were different at the level of statistical significance between individuals with LSCC and the controls. For NLR, p=0.003; for MLR, p=0.008; for SII, p<0.001. Both NLR and SII were different at a statistically significant level when compared at early and advanced stages of LSCC (p values were 0.011 and <0.001, respectively. MLR did not differ at the level of statistical significance (p=0.944). (See Table 3). Conclusion: SII is straightforward to calculate, economical and reproducible from FBC results. It can provide important clues to the likelihood of perineural or lymphatic involvement in cases of LSCC.Publication Metadata only Burun ameliyatı olmuş hastada komplikasyon değerlendirilmesi(2023-04-01) OYSU, ÇAĞATAY; KUCUR, CÜNEYT; Oysu Ç., Kucur C.Publication Open Access Accuracy of Frozen Section Examination in Oral Cavity Cancers(SAGE PUBLICATIONS INC, 2020-11-06) OYSU, ÇAĞATAY; Demir, Berat; Incaz, Sefa; Uckuyulu, Esin Irem; Oysu, CagatayPurpose: This study aimed to compare the intraoperative frozen section with the surgical margin in the postoperative surgical margins of the postoperative pathology of oral squamous cell carcinomas in order to examine the reliability of the frozen section. Methods: A retrospective analysis was conducted for patients who underwent surgery for oral squamous cell carcinoma in a tertiary hospital between January 2018 and 2019. The intraoperative frozen section examinations, grade of the tumor, number of lymph nodes, number of affected lymph nodes, depth of invasion, perineural invasion, lymphovascular invasion, and extranodal extension were recorded from the pathological records. The concordance between the frozen section examination and postoperative pathology 2 methods was examined using the Cronbach alpha coefficient. Sensitivity, specificity, positive predictive value, negative predictive value regarding surgical margins, and accuracy were calculated and reported. Results: Overall, 181patients who underwent surgery for oral cavity cancers were included; 118 (65.2%) were males. The mean (+/- standard deviation) age of the included participants was 57.4 +/- 16.1 years. The most common tumour subsite was the tongue (n = 71, 39.2%). There was concordancy between the frozen, positive intraoperative malignancy and the postoperative pathology malignancy. The frozen, negative intraoperative malignancy and postoperative safe surgical margin did not significantly differ. Conclusion: As a result of intraoperative frozen examination, we found conformity between the postoperative pathology results of patients with positive and negative surgical margins. Frozen section examination could be used safely to examine intraoperative surgical margins of oral squamous cell carcinoma.Publication Open Access Thyroid Surgery and Inadvertent Removal of Parathyroids(SPRINGER INDIA, 2021-06-01) YUMUŞAKHUYLU, ALİ CEMAL; Asya, Orhan; Yumusakhuylu, Ali Cemal; Gundogdu, Yavuz; Incaz, Sefa; Oysu, CagatayThis study aimed to determine the incidence of inadvertent parathyroid removal during thyroid surgery and define its associated risk factors. In this single-center record-based study, we retrospectively analyzed the clinical and pathological records of 462 patients undergoing thyroidectomy. Incidental parathyroidectomy was detected in 61 of 462 patients (13.2%). The incidence of inadvertent parathyroid removal was 17.6% (36 of 205 patients) in patients having malign thyroid diseases, compared with 9.7% (25 of 257 patients) in patients with benign thyroid diseases (p = 0.045). Incidentally removed parathyroid tissue was intrathyroidal in 8 of the 61 patients. Thus, the ratio of intrathyroidal parathyroid tissue among all patients was 1.7% (8 out of 462). Central neck dissection was carried out in 40 patients (8.7%). Fourteen of these 40 patients (35%) had an incidental parathyroid in their specimen compared with 47 of 422 patients (11.1%) who did not undergo central neck dissection (p<0.001). Incidental parathyroidectomy occurred in 13.2% of patients undergoing thyroidectomy in our study. The majority of patients had one parathyroid identified in their specimen. Central neck dissection was significantly predictive for incidental parathyroidectomy. Well-trained senior otolaryngology residents can safely perform thyroid surgery with similar rates of incidental parathyroidectomy as their masters.Publication Metadata only Diagnostic Features and Risk Factors for Childhood Thyroid Cancers(2022-09-01) ŞAHİN, PINAR; GÜRPINAR TOSUN, BUŞRA; YUMUŞAKHUYLU, ALİ CEMAL; GÜRAN, TÜLAY; HALİLOĞLU, BELMA; OYSU, ÇAĞATAY; DEMİRCİOĞLU, SERAP; BEREKET, ABDULLAH; ŞAHİN P., GÜRPINAR TOSUN B., YUMUŞAKHUYLU A. C. , GÜRAN T., Helvacioglu D., Abali Z. Y. , HALİLOĞLU B., OYSU Ç., BEREKET A., DEMİRCİOĞLU S.Publication Open Access Comparison of Voice Quality and Cost Effectiveness of Endoscopic Cordectomy Using Microdissection Electrodes with Laser Cordectomy and Radiotherapy(GALENOS YAYINCILIK, 2019-05-10) OYSU, ÇAĞATAY; Surmeli, Mehmet; Oysu, Cagatay; Yilmaz, Ayse Asli Sahin; Deveci, Ildem; Karabulut, Burak; Sunter, Ahmet Volkan; Yigit, Ozgur; Bicakci, Beyhan CeylanerObjective: To compare the acoustic parameters and the cost effectiveness achieved after endoscopic cordectomy using radiofrequency microdissection electrodes (ECRM) with those of transoral laser cordectomy and radiotherapy. Methods: The study included 81 disease-free patients previously treated for early larynx carcinoma (30 with ECRM, 27 with transoral laser cordectomy, 24 with primary radiotherapy). Post-treatment voice analysis was performed in all patients. Additionally, the cost effectiveness of all treatment procedures was calculated. Results: The GRBAS (G: Grade, R: Roughness, B: Breathiness, A: Asthenia, and S: Strain) scale showed a significant difference between the groups (p<0.001). The mean values for perceptive assessment score in the radiotherapy group were significantly lower than those in the ECRM group (p<0.05). There were no significant differences between the ECRM group and the transoral laser cordectomy group in terms of the perceptive assessment scores (p>0.05 for all). Percent jitter, percent shimmer and fundamental frequency (F0) were significantly different in the radiotherapy group than the ECRM and the transoral laser cordectomy groups (p<0.05). Maximum phonation time (MPT) in the radiotherapy group was significantly longer than the ECRM and transoral laser cordectomy groups (p<0.001). There were no significant differences between the ECRM group and the transoral laser cordectomy group in terms of the MPT (p>0.05). The mean cost of the ECRM technique was statistically lower than the other treatment techniques (p<0.05). Moreover, the length of hospital stay after ECRM was statistically significantly shorter than was after laser cordectomy (p<0.05). Conclusion: Objective and perceptive voice analysis after ECRM showed comparable results with transoral laser cordectomy, but poorer results than radiotherapy. Cost effectiveness of ECRM was found to be better than the other two treatment techniques.Publication Open Access Relationship of PPARG overexpression with prognostic parameters in papillary thyroid carcinoma(2022-02-01) ASYA, ORHAN; YUMUŞAKHUYLU, ALİ CEMAL; BAĞCI ÇULÇİ, PELİN; ŞAHİN, AKIN; OYSU, ÇAĞATAY; KAYA, HANDAN; ASYA O., YUMUŞAKHUYLU A. C., BAĞCI ÇULÇİ P., KAYA H., Gonen A., Gundogdu Y., Muradov T., ŞAHİN A., OYSU Ç.Objectives. PAX8/PPARG chromosomal rearrangement is frequently seen in thyroid cancer, and PPARG overexpression has been shown in the follicular variant of papillary thyroid carcinoma, but not in papillary thyroid carcinoma other than the follicular variant. The main aim of this study was to investigate the frequency of PPARG overexpression among papillary thyroid carcinoma and if there were any variants of papillary thyroid carcinoma with PPARG overexpression other than the follicular variant. Methods. Immunohistochemical analysis of PPARG overexpression was performed using a PPARG monoclonal antibody in a series of 111 paraffin-embedded blocks of thyroid tumours. Of the patients in our study, 100 were diagnosed with papillary thyroid carcinoma, 9 with follicular adenoma and 2 with follicular carcinoma. Results. PPARG staining was detected in 19 of the 111 cases. Sixteen patients with PPARG overexpression had papillary thyroid carcinoma and 3 had follicular adenoma. Conclusion. PPARG overexpression was detected mainly in follicular-variant papillary thyroid carcinoma. Vascular invasion, lymphatic invasion, thyroid capsule invasion and lymph node positivity were lower in patients with PPARG overexpression.Publication Open Access Evaluation of balance using cervical vestibular evoked myogenic potentials in blind individuals(2022-01-01) OYSU, ÇAĞATAY; DUYMAZ Y. K. , ŞAHİN YILMAZ A. A. , Sürmeli M., İldem D., SÜRMELİ R., KIRAY G., Doğan R., OYSU Ç.Objective: Our purpose in this study is to investigate whether blindness affects vestibulocollic reflex. Material and Methods: This is a prospective case control series. We recorded cervical vestibular evoked myogenic potential in 29 blind and 26 sighted subjects, and compared the latency and amplitude values. Results: Twenty one of the blind subjects were male and 8 were female, the average of age was 41.72±11.83 years. Nineteen of the sighted subjects were male and 7 were female, the average of age was 40.64±9.11 years. The average P13 latency value was 16.97±2.12 ms in the blind group and 15.40±0.88 ms in the sighted group. The average P13 latency value was longer in the blind group (p<0.005). In the blind subjects, the average N23 latency was 24.92±2.77 ms. In the sighted subjects, the average N23 latency was 23.73±0.85 ms. The average N23 latency value was longer in the blind group (p<0.005). The mean P13-N23 interpeak amplitude was 2.76±2.92 µV in the blind group. In the sighted group, it was 2.38±0.33 µV. There were not statistically significant differences between the mean P13-N23 interpeak amplitudes (p>0.005). Conclusion: We determined that the P13 latency values and N23 latency values were longer in the blind group. Our study has shown that cervical vestibular evoked myogenic potential responses in the blind individuals are different from the sighted individuals.
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